4w9x - Revision history

OCA at 11:27, 9 May 2024

2024-05-09T11:27:24Z

←Older revision		Revision as of 11:27, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4w9x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W9X FirstGlance]. <br>		<table><tr><td colspan='2'>[[4w9x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W9X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3JW:BARICITINIB'>3JW</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.14Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3JW:BARICITINIB'>3JW</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9x OCA], [https://pdbe.org/4w9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w9x RCSB], [https://www.ebi.ac.uk/pdbsum/4w9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9x OCA], [https://pdbe.org/4w9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w9x RCSB], [https://www.ebi.ac.uk/pdbsum/4w9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9x ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:58, 7 April 2023

2023-04-07T06:58:47Z

←Older revision		Revision as of 06:58, 7 April 2023
Line 1:		Line 1:

	==Crystal Structure of BMP-2-inducible kinase in complex with baricitinib==		==Crystal Structure of BMP-2-inducible kinase in complex with baricitinib==
-	<StructureSection load='4w9x' size='340' side='right' caption='[[4w9x]], [[Resolution\|resolution]] 2.14Å' scene=''>	+	<StructureSection load='4w9x' size='340' side='right'caption='[[4w9x]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4w9x]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4W9X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4w9x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W9X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3JW:BARICITINIB'>3JW</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3JW:BARICITINIB'>3JW</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w9w\|4w9w]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9x OCA], [https://pdbe.org/4w9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w9x RCSB], [https://www.ebi.ac.uk/pdbsum/4w9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9x ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BMP2K, BIKE, HRIHFB2017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9x OCA], [~~http~~://pdbe.org/4w9x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4w9x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4w9x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9x ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BMP2K_HUMAN BMP2K_HUMAN]] May be involved in osteoblast differentiation.	+	[https://www.uniprot.org/uniprot/BMP2K_HUMAN BMP2K_HUMAN] May be involved in osteoblast differentiation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Non-specific serine/threonine protein kinase~~]]	+	[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Elkins JM]]
-	[[Category: Elkins~~, J M~~]]	+	[[Category: Knapp S]]
-	[[Category: Knapp, S]]	+	[[Category: Krojer T]]
-	[[Category: Krojer, T]]	+	[[Category: Savitsky P]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Sorrell FJ]]
-	[[Category: Savitsky, P]]	+	[[Category: Williams E]]
-	[[Category: Sorrell~~, F J~~]]	+	[[Category: Von Delft F]]
-	[[Category: Williams, E]]	+
-	[[Category: ~~Catalytic domain]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Small-molecule]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 20:23, 24 January 2018

2018-01-24T20:23:10Z

←Older revision		Revision as of 20:23, 24 January 2018
Line 3:		Line 3:
	<StructureSection load='4w9x' size='340' side='right' caption='[[4w9x]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='4w9x' size='340' side='right' caption='[[4w9x]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4w9x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W9X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4w9x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W9X FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3JW:BARICITINIB'>3JW</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3JW:BARICITINIB'>3JW</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w9w\|4w9w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w9w\|4w9w]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BMP2K, BIKE, HRIHFB2017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9x OCA], [http://pdbe.org/4w9x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4w9x RCSB], [http://www.ebi.ac.uk/pdbsum/4w9x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9x OCA], [http://pdbe.org/4w9x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4w9x RCSB], [http://www.ebi.ac.uk/pdbsum/4w9x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
-	[[Category: Delft, F ~~Von~~]]	+	[[Category: Delft, F von]]
	[[Category: Edwards, A M]]		[[Category: Edwards, A M]]
	[[Category: Elkins, J M]]		[[Category: Elkins, J M]]

OCA at 06:56, 2 March 2016

2016-03-02T06:56:08Z

←Older revision		Revision as of 06:56, 2 March 2016
Line 1:		Line 1:
		+
	==Crystal Structure of BMP-2-inducible kinase in complex with baricitinib==		==Crystal Structure of BMP-2-inducible kinase in complex with baricitinib==
	<StructureSection load='4w9x' size='340' side='right' caption='[[4w9x]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='4w9x' size='340' side='right' caption='[[4w9x]], [[Resolution\|resolution]] 2.14Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w9w\|4w9w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w9w\|4w9w]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w9x RCSB], [http://www.ebi.ac.uk/pdbsum/4w9x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9x OCA], [http://pdbe.org/4w9x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4w9x RCSB], [http://www.ebi.ac.uk/pdbsum/4w9x PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BMP2K_HUMAN BMP2K_HUMAN]] May be involved in osteoblast differentiation.		[[http://www.uniprot.org/uniprot/BMP2K_HUMAN BMP2K_HUMAN]] May be involved in osteoblast differentiation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The highly diverse Numb-associated kinase (NAK) family has been linked to broad cellular functions including receptor-mediated endocytosis, Notch pathway modulation, osteoblast differentiation, and dendrite morphogenesis. Consequently, NAK kinases play a key role in a diverse range of diseases from Parkinson's and prostate cancer to HIV. Due to the plasticity of this kinase family, NAK kinases are often inhibited by approved or investigational drugs and have been associated with side effects, but they are also potential drug targets. The presence of cysteine residues in some NAK family members provides the possibility for selective targeting via covalent inhibition. Here we report the first high-resolution structures of kinases AAK1 and BIKE in complex with two drug candidates. The presented data allow a comprehensive structural characterization of the NAK kinase family and provide the basis for rational design of selective NAK inhibitors.
		+
		+	Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.,Sorrell FJ, Szklarz M, Abdul Azeez KR, Elkins JM, Knapp S Structure. 2016 Jan 29. pii: S0969-2126(16)00008-3. doi:, 10.1016/j.str.2015.12.015. PMID:26853940<ref>PMID:26853940</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4w9x" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 02:59, 25 December 2014

