4wnq - Revision history

OCA at 00:54, 28 December 2023

2023-12-28T00:54:31Z

←Older revision		Revision as of 00:54, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4wnq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WNQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wnq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WNQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wnq OCA], [https://pdbe.org/4wnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wnq RCSB], [https://www.ebi.ac.uk/pdbsum/4wnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wnq ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wnq OCA], [https://pdbe.org/4wnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wnq RCSB], [https://www.ebi.ac.uk/pdbsum/4wnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wnq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:17, 7 April 2023

2023-04-07T07:17:26Z

←Older revision		Revision as of 07:17, 7 April 2023
Line 3:		Line 3:
	<StructureSection load='4wnq' size='340' side='right'caption='[[4wnq]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4wnq' size='340' side='right'caption='[[4wnq]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wnq]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WNQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4WNQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wnq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WNQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4wnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wnq OCA], [~~http~~://pdbe.org/4wnq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4wnq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4wnq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4wnq ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wnq OCA], [https://pdbe.org/4wnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wnq RCSB], [https://www.ebi.ac.uk/pdbsum/4wnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wnq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Besra, G]]	+	[[Category: Besra G]]
-	~~[[Category: Boer, R de~~]]	+	[[Category: Chabrol E]]
-	[[Category: Chabrol, E]]	+	[[Category: Eckle SBG]]
-	[[Category: Eckle~~, S B.G~~]]	+	[[Category: Godfrey DI]]
-	[[Category: Godfrey~~, D I~~]]	+	[[Category: Gras S]]
-	[[Category: Gras, S]]	+	[[Category: Heemskerk MHM]]
-	[[Category: Heemskerk~~, M H.M~~]]	+	[[Category: Howell AR]]
-	[[Category: Howell~~, A R~~]]	+	[[Category: Le Nours J]]
-	[[Category: Lim~~, R T~~]]	+	[[Category: Lim RT]]
-	[[Category: McCluskey, J]]	+	[[Category: McCluskey J]]
-	[[Category: McPherson, K]]	+	[[Category: McPherson K]]
-	[[Category: Moretta, L]]	+	[[Category: Moretta L]]
-	~~[[Category: Nours, J Le~~]]	+	[[Category: Pellicci DG]]
-	[[Category: Pellicci~~, D G~~]]	+	[[Category: Ross F]]
-	[[Category: Ross, F]]	+	[[Category: Rossjohn J]]
-	[[Category: Rossjohn, J]]	+	[[Category: Uldrich AP]]
-	[[Category: Uldrich~~, A P~~]]	+	[[Category: De Boer R]]
-	[[Category: ~~Immune system]]~~	+
-	~~[[Category: Immunity~~]]	+

OCA at 08:32, 23 May 2019

2019-05-23T08:32:51Z

←Older revision		Revision as of 08:32, 23 May 2019
Line 1:		Line 1:

	==THE MOLECULAR BASES OF DELTA/ALPHA-BETA T-CELL MEDIATED ANTIGEN RECOGNITION==		==THE MOLECULAR BASES OF DELTA/ALPHA-BETA T-CELL MEDIATED ANTIGEN RECOGNITION==
-	<StructureSection load='4wnq' size='340' side='right' caption='[[4wnq]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4wnq' size='340' side='right'caption='[[4wnq]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wnq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WNQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wnq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WNQ FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wnq OCA], [http://pdbe.org/4wnq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wnq RCSB], [http://www.ebi.ac.uk/pdbsum/4wnq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wnq ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wnq OCA], [http://pdbe.org/4wnq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wnq RCSB], [http://www.ebi.ac.uk/pdbsum/4wnq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wnq ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Besra, G]]		[[Category: Besra, G]]
	[[Category: Boer, R de]]		[[Category: Boer, R de]]

OCA at 22:49, 5 August 2016

2016-08-05T22:49:44Z

←Older revision		Revision as of 22:49, 5 August 2016
Line 1:		Line 1:
		+
	==THE MOLECULAR BASES OF DELTA/ALPHA-BETA T-CELL MEDIATED ANTIGEN RECOGNITION==		==THE MOLECULAR BASES OF DELTA/ALPHA-BETA T-CELL MEDIATED ANTIGEN RECOGNITION==
	<StructureSection load='4wnq' size='340' side='right' caption='[[4wnq]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4wnq' size='340' side='right' caption='[[4wnq]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4wnq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WNQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wnq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WNQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wnq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wnq RCSB], [http://www.ebi.ac.uk/pdbsum/4wnq PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wnq OCA], [http://pdbe.org/4wnq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wnq RCSB], [http://www.ebi.ac.uk/pdbsum/4wnq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wnq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4wnq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:29, 17 December 2014

