4xdl - Revision history

OCA at 10:48, 10 January 2024

2024-01-10T10:48:12Z

←Older revision		Revision as of 10:48, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xdl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XDL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xdl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XDL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=40D:3-[2-BROMANYL-4-(TRIFLUOROMETHYL)PHENOXY]-N-METHYL-3-PHENYL-PROPAN-1-AMINE'>40D</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=40D:3-[2-BROMANYL-4-(TRIFLUOROMETHYL)PHENOXY]-N-METHYL-3-PHENYL-PROPAN-1-AMINE'>40D</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdl OCA], [https://pdbe.org/4xdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xdl RCSB], [https://www.ebi.ac.uk/pdbsum/4xdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdl OCA], [https://pdbe.org/4xdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xdl RCSB], [https://www.ebi.ac.uk/pdbsum/4xdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdl ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:24, 12 April 2023

2023-04-12T21:24:23Z

←Older revision		Revision as of 21:24, 12 April 2023
Line 1:		Line 1:

	==Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with a brominated fluoxetine derivative.==		==Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with a brominated fluoxetine derivative.==
-	<StructureSection load='4xdl' size='340' side='right' caption='[[4xdl]], [[Resolution\|resolution]] 3.50Å' scene=''>	+	<StructureSection load='4xdl' size='340' side='right'caption='[[4xdl]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xdl]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XDL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xdl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XDL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40D:3-[2-BROMANYL-4-(TRIFLUOROMETHYL)PHENOXY]-N-METHYL-3-PHENYL-PROPAN-1-AMINE'>40D</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=40D:3-[2-BROMANYL-4-(TRIFLUOROMETHYL)PHENOXY]-N-METHYL-3-PHENYL-PROPAN-1-AMINE'>40D</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bw5\|4bw5]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdl OCA], [https://pdbe.org/4xdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xdl RCSB], [https://www.ebi.ac.uk/pdbsum/4xdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdl ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KCNK10, TREK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdl OCA], [~~http~~://pdbe.org/4xdl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xdl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xdl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdl ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KCNKA_HUMAN KCNKA_HUMAN]] Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.	+	[https://www.uniprot.org/uniprot/KCNKA_HUMAN KCNKA_HUMAN] Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4xdl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xdl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Large Structures]]
-	[[Category: Bountra, C]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Brennan~~, P E~~]]	+	[[Category: Bountra C]]
-	[[Category: Burgess-Brown~~, N A~~]]	+	[[Category: Brennan PE]]
-	[[Category: Carpenter~~, E P~~]]	+	[[Category: Burgess-Brown NA]]
-	[[Category: Dong~~, Y Y~~]]	+	[[Category: Carpenter EP]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Dong YY]]
-	[[Category: Mackenzie, A]]	+	[[Category: Edwards AM]]
-	[[Category: Mukhopadhyay, S]]	+	[[Category: Mackenzie A]]
-	[[Category: Pike~~, A C.W~~]]	+	[[Category: Mukhopadhyay S]]
-	[[Category: Ruda~~, G F]]~~	+	[[Category: Pike ACW]]
-	~~[[Category: Structural genomic]]~~	+	[[Category: Ruda GF]]
-	~~[[Category: K2p]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Outward rectification]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 08:36, 10 January 2018

