4x44 - Revision history

OCA at 12:59, 1 March 2024

2024-03-01T12:59:49Z

←Older revision		Revision as of 12:59, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4x44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X44 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4x44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X44 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.0535Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x44 OCA], [https://pdbe.org/4x44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x44 RCSB], [https://www.ebi.ac.uk/pdbsum/4x44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x44 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x44 OCA], [https://pdbe.org/4x44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x44 RCSB], [https://www.ebi.ac.uk/pdbsum/4x44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x44 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:11, 12 April 2023

2023-04-12T21:11:19Z

←Older revision		Revision as of 21:11, 12 April 2023
Line 3:		Line 3:
	<StructureSection load='4x44' size='340' side='right'caption='[[4x44]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4x44' size='340' side='right'caption='[[4x44]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4x44]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X44 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4X44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4x44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X44 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x45\|4x45]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x44 OCA], [https://pdbe.org/4x44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x44 RCSB], [https://www.ebi.ac.uk/pdbsum/4x44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x44 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APRT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenine_phosphoribosyltransferase Adenine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.7 2.4.2.7] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4x44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x44 OCA], [~~http~~://pdbe.org/4x44 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4x44 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4x44 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4x44 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/APT_HUMAN APT_HUMAN]] Defects in APRT are the cause of adenine phosphoribosyltransferase deficiency (APRTD) [MIM:[~~http~~://omim.org/entry/614723 614723]]; also known as 2,8-dihydroxyadenine urolithiasis. An enzymatic deficiency that can lead to urolithiasis and renal failure. Patients have 2,8-dihydroxyadenine (DHA) urinary stones.<ref>PMID:1746557</ref> <ref>PMID:7915931</ref> <ref>PMID:3680503</ref> <ref>PMID:3343350</ref> <ref>PMID:1353080</ref> <ref>PMID:11243733</ref> <ref>PMID:15571218</ref> <ref>PMID:21635362</ref>	+	[https://www.uniprot.org/uniprot/APT_HUMAN APT_HUMAN] Defects in APRT are the cause of adenine phosphoribosyltransferase deficiency (APRTD) [MIM:[https://omim.org/entry/614723 614723]; also known as 2,8-dihydroxyadenine urolithiasis. An enzymatic deficiency that can lead to urolithiasis and renal failure. Patients have 2,8-dihydroxyadenine (DHA) urinary stones.<ref>PMID:1746557</ref> <ref>PMID:7915931</ref> <ref>PMID:3680503</ref> <ref>PMID:3343350</ref> <ref>PMID:1353080</ref> <ref>PMID:11243733</ref> <ref>PMID:15571218</ref> <ref>PMID:21635362</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/APT_HUMAN APT_HUMAN]] Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	+	[https://www.uniprot.org/uniprot/APT_HUMAN APT_HUMAN] Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.

	==See Also==		==See Also==
-	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]	+	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Adenine phosphoribosyltransferase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Mercaldi, G]]	+	[[Category: Mercaldi G]]
-	[[Category: Pereira~~, H M~~]]	+	[[Category: Pereira HM]]
-	[[Category: Pimenta, A]]	+	[[Category: Pimenta A]]
-	[[Category: Thiemann~~, O H]]~~	+	[[Category: Thiemann OH]]
-	~~[[Category: Aprt]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:54, 29 May 2019

2019-05-29T06:54:56Z

←Older revision		Revision as of 06:54, 29 May 2019
Line 1:		Line 1:
		+
	==Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase==		==Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase==
-	<StructureSection load='4x44' size='340' side='right' caption='[[4x44]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='4x44' size='340' side='right'caption='[[4x44]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4x44]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4x44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X44 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x45\|4x45]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x45\|4x45]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APRT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenine_phosphoribosyltransferase Adenine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.7 2.4.2.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenine_phosphoribosyltransferase Adenine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.7 2.4.2.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x44 OCA], [http://pdbe.org/4x44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x44 RCSB], [http://www.ebi.ac.uk/pdbsum/4x44 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x44 OCA], [http://pdbe.org/4x44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x44 RCSB], [http://www.ebi.ac.uk/pdbsum/4x44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x44 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 12:		Line 14:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/APT_HUMAN APT_HUMAN]] Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.		[[http://www.uniprot.org/uniprot/APT_HUMAN APT_HUMAN]] Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 17:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Adenine phosphoribosyltransferase]]		[[Category: Adenine phosphoribosyltransferase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Mercaldi, G]]		[[Category: Mercaldi, G]]
	[[Category: Pereira, H M]]		[[Category: Pereira, H M]]

