4w9o - Revision history

OCA at 10:41, 10 January 2024

2024-01-10T10:41:32Z

←Older revision		Revision as of 10:41, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4w9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W9O FirstGlance]. <br>		<table><tr><td colspan='2'>[[4w9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W9O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3JQ:(1S,5S,6R)-10-[(3,5-DICHLOROPHENYL)SULFONYL]-5-[(1R)-1,2-DIHYDROXYETHYL]-3-[2-(3,4-DIMETHOXYPHENOXY)ETHYL]-3,10-DIAZABICYCLO[4.3.1]DECAN-2-ONE'>3JQ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.27Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3JQ:(1S,5S,6R)-10-[(3,5-DICHLOROPHENYL)SULFONYL]-5-[(1R)-1,2-DIHYDROXYETHYL]-3-[2-(3,4-DIMETHOXYPHENOXY)ETHYL]-3,10-DIAZABICYCLO[4.3.1]DECAN-2-ONE'>3JQ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9o OCA], [https://pdbe.org/4w9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w9o RCSB], [https://www.ebi.ac.uk/pdbsum/4w9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9o OCA], [https://pdbe.org/4w9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w9o RCSB], [https://www.ebi.ac.uk/pdbsum/4w9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9o ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:58, 7 April 2023

2023-04-07T06:58:33Z

←Older revision		Revision as of 06:58, 7 April 2023
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	<StructureSection load='4w9o' size='340' side='right'caption='[[4w9o]], [[Resolution\|resolution]] 1.27Å' scene=''>		<StructureSection load='4w9o' size='340' side='right'caption='[[4w9o]], [[Resolution\|resolution]] 1.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4w9o]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4W9O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4w9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W9O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3JQ:(1S,5S,6R)-10-[(3,5-DICHLOROPHENYL)SULFONYL]-5-[(1R)-1,2-DIHYDROXYETHYL]-3-[2-(3,4-DIMETHOXYPHENOXY)ETHYL]-3,10-DIAZABICYCLO[4.3.1]DECAN-2-ONE'>3JQ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3JQ:(1S,5S,6R)-10-[(3,5-DICHLOROPHENYL)SULFONYL]-5-[(1R)-1,2-DIHYDROXYETHYL]-3-[2-(3,4-DIMETHOXYPHENOXY)ETHYL]-3,10-DIAZABICYCLO[4.3.1]DECAN-2-ONE'>3JQ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FKBP5, AIG6, FKBP51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9o OCA], [https://pdbe.org/4w9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w9o RCSB], [https://www.ebi.ac.uk/pdbsum/4w9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9o ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4w9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9o OCA], [~~http~~://pdbe.org/4w9o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4w9o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4w9o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9o ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN]] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.	+	[https://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[~~FK506 binding protein~~\|~~FK506 binding protein~~]]	+	*[[FKBP 3D structures\|FKBP 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Peptidylprolyl isomerase]]~~	+	[[Category: Bracher A]]
-	[[Category: Bracher, A]]	+	[[Category: Hausch F]]
-	[[Category: Hausch, F]]	+	[[Category: Kirschner K]]
-	[[Category: Kirschner, K]]	+	[[Category: Kozany C]]
-	[[Category: Kozany, C]]	+	[[Category: Pomplun S]]
-	[[Category: Pomplun, S]]	+	[[Category: Wang Y]]
-	[[Category: Wang, Y]]	+
-	~~[[Category: Fk-506 binding domain]]~~	+
-	~~[[Category: Hsp90 cochaperone]]~~	+
-	~~[[Category: Immunophiline]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Ligand selectivity]]~~	+
-	~~[[Category: Peptidyl-prolyl isomerase~~]]	+

OCA at 08:52, 23 May 2019

2019-05-23T08:52:17Z

←Older revision		Revision as of 08:52, 23 May 2019
Line 1:		Line 1:

	==The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1R)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one==		==The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1R)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one==
-	<StructureSection load='4w9o' size='340' side='right' caption='[[4w9o]], [[Resolution\|resolution]] 1.27Å' scene=''>	+	<StructureSection load='4w9o' size='340' side='right'caption='[[4w9o]], [[Resolution\|resolution]] 1.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4w9o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W9O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4w9o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W9O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3JQ:(1S,5S,6R)-10-[(3,5-DICHLOROPHENYL)SULFONYL]-5-[(1R)-1,2-DIHYDROXYETHYL]-3-[2-(3,4-DIMETHOXYPHENOXY)ETHYL]-3,10-DIAZABICYCLO[4.3.1]DECAN-2-ONE'>3JQ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3JQ:(1S,5S,6R)-10-[(3,5-DICHLOROPHENYL)SULFONYL]-5-[(1R)-1,2-DIHYDROXYETHYL]-3-[2-(3,4-DIMETHOXYPHENOXY)ETHYL]-3,10-DIAZABICYCLO[4.3.1]DECAN-2-ONE'>3JQ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FKBP5, AIG6, FKBP51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9o OCA], [http://pdbe.org/4w9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4w9o RCSB], [http://www.ebi.ac.uk/pdbsum/4w9o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9o OCA], [http://pdbe.org/4w9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4w9o RCSB], [http://www.ebi.ac.uk/pdbsum/4w9o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9o ProSAT]</span></td></tr>
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Bracher, A]]		[[Category: Bracher, A]]

