4ux5 - Revision history

OCA at 11:24, 9 May 2024

2024-05-09T11:24:12Z

←Older revision		Revision as of 11:24, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ux5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans] and [https://en.wikipedia.org/wiki/Pyricularia_oryzae Pyricularia oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UX5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ux5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans] and [https://en.wikipedia.org/wiki/Pyricularia_oryzae Pyricularia oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UX5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ux5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux5 OCA], [https://pdbe.org/4ux5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ux5 RCSB], [https://www.ebi.ac.uk/pdbsum/4ux5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ux5 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ux5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux5 OCA], [https://pdbe.org/4ux5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ux5 RCSB], [https://www.ebi.ac.uk/pdbsum/4ux5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ux5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:48, 29 March 2023

2023-03-29T07:48:41Z

←Older revision		Revision as of 07:48, 29 March 2023
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	<StructureSection load='4ux5' size='340' side='right'caption='[[4ux5]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4ux5' size='340' side='right'caption='[[4ux5]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ux5]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Magnaporthe_oryzae Magnaporthe~~ oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UX5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ux5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans] and [https://en.wikipedia.org/wiki/Pyricularia_oryzae Pyricularia oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UX5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ux5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux5 OCA], [~~http~~://pdbe.org/4ux5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ux5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ux5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ux5 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ux5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux5 OCA], [https://pdbe.org/4ux5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ux5 RCSB], [https://www.ebi.ac.uk/pdbsum/4ux5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ux5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/L7I1M8_MAGOY L7I1M8_MAGOY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Candida albicans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Magnaporthe~~ oryzae]]	+	[[Category: Pyricularia oryzae]]
-	[[Category: Huang, J]]	+	[[Category: Huang J]]
-	[[Category: Liu, H]]	+	[[Category: Liu H]]
-	[[Category: Liu, J]]	+	[[Category: Liu J]]
-	[[Category: Peng, Y]]	+	[[Category: Peng Y]]
-	[[Category: Taylor~~, I A~~]]	+	[[Category: Taylor IA]]
-	[[Category: Wang, D]]	+	[[Category: Wang D]]
-	[[Category: Yang, J]]	+	[[Category: Yang J]]
-	[[Category: Zhao, W]]	+	[[Category: Zhao W]]
-	[[Category: Zhao, Y]]	+	[[Category: Zhao Y]]
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription factor]]~~	+
-	~~[[Category: Virulence gene~~]]	+

OCA at 08:37, 23 May 2019

2019-05-23T08:37:06Z

←Older revision		Revision as of 08:37, 23 May 2019
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	==Structure of DNA complex of PCG2==		==Structure of DNA complex of PCG2==
-	<StructureSection load='4ux5' size='340' side='right' caption='[[4ux5]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4ux5' size='340' side='right'caption='[[4ux5]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ux5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Magnaporthe_oryzae Magnaporthe oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UX5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ux5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Magnaporthe_oryzae Magnaporthe oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UX5 FirstGlance]. <br>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Magnaporthe oryzae]]		[[Category: Magnaporthe oryzae]]
	[[Category: Huang, J]]		[[Category: Huang, J]]

OCA at 20:01, 11 August 2016

2016-08-11T20:01:02Z

←Older revision		Revision as of 20:01, 11 August 2016
Line 1:		Line 1:
		+
	==Structure of DNA complex of PCG2==		==Structure of DNA complex of PCG2==
	<StructureSection load='4ux5' size='340' side='right' caption='[[4ux5]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4ux5' size='340' side='right' caption='[[4ux5]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ux5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Magnaporthe_oryzae Magnaporthe oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UX5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ux5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Magnaporthe_oryzae Magnaporthe oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UX5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ux5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ux5 RCSB], [http://www.ebi.ac.uk/pdbsum/4ux5 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ux5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux5 OCA], [http://pdbe.org/4ux5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ux5 RCSB], [http://www.ebi.ac.uk/pdbsum/4ux5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ux5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ux5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:27, 14 January 2015

