4xu3 - Revision history

OCA at 07:49, 27 September 2023

2023-09-27T07:49:31Z

←Older revision		Revision as of 07:49, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xu3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XU3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xu3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XU3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=44R:N-({2-[(6-AMINO-9H-PURIN-9-YL)METHOXY]ETHYL}SULFAMOYL)-5-[(3AS,4S,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANAMIDE'>44R</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.242677Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=44R:N-({2-[(6-AMINO-9H-PURIN-9-YL)METHOXY]ETHYL}SULFAMOYL)-5-[(3AS,4S,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANAMIDE'>44R</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xu3 OCA], [https://pdbe.org/4xu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xu3 RCSB], [https://www.ebi.ac.uk/pdbsum/4xu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xu3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xu3 OCA], [https://pdbe.org/4xu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xu3 RCSB], [https://www.ebi.ac.uk/pdbsum/4xu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xu3 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:52, 26 April 2023

2023-04-26T17:52:52Z

←Older revision		Revision as of 17:52, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4xu3' size='340' side='right'caption='[[4xu3]], [[Resolution\|resolution]] 2.24Å' scene=''>		<StructureSection load='4xu3' size='340' side='right'caption='[[4xu3]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xu3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XU3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XU3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xu3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XU3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44R:N-({2-[(6-AMINO-9H-PURIN-9-YL)METHOXY]ETHYL}SULFAMOYL)-5-[(3AS,4S,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANAMIDE'>44R</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=44R:N-({2-[(6-AMINO-9H-PURIN-9-YL)METHOXY]ETHYL}SULFAMOYL)-5-[(3AS,4S,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANAMIDE'>44R</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xtu\|4xtu]], [[4xtv\|4xtv]], [[4xtw\|4xtw]], [[4xtx\|4xtx]], [[4xty\|4xty]], [[4xtz\|4xtz]], [[4xu0\|4xu0]], [[4xu1\|4xu1]], [[4xu2\|4xu2]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xu3 OCA], [https://pdbe.org/4xu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xu3 RCSB], [https://www.ebi.ac.uk/pdbsum/4xu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xu3 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">birA, CH81_03124, CH82_03406, CH84_03412, CH85_03111, CH87_01691, CH88_02592, CO60_3782, ER17_17395, FF22_02902, FI98_01129, IQ38_01820, IQ39_01720, IQ40_01775, IQ41_01700, IQ42_01770, IQ43_01710, IQ44_01750, IQ45_01765, IQ46_01705, IQ47_01735, IQ48_01770, IU12_01860, IU13_01785, IU14_01730, IU16_01770, IU17_01745, IU18_01730, IU19_01775, IU20_01750, IU22_01755, IU23_01750, IU24_01735, IZ84_17515, JE53_17495, LJ70_17695, T209_01770 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biotin--[acetyl-CoA-carboxylase]_ligase Biotin--[acetyl-CoA-carboxylase] ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.15 6.3.4.15] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xu3 OCA], [~~http~~://pdbe.org/4xu3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xu3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xu3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xu3 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BIRA_MYCTU BIRA_MYCTU] Catalyzes the transfer of biotin onto a conserved lysine residue of the biotin carboxyl carrier protein (BCCP) domain of acetyl-CoA carboxylase and converts it to active holo-BCCP (PubMed:18509457, PubMed:24723382). Forms an acyl-adenylate intermediate (PubMed:18509457, PubMed:24723382). Cannot use GTP or desthiobiotin (PubMed:18509457).<ref>PMID:18509457</ref> <ref>PMID:24723382</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Finzel, B C~~]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: Mora-Rey, T ~~De la~~]]	+	[[Category: De la Mora-Rey T]]
-	[[Category: ~~Biotin-protein ligase]]~~	+	[[Category: Finzel BC]]
-	~~[[Category: Bisubstrate inhibitor]]~~	+
-	~~[[Category: Ligase-ligase inhibitor complex~~]]	+