OCA at 16:31, 11 August 2016

2016-08-11T16:31:30Z

←Older revision		Revision as of 16:31, 11 August 2016
Line 1:		Line 1:
		+
	==The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1R)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one==		==The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1R)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one==
	<StructureSection load='4w9o' size='340' side='right' caption='[[4w9o]], [[Resolution\|resolution]] 1.27Å' scene=''>		<StructureSection load='4w9o' size='340' side='right' caption='[[4w9o]], [[Resolution\|resolution]] 1.27Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3JQ:(1S,5S,6R)-10-[(3,5-DICHLOROPHENYL)SULFONYL]-5-[(1R)-1,2-DIHYDROXYETHYL]-3-[2-(3,4-DIMETHOXYPHENOXY)ETHYL]-3,10-DIAZABICYCLO[4.3.1]DECAN-2-ONE'>3JQ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3JQ:(1S,5S,6R)-10-[(3,5-DICHLOROPHENYL)SULFONYL]-5-[(1R)-1,2-DIHYDROXYETHYL]-3-[2-(3,4-DIMETHOXYPHENOXY)ETHYL]-3,10-DIAZABICYCLO[4.3.1]DECAN-2-ONE'>3JQ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w9o RCSB], [http://www.ebi.ac.uk/pdbsum/4w9o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9o OCA], [http://pdbe.org/4w9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4w9o RCSB], [http://www.ebi.ac.uk/pdbsum/4w9o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4w9o" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[FK506 binding protein\|FK506 binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:01, 25 December 2014

2014-12-25T04:01:59Z

←Older revision		Revision as of 04:01, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w9o RCSB], [http://www.ebi.ac.uk/pdbsum/4w9o PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w9o RCSB], [http://www.ebi.ac.uk/pdbsum/4w9o PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN]] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:31, 3 December 2014

2014-12-03T09:31:40Z

←Older revision		Revision as of 09:31, 3 December 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1R)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one==
		+	<StructureSection load='4w9o' size='340' side='right' caption='[[4w9o]], [[Resolution\|resolution]] 1.27Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4w9o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W9O FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3JQ:(1S,5S,6R)-10-[(3,5-DICHLOROPHENYL)SULFONYL]-5-[(1R)-1,2-DIHYDROXYETHYL]-3-[2-(3,4-DIMETHOXYPHENOXY)ETHYL]-3,10-DIAZABICYCLO[4.3.1]DECAN-2-ONE'>3JQ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w9o RCSB], [http://www.ebi.ac.uk/pdbsum/4w9o PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To create highly efficient inhibitors for FK506-binding proteins, a new asymmetric synthesis for pro-(S)-C5 -branched [4.3.1] aza-amide bicycles was developed. The key step of the synthesis is an HF-driven N-acyliminium cyclization. Functionalization of the C5 moiety resulted in novel protein contacts with the psychiatric risk factor FKBP51, which led to a more than 280-fold enhancement in affinity. The most potent ligands facilitated the differentiation of N2a neuroblastoma cells with low nanomolar potency.

-	~~The entry 4w9o is ON HOLD until Paper Publication~~	+	Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs).,Pomplun S, Wang Y, Kirschner A, Kozany C, Bracher A, Hausch F Angew Chem Int Ed Engl. 2014 Nov 20. doi: 10.1002/anie.201408776. PMID:25412894<ref>PMID:25412894</ref>

-	~~Authors: Pomplun~~, S.~~, Wang, Y~~., Kirschner, K., Kozany, C., ~~Bracher~~, ~~A., Hausch, F.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Peptidylprolyl isomerase]]
		+	[[Category: Bracher, A]]
		+	[[Category: Hausch, F]]
		+	[[Category: Kirschner, K]]
		+	[[Category: Kozany, C]]
		+	[[Category: Pomplun, S]]
		+	[[Category: Wang, Y]]
		+	[[Category: Fk-506 binding domain]]
		+	[[Category: Hsp90 cochaperone]]
		+	[[Category: Immunophiline]]
		+	[[Category: Isomerase]]
		+	[[Category: Ligand selectivity]]
		+	[[Category: Peptidyl-prolyl isomerase]]

OCA: Protected "4w9o" [edit=sysop:move=sysop]

2014-09-04T04:50:47Z

Protected "4w9o" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:50, 4 September 2014

OCA: New page: '''Unreleased structure''' The entry 4w9o is ON HOLD until Paper Publication Authors: Pomplun, S., Wang, Y., Kirschner, K., Kozany, C., Bracher, A., Hausch, F. Description:

2014-09-04T04:50:45Z

New page: '''Unreleased structure''' The entry 4w9o is ON HOLD until Paper Publication Authors: Pomplun, S., Wang, Y., Kirschner, K., Kozany, C., Bracher, A., Hausch, F. Description:

New page

'''Unreleased structure'''

The entry 4w9o is ON HOLD until Paper Publication

Authors: Pomplun, S., Wang, Y., Kirschner, K., Kozany, C., Bracher, A., Hausch, F.

Description: