4wod - Revision history

OCA at 10:43, 10 January 2024

2024-01-10T10:43:59Z

←Older revision		Revision as of 10:43, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4wod]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WOD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wod]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WOD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wod OCA], [https://pdbe.org/4wod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wod RCSB], [https://www.ebi.ac.uk/pdbsum/4wod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wod ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wod OCA], [https://pdbe.org/4wod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wod RCSB], [https://www.ebi.ac.uk/pdbsum/4wod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wod ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:18, 7 April 2023

2023-04-07T07:18:17Z

←Older revision		Revision as of 07:18, 7 April 2023
Line 3:		Line 3:
	<StructureSection load='4wod' size='340' side='right'caption='[[4wod]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4wod' size='340' side='right'caption='[[4wod]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wod]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Blood_fluke Blood fluke~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WOD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4WOD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wod]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WOD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Smp_194770 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 Blood fluke])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wod OCA], [https://pdbe.org/4wod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wod RCSB], [https://www.ebi.ac.uk/pdbsum/4wod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wod ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Taurocyamine_kinase Taurocyamine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.4 2.7.3.4] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4wod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wod OCA], [~~http~~://pdbe.org/4wod PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4wod RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4wod PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4wod ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KTRC_SCHMA KTRC_SCHMA]] This family of enzymes reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).<ref>PMID:18765922</ref>	+	[https://www.uniprot.org/uniprot/KTRC_SCHMA KTRC_SCHMA] This family of enzymes reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).<ref>PMID:18765922</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Blood fluke]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Taurocyamine kinase~~]]	+	[[Category: Schistosoma mansoni]]
-	[[Category: Awama, A]]	+	[[Category: Awama A]]
-	[[Category: Gouet, P]]	+	[[Category: Gouet P]]
-	[[Category: Marcillat, O]]	+	[[Category: Marcillat O]]
-	[[Category: Merceron, R]]	+	[[Category: Merceron R]]
-	[[Category: Montserret, R]]	+	[[Category: Montserret R]]
-	~~[[Category: Duplicated]]~~	+
-	~~[[Category: Substrate specificity]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transition state~~]]	+

OCA at 08:54, 23 May 2019

2019-05-23T08:54:00Z

←Older revision		Revision as of 08:54, 23 May 2019
Line 1:		Line 1:

	==The duplicated taurocyamine kinase from Schistosoma mansoni complexed with arginine==		==The duplicated taurocyamine kinase from Schistosoma mansoni complexed with arginine==
-	<StructureSection load='4wod' size='340' side='right' caption='[[4wod]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4wod' size='340' side='right'caption='[[4wod]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wod]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WOD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wod]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WOD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Smp_194770 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 Blood fluke])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Taurocyamine_kinase Taurocyamine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.4 2.7.3.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Taurocyamine_kinase Taurocyamine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.4 2.7.3.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wod OCA], [http://pdbe.org/4wod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wod RCSB], [http://www.ebi.ac.uk/pdbsum/4wod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wod ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wod OCA], [http://pdbe.org/4wod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wod RCSB], [http://www.ebi.ac.uk/pdbsum/4wod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wod ProSAT]</span></td></tr>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Blood fluke]]
		+	[[Category: Large Structures]]
	[[Category: Taurocyamine kinase]]		[[Category: Taurocyamine kinase]]
	[[Category: Awama, A]]		[[Category: Awama, A]]

OCA at 01:52, 10 March 2017

2017-03-10T01:52:38Z

←Older revision		Revision as of 01:52, 10 March 2017
Line 1:		Line 1:
		+
	==The duplicated taurocyamine kinase from Schistosoma mansoni complexed with arginine==		==The duplicated taurocyamine kinase from Schistosoma mansoni complexed with arginine==
	<StructureSection load='4wod' size='340' side='right' caption='[[4wod]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4wod' size='340' side='right' caption='[[4wod]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Taurocyamine_kinase Taurocyamine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.4 2.7.3.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Taurocyamine_kinase Taurocyamine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.4 2.7.3.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wod OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wod RCSB], [http://www.ebi.ac.uk/pdbsum/4wod PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wod OCA], [http://pdbe.org/4wod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wod RCSB], [http://www.ebi.ac.uk/pdbsum/4wod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wod ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4wod" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:54, 22 April 2015

2015-04-22T06:54:01Z

←Older revision		Revision as of 06:54, 22 April 2015
Line 1:		Line 1:
-	==The ~~substrate -free and -bound crystal structures of the~~ duplicated taurocyamine kinase from ~~the human parasite~~ Schistosoma mansoni==	+	==The duplicated taurocyamine kinase from Schistosoma mansoni complexed with arginine==
	<StructureSection load='4wod' size='340' side='right' caption='[[4wod]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4wod' size='340' side='right' caption='[[4wod]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 12:53, 15 April 2015