OCA at 00:10, 6 June 2019

2019-06-06T00:10:16Z

←Older revision		Revision as of 00:10, 6 June 2019
Line 1:		Line 1:
		+
	==Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 90 that has an acyclic ether in place of the ribose==		==Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 90 that has an acyclic ether in place of the ribose==
-	<StructureSection load='4xu3' size='340' side='right' caption='[[4xu3]], [[Resolution\|resolution]] 2.24Å' scene=''>	+	<StructureSection load='4xu3' size='340' side='right'caption='[[4xu3]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xu3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XU3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xu3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XU3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44R:N-({2-[(6-AMINO-9H-PURIN-9-YL)METHOXY]ETHYL}SULFAMOYL)-5-[(3AS,4S,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANAMIDE'>44R</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44R:N-({2-[(6-AMINO-9H-PURIN-9-YL)METHOXY]ETHYL}SULFAMOYL)-5-[(3AS,4S,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANAMIDE'>44R</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xtu\|4xtu]], [[4xtv\|4xtv]], [[4xtw\|4xtw]], [[4xtx\|4xtx]], [[4xty\|4xty]], [[4xtz\|4xtz]], [[4xu0\|4xu0]], [[4xu1\|4xu1]], [[4xu2\|4xu2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xtu\|4xtu]], [[4xtv\|4xtv]], [[4xtw\|4xtw]], [[4xtx\|4xtx]], [[4xty\|4xty]], [[4xtz\|4xtz]], [[4xu0\|4xu0]], [[4xu1\|4xu1]], [[4xu2\|4xu2]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">birA, CH81_03124, CH82_03406, CH84_03412, CH85_03111, CH87_01691, CH88_02592, CO60_3782, ER17_17395, FF22_02902, FI98_01129, IQ38_01820, IQ39_01720, IQ40_01775, IQ41_01700, IQ42_01770, IQ43_01710, IQ44_01750, IQ45_01765, IQ46_01705, IQ47_01735, IQ48_01770, IU12_01860, IU13_01785, IU14_01730, IU16_01770, IU17_01745, IU18_01730, IU19_01775, IU20_01750, IU22_01755, IU23_01750, IU24_01735, IZ84_17515, JE53_17495, LJ70_17695, T209_01770 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biotin--[acetyl-CoA-carboxylase]_ligase Biotin--[acetyl-CoA-carboxylase] ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.15 6.3.4.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biotin--[acetyl-CoA-carboxylase]_ligase Biotin--[acetyl-CoA-carboxylase] ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.15 6.3.4.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xu3 OCA], [http://pdbe.org/4xu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xu3 RCSB], [http://www.ebi.ac.uk/pdbsum/4xu3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xu3 OCA], [http://pdbe.org/4xu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xu3 RCSB], [http://www.ebi.ac.uk/pdbsum/4xu3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xu3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4xu3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xu3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Biotin Protein Ligase 3D structures\|Biotin Protein Ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Finzel, B C]]		[[Category: Finzel, B C]]
	[[Category: Mora-Rey, T De la]]		[[Category: Mora-Rey, T De la]]

OCA at 07:46, 7 October 2015

2015-10-07T07:46:24Z

←Older revision		Revision as of 07:46, 7 October 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xtu\|4xtu]], [[4xtv\|4xtv]], [[4xtw\|4xtw]], [[4xtx\|4xtx]], [[4xty\|4xty]], [[4xtz\|4xtz]], [[4xu0\|4xu0]], [[4xu1\|4xu1]], [[4xu2\|4xu2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xtu\|4xtu]], [[4xtv\|4xtv]], [[4xtw\|4xtw]], [[4xtx\|4xtx]], [[4xty\|4xty]], [[4xtz\|4xtz]], [[4xu0\|4xu0]], [[4xu1\|4xu1]], [[4xu2\|4xu2]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biotin--[acetyl-CoA-carboxylase]_ligase Biotin--[acetyl-CoA-carboxylase] ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.15 6.3.4.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biotin--[acetyl-CoA-carboxylase]_ligase Biotin--[acetyl-CoA-carboxylase] ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.15 6.3.4.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xu3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xu3 RCSB], [http://www.ebi.ac.uk/pdbsum/4xu3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xu3 OCA], [http://pdbe.org/4xu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xu3 RCSB], [http://www.ebi.ac.uk/pdbsum/4xu3 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xu3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:28, 2 September 2015