2014-12-25T02:59:11Z

←Older revision		Revision as of 02:59, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4w9x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W9X FirstGlance]. <br>		<table><tr><td colspan='2'>[[4w9x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W9X FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3JW:BARICITINIB'>3JW</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3JW:BARICITINIB'>3JW</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w9w\|4w9w]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w9w\|4w9w]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w9x RCSB], [http://www.ebi.ac.uk/pdbsum/4w9x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w9x RCSB], [http://www.ebi.ac.uk/pdbsum/4w9x PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BMP2K_HUMAN BMP2K_HUMAN]] May be involved in osteoblast differentiation.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Delft, F Von.]]	+	[[Category: Delft, F Von]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Elkins, J M.]]	+	[[Category: Elkins, J M]]
-	[[Category: Knapp, S.]]	+	[[Category: Knapp, S]]
-	[[Category: Krojer, T.]]	+	[[Category: Krojer, T]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Savitsky, P.]]	+	[[Category: Savitsky, P]]
-	[[Category: Sorrell, F J.]]	+	[[Category: Sorrell, F J]]
-	[[Category: Williams, E.]]	+	[[Category: Williams, E]]
	[[Category: Catalytic domain]]		[[Category: Catalytic domain]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
Line 28:		Line 30:
	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Small-molecule]]		[[Category: Small-molecule]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:21, 10 September 2014

2014-09-10T10:21:42Z

←Older revision		Revision as of 10:21, 10 September 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of BMP-2-inducible kinase in complex with baricitinib==
-		+	<StructureSection load='4w9x' size='340' side='right' caption='[[4w9x]], [[Resolution\|resolution]] 2.14Å' scene=''>
-	~~The entry~~ 4w9x is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4w9x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W9X FirstGlance]. <br>
-	~~Authors~~: ~~Sorrell, F~~.J.~~, Elkins, J~~.M., ~~Krojer~~, T., ~~Williams, E~~., ~~Savitsky, P~~., ~~Von Delft, F~~., Arrowsmith, C.H., Edwards, A.M., ~~Bountra, C~~., Knapp, S., Structural Genomics Consortium ~~(SGC)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3JW:BARICITINIB'>3JW</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w9w\|4w9w]]</td></tr>
-	~~Description~~: ~~Crystal Structure of BMP~~-~~2-inducible kinase in complex with baricitinib~~	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w9x RCSB], [http://www.ebi.ac.uk/pdbsum/4w9x PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Delft, F Von.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Elkins, J M.]]
		+	[[Category: Knapp, S.]]
		+	[[Category: Krojer, T.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Savitsky, P.]]
		+	[[Category: Sorrell, F J.]]
		+	[[Category: Williams, E.]]
		+	[[Category: Catalytic domain]]
		+	[[Category: Inhibitor]]
		+	[[Category: Kinase]]
		+	[[Category: Protein binding]]
		+	[[Category: Sgc]]
		+	[[Category: Small-molecule]]
		+	[[Category: Structural genomic]]
		+	[[Category: Structural genomics consortium]]
		+	[[Category: Transferase]]

OCA: Protected "4w9x" [edit=sysop:move=sysop]

2014-09-04T04:51:22Z

Protected "4w9x" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:51, 4 September 2014

OCA: New page: '''Unreleased structure''' The entry 4w9x is ON HOLD Authors: Sorrell, F.J., Elkins, J.M., Krojer, T., Williams, E., Savitsky, P., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountr...

2014-09-04T04:51:20Z

New page: '''Unreleased structure''' The entry 4w9x is ON HOLD Authors: Sorrell, F.J., Elkins, J.M., Krojer, T., Williams, E., Savitsky, P., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountr...

New page

'''Unreleased structure'''

The entry 4w9x is ON HOLD

Authors: Sorrell, F.J., Elkins, J.M., Krojer, T., Williams, E., Savitsky, P., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

Description: Crystal Structure of BMP-2-inducible kinase in complex with baricitinib