4xl1 - Revision history

OCA at 17:41, 26 April 2023

2023-04-26T17:41:42Z

←Older revision		Revision as of 17:41, 26 April 2023
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	<StructureSection load='4xl1' size='340' side='right'caption='[[4xl1]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4xl1' size='340' side='right'caption='[[4xl1]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xl1]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XL1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XL1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xl1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XL1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL~~-~~D-GLUCOSAMINE~~'>~~NAG~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~MLY~~:N-~~DIMETHYL~~-~~LYSINE~~'>~~MLY~~</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xl1 OCA], [https://pdbe.org/4xl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xl1 RCSB], [https://www.ebi.ac.uk/pdbsum/4xl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xl1 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Notch1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Dll4, Dll4_predicted, rCG_26804 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xl1 OCA], [~~http~~://pdbe.org/4xl1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xl1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xl1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xl1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NOTC1_RAT NOTC1_RAT]] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression.<ref>PMID:11182080</ref> ~~[[http://www.uniprot.org/uniprot/D3ZHH1_RAT D3ZHH1_RAT]] Putative Notch ligand involved in the mediation of Notch signaling.[RuleBase:RU280815]~~	+	[https://www.uniprot.org/uniprot/NOTC1_RAT NOTC1_RAT] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression.<ref>PMID:11182080</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Garcia, K C~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Jude, K M~~]]	+	[[Category: Garcia KC]]
-	[[Category: ~~Luca, V C~~]]	+	[[Category: Jude KM]]
-	[[Category: ~~Egf domain]]~~	+	[[Category: Luca VC]]
-	~~[[Category: Glycosylation]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Receptor-ligand complex~~]]	+

OCA at 16:04, 20 November 2019

2019-11-20T16:04:52Z

←Older revision		Revision as of 16:04, 20 November 2019
Line 1:		Line 1:

	==Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF1)==		==Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF1)==
-	<StructureSection load='4xl1' size='340' side='right' caption='[[4xl1]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4xl1' size='340' side='right'caption='[[4xl1]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xl1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XL1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xl1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XL1 FirstGlance]. <br>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Garcia, K C]]		[[Category: Garcia, K C]]
	[[Category: Jude, K M]]		[[Category: Jude, K M]]

OCA at 15:31, 15 November 2017

2017-11-15T15:31:17Z

←Older revision		Revision as of 15:31, 15 November 2017
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	<StructureSection load='4xl1' size='340' side='right' caption='[[4xl1]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4xl1' size='340' side='right' caption='[[4xl1]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xl1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XL1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xl1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XL1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Notch1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Dll4, Dll4_predicted, rCG_26804 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xl1 OCA], [http://pdbe.org/4xl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xl1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xl1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xl1 OCA], [http://pdbe.org/4xl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xl1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xl1 ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Garcia, K C]]		[[Category: Garcia, K C]]
	[[Category: Jude, K M]]		[[Category: Jude, K M]]

OCA at 13:26, 19 April 2017

2017-04-19T13:26:29Z

←Older revision		Revision as of 13:26, 19 April 2017
Line 1:		Line 1:
		+
	==Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF1)==		==Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF1)==
	<StructureSection load='4xl1' size='340' side='right' caption='[[4xl1]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4xl1' size='340' side='right' caption='[[4xl1]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xl1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xl1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xl1 OCA], [http://pdbe.org/4xl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xl1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xl1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xl1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:01, 11 March 2015

