4xju - Revision history

OCA at 10:48, 10 January 2024

2024-01-10T10:48:49Z

←Older revision		Revision as of 10:48, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xju]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XJU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xju]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XJU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=19D:(1R,2R,3R,4R,5R,7R)-2-(ACETYLAMINO)-7-[(1R)-1,2-DIHYDROXYETHYL]-4-FLUORO-3-HYDROXY-6,8-DIOXABICYCLO[3.2.1]OCTANE-5-CARBOXYLIC+ACID'>19D</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.94Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=19D:(1R,2R,3R,4R,5R,7R)-2-(ACETYLAMINO)-7-[(1R)-1,2-DIHYDROXYETHYL]-4-FLUORO-3-HYDROXY-6,8-DIOXABICYCLO[3.2.1]OCTANE-5-CARBOXYLIC+ACID'>19D</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xju OCA], [https://pdbe.org/4xju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xju RCSB], [https://www.ebi.ac.uk/pdbsum/4xju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xju ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xju OCA], [https://pdbe.org/4xju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xju RCSB], [https://www.ebi.ac.uk/pdbsum/4xju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xju ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:40, 26 April 2023

2023-04-26T17:40:34Z

←Older revision		Revision as of 17:40, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4xju' size='340' side='right'caption='[[4xju]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='4xju' size='340' side='right'caption='[[4xju]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xju]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strpn Strpn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XJU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xju]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XJU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19D:(1R,2R,3R,4R,5R,7R)-2-(ACETYLAMINO)-7-[(1R)-1,2-DIHYDROXYETHYL]-4-FLUORO-3-HYDROXY-6,8-DIOXABICYCLO[3.2.1]OCTANE-5-CARBOXYLIC+ACID'>19D</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=19D:(1R,2R,3R,4R,5R,7R)-2-(ACETYLAMINO)-7-[(1R)-1,2-DIHYDROXYETHYL]-4-FLUORO-3-HYDROXY-6,8-DIOXABICYCLO[3.2.1]OCTANE-5-CARBOXYLIC+ACID'>19D</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nanB, SP_1687 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xju OCA], [https://pdbe.org/4xju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xju RCSB], [https://www.ebi.ac.uk/pdbsum/4xju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xju ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xju OCA], [~~http~~://pdbe.org/4xju PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xju RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xju PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xju ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NANB_STRPN NANB_STRPN]

	==See Also==		==See Also==
-	*[[~~Sialidase~~\|~~Sialidase~~]]	+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Exo-alpha-sialidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Strpn~~]]	+	[[Category: Streptococcus pneumoniae TIGR4]]
-	[[Category: Brear, P]]	+	[[Category: Brear P]]
-	~~[[Category: Allosteric inhibitor]]~~	+
-	~~[[Category: Crystallization artefact]]~~	+
-	~~[[Category: Drug design]]~~	+
-	~~[[Category: Glycosidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Intramolecular trans-sialidase]]~~	+
-	~~[[Category: Neuraminidase]]~~	+
-	~~[[Category: Serendipitous allosteric site~~]]	+

