4us8 - Revision history

OCA at 10:35, 10 January 2024

2024-01-10T10:35:15Z

←Older revision		Revision as of 10:35, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4us8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Megalodesulfovibrio_gigas Megalodesulfovibrio gigas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4US8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4US8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4us8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Megalodesulfovibrio_gigas Megalodesulfovibrio gigas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4US8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4US8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PCD:(MOLYBDOPTERIN-CYTOSINE+DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V)'>PCD</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.49Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PCD:(MOLYBDOPTERIN-CYTOSINE+DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V)'>PCD</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4us8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4us8 OCA], [https://pdbe.org/4us8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4us8 RCSB], [https://www.ebi.ac.uk/pdbsum/4us8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4us8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4us8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4us8 OCA], [https://pdbe.org/4us8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4us8 RCSB], [https://www.ebi.ac.uk/pdbsum/4us8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4us8 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:35, 29 March 2023

2023-03-29T07:35:23Z

←Older revision		Revision as of 07:35, 29 March 2023
Line 3:		Line 3:
	<StructureSection load='4us8' size='340' side='right'caption='[[4us8]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='4us8' size='340' side='right'caption='[[4us8]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4us8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Desulfovibrio_gigas Desulfovibrio~~ gigas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4US8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4US8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4us8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Megalodesulfovibrio_gigas Megalodesulfovibrio gigas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4US8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4US8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PCD:(MOLYBDOPTERIN-CYTOSINE+DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V)'>PCD</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PCD:(MOLYBDOPTERIN-CYTOSINE+DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V)'>PCD</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4us8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4us8 OCA], [https://pdbe.org/4us8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4us8 RCSB], [https://www.ebi.ac.uk/pdbsum/4us8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4us8 ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4us9\|4us9]], [[4usa\|4usa]]</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(FAD-independent) Aldehyde dehydrogenase (FAD-independent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.99.7 1.2.99.7] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4us8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4us8 OCA], [~~http~~://pdbe.org/4us8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4us8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4us8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4us8 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MOP_MEGGA MOP_MEGGA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Desulfovibrio gigas]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Correia, H D~~]]	+	[[Category: Megalodesulfovibrio gigas]]
-	[[Category: ~~Romao, M J~~]]	+	[[Category: Correia HD]]
-	[[Category: ~~Santos-Silva, T~~]]	+	[[Category: Romao MJ]]
-	[[Category: ~~Aldehyde]]~~	+	[[Category: Santos-Silva T]]
-	~~[[Category: Oxidation]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Pi stacking~~]]	+

OCA at 08:22, 4 November 2020

2020-11-04T08:22:05Z

←Older revision		Revision as of 08:22, 4 November 2020
Line 1:		Line 1:

	==Aldehyde Oxidoreductase from Desulfovibrio gigas (MOP), soaked with benzaldehyde==		==Aldehyde Oxidoreductase from Desulfovibrio gigas (MOP), soaked with benzaldehyde==
-	<StructureSection load='4us8' size='340' side='right' caption='[[4us8]], [[Resolution\|resolution]] 1.49Å' scene=''>	+	<StructureSection load='4us8' size='340' side='right'caption='[[4us8]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4us8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_gigas Desulfovibrio gigas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4US8 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4US8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4us8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_gigas Desulfovibrio gigas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4US8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4US8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PCD:(MOLYBDOPTERIN-CYTOSINE+DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V)'>PCD</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PCD:(MOLYBDOPTERIN-CYTOSINE+DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V)'>PCD</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4us9\|4us9]], [[4usa\|4usa]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4us9\|4us9]], [[4usa\|4usa]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(FAD-independent) Aldehyde dehydrogenase (FAD-independent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.99.7 1.2.99.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(FAD-independent) Aldehyde dehydrogenase (FAD-independent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.99.7 1.2.99.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4us8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4us8 OCA], [http://pdbe.org/4us8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4us8 RCSB], [http://www.ebi.ac.uk/pdbsum/4us8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4us8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4us8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4us8 OCA], [http://pdbe.org/4us8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4us8 RCSB], [http://www.ebi.ac.uk/pdbsum/4us8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4us8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Desulfovibrio gigas]]		[[Category: Desulfovibrio gigas]]
		+	[[Category: Large Structures]]
	[[Category: Correia, H D]]		[[Category: Correia, H D]]
	[[Category: Romao, M J]]		[[Category: Romao, M J]]

OCA at 01:11, 19 January 2017

2017-01-19T01:11:02Z

←Older revision		Revision as of 01:11, 19 January 2017
Line 1:		Line 1:
		+
	==Aldehyde Oxidoreductase from Desulfovibrio gigas (MOP), soaked with benzaldehyde==		==Aldehyde Oxidoreductase from Desulfovibrio gigas (MOP), soaked with benzaldehyde==
	<StructureSection load='4us8' size='340' side='right' caption='[[4us8]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='4us8' size='340' side='right' caption='[[4us8]], [[Resolution\|resolution]] 1.49Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4us9\|4us9]], [[4usa\|4usa]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4us9\|4us9]], [[4usa\|4usa]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(FAD-independent) Aldehyde dehydrogenase (FAD-independent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.99.7 1.2.99.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(FAD-independent) Aldehyde dehydrogenase (FAD-independent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.99.7 1.2.99.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4us8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4us8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4us8 RCSB], [http://www.ebi.ac.uk/pdbsum/4us8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4us8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4us8 OCA], [http://pdbe.org/4us8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4us8 RCSB], [http://www.ebi.ac.uk/pdbsum/4us8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4us8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4us8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:06, 20 January 2015

