4xm5 - Revision history

OCA at 11:29, 9 May 2024

2024-05-09T11:29:56Z

←Older revision		Revision as of 11:29, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xm5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XM5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xm5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XM5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.34Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xm5 OCA], [https://pdbe.org/4xm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xm5 RCSB], [https://www.ebi.ac.uk/pdbsum/4xm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xm5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xm5 OCA], [https://pdbe.org/4xm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xm5 RCSB], [https://www.ebi.ac.uk/pdbsum/4xm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xm5 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:42, 26 April 2023

2023-04-26T17:42:39Z

←Older revision		Revision as of 17:42, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4xm5' size='340' side='right'caption='[[4xm5]], [[Resolution\|resolution]] 2.34Å' scene=''>		<StructureSection load='4xm5' size='340' side='right'caption='[[4xm5]], [[Resolution\|resolution]] 2.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xm5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_2001 Atcc 2001~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XM5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XM5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xm5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XM5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLX1, CAGL0K06941g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5478 ATCC 2001])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xm5 OCA], [https://pdbe.org/4xm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xm5 RCSB], [https://www.ebi.ac.uk/pdbsum/4xm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xm5 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xm5 OCA], [~~http~~://pdbe.org/4xm5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xm5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xm5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xm5 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SLX1_CANGA SLX1_CANGA]] Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	+	[https://www.uniprot.org/uniprot/SLX1_CANGA SLX1_CANGA] Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Endonuclease\|Endonuclease]]	+	*[[Endonuclease 3D structures\|Endonuclease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 2001]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gaur, V]]	+	[[Category: Gaur V]]
-	[[Category: Gorecka~~, K M~~]]	+	[[Category: Gorecka KM]]
-	[[Category: Komorowska, W]]	+	[[Category: Komorowska W]]
-	[[Category: Nowotny, M]]	+	[[Category: Nowotny M]]
-	~~[[Category: Sanctis, D de~~]]	+	[[Category: Szczepanowski RH]]
-	[[Category: Szczepanowski~~, R H~~]]	+	[[Category: West SC]]
-	[[Category: West~~, S C~~]]	+	[[Category: Wyatt HDM]]
-	[[Category: Wyatt~~, H D.M~~]]	+	[[Category: De Sanctis D]]
-	[[Category: ~~Dna repair]]~~	+
-	~~[[Category: Giy-yig]]~~	+
-	~~[[Category: Homogolous recombination]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nuclease~~]]	+

OCA at 07:36, 29 May 2019

2019-05-29T07:36:20Z

←Older revision		Revision as of 07:36, 29 May 2019
Line 1:		Line 1:

	==C. glabrata Slx1.==		==C. glabrata Slx1.==
-	<StructureSection load='4xm5' size='340' side='right' caption='[[4xm5]], [[Resolution\|resolution]] 2.34Å' scene=''>	+	<StructureSection load='4xm5' size='340' side='right'caption='[[4xm5]], [[Resolution\|resolution]] 2.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xm5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XM5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xm5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_2001 Atcc 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XM5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLX1, CAGL0K06941g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5478 ATCC 2001])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xm5 OCA], [http://pdbe.org/4xm5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xm5 RCSB], [http://www.ebi.ac.uk/pdbsum/4xm5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xm5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xm5 OCA], [http://pdbe.org/4xm5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xm5 RCSB], [http://www.ebi.ac.uk/pdbsum/4xm5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xm5 ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4xm5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xm5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Endonuclease\|Endonuclease]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 2001]]
		+	[[Category: Large Structures]]
	[[Category: Gaur, V]]		[[Category: Gaur, V]]
	[[Category: Gorecka, K M]]		[[Category: Gorecka, K M]]

OCA at 01:56, 10 March 2017

2017-03-10T01:56:13Z

←Older revision		Revision as of 01:56, 10 March 2017
Line 1:		Line 1:
		+
	==C. glabrata Slx1.==		==C. glabrata Slx1.==
	<StructureSection load='4xm5' size='340' side='right' caption='[[4xm5]], [[Resolution\|resolution]] 2.34Å' scene=''>		<StructureSection load='4xm5' size='340' side='right' caption='[[4xm5]], [[Resolution\|resolution]] 2.34Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4xm5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XM5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xm5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XM5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xm5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xm5 RCSB], [http://www.ebi.ac.uk/pdbsum/4xm5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xm5 OCA], [http://pdbe.org/4xm5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xm5 RCSB], [http://www.ebi.ac.uk/pdbsum/4xm5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xm5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xm5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:57, 26 March 2015