OCA at 06:58, 29 May 2019

2019-05-29T06:58:12Z

←Older revision		Revision as of 06:58, 29 May 2019
Line 1:		Line 1:
		+
	==Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 4-acetamido-2-fluoro-3-hydroxy-6-[1,2-dihydroxyethyl]-7,8-dioxabicyclo[3.2.1]octane-1-carboxylic acid==		==Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 4-acetamido-2-fluoro-3-hydroxy-6-[1,2-dihydroxyethyl]-7,8-dioxabicyclo[3.2.1]octane-1-carboxylic acid==
-	<StructureSection load='4xju' size='340' side='right' caption='[[4xju]], [[Resolution\|resolution]] 1.94Å' scene=''>	+	<StructureSection load='4xju' size='340' side='right'caption='[[4xju]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xju]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XJU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xju]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XJU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19D:(1R,2R,3R,4R,5R,7R)-2-(ACETYLAMINO)-7-[(1R)-1,2-DIHYDROXYETHYL]-4-FLUORO-3-HYDROXY-6,8-DIOXABICYCLO[3.2.1]OCTANE-5-CARBOXYLIC+ACID'>19D</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19D:(1R,2R,3R,4R,5R,7R)-2-(ACETYLAMINO)-7-[(1R)-1,2-DIHYDROXYETHYL]-4-FLUORO-3-HYDROXY-6,8-DIOXABICYCLO[3.2.1]OCTANE-5-CARBOXYLIC+ACID'>19D</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nanB, SP_1687 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xju OCA], [http://pdbe.org/4xju PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xju RCSB], [http://www.ebi.ac.uk/pdbsum/4xju PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xju OCA], [http://pdbe.org/4xju PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xju RCSB], [http://www.ebi.ac.uk/pdbsum/4xju PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xju ProSAT]</span></td></tr>
	</table>		</table>
		+
		+	==See Also==
		+	*[[Sialidase\|Sialidase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
		+	[[Category: Large Structures]]
		+	[[Category: Strpn]]
	[[Category: Brear, P]]		[[Category: Brear, P]]
	[[Category: Allosteric inhibitor]]		[[Category: Allosteric inhibitor]]

OCA at 20:22, 13 January 2016

2016-01-13T20:22:56Z

←Older revision		Revision as of 20:22, 13 January 2016
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	==Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 4-acetamido-2-fluoro-3-hydroxy-6-[1,2-dihydroxyethyl]-7,8-dioxabicyclo[3.2.1]octane-1-carboxylic acid==
-		+	<StructureSection load='4xju' size='340' side='right' caption='[[4xju]], [[Resolution\|resolution]] 1.94Å' scene=''>
-	~~The entry 4xju is ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4xju]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XJU FirstGlance]. <br>
-	~~Authors: Brear, P.~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19D:(1R,2R,3R,4R,5R,7R)-2-(ACETYLAMINO)-7-[(1R)-1,2-DIHYDROXYETHYL]-4-FLUORO-3-HYDROXY-6,8-DIOXABICYCLO[3.2.1]OCTANE-5-CARBOXYLIC+ACID'>19D</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	~~Description:~~ Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 4-acetamido-2-fluoro-3-hydroxy-6-[1,2-dihydroxyethyl]-7,8-dioxabicyclo[3.2.1]octane-1-carboxylic acid	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xju OCA], [http://pdbe.org/4xju PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xju RCSB], [http://www.ebi.ac.uk/pdbsum/4xju PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Exo-alpha-sialidase]]
	[[Category: Brear, P]]		[[Category: Brear, P]]
		+	[[Category: Allosteric inhibitor]]
		+	[[Category: Crystallization artefact]]
		+	[[Category: Drug design]]
		+	[[Category: Glycosidase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Intramolecular trans-sialidase]]
		+	[[Category: Neuraminidase]]
		+	[[Category: Serendipitous allosteric site]]

OCA: Protected "4xju" [edit=sysop:move=sysop]

2015-01-21T15:55:52Z

Protected "4xju" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:55, 21 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xju is ON HOLD until Paper Publication Authors: Brear, P. Description: Crystal structure of the NanB sialidase from streptococcus pneumoniae in co...

2015-01-21T15:55:51Z

New page: '''Unreleased structure''' The entry 4xju is ON HOLD until Paper Publication Authors: Brear, P. Description: Crystal structure of the NanB sialidase from streptococcus pneumoniae in co...

New page

'''Unreleased structure'''

The entry 4xju is ON HOLD until Paper Publication

Authors: Brear, P.

Description: Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 4-acetamido-2-fluoro-3-hydroxy-6-[1,2-dihydroxyethyl]-7,8-dioxabicyclo[3.2.1]octane-1-carboxylic acid
[[Category: Unreleased Structures]]
[[Category: Brear, P]]