2015-03-11T06:01:25Z

←Older revision		Revision as of 06:01, 11 March 2015
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/NOTC1_RAT NOTC1_RAT]] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression.<ref>PMID:11182080</ref> [[http://www.uniprot.org/uniprot/D3ZHH1_RAT D3ZHH1_RAT]] Putative Notch ligand involved in the mediation of Notch signaling.[RuleBase:RU280815]		[[http://www.uniprot.org/uniprot/NOTC1_RAT NOTC1_RAT]] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression.<ref>PMID:11182080</ref> [[http://www.uniprot.org/uniprot/D3ZHH1_RAT D3ZHH1_RAT]] Putative Notch ligand involved in the mediation of Notch signaling.[RuleBase:RU280815]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Notch receptors guide mammalian cell fate decisions by engaging the proteins Jagged and Delta-like (DLL). The 2.3 angstrom resolution crystal structure of the interacting regions of the Notch1-DLL4 complex reveals a two-site, antiparallel binding orientation assisted by Notch1 O-linked glycosylation. Notch1 epidermal growth factor-like repeats 11 and 12 interact with the DLL4 Delta/Serrate/Lag-2 (DSL) domain and module at the N-terminus of Notch ligands (MNNL) domains, respectively. Threonine and serine residues on Notch1 are functionalized with O-fucose and O-glucose, which act as surrogate amino acids by making specific, and essential, contacts to residues on DLL4. The elucidation of a direct chemical role for O-glycans in Notch1 ligand engagement demonstrates how, by relying on posttranslational modifications of their ligand binding sites, Notch proteins have linked their functional capacity to developmentally regulated biosynthetic pathways.
		+
		+	Structural biology. Structural basis for Notch1 engagement of Delta-like 4.,Luca VC, Jude KM, Pierce NW, Nachury MV, Fischer S, Garcia KC Science. 2015 Feb 20;347(6224):847-53. doi: 10.1126/science.1261093. PMID:25700513<ref>PMID:25700513</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:39, 4 March 2015

2015-03-04T11:39:28Z

←Older revision		Revision as of 11:39, 4 March 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF1)==
-		+	<StructureSection load='4xl1' size='340' side='right' caption='[[4xl1]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~The entry~~ 4xl1 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4xl1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XL1 FirstGlance]. <br>
-	~~Authors~~: ~~Luca~~, V.C., ~~Jude~~, K.M., ~~Garcia~~, K.C.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
-	~~Description:~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xl1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xl1 PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: Jude, K.M]]	+	== Function ==
-	[[Category: ~~Garcia~~, K.C]]	+	[[http://www.uniprot.org/uniprot/NOTC1_RAT NOTC1_RAT]] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression.<ref>PMID:11182080</ref> [[http://www.uniprot.org/uniprot/D3ZHH1_RAT D3ZHH1_RAT]] Putative Notch ligand involved in the mediation of Notch signaling.[RuleBase:RU280815]
-	[[Category: ~~Luca, V.C~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Garcia, K C]]
		+	[[Category: Jude, K M]]
		+	[[Category: Luca, V C]]
		+	[[Category: Egf domain]]
		+	[[Category: Glycosylation]]
		+	[[Category: Protein binding]]
		+	[[Category: Receptor-ligand complex]]

OCA at 10:28, 12 February 2015

2015-02-12T10:28:53Z

←Older revision		Revision as of 10:28, 12 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xl1 is ON HOLD	+	The entry 4xl1 is ON HOLD until Paper Publication

	Authors: Luca, V.C., Jude, K.M., Garcia, K.C.		Authors: Luca, V.C., Jude, K.M., Garcia, K.C.

OCA: Protected "4xl1" [edit=sysop:move=sysop]

2015-01-21T15:58:36Z

Protected "4xl1" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:58, 21 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xl1 is ON HOLD Authors: Luca, V.C., Jude, K.M., Garcia, K.C. Description: Category: Unreleased Structures Category: Jude, K.M [[Category:...

2015-01-21T15:58:35Z

New page: '''Unreleased structure''' The entry 4xl1 is ON HOLD Authors: Luca, V.C., Jude, K.M., Garcia, K.C. Description: Category: Unreleased Structures Category: Jude, K.M [[Category:...

New page

'''Unreleased structure'''

The entry 4xl1 is ON HOLD

Authors: Luca, V.C., Jude, K.M., Garcia, K.C.

Description:
[[Category: Unreleased Structures]]
[[Category: Jude, K.M]]
[[Category: Garcia, K.C]]
[[Category: Luca, V.C]]