4xqt - Revision history

OCA at 07:48, 27 September 2023

2023-09-27T07:48:17Z

←Older revision		Revision as of 07:48, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xqt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XQT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xqt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XQT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqt OCA], [https://pdbe.org/4xqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xqt RCSB], [https://www.ebi.ac.uk/pdbsum/4xqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqt OCA], [https://pdbe.org/4xqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xqt RCSB], [https://www.ebi.ac.uk/pdbsum/4xqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqt ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:48, 26 April 2023

2023-04-26T17:48:07Z

←Older revision		Revision as of 17:48, 26 April 2023
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	<StructureSection load='4xqt' size='340' side='right'caption='[[4xqt]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4xqt' size='340' side='right'caption='[[4xqt]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xqt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xqt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XQT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xqr\|4xqr]], [[4xqs\|4xqs]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqt OCA], [https://pdbe.org/4xqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xqt RCSB], [https://www.ebi.ac.uk/pdbsum/4xqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqt ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqt OCA], [~~http~~://pdbe.org/4xqt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xqt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xqt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqt ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.	+	[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

	==See Also==		==See Also==
-	*[[Farnesyl diphosphate synthase\|Farnesyl diphosphate synthase]]	+	*[[Farnesyl diphosphate synthase 3D structures\|Farnesyl diphosphate synthase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berghuis~~, A M~~]]	+	[[Category: Berghuis AM]]
-	[[Category: Park, J]]	+	[[Category: Park J]]
-	~~[[Category: Transferase~~]]	+

OCA at 00:15, 6 June 2019

2019-06-06T00:15:59Z

←Older revision		Revision as of 00:15, 6 June 2019
Line 1:		Line 1:
		+
	==Crystal structure of human FPPS in complex with three magnesium ions==		==Crystal structure of human FPPS in complex with three magnesium ions==
-	<StructureSection load='4xqt' size='340' side='right' caption='[[4xqt]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4xqt' size='340' side='right'caption='[[4xqt]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xqt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xqt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XQT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xqr\|4xqr]], [[4xqs\|4xqs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xqr\|4xqr]], [[4xqs\|4xqs]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqt OCA], [http://pdbe.org/4xqt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xqt RCSB], [http://www.ebi.ac.uk/pdbsum/4xqt PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqt OCA], [http://pdbe.org/4xqt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xqt RCSB], [http://www.ebi.ac.uk/pdbsum/4xqt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.		[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
		+
		+	==See Also==
		+	*[[Farnesyl diphosphate synthase\|Farnesyl diphosphate synthase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Berghuis, A M]]		[[Category: Berghuis, A M]]
	[[Category: Park, J]]		[[Category: Park, J]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 17:14, 20 January 2016

2016-01-20T17:14:28Z

←Older revision		Revision as of 17:14, 20 January 2016
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of human FPPS in complex with three magnesium ions==
-		+	<StructureSection load='4xqt' size='340' side='right' caption='[[4xqt]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~The entry~~ 4xqt is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4xqt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XQT FirstGlance]. <br>
-	~~Authors~~: ~~Park~~, J., ~~Berghuis~~, A.M.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xqr\|4xqr]], [[4xqs\|4xqs]]</td></tr>
-	~~Description~~: ~~Crystal structure of human FPPS~~ in ~~complex~~ with ~~three magnesium ions~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqt OCA], [http://pdbe.org/4xqt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xqt RCSB], [http://www.ebi.ac.uk/pdbsum/4xqt PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Berghuis, A M]]
	[[Category: Park, J]]		[[Category: Park, J]]
-	[[Category: ~~Berghuis, A.M~~]]	+	[[Category: Transferase]]

OCA at 12:18, 25 February 2015

2015-02-25T12:18:09Z

←Older revision		Revision as of 12:18, 25 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xqt is ON HOLD	+	The entry 4xqt is ON HOLD until Paper Publication

	Authors: Park, J., Berghuis, A.M.		Authors: Park, J., Berghuis, A.M.

OCA: Protected "4xqt" [edit=sysop:move=sysop]

2015-01-28T15:43:10Z

Protected "4xqt" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:43, 28 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xqt is ON HOLD Authors: Park, J., Berghuis, A.M. Description: Crystal structure of human FPPS in complex with three magnesium ions [[Category: Unr...

2015-01-28T15:43:08Z

New page: '''Unreleased structure''' The entry 4xqt is ON HOLD Authors: Park, J., Berghuis, A.M. Description: Crystal structure of human FPPS in complex with three magnesium ions [[Category: Unr...

New page

'''Unreleased structure'''

The entry 4xqt is ON HOLD

Authors: Park, J., Berghuis, A.M.

Description: Crystal structure of human FPPS in complex with three magnesium ions
[[Category: Unreleased Structures]]
[[Category: Park, J]]
[[Category: Berghuis, A.M]]