4x1d - Revision history

OCA at 15:24, 8 November 2023

2023-11-08T15:24:32Z

←Older revision		Revision as of 15:24, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4x1d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X1D FirstGlance]. <br>		<table><tr><td colspan='2'>[[4x1d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X1D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1d OCA], [https://pdbe.org/4x1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x1d RCSB], [https://www.ebi.ac.uk/pdbsum/4x1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x1d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1d OCA], [https://pdbe.org/4x1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x1d RCSB], [https://www.ebi.ac.uk/pdbsum/4x1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x1d ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:06, 12 April 2023

2023-04-12T21:06:39Z

←Older revision		Revision as of 21:06, 12 April 2023
Line 3:		Line 3:
	<StructureSection load='4x1d' size='340' side='right'caption='[[4x1d]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4x1d' size='340' side='right'caption='[[4x1d]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4x1d]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4X1D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4x1d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X1D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x1b\|4x1b]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1d OCA], [https://pdbe.org/4x1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x1d RCSB], [https://www.ebi.ac.uk/pdbsum/4x1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x1d ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4x1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1d OCA], [~~http~~://pdbe.org/4x1d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4x1d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4x1d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4x1d ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[~~http~~://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>	+	[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.	+	[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:

	==See Also==		==See Also==
-	*[[Transferrin\|Transferrin]]	+	*[[Transferrin 3D structures\|Transferrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 29:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Sun, H]]	+	[[Category: Sun H]]
-	[[Category: Wang, M]]	+	[[Category: Wang M]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	~~[[Category: Ferric]]~~	+
-	~~[[Category: Malonate]]~~	+
-	~~[[Category: Metal transport]]~~	+
-	~~[[Category: Transferrin]]~~	+
-	~~[[Category: Ytterbium~~]]	+

OCA at 09:06, 23 May 2019

2019-05-23T09:06:51Z

←Older revision		Revision as of 09:06, 23 May 2019
Line 1:		Line 1:

	==Ytterbium-bound human serum transferrin==		==Ytterbium-bound human serum transferrin==
-	<StructureSection load='4x1d' size='340' side='right' caption='[[4x1d]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4x1d' size='340' side='right'caption='[[4x1d]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4x1d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X1D FirstGlance]. <br>		<table><tr><td colspan='2'>[[4x1d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X1D FirstGlance]. <br>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Sun, H]]		[[Category: Sun, H]]
	[[Category: Wang, M]]		[[Category: Wang, M]]

OCA at 01:58, 10 March 2017

2017-03-10T01:58:33Z

←Older revision		Revision as of 01:58, 10 March 2017
Line 1:		Line 1:
		+
	==Ytterbium-bound human serum transferrin==		==Ytterbium-bound human serum transferrin==
	<StructureSection load='4x1d' size='340' side='right' caption='[[4x1d]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4x1d' size='340' side='right' caption='[[4x1d]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x1b\|4x1b]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x1b\|4x1b]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x1d RCSB], [http://www.ebi.ac.uk/pdbsum/4x1d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1d OCA], [http://pdbe.org/4x1d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x1d RCSB], [http://www.ebi.ac.uk/pdbsum/4x1d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x1d ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4x1d" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transferrin\|Transferrin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:17, 22 April 2015

2015-04-22T07:17:43Z

←Older revision		Revision as of 07:17, 22 April 2015
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.		[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	X-ray crystal structures of human serum transferrin (77 kDa) with YbIII or FeIII bound to the C-lobe and malonate as the synergistic anion show that the large YbIII ion causes the expansion of the metal binding pocket while octahedral metal coordination geometry is preserved, an unusual geometry for a lanthanide ion.
		+
		+	"Anion clamp" allows flexible protein to impose coordination geometry on metal ions.,Wang M, Lai TP, Wang L, Zhang H, Yang N, Sadler PJ, Sun H Chem Commun (Camb). 2015 Apr 9. PMID:25854324<ref>PMID:25854324</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:18, 8 April 2015

2015-04-08T11:18:09Z

←Older revision		Revision as of 11:18, 8 April 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Ytterbium-bound human serum transferrin==
-		+	<StructureSection load='4x1d' size='340' side='right' caption='[[4x1d]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~The entry~~ 4x1d is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4x1d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X1D FirstGlance]. <br>
-	~~Authors~~: ~~Wang~~, M., ~~Zhang, H~~., ~~Sun, H~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x1b\|4x1b]]</td></tr>
-	~~Description~~: ~~Ytterbium-bound human serum~~ transferrin	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x1d RCSB], [http://www.ebi.ac.uk/pdbsum/4x1d PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Sun, H]]
	[[Category: Wang, M]]		[[Category: Wang, M]]
	[[Category: Zhang, H]]		[[Category: Zhang, H]]
-	[[Category: ~~Sun, H~~]]	+	[[Category: Ferric]]
		+	[[Category: Malonate]]
		+	[[Category: Metal transport]]
		+	[[Category: Transferrin]]
		+	[[Category: Ytterbium]]

OCA at 20:19, 24 December 2014

2014-12-24T20:19:29Z

←Older revision		Revision as of 20:19, 24 December 2014
Line 6:		Line 6:

	Description: Ytterbium-bound human serum transferrin		Description: Ytterbium-bound human serum transferrin
		+	[[Category: Unreleased Structures]]
		+	[[Category: Wang, M]]
		+	[[Category: Zhang, H]]
		+	[[Category: Sun, H]]

OCA at 11:39, 17 December 2014

2014-12-17T11:39:48Z

←Older revision		Revision as of 11:39, 17 December 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4x1d is ON HOLD	+	The entry 4x1d is ON HOLD until Paper Publication

	Authors: Wang, M., Zhang, H., Sun, H.		Authors: Wang, M., Zhang, H., Sun, H.

-	Description: ~~ytterbium~~-bound human serum transferrin	+	Description: Ytterbium-bound human serum transferrin

OCA: Protected "4x1d" [edit=sysop:move=sysop]

2014-12-03T08:45:17Z

Protected "4x1d" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:45, 3 December 2014

OCA: New page: '''Unreleased structure''' The entry 4x1d is ON HOLD Authors: Wang, M., Zhang, H., Sun, H. Description: ytterbium-bound human serum transferrin

2014-12-03T08:45:15Z

New page: '''Unreleased structure''' The entry 4x1d is ON HOLD Authors: Wang, M., Zhang, H., Sun, H. Description: ytterbium-bound human serum transferrin

New page

'''Unreleased structure'''

The entry 4x1d is ON HOLD

Authors: Wang, M., Zhang, H., Sun, H.

Description: ytterbium-bound human serum transferrin