2015-04-15T12:53:01Z

←Older revision		Revision as of 12:53, 15 April 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==The substrate -free and -bound crystal structures of the duplicated taurocyamine kinase from the human parasite Schistosoma mansoni==
		+	<StructureSection load='4wod' size='340' side='right' caption='[[4wod]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4wod]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WOD FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Taurocyamine_kinase Taurocyamine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.4 2.7.3.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wod OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wod RCSB], [http://www.ebi.ac.uk/pdbsum/4wod PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KTRC_SCHMA KTRC_SCHMA]] This family of enzymes reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).<ref>PMID:18765922</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The taurocyamine kinase from the blood fluke Schistosoma mansoni (SmTK) belongs to the phosphagen kinase (PK) family and catalyzes the reversible Mg2+-dependent transfer of a phosphoryl group between ATP and taurocyamine. SmTK is derived from gene duplication, as are all known trematode TKs. Our crystallographic study of SmTK reveals the first atomic structure of both a TK and a PK with a bilobal structure. The two unliganded lobes present a canonical open conformation and interact via their respective C- and N-terminal domains at a helix-mediated interface. This spatial arrangement differs from that observed in true dimeric PKs, in which both N-terminal domains make contact. Our structures of SmTK complexed with taurocyamine or L-arginine compounds explain the mechanism by which an arginine residue of the phosphagen-specificity loop is crucial for substrate specificity. An SmTK crystal was soaked with the dead-end transition-state analog (TSA) components taurocyamine-NO32--MgADP. One SmTK monomer was observed with two bound TSAs and an asymmetric conformation, with the first lobe semi-closed and the second closed. However, isothermal titration calorimetry and enzyme kinetics experiments showed that the two lobes function independently. A small-angle X-ray scattering model of SmTK-TSA in solution with two closed active sites was generated.

-	The ~~entry 4wod is ON HOLD until Paper Publication~~	+	The substrate -free and -bound crystal structures of the duplicated taurocyamine kinase from the human parasite Schistosoma mansoni.,Merceron R, Awama AM, Montserret R, Marcillat O, Gouet P J Biol Chem. 2015 Apr 2. pii: jbc.M114.628909. PMID:25837252<ref>PMID:25837252</ref>

-	~~Authors: Merceron~~, R.~~, Awama, A~~.~~, Montserret, R., Marcillat, O., Gouet, P~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~The substrate -free and -bound crystal structures of the duplicated taurocyamine~~ kinase ~~from the human parasite Schistosoma mansoni~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Taurocyamine kinase]]
		+	[[Category: Awama, A]]
		+	[[Category: Gouet, P]]
		+	[[Category: Marcillat, O]]
	[[Category: Merceron, R]]		[[Category: Merceron, R]]
	[[Category: Montserret, R]]		[[Category: Montserret, R]]
-	[[Category: ~~Awama, A~~]]	+	[[Category: Duplicated]]
-	[[Category: ~~Marcillat, O~~]]	+	[[Category: Substrate specificity]]
-	[[Category: ~~Gouet, P~~]]	+	[[Category: Transferase]]
		+	[[Category: Transition state]]

OCA at 08:12, 8 April 2015

2015-04-08T08:12:33Z

←Older revision		Revision as of 08:12, 8 April 2015
Line 5:		Line 5:
	Authors: Merceron, R., Awama, A., Montserret, R., Marcillat, O., Gouet, P.		Authors: Merceron, R., Awama, A., Montserret, R., Marcillat, O., Gouet, P.

-	Description: The substrate free and bound ~~duplicated~~ crystal structures of the taurocyamine kinase from the human parasite Schistosoma mansoni	+	Description: The substrate -free and -bound crystal structures of the duplicated taurocyamine kinase from the human parasite Schistosoma mansoni
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Merceron, R]]		[[Category: Merceron, R]]

OCA at 19:45, 24 December 2014

2014-12-24T19:45:55Z

←Older revision		Revision as of 19:45, 24 December 2014
Line 6:		Line 6:

	Description: The substrate free and bound duplicated crystal structures of the taurocyamine kinase from the human parasite Schistosoma mansoni		Description: The substrate free and bound duplicated crystal structures of the taurocyamine kinase from the human parasite Schistosoma mansoni
		+	[[Category: Unreleased Structures]]
		+	[[Category: Merceron, R]]
		+	[[Category: Montserret, R]]
		+	[[Category: Awama, A]]
		+	[[Category: Marcillat, O]]
		+	[[Category: Gouet, P]]

OCA: Protected "4wod" [edit=sysop:move=sysop]

2014-10-22T10:23:12Z

Protected "4wod" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:23, 22 October 2014

OCA: New page: '''Unreleased structure''' The entry 4wod is ON HOLD until Paper Publication Authors: Merceron, R., Awama, A., Montserret, R., Marcillat, O., Gouet, P. Description: The substrate free ...

2014-10-22T10:23:11Z

New page: '''Unreleased structure''' The entry 4wod is ON HOLD until Paper Publication Authors: Merceron, R., Awama, A., Montserret, R., Marcillat, O., Gouet, P. Description: The substrate free ...

New page

'''Unreleased structure'''

The entry 4wod is ON HOLD until Paper Publication

Authors: Merceron, R., Awama, A., Montserret, R., Marcillat, O., Gouet, P.

Description: The substrate free and bound duplicated crystal structures of the taurocyamine kinase from the human parasite Schistosoma mansoni