2015-03-26T13:57:51Z

←Older revision		Revision as of 13:57, 26 March 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==C. glabrata Slx1.==
		+	<StructureSection load='4xm5' size='340' side='right' caption='[[4xm5]], [[Resolution\|resolution]] 2.34Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xm5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XM5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xm5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xm5 RCSB], [http://www.ebi.ac.uk/pdbsum/4xm5 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SLX1_CANGA SLX1_CANGA]] Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The SLX1-SLX4 endonuclease required for homologous recombination and DNA repair in eukaryotic cells cleaves a variety of branched DNA structures. The nuclease subunit SLX1 is activated by association with a scaffolding protein SLX4. At the present time, little is known about the structure of SLX1-SLX4 or its mechanism of action. Here, we report the structural insights into SLX1-SLX4 by detailing the crystal structure of Candida glabrata (Cg) Slx1 alone and in combination with the C-terminal region of Slx4. The structure of Slx1 reveals a compact arrangement of the GIY-YIG nuclease and RING domains, which is reinforced by a long alpha helix. Slx1 forms a stable homodimer that blocks its active site. Slx1-Slx4 interaction is mutually exclusive with Slx1 homodimerization, suggesting a mechanism for Slx1 activation by Slx4.

-	~~The entry 4xm5 is ON HOLD until Paper Publication~~	+	Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease.,Gaur V, Wyatt HD, Komorowska W, Szczepanowski RH, de Sanctis D, Gorecka KM, West SC, Nowotny M Cell Rep. 2015 Mar 3. pii: S2211-1247(15)00165-5. doi:, 10.1016/j.celrep.2015.02.019. PMID:25753413<ref>PMID:25753413</ref>

-	~~Authors: Gaur~~, V.~~, Wyatt, H.D.M., Komorowska, W., Szczepanowski, R.H., de Sanctis, D., Gorecka, K.M., West,~~ S.~~C., Nowotny, M~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description:~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Gaur, V]]		[[Category: Gaur, V]]
-	[[Category: Gorecka, K.M]]	+	[[Category: Gorecka, K M]]
		+	[[Category: Komorowska, W]]
	[[Category: Nowotny, M]]		[[Category: Nowotny, M]]
-	[[Category: De Sanctis, D]]	+	[[Category: Sanctis, D de]]
-	[[Category: ~~Komorowska~~, W]]	+	[[Category: Szczepanowski, R H]]
-	[[Category: West, S.C]]	+	[[Category: West, S C]]
-	[[Category: Wyatt, H.D.M]]	+	[[Category: Wyatt, H D.M]]
-	[[Category: ~~Szczepanowski, R.H~~]]	+	[[Category: Dna repair]]
		+	[[Category: Giy-yig]]
		+	[[Category: Homogolous recombination]]
		+	[[Category: Hydrolase]]
		+	[[Category: Nuclease]]

OCA at 10:30, 12 February 2015

2015-02-12T10:30:25Z

←Older revision		Revision as of 10:30, 12 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xm5 is ON HOLD	+	The entry 4xm5 is ON HOLD until Paper Publication

	Authors: Gaur, V., Wyatt, H.D.M., Komorowska, W., Szczepanowski, R.H., de Sanctis, D., Gorecka, K.M., West, S.C., Nowotny, M.		Authors: Gaur, V., Wyatt, H.D.M., Komorowska, W., Szczepanowski, R.H., de Sanctis, D., Gorecka, K.M., West, S.C., Nowotny, M.

OCA: Protected "4xm5" [edit=sysop:move=sysop]

2015-01-21T16:01:04Z

Protected "4xm5" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:01, 21 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xm5 is ON HOLD Authors: Gaur, V., Wyatt, H.D.M., Komorowska, W., Szczepanowski, R.H., de Sanctis, D., Gorecka, K.M., West, S.C., Nowotny, M. Descr...

2015-01-21T16:01:03Z

New page: '''Unreleased structure''' The entry 4xm5 is ON HOLD Authors: Gaur, V., Wyatt, H.D.M., Komorowska, W., Szczepanowski, R.H., de Sanctis, D., Gorecka, K.M., West, S.C., Nowotny, M. Descr...

New page

'''Unreleased structure'''

The entry 4xm5 is ON HOLD

Authors: Gaur, V., Wyatt, H.D.M., Komorowska, W., Szczepanowski, R.H., de Sanctis, D., Gorecka, K.M., West, S.C., Nowotny, M.

Description:
[[Category: Unreleased Structures]]
[[Category: Gaur, V]]
[[Category: Gorecka, K.M]]
[[Category: Nowotny, M]]
[[Category: De Sanctis, D]]
[[Category: Komorowska, W]]
[[Category: West, S.C]]
[[Category: Wyatt, H.D.M]]
[[Category: Szczepanowski, R.H]]