2015-01-14T13:27:58Z

←Older revision		Revision as of 13:27, 14 January 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structure of DNA complex of PCG2==
		+	<StructureSection load='4ux5' size='340' side='right' caption='[[4ux5]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ux5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Magnaporthe_oryzae Magnaporthe oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UX5 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ux5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ux5 RCSB], [http://www.ebi.ac.uk/pdbsum/4ux5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The MBP1 family proteins are the DNA binding subunits of MBF cell-cycle transcription factor complexes and contain an N terminal winged helix-turn-helix (wHTH) DNA binding domain (DBD). Although the DNA binding mechanism of MBP1 from Saccharomyces cerevisiae has been extensively studied, the structural framework and the DNA binding mode of other MBP1 family proteins remains to be disclosed. Here, we determined the crystal structure of the DBD of PCG2, the Magnaporthe oryzae orthologue of MBP1, bound to MCB-DNA. The structure revealed that the wing, the 20-loop, helix A and helix B in PCG2-DBD are important elements for DNA binding. Unlike previously characterized wHTH proteins, PCG2-DBD utilizes the wing and helix-B to bind the minor groove and the major groove of the MCB-DNA whilst the 20-loop and helix A interact non-specifically with DNA. Notably, two glutamines Q89 and Q82 within the wing were found to recognize the MCB core CGCG sequence through making hydrogen bond interactions. Further in vitro assays confirmed essential roles of Q89 and Q82 in the DNA binding. These data together indicate that the MBP1 homologue PCG2 employs an unusual mode of binding to target DNA and demonstrate the versatility of wHTH domains.

-	~~The entry 4ux5 is ON HOLD until Paper Publication~~	+	Structural basis of DNA recognition by PCG2 reveals a novel DNA binding mode for winged helix-turn-helix domains.,Liu J, Huang J, Zhao Y, Liu H, Wang D, Yang J, Zhao W, Taylor IA, Peng YL Nucleic Acids Res. 2014 Dec 29. pii: gku1351. PMID:25550425<ref>PMID:25550425</ref>

-	~~Authors: Liu~~, J., Huang, J~~., Zhao, Y.,~~ Liu, H~~., Wang, D., Yang, J., Zhao, W., Taylor, I.A., Peng, Y.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Structure of DNA complex of PCG2~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: ~~Taylor~~, ~~I.A~~]]	+	__TOC__
-	[[Category: ~~Zhao~~, W]]	+	</StructureSection>
		+	[[Category: Magnaporthe oryzae]]
		+	[[Category: Huang, J]]
		+	[[Category: Liu, H]]
		+	[[Category: Liu, J]]
		+	[[Category: Peng, Y]]
		+	[[Category: Taylor, I A]]
	[[Category: Wang, D]]		[[Category: Wang, D]]
	[[Category: Yang, J]]		[[Category: Yang, J]]
-	[[Category: ~~Liu~~, ~~H]]~~	+	[[Category: Zhao, W]]
-	~~[[Category: Huang, J]]~~	+
-	~~[[Category: Liu, J~~]]	+
	[[Category: Zhao, Y]]		[[Category: Zhao, Y]]
-	[[Category: ~~Peng, Y~~]]	+	[[Category: Transcription]]
		+	[[Category: Transcription factor]]
		+	[[Category: Virulence gene]]

OCA at 18:50, 24 December 2014

2014-12-24T18:50:03Z

←Older revision		Revision as of 18:50, 24 December 2014
Line 6:		Line 6:

	Description: Structure of DNA complex of PCG2		Description: Structure of DNA complex of PCG2
		+	[[Category: Unreleased Structures]]
		+	[[Category: Taylor, I.A]]
		+	[[Category: Zhao, W]]
		+	[[Category: Wang, D]]
		+	[[Category: Yang, J]]
		+	[[Category: Liu, H]]
		+	[[Category: Huang, J]]
		+	[[Category: Liu, J]]
		+	[[Category: Zhao, Y]]
		+	[[Category: Peng, Y]]

OCA: Protected "4ux5" [edit=sysop:move=sysop]

2014-08-27T07:25:31Z

Protected "4ux5" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:25, 27 August 2014

OCA: New page: '''Unreleased structure''' The entry 4ux5 is ON HOLD until Paper Publication Authors: Liu, J., Huang, J., Zhao, Y., Liu, H., Wang, D., Yang, J., Zhao, W., Taylor, I.A., Peng, Y. Descri...

2014-08-27T07:25:30Z

New page: '''Unreleased structure''' The entry 4ux5 is ON HOLD until Paper Publication Authors: Liu, J., Huang, J., Zhao, Y., Liu, H., Wang, D., Yang, J., Zhao, W., Taylor, I.A., Peng, Y. Descri...

New page

'''Unreleased structure'''

The entry 4ux5 is ON HOLD until Paper Publication

Authors: Liu, J., Huang, J., Zhao, Y., Liu, H., Wang, D., Yang, J., Zhao, W., Taylor, I.A., Peng, Y.

Description: Structure of DNA complex of PCG2