4wis - Revision history

OCA at 11:27, 9 May 2024

2024-05-09T11:27:50Z

←Older revision		Revision as of 11:27, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4wis]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_vanettenii_77-13-4 Fusarium vanettenii 77-13-4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WIS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wis]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_vanettenii_77-13-4 Fusarium vanettenii 77-13-4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WIS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wis OCA], [https://pdbe.org/4wis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wis RCSB], [https://www.ebi.ac.uk/pdbsum/4wis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wis ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wis OCA], [https://pdbe.org/4wis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wis RCSB], [https://www.ebi.ac.uk/pdbsum/4wis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wis ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:10, 7 April 2023

2023-04-07T07:10:36Z

←Older revision		Revision as of 07:10, 7 April 2023
Line 1:		Line 1:

	==Crystal structure of the lipid scramblase nhTMEM16 in crystal form 1==		==Crystal structure of the lipid scramblase nhTMEM16 in crystal form 1==
-	<StructureSection load='4wis' size='340' side='right' caption='[[4wis]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<StructureSection load='4wis' size='340' side='right'caption='[[4wis]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wis]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Fusarium_solani_subsp._pisi~~ Fusarium ~~solani subsp. pisi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WIS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4WIS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wis]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_vanettenii_77-13-4 Fusarium vanettenii 77-13-4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WIS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NECHADRAFT_66456 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=660122 Fusarium solani subsp. pisi])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wis OCA], [https://pdbe.org/4wis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wis RCSB], [https://www.ebi.ac.uk/pdbsum/4wis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wis ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4wis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wis OCA], [~~http~~://pdbe.org/4wis PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4wis RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4wis PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4wis ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C7Z7K1_FUSV7 C7Z7K1_FUSV7]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4wis" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4wis" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Anoctamin 3D structures\|Anoctamin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Fusarium ~~solani subsp. pisi~~]]	+	[[Category: Fusarium vanettenii 77-13-4]]
-	[[Category: ~~Brunner, J D~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Dutzler, R~~]]	+	[[Category: Brunner JD]]
-	[[Category: ~~Lim, N K~~]]	+	[[Category: Dutzler R]]
-	[[Category: ~~Schenck, S~~]]	+	[[Category: Lim NK]]
-	[[Category: ~~Calcium activation]]~~	+	[[Category: Schenck S]]
-	~~[[Category: Lipid transport]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 05:45, 25 April 2018

2018-04-25T05:45:30Z

←Older revision		Revision as of 05:45, 25 April 2018
Line 1:		Line 1:
		+
	==Crystal structure of the lipid scramblase nhTMEM16 in crystal form 1==		==Crystal structure of the lipid scramblase nhTMEM16 in crystal form 1==
	<StructureSection load='4wis' size='340' side='right' caption='[[4wis]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='4wis' size='340' side='right' caption='[[4wis]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wis]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WIS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WIS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wis]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusarium_solani_subsp._pisi Fusarium solani subsp. pisi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WIS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WIS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wis OCA], [http://pdbe.org/4wis PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wis RCSB], [http://www.ebi.ac.uk/pdbsum/4wis PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NECHADRAFT_66456 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=660122 Fusarium solani subsp. pisi])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wis OCA], [http://pdbe.org/4wis PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wis RCSB], [http://www.ebi.ac.uk/pdbsum/4wis PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wis ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Fusarium solani subsp. pisi]]
	[[Category: Brunner, J D]]		[[Category: Brunner, J D]]
	[[Category: Dutzler, R]]		[[Category: Dutzler, R]]

OCA at 07:47, 7 October 2015

2015-10-07T07:47:19Z

←Older revision		Revision as of 07:47, 7 October 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[4wis]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WIS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WIS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wis]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WIS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WIS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wis OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wis RCSB], [http://www.ebi.ac.uk/pdbsum/4wis PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wis OCA], [http://pdbe.org/4wis PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wis RCSB], [http://www.ebi.ac.uk/pdbsum/4wis PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4wis" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:56, 19 November 2014

2014-11-19T10:56:14Z

←Older revision		Revision as of 10:56, 19 November 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wis OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wis RCSB], [http://www.ebi.ac.uk/pdbsum/4wis PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wis OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wis RCSB], [http://www.ebi.ac.uk/pdbsum/4wis PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The TMEM16 family of proteins, also known as anoctamins, features a remarkable functional diversity. This family contains the long sought-after Ca2+-activated chloride channels as well as lipid scramblases and cation channels. Here we present the crystal structure of a TMEM16 family member from the fungus Nectria haematococca that operates as a Ca2+-activated lipid scramblase. Each subunit of the homodimeric protein contains ten transmembrane helices and a hydrophilic membrane-traversing cavity that is exposed to the lipid bilayer as a potential site of catalysis. This cavity harbours a conserved Ca2+-binding site located within the hydrophobic core of the membrane. Mutations of residues involved in Ca2+ coordination affect both lipid scrambling in N. haematococca TMEM16 and ion conduction in the Cl- channel TMEM16A. The structure reveals the general architecture of the family and its mode of Ca2+ activation. It also provides insight into potential scrambling mechanisms and serves as a framework to unravel the conduction of ions in certain TMEM16 proteins.
		+
		+	X-ray structure of a calcium-activated TMEM16 lipid scramblase.,Brunner JD, Lim NK, Schenck S, Duerst A, Dutzler R Nature. 2014 Nov 12. doi: 10.1038/nature13984. PMID:25383531<ref>PMID:25383531</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:04, 12 November 2014

2014-11-12T07:04:16Z

←Older revision		Revision as of 07:04, 12 November 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of the lipid scramblase nhTMEM16 in crystal form 1==
-		+	<StructureSection load='4wis' size='340' side='right' caption='[[4wis]], [[Resolution\|resolution]] 3.30Å' scene=''>
-	~~The entry~~ 4wis is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4wis]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WIS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WIS FirstGlance]. <br>
-	~~Authors~~: ~~Dutzler~~, R., Brunner, J.D., Lim, N.K., Schenck, S.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wis OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wis RCSB], [http://www.ebi.ac.uk/pdbsum/4wis PDBsum]</span></td></tr>
-	~~Description~~: ~~Crystal structure of the lipid scramblase nhTMEM16 in crystal form 1~~	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brunner, J D]]
		+	[[Category: Dutzler, R]]
		+	[[Category: Lim, N K]]
		+	[[Category: Schenck, S]]
		+	[[Category: Calcium activation]]
		+	[[Category: Lipid transport]]
		+	[[Category: Membrane protein]]
		+	[[Category: Transport protein]]

OCA: Protected "4wis" [edit=sysop:move=sysop]

2014-10-08T06:57:00Z

Protected "4wis" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:57, 8 October 2014

OCA: New page: '''Unreleased structure''' The entry 4wis is ON HOLD Authors: Dutzler, R., Brunner, J.D., Lim, N.K., Schenck, S. Description: Crystal structure of the lipid scramblase nhTMEM16 in crys...

2014-10-08T06:56:58Z

New page: '''Unreleased structure''' The entry 4wis is ON HOLD Authors: Dutzler, R., Brunner, J.D., Lim, N.K., Schenck, S. Description: Crystal structure of the lipid scramblase nhTMEM16 in crys...

New page

'''Unreleased structure'''

The entry 4wis is ON HOLD

Authors: Dutzler, R., Brunner, J.D., Lim, N.K., Schenck, S.

Description: Crystal structure of the lipid scramblase nhTMEM16 in crystal form 1