2014-12-17T10:29:12Z

←Older revision		Revision as of 10:29, 17 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wnq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wnq RCSB], [http://www.ebi.ac.uk/pdbsum/4wnq PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wnq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wnq RCSB], [http://www.ebi.ac.uk/pdbsum/4wnq PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	alphabeta and gammadelta T cells are disparate T cell lineages that can respond to distinct antigens (Ags) via the use of the alphabeta and gammadelta T cell Ag receptors (TCRs), respectively. Here we characterize a population of human T cells, which we term delta/alphabeta T cells, expressing TCRs comprised of a TCR-delta variable gene (Vdelta1) fused to joining alpha and constant alpha domains, paired with an array of TCR-beta chains. We demonstrate that these cells, which represent approximately 50% of all Vdelta1(+) human T cells, can recognize peptide- and lipid-based Ags presented by human leukocyte antigen (HLA) and CD1d, respectively. Similar to type I natural killer T (NKT) cells, CD1d-lipid Ag-reactive delta/alphabeta T cells recognized alpha-galactosylceramide (alpha-GalCer); however, their fine specificity for other lipid Ags presented by CD1d, such as alpha-glucosylceramide, was distinct from type I NKT cells. Thus, delta/alphabetaTCRs contribute new patterns of Ag specificity to the human immune system. Furthermore, we provide the molecular bases of how delta/alphabetaTCRs bind to their targets, with the Vdelta1-encoded region providing a major contribution to delta/alphabetaTCR binding. Our findings highlight how components from alphabeta and gammadeltaTCR gene loci can recombine to confer Ag specificity, thus expanding our understanding of T cell biology and TCR diversity.
		+
		+	The molecular bases of delta/alphabeta T cell-mediated antigen recognition.,Pellicci DG, Uldrich AP, Le Nours J, Ross F, Chabrol E, Eckle SB, de Boer R, Lim RT, McPherson K, Besra G, Howell AR, Moretta L, McCluskey J, Heemskerk MH, Gras S, Rossjohn J, Godfrey DI J Exp Med. 2014 Dec 15;211(13):2599-615. doi: 10.1084/jem.20141764. Epub 2014 Dec, 1. PMID:25452463<ref>PMID:25452463</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:19, 26 November 2014

2014-11-26T08:19:05Z

←Older revision		Revision as of 08:19, 26 November 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==THE MOLECULAR BASES OF DELTA/ALPHA-BETA T-CELL MEDIATED ANTIGEN RECOGNITION==
-		+	<StructureSection load='4wnq' size='340' side='right' caption='[[4wnq]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~The entry~~ 4wnq is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4wnq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WNQ FirstGlance]. <br>
-	~~Authors~~: ~~Pellicci, D~~.G., ~~Uldrich, A~~.P., ~~Le Nours, J~~., ~~Ross, F~~., Chabrol, E., Eckle, S.B.G., ~~de Boer~~, R., Lim, R.T., McPherson, K~~., Besra, G., Howell, A.R.,~~ Moretta, L~~., McCluskey~~, J., ~~Heemskerk, M.H.M., Gras, S.~~, Rossjohn, J., ~~Godfrey, D.I.~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wnq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wnq RCSB], [http://www.ebi.ac.uk/pdbsum/4wnq PDBsum]</span></td></tr>
-		+	</table>
-	~~Description~~:	+	__TOC__
		+	</StructureSection>
		+	[[Category: Besra, G]]
		+	[[Category: Boer, R de]]
		+	[[Category: Chabrol, E]]
		+	[[Category: Eckle, S B.G]]
		+	[[Category: Godfrey, D I]]
		+	[[Category: Gras, S]]
		+	[[Category: Heemskerk, M H.M]]
		+	[[Category: Howell, A R]]
		+	[[Category: Lim, R T]]
		+	[[Category: McCluskey, J]]
		+	[[Category: McPherson, K]]
		+	[[Category: Moretta, L]]
		+	[[Category: Nours, J Le]]
		+	[[Category: Pellicci, D G]]
		+	[[Category: Ross, F]]
		+	[[Category: Rossjohn, J]]
		+	[[Category: Uldrich, A P]]
		+	[[Category: Immune system]]
		+	[[Category: Immunity]]

OCA at 10:32, 29 October 2014

2014-10-29T10:32:33Z

←Older revision		Revision as of 10:32, 29 October 2014
Line 3:		Line 3:
	The entry 4wnq is ON HOLD until Paper Publication		The entry 4wnq is ON HOLD until Paper Publication

-	Authors: Pellicci, D.G., Uldrich, A.P., Le Nours, J., Ross, F., Chabrol, E., Eckle, S.B.G., de Boer, R., Lim, R.T., McPherson, K., Besra, G., Howell, A.R., Moretta, L., McCluskey, J., Heemskerk, M.H.M, Gras, S., Rossjohn, J., Godfrey, D.I.	+	Authors: Pellicci, D.G., Uldrich, A.P., Le Nours, J., Ross, F., Chabrol, E., Eckle, S.B.G., de Boer, R., Lim, R.T., McPherson, K., Besra, G., Howell, A.R., Moretta, L., McCluskey, J., Heemskerk, M.H.M., Gras, S., Rossjohn, J., Godfrey, D.I.

	Description:		Description:

OCA: Protected "4wnq" [edit=sysop:move=sysop]

2014-10-22T10:21:53Z

Protected "4wnq" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:21, 22 October 2014

OCA: New page: '''Unreleased structure''' The entry 4wnq is ON HOLD until Paper Publication Authors: Pellicci, D.G., Uldrich, A.P., Le Nours, J., Ross, F., Chabrol, E., Eckle, S.B.G., de Boer, R., Lim...

2014-10-22T10:21:51Z

New page: '''Unreleased structure''' The entry 4wnq is ON HOLD until Paper Publication Authors: Pellicci, D.G., Uldrich, A.P., Le Nours, J., Ross, F., Chabrol, E., Eckle, S.B.G., de Boer, R., Lim...

New page

'''Unreleased structure'''

The entry 4wnq is ON HOLD until Paper Publication

Authors: Pellicci, D.G., Uldrich, A.P., Le Nours, J., Ross, F., Chabrol, E., Eckle, S.B.G., de Boer, R., Lim, R.T., McPherson, K., Besra, G., Howell, A.R., Moretta, L., McCluskey, J., Heemskerk, M.H.M, Gras, S., Rossjohn, J., Godfrey, D.I.

Description: