4xhr - Revision history

OCA at 09:59, 19 April 2023

2023-04-19T09:59:25Z

←Older revision		Revision as of 09:59, 19 April 2023
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	<StructureSection load='4xhr' size='340' side='right'caption='[[4xhr]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='4xhr' size='340' side='right'caption='[[4xhr]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xhr]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XHR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xhr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XHR FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xiz\|4xiz]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhr OCA], [https://pdbe.org/4xhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xhr RCSB], [https://www.ebi.ac.uk/pdbsum/4xhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhr ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UPS1, YLR193C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), MDM35, YKL053C-A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhr OCA], [~~http~~://pdbe.org/4xhr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xhr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xhr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhr ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/UPS1_YEAST UPS1_YEAST]] Required for maintenance of normal mitochondrial morphology as well as PCP1-dependent processing of MGM1. With UPS2, controls the level of cardiolipin in mitochondria. Cardiolipin is a unique phospholipid with four fatty acid chains and is present mainly in the mitochondrial inner membrane where it stabilizes the electron transport chain supercomplex between complexes III and IV through direct interaction of their subunits.<ref>PMID:16754953</ref> <ref>PMID:19221197</ref> <ref>PMID:19506038</ref> <ref>PMID:20622808</ref> [[http://www.uniprot.org/uniprot/MDM35_YEAST MDM35_YEAST]] Involved in mitochondrial distribution and morphology. Mediates the import of UPS1, UPS2 and UPS3, 3 atypical mitochondrial intermembrane space (IMS) proteins lacking the two major IMS-targeting signals, into the intermembrane space.<ref>PMID:11907266</ref> <ref>PMID:20622808</ref> <ref>PMID:20657548</ref>	+	[https://www.uniprot.org/uniprot/UPS1_YEAST UPS1_YEAST] Required for maintenance of normal mitochondrial morphology as well as PCP1-dependent processing of MGM1. With UPS2, controls the level of cardiolipin in mitochondria. Cardiolipin is a unique phospholipid with four fatty acid chains and is present mainly in the mitochondrial inner membrane where it stabilizes the electron transport chain supercomplex between complexes III and IV through direct interaction of their subunits.<ref>PMID:16754953</ref> <ref>PMID:19221197</ref> <ref>PMID:19506038</ref> <ref>PMID:20622808</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: He, F]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: Wang, C]]	+	[[Category: He F]]
-	[[Category: Yu, F]]	+	[[Category: Wang C]]
-	[[Category: Zhang, P]]	+	[[Category: Yu F]]
-	~~[[Category: Lipid transport-oxidoreductase complex]]~~	+	[[Category: Zhang P]]
-	~~[[Category: Phospholipid~~]]	+

OCA at 06:54, 29 May 2019

2019-05-29T06:54:10Z

←Older revision		Revision as of 06:54, 29 May 2019
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	==Structure of a phospholipid trafficking complex, native==		==Structure of a phospholipid trafficking complex, native==
-	<StructureSection load='4xhr' size='340' side='right' caption='[[4xhr]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='4xhr' size='340' side='right'caption='[[4xhr]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xhr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xhr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHR FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xiz\|4xiz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xiz\|4xiz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UPS1, YLR193C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), MDM35, YKL053C-A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhr OCA], [http://pdbe.org/4xhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xhr RCSB], [http://www.ebi.ac.uk/pdbsum/4xhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhr OCA], [http://pdbe.org/4xhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xhr RCSB], [http://www.ebi.ac.uk/pdbsum/4xhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhr ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: He, F]]		[[Category: He, F]]
	[[Category: Wang, C]]		[[Category: Wang, C]]

OCA at 13:20, 10 May 2017

2017-05-10T13:20:44Z

←Older revision		Revision as of 13:20, 10 May 2017
Line 1:		Line 1:
		+
	==Structure of a phospholipid trafficking complex, native==		==Structure of a phospholipid trafficking complex, native==
	<StructureSection load='4xhr' size='340' side='right' caption='[[4xhr]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='4xhr' size='340' side='right' caption='[[4xhr]], [[Resolution\|resolution]] 2.55Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4xhr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHR FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xhr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHR FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xiz\|4xiz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xiz\|4xiz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xhr RCSB], [http://www.ebi.ac.uk/pdbsum/4xhr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhr OCA], [http://pdbe.org/4xhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xhr RCSB], [http://www.ebi.ac.uk/pdbsum/4xhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xhr" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:07, 1 July 2015