2015-01-20T11:06:26Z

←Older revision		Revision as of 11:06, 20 January 2015
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Desulfovibrio gigas]]		[[Category: Desulfovibrio gigas]]
-	[[Category: Correia, H D.]]	+	[[Category: Correia, H D]]
-	[[Category: Romao, M J.]]	+	[[Category: Romao, M J]]
-	[[Category: Santos-Silva, T.]]	+	[[Category: Santos-Silva, T]]
	[[Category: Aldehyde]]		[[Category: Aldehyde]]
	[[Category: Oxidation]]		[[Category: Oxidation]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Pi stacking]]		[[Category: Pi stacking]]

OCA at 07:37, 8 October 2014

2014-10-08T07:37:31Z

←Older revision		Revision as of 07:37, 8 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Aldehyde Oxidoreductase from Desulfovibrio gigas (MOP), soaked with benzaldehyde==
		+	<StructureSection load='4us8' size='340' side='right' caption='[[4us8]], [[Resolution\|resolution]] 1.49Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4us8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_gigas Desulfovibrio gigas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4US8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4US8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PCD:(MOLYBDOPTERIN-CYTOSINE+DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V)'>PCD</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4us9\|4us9]], [[4usa\|4usa]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(FAD-independent) Aldehyde dehydrogenase (FAD-independent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.99.7 1.2.99.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4us8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4us8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4us8 RCSB], [http://www.ebi.ac.uk/pdbsum/4us8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Desulfovibrio gigas aldehyde oxidoreductase (DgAOR) is a mononuclear molybdenum-containing enzyme from the xanthine oxidase (XO) family, a group of enzymes capable of catalyzing the oxidative hydroxylation of aldehydes and heterocyclic compounds. The kinetic studies reported in this work showed that DgAOR catalyzes the oxidative hydroxylation of aromatic aldehydes, but not heterocyclic compounds. NMR spectroscopy studies using 13C-labeled benzaldehyde confirmed that DgAOR catalyzes the conversion of aldehydes to the respective carboxylic acids. Steady-state kinetics in solution showed that high concentrations of the aromatic aldehydes produce substrate inhibition and in the case of 3-phenyl propionaldehyde a suicide substrate behavior. Hydroxyl-substituted aromatic aldehydes present none of these behaviors but the kinetic parameters are largely affected by the position of the OH group. High-resolution crystallographic structures obtained from single crystals of active-DgAOR soaked with benzaldehyde showed that the side chains of Phe425 and Tyr535 are important for the stabilization of the substrate in the active site. On the other hand, the X-ray data of DgAOR soaked with trans-cinnamaldehyde showed a cinnamic acid molecule in the substrate channel. The X-ray data of DgAOR soaked with 3-phenyl propionaldehyde showed clearly how high substrate concentrations inactivate the enzyme by binding covalently at the surface of the enzyme and blocking the substrate channel. The different reactivity of DgAOR versus aldehyde oxidase and XO towards aromatic aldehydes and N-heterocyclic compounds is explained on the basis of the present kinetic and structural data.

-	~~The entry 4us8 is ON HOLD until Paper Publication~~	+	Aromatic aldehydes at the active site of aldehyde oxidoreductase from Desulfovibrio gigas: reactivity and molecular details of the enzyme-substrate and enzyme-product interaction.,Correia HD, Marangon J, Brondino CD, Moura JJ, Romao MJ, Gonzalez PJ, Santos-Silva T J Biol Inorg Chem. 2014 Sep 27. PMID:25261288<ref>PMID:25261288</ref>

-	~~Authors~~: Correia, H.D., Romao, M.J., Santos-Silva, T.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: Aldehyde Oxidoreductase ~~from Desulfovibrio gigas (MOP), soaked with benzaldehyde~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Desulfovibrio gigas]]
		+	[[Category: Correia, H D.]]
		+	[[Category: Romao, M J.]]
		+	[[Category: Santos-Silva, T.]]
		+	[[Category: Aldehyde]]
		+	[[Category: Oxidation]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Pi stacking]]

OCA: Protected "4us8" [edit=sysop:move=sysop]

2014-07-16T10:00:42Z

Protected "4us8" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:00, 16 July 2014

OCA: New page: '''Unreleased structure''' The entry 4us8 is ON HOLD until Paper Publication Authors: Correia, H.D., Romao, M.J., Santos-Silva, T. Description: Aldehyde Oxidoreductase from Desulfovibr...

2014-07-16T10:00:41Z

New page: '''Unreleased structure''' The entry 4us8 is ON HOLD until Paper Publication Authors: Correia, H.D., Romao, M.J., Santos-Silva, T. Description: Aldehyde Oxidoreductase from Desulfovibr...

New page

'''Unreleased structure'''

The entry 4us8 is ON HOLD until Paper Publication

Authors: Correia, H.D., Romao, M.J., Santos-Silva, T.

Description: Aldehyde Oxidoreductase from Desulfovibrio gigas (MOP), soaked with benzaldehyde