2018-01-10T08:36:23Z

←Older revision		Revision as of 08:36, 10 January 2018
Line 3:		Line 3:
	<StructureSection load='4xdl' size='340' side='right' caption='[[4xdl]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='4xdl' size='340' side='right' caption='[[4xdl]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xdl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XDL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xdl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XDL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40D:3-[2-BROMANYL-4-(TRIFLUOROMETHYL)PHENOXY]-N-METHYL-3-PHENYL-PROPAN-1-AMINE'>40D</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40D:3-[2-BROMANYL-4-(TRIFLUOROMETHYL)PHENOXY]-N-METHYL-3-PHENYL-PROPAN-1-AMINE'>40D</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bw5\|4bw5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bw5\|4bw5]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KCNK10, TREK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdl OCA], [http://pdbe.org/4xdl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xdl RCSB], [http://www.ebi.ac.uk/pdbsum/4xdl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdl OCA], [http://pdbe.org/4xdl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xdl RCSB], [http://www.ebi.ac.uk/pdbsum/4xdl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdl ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4xdl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xdl" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Potassium Channel\|Potassium Channel]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~ARROWSMITH~~, C H]]	+	[[Category: Human]]
-	[[Category: ~~BOUNTRA~~, C]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: ~~BRENNAN~~, P E]]	+	[[Category: Bountra, C]]
-	[[Category: ~~BURGESS~~-~~BROWN~~, N A]]	+	[[Category: Brennan, P E]]
-	[[Category: ~~CARPENTER~~, E P]]	+	[[Category: Burgess-Brown, N A]]
-	[[Category: ~~DONG~~, Y Y]]	+	[[Category: Carpenter, E P]]
-	[[Category: ~~EDWARDS~~, A M]]	+	[[Category: Dong, Y Y]]
-	[[Category: ~~MACKENZIE~~, A]]	+	[[Category: Edwards, A M]]
-	[[Category: ~~MUKHOPADHYAY~~, S]]	+	[[Category: Mackenzie, A]]
-	[[Category: ~~PIKE~~, A C.W]]	+	[[Category: Mukhopadhyay, S]]
-	[[Category: ~~RUDA~~, G F]]	+	[[Category: Pike, A C.W]]
		+	[[Category: Ruda, G F]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: K2p]]		[[Category: K2p]]

OCA at 00:14, 26 January 2017

2017-01-26T00:14:10Z

←Older revision		Revision as of 00:14, 26 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with a brominated fluoxetine derivative.==		==Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with a brominated fluoxetine derivative.==
	<StructureSection load='4xdl' size='340' side='right' caption='[[4xdl]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='4xdl' size='340' side='right' caption='[[4xdl]], [[Resolution\|resolution]] 3.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40D:3-[2-BROMANYL-4-(TRIFLUOROMETHYL)PHENOXY]-N-METHYL-3-PHENYL-PROPAN-1-AMINE'>40D</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40D:3-[2-BROMANYL-4-(TRIFLUOROMETHYL)PHENOXY]-N-METHYL-3-PHENYL-PROPAN-1-AMINE'>40D</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bw5\|4bw5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bw5\|4bw5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xdl RCSB], [http://www.ebi.ac.uk/pdbsum/4xdl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdl OCA], [http://pdbe.org/4xdl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xdl RCSB], [http://www.ebi.ac.uk/pdbsum/4xdl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xdl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Potassium Channel\|Potassium Channel]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:16, 1 April 2015

2015-04-01T07:16:10Z

←Older revision		Revision as of 07:16, 1 April 2015
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KCNKA_HUMAN KCNKA_HUMAN]] Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.		[[http://www.uniprot.org/uniprot/KCNKA_HUMAN KCNKA_HUMAN]] Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by multiple stimuli such as stretch, fatty acids, and pH and by several drugs. However, the mechanisms that control channel gating are unclear. Here we present crystal structures of the human TREK-2 channel (up to 3.4 angstrom resolution) in two conformations and in complex with norfluoxetine, the active metabolite of fluoxetine (Prozac) and a state-dependent blocker of TREK channels. Norfluoxetine binds within intramembrane fenestrations found in only one of these two conformations. Channel activation by arachidonic acid and mechanical stretch involves conversion between these states through movement of the pore-lining helices. These results provide an explanation for TREK channel mechanosensitivity, regulation by diverse stimuli, and possible off-target effects of the serotonin reuptake inhibitor Prozac.
		+
		+	K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.,Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP Science. 2015 Mar 13;347(6227):1256-9. doi: 10.1126/science.1261512. PMID:25766236<ref>PMID:25766236</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:17, 18 March 2015

2015-03-18T12:17:08Z

←Older revision		Revision as of 12:17, 18 March 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with a brominated fluoxetine derivative.==
-		+	<StructureSection load='4xdl' size='340' side='right' caption='[[4xdl]], [[Resolution\|resolution]] 3.50Å' scene=''>
-	~~The entry~~ 4xdl is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4xdl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XDL FirstGlance]. <br>
-	~~Authors~~: ~~MACKENZIE, A~~.~~, PIKE, A~~.C.W.~~, DONG, Y~~.Y.~~, MUKHOPADHYAY, S~~.~~, RUDA, G~~.F., ~~BRENNAN~~, ~~P.E.~~, ~~ARROWSMITH~~, C.H.~~, EDWARDS, A~~.M., ~~BOUNTRA, C~~.~~, BURGESS~~-~~BROWN~~, N.A., ~~CARPENTER, E~~.P.~~, Structural Genomics Consortium (SGC)~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40D:3-[2-BROMANYL-4-(TRIFLUOROMETHYL)PHENOXY]-N-METHYL-3-PHENYL-PROPAN-1-AMINE'>40D</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bw5\|4bw5]]</td></tr>
-	~~Description:~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xdl RCSB], [http://www.ebi.ac.uk/pdbsum/4xdl PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Ruda~~, ~~G.F~~]]	+	== Function ==
-	[[Category: ~~Pike~~, A.C.W]]	+	[[http://www.uniprot.org/uniprot/KCNKA_HUMAN KCNKA_HUMAN]] Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
-	[[Category: ~~Burgess-Brown~~, ~~N.A~~]]	+	__TOC__
-	[[Category: ~~Mukhopadhyay~~, S]]	+	</StructureSection>
-	[[Category: ~~Carpenter~~, E.P]]	+	[[Category: ARROWSMITH, C H]]
-	[[Category: ~~Bountra~~, C]]	+	[[Category: BOUNTRA, C]]
-	[[Category: ~~Mackenzie~~, A]]	+	[[Category: BRENNAN, P E]]
-	[[Category: ~~Arrowsmith~~, ~~C.H~~]]	+	[[Category: BURGESS-BROWN, N A]]
-	[[Category: ~~Dong~~, ~~Y.Y~~]]	+	[[Category: CARPENTER, E P]]
-	[[Category: ~~Edwards~~, A.M]]	+	[[Category: DONG, Y Y]]
-	[[Category: ~~Brennan~~, ~~P.E~~]]	+	[[Category: EDWARDS, A M]]
-	[[Category: Structural ~~Genomics Consortium (~~Sgc)]]	+	[[Category: MACKENZIE, A]]
		+	[[Category: MUKHOPADHYAY, S]]
		+	[[Category: PIKE, A C.W]]
		+	[[Category: RUDA, G F]]
		+	[[Category: Structural genomic]]
		+	[[Category: K2p]]
		+	[[Category: Membrane protein]]
		+	[[Category: Outward rectification]]
		+	[[Category: Sgc]]
		+	[[Category: Transport protein]]

OCA: Protected "4xdl" [edit=sysop:move=sysop]

2014-12-31T14:01:20Z

Protected "4xdl" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:01, 31 December 2014

OCA: New page: '''Unreleased structure''' The entry 4xdl is ON HOLD Authors: MACKENZIE, A., PIKE, A.C.W., DONG, Y.Y., MUKHOPADHYAY, S., RUDA, G.F., BRENNAN, P.E., ARROWSMITH, C.H., EDWARDS, A.M., BOUN...

2014-12-31T14:01:19Z

New page: '''Unreleased structure''' The entry 4xdl is ON HOLD Authors: MACKENZIE, A., PIKE, A.C.W., DONG, Y.Y., MUKHOPADHYAY, S., RUDA, G.F., BRENNAN, P.E., ARROWSMITH, C.H., EDWARDS, A.M., BOUN...

New page

'''Unreleased structure'''

The entry 4xdl is ON HOLD

Authors: MACKENZIE, A., PIKE, A.C.W., DONG, Y.Y., MUKHOPADHYAY, S., RUDA, G.F., BRENNAN, P.E., ARROWSMITH, C.H., EDWARDS, A.M., BOUNTRA, C., BURGESS-BROWN, N.A., CARPENTER, E.P., Structural Genomics Consortium (SGC)

Description:
[[Category: Unreleased Structures]]
[[Category: Ruda, G.F]]
[[Category: Pike, A.C.W]]
[[Category: Burgess-Brown, N.A]]
[[Category: Mukhopadhyay, S]]
[[Category: Carpenter, E.P]]
[[Category: Bountra, C]]
[[Category: Mackenzie, A]]
[[Category: Arrowsmith, C.H]]
[[Category: Dong, Y.Y]]
[[Category: Edwards, A.M]]
[[Category: Brennan, P.E]]
[[Category: Structural Genomics Consortium (Sgc)]]