4uxs - Revision history

OCA at 11:24, 9 May 2024

2024-05-09T11:24:33Z

←Older revision		Revision as of 11:24, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UXS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UXS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [https://pdbe.org/4uxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [https://www.ebi.ac.uk/pdbsum/4uxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uxs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [https://pdbe.org/4uxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [https://www.ebi.ac.uk/pdbsum/4uxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uxs ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:50, 29 March 2023

2023-03-29T07:50:19Z

←Older revision		Revision as of 07:50, 29 March 2023
Line 3:		Line 3:
	<SX load='4uxs' size='340' side='right' viewer='molstar' caption='[[4uxs]], [[Resolution\|resolution]] 7.00Å' scene=''>		<SX load='4uxs' size='340' side='right' viewer='molstar' caption='[[4uxs]], [[Resolution\|resolution]] 7.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4UXS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UXS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uxo\|4uxo]], [[4uxp\|4uxp]], [[4uxr\|4uxr]], [[4uxt\|4uxt]], [[4uxy\|4uxy]], [[4uy0\|4uy0]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [https://pdbe.org/4uxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [https://www.ebi.ac.uk/pdbsum/4uxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uxs ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [~~http~~://pdbe.org/4uxs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uxs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uxs ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Autosomal dominant nonsyndromic intellectual disability;Hereditary sensory and autonomic neuropathy type 2;Autosomal recessive spastic paraplegia type 30. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21487076</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21820098</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21376300</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Motor for anterograde axonal transport of synaptic vesicle precursors (By similarity). [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain ~~(By similarity)~~.	+	[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</SX>		</SX>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Atherton, J]]	+	[[Category: Atherton J]]
-	[[Category: Farabella, I]]	+	[[Category: Farabella I]]
-	[[Category: Houdusse, A]]	+	[[Category: Houdusse A]]
-	[[Category: Moores, C]]	+	[[Category: Moores C]]
-	[[Category: Rosenfeld~~, S S~~]]	+	[[Category: Rosenfeld SS]]
-	[[Category: Topf, M]]	+	[[Category: Topf M]]
-	[[Category: Yu~~, I M]]~~	+	[[Category: Yu IM]]
-	~~[[Category: Cryo-em]]~~	+
-	~~[[Category: Kinesin]]~~	+
-	~~[[Category: Microtubule]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 19:16, 10 April 2020

2020-04-10T19:16:20Z

←Older revision		Revision as of 19:16, 10 April 2020
Line 3:		Line 3:
	<SX load='4uxs' size='340' side='right' viewer='molstar' caption='[[4uxs]], [[Resolution\|resolution]] 7.00Å' scene=''>		<SX load='4uxs' size='340' side='right' viewer='molstar' caption='[[4uxs]], [[Resolution\|resolution]] 7.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UXS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4UXS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uxo\|4uxo]], [[4uxp\|4uxp]], [[4uxr\|4uxr]], [[4uxt\|4uxt]], [[4uxy\|4uxy]], [[4uy0\|4uy0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uxo\|4uxo]], [[4uxp\|4uxp]], [[4uxr\|4uxr]], [[4uxt\|4uxt]], [[4uxy\|4uxy]], [[4uy0\|4uy0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [http://pdbe.org/4uxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [http://www.ebi.ac.uk/pdbsum/4uxs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uxs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [http://pdbe.org/4uxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [http://www.ebi.ac.uk/pdbsum/4uxs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uxs ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 24:
	==See Also==		==See Also==
	*[[Kinesin 3D Structures\|Kinesin 3D Structures]]		*[[Kinesin 3D Structures\|Kinesin 3D Structures]]
-	*[[Tubulin\|Tubulin]]	+	*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:59, 6 March 2020

2020-03-06T17:59:35Z

←Older revision		Revision as of 17:59, 6 March 2020
Line 1:		Line 1:

	==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==		==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==
-	<~~StructureSection~~ load='4uxs' size='340' side='right'caption='[[4uxs]], [[Resolution\|resolution]] 7.00Å' scene=''>	+	<SX load='4uxs' size='340' side='right' viewer='molstar' caption='[[4uxs]], [[Resolution\|resolution]] 7.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UXS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UXS FirstGlance]. <br>
Line 28:		Line 28:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Human]]		[[Category: Human]]