OCA at 16:15, 2 December 2015

2015-12-02T16:15:21Z

←Older revision		Revision as of 16:15, 2 December 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase==
-		+	<StructureSection load='4x44' size='340' side='right' caption='[[4x44]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	~~The entry~~ 4x44 is ~~ON HOLD until Dec 02 2016~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4x44]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X44 FirstGlance]. <br>
-	~~Authors~~: ~~Pimenta~~, A., ~~Pereira, H~~.M., ~~Mercaldi~~, G., ~~Thiemann, O~~.H.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x45\|4x45]]</td></tr>
-	~~Description~~: ~~Crystal Structure~~ of ~~Mutant R89Q of human Adenine~~ phosphoribosyltransferase	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenine_phosphoribosyltransferase Adenine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.7 2.4.2.7] </span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x44 OCA], [http://pdbe.org/4x44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x44 RCSB], [http://www.ebi.ac.uk/pdbsum/4x44 PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Pereira~~, H.M]]	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/APT_HUMAN APT_HUMAN]] Defects in APRT are the cause of adenine phosphoribosyltransferase deficiency (APRTD) [MIM:[http://omim.org/entry/614723 614723]]; also known as 2,8-dihydroxyadenine urolithiasis. An enzymatic deficiency that can lead to urolithiasis and renal failure. Patients have 2,8-dihydroxyadenine (DHA) urinary stones.<ref>PMID:1746557</ref> <ref>PMID:7915931</ref> <ref>PMID:3680503</ref> <ref>PMID:3343350</ref> <ref>PMID:1353080</ref> <ref>PMID:11243733</ref> <ref>PMID:15571218</ref> <ref>PMID:21635362</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/APT_HUMAN APT_HUMAN]] Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Adenine phosphoribosyltransferase]]
	[[Category: Mercaldi, G]]		[[Category: Mercaldi, G]]
-	[[Category: ~~Thiemann~~, O.H]]	+	[[Category: Pereira, H M]]
	[[Category: Pimenta, A]]		[[Category: Pimenta, A]]
		+	[[Category: Thiemann, O H]]
		+	[[Category: Aprt]]
		+	[[Category: Transferase]]

OCA at 20:27, 24 December 2014

2014-12-24T20:27:21Z

←Older revision		Revision as of 20:27, 24 December 2014
Line 6:		Line 6:

	Description: Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase		Description: Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase
		+	[[Category: Unreleased Structures]]
		+	[[Category: Pereira, H.M]]
		+	[[Category: Mercaldi, G]]
		+	[[Category: Thiemann, O.H]]
		+	[[Category: Pimenta, A]]

OCA at 09:58, 24 December 2014

2014-12-24T09:58:39Z

←Older revision		Revision as of 09:58, 24 December 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4x44 is ON HOLD	+	The entry 4x44 is ON HOLD until Dec 02 2016

	Authors: Pimenta, A., Pereira, H.M., Mercaldi, G., Thiemann, O.H.		Authors: Pimenta, A., Pereira, H.M., Mercaldi, G., Thiemann, O.H.

	Description: Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase		Description: Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase

OCA: Protected "4x44" [edit=sysop:move=sysop]

2014-12-10T14:21:13Z

Protected "4x44" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:21, 10 December 2014

OCA: New page: '''Unreleased structure''' The entry 4x44 is ON HOLD Authors: Pimenta, A., Pereira, H.M., Mercaldi, G., Thiemann, O.H. Description: Crystal Structure of Mutant R89Q of human Adenine ph...

2014-12-10T14:21:12Z

New page: '''Unreleased structure''' The entry 4x44 is ON HOLD Authors: Pimenta, A., Pereira, H.M., Mercaldi, G., Thiemann, O.H. Description: Crystal Structure of Mutant R89Q of human Adenine ph...

New page

'''Unreleased structure'''

The entry 4x44 is ON HOLD

Authors: Pimenta, A., Pereira, H.M., Mercaldi, G., Thiemann, O.H.

Description: Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase