4v24 - Revision history

OCA at 10:39, 10 January 2024

2024-01-10T10:39:18Z

←Older revision		Revision as of 10:39, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4v24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V24 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4v24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V24 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GYR:{(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL'>GYR</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GYR:{(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL'>GYR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v24 OCA], [https://pdbe.org/4v24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v24 RCSB], [https://www.ebi.ac.uk/pdbsum/4v24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v24 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v24 OCA], [https://pdbe.org/4v24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v24 RCSB], [https://www.ebi.ac.uk/pdbsum/4v24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v24 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:59, 29 March 2023

2023-03-29T07:59:01Z

←Older revision		Revision as of 07:59, 29 March 2023
Line 3:		Line 3:
	<StructureSection load='4v24' size='340' side='right'caption='[[4v24]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4v24' size='340' side='right'caption='[[4v24]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4v24]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V24 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4V24 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4v24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V24 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GYR:{(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL'>GYR</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GYR:{(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL'>GYR</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sphinganine_kinase Sphinganine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.91 2.7.1.91] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v24 OCA], [https://pdbe.org/4v24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v24 RCSB], [https://www.ebi.ac.uk/pdbsum/4v24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v24 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4v24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v24 OCA], [~~http~~://pdbe.org/4v24 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4v24 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4v24 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4v24 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN]] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>	+	[https://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4v24" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4v24" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sphingosine kinase\|Sphingosine kinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Sphinganine kinase]]~~	+	[[Category: Bountra C]]
-	[[Category: Bountra, C]]	+	[[Category: Edwards A]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Elkins JM]]
-	[[Category: Edwards, A]]	+	[[Category: Knapp S]]
-	[[Category: Elkins~~, J M~~]]	+	[[Category: Shrestha L]]
-	[[Category: Knapp, S]]	+	[[Category: Sorrell F]]
-	[[Category: Shrestha, L]]	+	[[Category: Tallant C]]
-	[[Category: Sorrell, F]]	+	[[Category: Wang D]]
-	[[Category: Tallant, C]]	+	[[Category: Wang J]]
-	[[Category: Wang, D]]	+	[[Category: Von Delft F]]
-	[[Category: Wang, J]]	+
-	[[Category: ~~Kinase]]~~	+
-	~~[[Category: Sphingosine]]~~	+
-	~~[[Category: Sphk1]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:15, 26 February 2020

2020-02-26T11:15:58Z

←Older revision		Revision as of 11:15, 26 February 2020
Line 1:		Line 1:

	==Sphingosine kinase 1 in complex with PF-543==		==Sphingosine kinase 1 in complex with PF-543==
-	<StructureSection load='4v24' size='340' side='right' caption='[[4v24]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4v24' size='340' side='right'caption='[[4v24]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4v24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V24 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4v24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V24 FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Sphinganine kinase]]		[[Category: Sphinganine kinase]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 20:23, 24 January 2018

2018-01-24T20:23:04Z

←Older revision		Revision as of 20:23, 24 January 2018
Line 3:		Line 3:
	<StructureSection load='4v24' size='340' side='right' caption='[[4v24]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4v24' size='340' side='right' caption='[[4v24]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4v24]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V24 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4v24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V24 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GYR:{(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL'>GYR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GYR:{(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL'>GYR</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sphinganine_kinase Sphinganine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.91 2.7.1.91] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sphinganine_kinase Sphinganine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.91 2.7.1.91] </span></td></tr>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Sphinganine kinase]]		[[Category: Sphinganine kinase]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
		+	[[Category: Delft, F von]]
	[[Category: Edwards, A]]		[[Category: Edwards, A]]
	[[Category: Elkins, J M]]		[[Category: Elkins, J M]]
Line 33:		Line 35:
	[[Category: Wang, D]]		[[Category: Wang, D]]
	[[Category: Wang, J]]		[[Category: Wang, J]]
-	[[Category: VonDelft, F]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Sphingosine]]		[[Category: Sphingosine]]
	[[Category: Sphk1]]		[[Category: Sphk1]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 18:11, 5 August 2016

2016-08-05T18:11:26Z

←Older revision		Revision as of 18:11, 5 August 2016
Line 1:		Line 1:
		+
	==Sphingosine kinase 1 in complex with PF-543==		==Sphingosine kinase 1 in complex with PF-543==
	<StructureSection load='4v24' size='340' side='right' caption='[[4v24]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4v24' size='340' side='right' caption='[[4v24]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GYR:{(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL'>GYR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GYR:{(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL'>GYR</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sphinganine_kinase Sphinganine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.91 2.7.1.91] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sphinganine_kinase Sphinganine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.91 2.7.1.91] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v24 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v24 RCSB], [http://www.ebi.ac.uk/pdbsum/4v24 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v24 OCA], [http://pdbe.org/4v24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v24 RCSB], [http://www.ebi.ac.uk/pdbsum/4v24 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4v24 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4v24" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:37, 31 December 2014

2014-12-31T09:37:27Z

←Older revision		Revision as of 09:37, 31 December 2014
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN]] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>		[[http://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN]] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The most potent inhibitor of Sphingosine Kinase 1 (SPHK1) so far identified is PF-543. The crystal structure of SPHK1 in complex with inhibitor PF-543 to 1.8 A resolution reveals the inhibitor bound in a bent conformation analogous to that expected of a bound sphingosine substrate but with a rotated head group. The structural data presented will aid in the design of SPHK1 and SPHK2 inhibitors with improved properties.
		+
		+	Crystal Structure of Sphingosine Kinase 1 with PF-543.,Wang J, Knapp S, Pyne NJ, Pyne S, Elkins JM ACS Med Chem Lett. 2014 Oct 27;5(12):1329-33. doi: 10.1021/ml5004074. eCollection, 2014 Dec 11. PMID:25516793<ref>PMID:25516793</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:52, 25 December 2014

2014-12-25T20:52:42Z

←Older revision		Revision as of 20:52, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v24 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v24 RCSB], [http://www.ebi.ac.uk/pdbsum/4v24 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v24 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v24 RCSB], [http://www.ebi.ac.uk/pdbsum/4v24 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN]] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Sphinganine kinase]]		[[Category: Sphinganine kinase]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Edwards, A.]]	+	[[Category: Edwards, A]]
-	[[Category: Elkins, J M.]]	+	[[Category: Elkins, J M]]
-	[[Category: Knapp, S.]]	+	[[Category: Knapp, S]]
-	[[Category: Shrestha, L.]]	+	[[Category: Shrestha, L]]
-	[[Category: Sorrell, F.]]	+	[[Category: Sorrell, F]]
-	[[Category: Tallant, C.]]	+	[[Category: Tallant, C]]
-	[[Category: Wang, D.]]	+	[[Category: Wang, D]]
-	[[Category: Wang, J.]]	+	[[Category: Wang, J]]
-	[[Category: VonDelft, F.]]	+	[[Category: VonDelft, F]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Sphingosine]]		[[Category: Sphingosine]]
	[[Category: Sphk1]]		[[Category: Sphk1]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA: Protected "4v24" [edit=sysop:move=sysop]

2014-10-20T11:06:15Z

Protected "4v24" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:06, 20 October 2014

OCA: New page: ==Sphingosine kinase 1 in complex with PF-543== == Structural high...

2014-10-20T11:06:12Z

New page: ==Sphingosine kinase 1 in complex with PF-543== <StructureSection load='4v24' size='340' side='right' caption='4v24, resolution 1.80Å' scene=''> == Structural high...

New page

==Sphingosine kinase 1 in complex with PF-543==
<StructureSection load='4v24' size='340' side='right' caption='[[4v24]], [[Resolution|resolution]] 1.80Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4v24]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V24 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V24 FirstGlance]. 
</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GYR:{(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL'>GYR</scene></td></tr>
<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Sphinganine_kinase Sphinganine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.91 2.7.1.91] </td></tr>
<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v24 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v24 RCSB], [http://www.ebi.ac.uk/pdbsum/4v24 PDBsum]</td></tr>
</table>
__TOC__
</StructureSection>
[[Category: Sphinganine kinase]]
[[Category: Bountra, C.]]
[[Category: Edwards, A.]]
[[Category: Elkins, J M.]]
[[Category: Knapp, S.]]
[[Category: Shrestha, L.]]
[[Category: Sorrell, F.]]
[[Category: Tallant, C.]]
[[Category: Wang, D.]]
[[Category: Wang, J.]]
[[Category: VonDelft, F.]]
[[Category: Kinase]]
[[Category: Sphingosine]]
[[Category: Sphk1]]
[[Category: Transferase]]