2015-07-01T12:07:00Z

←Older revision		Revision as of 12:07, 1 July 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structure of a phospholipid trafficking complex, native==
		+	<StructureSection load='4xhr' size='340' side='right' caption='[[4xhr]], [[Resolution\|resolution]] 2.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xhr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHR FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xiz\|4xiz]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xhr RCSB], [http://www.ebi.ac.uk/pdbsum/4xhr PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UPS1_YEAST UPS1_YEAST]] Required for maintenance of normal mitochondrial morphology as well as PCP1-dependent processing of MGM1. With UPS2, controls the level of cardiolipin in mitochondria. Cardiolipin is a unique phospholipid with four fatty acid chains and is present mainly in the mitochondrial inner membrane where it stabilizes the electron transport chain supercomplex between complexes III and IV through direct interaction of their subunits.<ref>PMID:16754953</ref> <ref>PMID:19221197</ref> <ref>PMID:19506038</ref> <ref>PMID:20622808</ref> [[http://www.uniprot.org/uniprot/MDM35_YEAST MDM35_YEAST]] Involved in mitochondrial distribution and morphology. Mediates the import of UPS1, UPS2 and UPS3, 3 atypical mitochondrial intermembrane space (IMS) proteins lacking the two major IMS-targeting signals, into the intermembrane space.<ref>PMID:11907266</ref> <ref>PMID:20622808</ref> <ref>PMID:20657548</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ups1 forms a complex with Mdm35 and is critical for the transport of phosphatidic acid (PA) from the mitochondrial outer membrane to the inner membrane. We report the crystal structure of the Ups1-Mdm35-PA complex and the functional characterization of Ups1-Mdm35 in PA binding and transfer. Ups1 features a barrel-like structure consisting of an antiparallel beta-sheet and three alpha-helices. Mdm35 adopts a three-helical clamp-like structure to wrap around Ups1 to form a stable complex. The beta-sheet and alpha-helices of Ups1 form a long tunnel-like pocket to accommodate the substrate PA, and a short helix alpha2 acts as a lid to cover the pocket. The hydrophobic residues lining the pocket and helix alpha2 are critical for PA binding and transfer. In addition, a hydrophilic patch on the surface of Ups1 near the PA phosphate-binding site also plays an important role in the function of Ups1-Mdm35. Our study reveals the molecular basis of the function of Ups1-Mdm35 and sheds new light on the mechanism of intramitochondrial phospholipid transport by the MSF1/PRELI family proteins.

-	~~The entry 4xhr is ON HOLD until Paper Publication~~	+	Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex.,Yu F, He F, Yao H, Wang C, Wang J, Li J, Qi X, Xue H, Ding J, Zhang P EMBO Rep. 2015 Jun 12. pii: e201540137. PMID:26071601<ref>PMID:26071601</ref>

-	~~Authors: Yu~~, F.~~, He, F~~.~~, Wang, C., Zhang, P~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Structure of a phospholipid trafficking complex, native~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: He, F]]		[[Category: He, F]]
		+	[[Category: Wang, C]]
		+	[[Category: Yu, F]]
	[[Category: Zhang, P]]		[[Category: Zhang, P]]
-	[[Category: ~~Yu, F~~]]	+	[[Category: Lipid transport-oxidoreductase complex]]
-	[[Category: ~~Wang, C~~]]	+	[[Category: Phospholipid]]

OCA at 12:03, 25 February 2015

2015-02-25T12:03:50Z

←Older revision		Revision as of 12:03, 25 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xhr is ON HOLD	+	The entry 4xhr is ON HOLD until Paper Publication

	Authors: Yu, F., He, F., Wang, C., Zhang, P.		Authors: Yu, F., He, F., Wang, C., Zhang, P.

OCA at 10:24, 12 February 2015

2015-02-12T10:24:16Z

←Older revision		Revision as of 10:24, 12 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xhr is ON HOLD ~~until sometime in the future~~	+	The entry 4xhr is ON HOLD

	Authors: Yu, F., He, F., Wang, C., Zhang, P.		Authors: Yu, F., He, F., Wang, C., Zhang, P.

OCA at 14:29, 7 February 2015

2015-02-07T14:29:37Z

←Older revision		Revision as of 14:29, 7 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xhr is ON HOLD	+	The entry 4xhr is ON HOLD until sometime in the future

	Authors: Yu, F., He, F., Wang, C., Zhang, P.		Authors: Yu, F., He, F., Wang, C., Zhang, P.

OCA at 15:52, 21 January 2015

2015-01-21T15:52:18Z

←Older revision		Revision as of 15:52, 21 January 2015
Line 5:		Line 5:
	Authors: Yu, F., He, F., Wang, C., Zhang, P.		Authors: Yu, F., He, F., Wang, C., Zhang, P.

-	Description: ~~structure~~ of a phospholipid trafficking ~~complex_native~~	+	Description: Structure of a phospholipid trafficking complex, native
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: He, F]]		[[Category: He, F]]

OCA: Protected "4xhr" [edit=sysop:move=sysop]

2015-01-14T12:43:22Z

Protected "4xhr" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:43, 14 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xhr is ON HOLD Authors: Yu, F., He, F., Wang, C., Zhang, P. Description: structure of a phospholipid trafficking complex_native [[Category: Unrele...

2015-01-14T12:43:20Z

New page: '''Unreleased structure''' The entry 4xhr is ON HOLD Authors: Yu, F., He, F., Wang, C., Zhang, P. Description: structure of a phospholipid trafficking complex_native [[Category: Unrele...

New page

'''Unreleased structure'''

The entry 4xhr is ON HOLD

Authors: Yu, F., He, F., Wang, C., Zhang, P.

Description: structure of a phospholipid trafficking complex_native
[[Category: Unreleased Structures]]
[[Category: He, F]]
[[Category: Zhang, P]]
[[Category: Yu, F]]
[[Category: Wang, C]]