4xip - Revision history

OCA at 13:01, 1 March 2024

2024-03-01T13:01:03Z

←Older revision		Revision as of 13:01, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xip]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XIP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xip]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XIP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=40W:4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDOL-1-YL)BENZAMIDE'>40W</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=40W:4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDOL-1-YL)BENZAMIDE'>40W</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xip OCA], [https://pdbe.org/4xip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xip RCSB], [https://www.ebi.ac.uk/pdbsum/4xip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xip ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xip OCA], [https://pdbe.org/4xip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xip RCSB], [https://www.ebi.ac.uk/pdbsum/4xip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xip ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>		[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Two novel series of oxazepine and diazepine based HSP90 inhibitors are reported. This effort relied on structure based design and isothermal calorimetry to identify small drug like macrocycles. Computational modelling was used to build into a solvent exposed pocket near the opening of the ATP binding site, which led to potent inhibitors of HSP90 (25-30).
-
-	Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors.,Neubert T, Numa M, Ernst J, Clemens J, Krenitsky P, Liu M, Fleck B, Woody L, Zuccola H, Stamos D Bioorg Med Chem Lett. 2015 Mar 15;25(6):1338-42. doi: 10.1016/j.bmcl.2015.01.023., Epub 2015 Jan 20. PMID:25677667<ref>PMID:25677667</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4xip" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:37, 26 April 2023

2023-04-26T17:37:16Z

←Older revision		Revision as of 17:37, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4xip' size='340' side='right'caption='[[4xip]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4xip' size='340' side='right'caption='[[4xip]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xip]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XIP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XIP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xip]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XIP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40W:4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDOL-1-YL)BENZAMIDE'>40W</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=40W:4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDOL-1-YL)BENZAMIDE'>40W</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xiq\|4xiq]], [[4xir\|4xir]], [[4xit\|4xit]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xip OCA], [https://pdbe.org/4xip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xip RCSB], [https://www.ebi.ac.uk/pdbsum/4xip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xip ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xip OCA], [~~http~~://pdbe.org/4xip PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xip RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xip PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xip ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Neubert, T]]	+	[[Category: Neubert T]]
-	[[Category: Zuccola~~, H J]]~~	+	[[Category: Zuccola HJ]]
-	~~[[Category: Chaperone-chaperone inhibitor complex~~]]	+

OCA at 07:35, 29 May 2019

2019-05-29T07:35:33Z

←Older revision		Revision as of 07:35, 29 May 2019
Line 1:		Line 1:

	==Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors==		==Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors==
-	<StructureSection load='4xip' size='340' side='right' caption='[[4xip]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4xip' size='340' side='right'caption='[[4xip]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xip]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XIP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xip]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XIP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40W:4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDOL-1-YL)BENZAMIDE'>40W</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40W:4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDOL-1-YL)BENZAMIDE'>40W</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xiq\|4xiq]], [[4xir\|4xir]], [[4xit\|4xit]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xiq\|4xiq]], [[4xir\|4xir]], [[4xit\|4xit]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xip OCA], [http://pdbe.org/4xip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xip RCSB], [http://www.ebi.ac.uk/pdbsum/4xip PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xip OCA], [http://pdbe.org/4xip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xip RCSB], [http://www.ebi.ac.uk/pdbsum/4xip PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xip ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Neubert, T]]		[[Category: Neubert, T]]
	[[Category: Zuccola, H J]]		[[Category: Zuccola, H J]]
	[[Category: Chaperone-chaperone inhibitor complex]]		[[Category: Chaperone-chaperone inhibitor complex]]

OCA at 08:30, 1 June 2016

2016-06-01T08:30:33Z

←Older revision		Revision as of 08:30, 1 June 2016
Line 1:		Line 1:
		+
	==Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors==		==Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors==
	<StructureSection load='4xip' size='340' side='right' caption='[[4xip]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4xip' size='340' side='right' caption='[[4xip]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40W:4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDOL-1-YL)BENZAMIDE'>40W</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40W:4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDOL-1-YL)BENZAMIDE'>40W</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xiq\|4xiq]], [[4xir\|4xir]], [[4xit\|4xit]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xiq\|4xiq]], [[4xir\|4xir]], [[4xit\|4xit]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xip OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xip RCSB], [http://www.ebi.ac.uk/pdbsum/4xip PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xip OCA], [http://pdbe.org/4xip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xip RCSB], [http://www.ebi.ac.uk/pdbsum/4xip PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xip" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Proteins\|Heat Shock Proteins]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:22, 4 March 2015

2015-03-04T11:22:49Z

←Older revision		Revision as of 11:22, 4 March 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors==
		+	<StructureSection load='4xip' size='340' side='right' caption='[[4xip]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xip]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XIP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40W:4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDOL-1-YL)BENZAMIDE'>40W</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xiq\|4xiq]], [[4xir\|4xir]], [[4xit\|4xit]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xip OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xip RCSB], [http://www.ebi.ac.uk/pdbsum/4xip PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Two novel series of oxazepine and diazepine based HSP90 inhibitors are reported. This effort relied on structure based design and isothermal calorimetry to identify small drug like macrocycles. Computational modelling was used to build into a solvent exposed pocket near the opening of the ATP binding site, which led to potent inhibitors of HSP90 (25-30).

-	~~The entry 4xip is ON HOLD~~	+	Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors.,Neubert T, Numa M, Ernst J, Clemens J, Krenitsky P, Liu M, Fleck B, Woody L, Zuccola H, Stamos D Bioorg Med Chem Lett. 2015 Mar 15;25(6):1338-42. doi: 10.1016/j.bmcl.2015.01.023., Epub 2015 Jan 20. PMID:25677667<ref>PMID:25677667</ref>

-	~~Authors: Zuccola~~, H.J.~~, Neubert, T~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description:~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
-	~~[[Category: Zuccola, H.J]]~~	+	__TOC__
		+	</StructureSection>
	[[Category: Neubert, T]]		[[Category: Neubert, T]]
		+	[[Category: Zuccola, H J]]
		+	[[Category: Chaperone-chaperone inhibitor complex]]

OCA: Protected "4xip" [edit=sysop:move=sysop]

2015-01-14T12:46:28Z

Protected "4xip" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:46, 14 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xip is ON HOLD Authors: Zuccola, H.J., Neubert, T. Description: Category: Unreleased Structures Category: Zuccola, H.J [[Category: Neuber...

2015-01-14T12:46:27Z

New page: '''Unreleased structure''' The entry 4xip is ON HOLD Authors: Zuccola, H.J., Neubert, T. Description: Category: Unreleased Structures Category: Zuccola, H.J [[Category: Neuber...

New page

'''Unreleased structure'''

The entry 4xip is ON HOLD

Authors: Zuccola, H.J., Neubert, T.

Description:
[[Category: Unreleased Structures]]
[[Category: Zuccola, H.J]]
[[Category: Neubert, T]]