OCA at 11:00, 26 February 2020

2020-02-26T11:00:51Z

←Older revision		Revision as of 11:00, 26 February 2020
Line 1:		Line 1:

	==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==		==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==
-	<StructureSection load='4uxs' size='340' side='right' caption='[[4uxs]], [[Resolution\|resolution]] 7.00Å' scene=''>	+	<StructureSection load='4uxs' size='340' side='right'caption='[[4uxs]], [[Resolution\|resolution]] 7.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UXS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UXS FirstGlance]. <br>
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4uxs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4uxs" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kinesin 3D Structures\|Kinesin 3D Structures]]
		+	*[[Tubulin\|Tubulin]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 31:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Atherton, J]]		[[Category: Atherton, J]]
	[[Category: Farabella, I]]		[[Category: Farabella, I]]

OCA at 22:43, 15 November 2017

2017-11-15T22:43:50Z

←Older revision		Revision as of 22:43, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='4uxs' size='340' side='right' caption='[[4uxs]], [[Resolution\|resolution]] 7.00Å' scene=''>		<StructureSection load='4uxs' size='340' side='right' caption='[[4uxs]], [[Resolution\|resolution]] 7.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from ~~[http://en.wikipedia.org/wiki/ ],~~ [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UXS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UXS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uxo\|4uxo]], [[4uxp\|4uxp]], [[4uxr\|4uxr]], [[4uxt\|4uxt]], [[4uxy\|4uxy]], [[4uy0\|4uy0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uxo\|4uxo]], [[4uxp\|4uxp]], [[4uxr\|4uxr]], [[4uxt\|4uxt]], [[4uxy\|4uxy]], [[4uy0\|4uy0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [http://pdbe.org/4uxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [http://www.ebi.ac.uk/pdbsum/4uxs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [http://pdbe.org/4uxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [http://www.ebi.ac.uk/pdbsum/4uxs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uxs ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4uxs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4uxs" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Tubulin\|Tubulin]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Atherton, J]]		[[Category: Atherton, J]]
	[[Category: Farabella, I]]		[[Category: Farabella, I]]

OCA at 04:32, 11 May 2016

2016-05-11T04:32:30Z

←Older revision		Revision as of 04:32, 11 May 2016
Line 1:		Line 1:
		+
	==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==		==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==
	<StructureSection load='4uxs' size='340' side='right' caption='[[4uxs]], [[Resolution\|resolution]] 7.00Å' scene=''>		<StructureSection load='4uxs' size='340' side='right' caption='[[4uxs]], [[Resolution\|resolution]] 7.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uxo\|4uxo]], [[4uxp\|4uxp]], [[4uxr\|4uxr]], [[4uxt\|4uxt]], [[4uxy\|4uxy]], [[4uy0\|4uy0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uxo\|4uxo]], [[4uxp\|4uxp]], [[4uxr\|4uxr]], [[4uxt\|4uxt]], [[4uxy\|4uxy]], [[4uy0\|4uy0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [http://www.ebi.ac.uk/pdbsum/4uxs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [http://pdbe.org/4uxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [http://www.ebi.ac.uk/pdbsum/4uxs PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4uxs" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tubulin\|Tubulin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:51, 25 January 2015

2015-01-25T07:51:23Z

←Older revision		Revision as of 07:51, 25 January 2015
Line 25:		Line 25:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Atherton, J.]]	+	[[Category: Atherton, J]]
-	[[Category: Farabella, I.]]	+	[[Category: Farabella, I]]
-	[[Category: Houdusse, A.]]	+	[[Category: Houdusse, A]]
-	[[Category: Moores, C.]]	+	[[Category: Moores, C]]
-	[[Category: Rosenfeld, S S.]]	+	[[Category: Rosenfeld, S S]]
-	[[Category: Topf, M.]]	+	[[Category: Topf, M]]
-	[[Category: Yu, I M.]]	+	[[Category: Yu, I M]]
	[[Category: Cryo-em]]		[[Category: Cryo-em]]
	[[Category: Kinesin]]		[[Category: Kinesin]]
	[[Category: Microtubule]]		[[Category: Microtubule]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 08:20, 22 October 2014

2014-10-22T08:20:01Z

←Older revision		Revision as of 08:20, 22 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UXS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UXS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uxo\|4uxo]], [[4uxp\|4uxp]], [[4uxr\|4uxr]], [[4uxt\|4uxt]], [[4uxy\|4uxy]], [[4uy0\|4uy0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uxo\|4uxo]], [[4uxp\|4uxp]], [[4uxr\|4uxr]], [[4uxt\|4uxt]], [[4uxy\|4uxy]], [[4uy0\|4uy0]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [http://www.ebi.ac.uk/pdbsum/4uxs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [http://www.ebi.ac.uk/pdbsum/4uxs PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Autosomal dominant nonsyndromic intellectual disability;Hereditary sensory and autonomic neuropathy type 2;Autosomal recessive spastic paraplegia type 30. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21487076</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21820098</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21376300</ref>		[[http://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Autosomal dominant nonsyndromic intellectual disability;Hereditary sensory and autonomic neuropathy type 2;Autosomal recessive spastic paraplegia type 30. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21487076</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21820098</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21376300</ref>

OCA at 10:16, 24 September 2014

2014-09-24T10:16:38Z

←Older revision		Revision as of 10:16, 24 September 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==
		+	<StructureSection load='4uxs' size='340' side='right' caption='[[4uxs]], [[Resolution\|resolution]] 7.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UXS FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uxo\|4uxo]], [[4uxp\|4uxp]], [[4uxr\|4uxr]], [[4uxt\|4uxt]], [[4uxy\|4uxy]], [[4uy0\|4uy0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [http://www.ebi.ac.uk/pdbsum/4uxs PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Autosomal dominant nonsyndromic intellectual disability;Hereditary sensory and autonomic neuropathy type 2;Autosomal recessive spastic paraplegia type 30. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21487076</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21820098</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21376300</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Motor for anterograde axonal transport of synaptic vesicle precursors (By similarity). [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Kinesins are a superfamily of microtubule-based ATP-powered motors, important for multiple, essential cellular functions. How microtubule binding stimulates their ATPase and controls force generation is not understood. To address this fundamental question, we visualized microtubule-bound kinesin-1 and kinesin-3 motor domains at multiple steps in their ATPase cycles - including their nucleotide-free states - at ~7A resolution using cryo-electron microscopy. In both motors, microtubule binding promotes ordered conformations of conserved loops that stimulate ADP release, enhance microtubule affinity and prime the catalytic site for ATP binding. ATP binding causes only small shifts of these nucleotide-coordinating loops but induces large conformational changes elsewhere that allow force generation and neck linker docking towards the microtubule plus end. Family-specific differences across the kinesin-microtubule interface account for the distinctive properties of each motor. Our data thus provide evidence for a conserved ATP-driven mechanism for kinesins and reveal the critical mechanistic contribution of the microtubule interface.

-	~~The entry 4uxs is ON HOLD until Paper Publication~~	+	Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins.,Atherton J, Farabella I, Yu IM, Rosenfeld SS, Houdusse A, Topf M, Moores CA Elife. 2014 Sep 10:e03680. doi: 10.7554/eLife.03680. PMID:25209998<ref>PMID:25209998</ref>

-	~~Authors~~: Atherton, J., Farabella, I., ~~Yu, I.M~~., Rosenfeld, S.S.~~, Houdusse, A.,~~ Topf, M., ~~Moores, C~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Conserved mechanisms of microtubule~~-~~stimulated ADP release, ATP binding, and force generation in transport kinesins~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bos taurus]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Atherton, J.]]
		+	[[Category: Farabella, I.]]
		+	[[Category: Houdusse, A.]]
		+	[[Category: Moores, C.]]
		+	[[Category: Rosenfeld, S S.]]
		+	[[Category: Topf, M.]]
		+	[[Category: Yu, I M.]]
		+	[[Category: Cryo-em]]
		+	[[Category: Kinesin]]
		+	[[Category: Microtubule]]
		+	[[Category: Transport protein]]