2015-09-02T12:28:10Z

←Older revision		Revision as of 12:28, 2 September 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 90 that has an acyclic ether in place of the ribose==
		+	<StructureSection load='4xu3' size='340' side='right' caption='[[4xu3]], [[Resolution\|resolution]] 2.24Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xu3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XU3 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44R:N-({2-[(6-AMINO-9H-PURIN-9-YL)METHOXY]ETHYL}SULFAMOYL)-5-[(3AS,4S,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANAMIDE'>44R</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xtu\|4xtu]], [[4xtv\|4xtv]], [[4xtw\|4xtw]], [[4xtx\|4xtx]], [[4xty\|4xty]], [[4xtz\|4xtz]], [[4xu0\|4xu0]], [[4xu1\|4xu1]], [[4xu2\|4xu2]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biotin--[acetyl-CoA-carboxylase]_ligase Biotin--[acetyl-CoA-carboxylase] ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.15 6.3.4.15] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xu3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xu3 RCSB], [http://www.ebi.ac.uk/pdbsum/4xu3 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mycobacterium tuberculosis (Mtb) responsible for both latent and symptomatic tuberculosis (TB) remains the second leading cause of mortality among infectious diseases worldwide. Mycobacterial biotin protein ligase (MtBPL) is an essential enzyme in Mtb and regulates lipid metabolism through the post-translational biotinylation of acyl coenzyme A carboxylases. We report the synthesis and evaluation of a systematic series of potent nucleoside-based inhibitors of MtBPL that contain modifications to the ribofuranosyl ring of the nucleoside. All compounds were characterized by isothermal titration calorimetry (ITC) and shown to bind potently with KD's below 2 nM. Additionally, we obtained high-resolution co-crystal structures for a majority of the compounds. Despite fairly uniform biochemical potency, the whole-cell Mtb activity varied greatly with minimum inhibitory concentrations (MIC) ranging from 0.78 to >100 microM. Cellular accumulation studies in Mtb showed a nearly 10-fold enhanced accumulation of a C-2'-alpha analog over the corresponding C-2'-beta analog, consistent with their differential whole-cell activity.

-	~~The entry 4xu3 is ON HOLD until Paper Publication~~	+	Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.,Bockman MR, Kalinda AS, Petrelli R, De la Mora-Rey T, Tiwari D, Liu F, Dawadi S, Nandakumar M, Rhee KY, Schnappinger D, Finzel BC, Aldrich CC J Med Chem. 2015 Aug 24. PMID:26299766<ref>PMID:26299766</ref>

-	~~Authors: De la Mora-Rey~~, T.~~, Finzel, B~~.C.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description:~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: ~~De La~~ Mora-Rey, T]]	+	__TOC__
-	[[Category: ~~Finzel, B.C~~]]	+	</StructureSection>
		+	[[Category: Finzel, B C]]
		+	[[Category: Mora-Rey, T De la]]
		+	[[Category: Biotin-protein ligase]]
		+	[[Category: Bisubstrate inhibitor]]
		+	[[Category: Ligase-ligase inhibitor complex]]

OCA at 08:52, 30 April 2015

2015-04-30T08:52:19Z

←Older revision		Revision as of 08:52, 30 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xu3 is ON HOLD	+	The entry 4xu3 is ON HOLD until Paper Publication

	Authors: De la Mora-Rey, T., Finzel, B.C.		Authors: De la Mora-Rey, T., Finzel, B.C.

OCA at 10:43, 12 February 2015

2015-02-12T10:43:19Z

←Older revision		Revision as of 10:43, 12 February 2015
Line 5:		Line 5:
	Authors: De la Mora-Rey, T., Finzel, B.C.		Authors: De la Mora-Rey, T., Finzel, B.C.

-	Description: ~~Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 90~~	+	Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: De La Mora-Rey, T]]		[[Category: De La Mora-Rey, T]]
	[[Category: Finzel, B.C]]		[[Category: Finzel, B.C]]

OCA: Protected "4xu3" [edit=sysop:move=sysop]

2015-02-07T14:49:26Z

Protected "4xu3" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:49, 7 February 2015

OCA: New page: '''Unreleased structure''' The entry 4xu3 is ON HOLD Authors: De la Mora-Rey, T., Finzel, B.C. Description: Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibito...

2015-02-07T14:49:25Z

New page: '''Unreleased structure''' The entry 4xu3 is ON HOLD Authors: De la Mora-Rey, T., Finzel, B.C. Description: Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibito...

New page

'''Unreleased structure'''

The entry 4xu3 is ON HOLD

Authors: De la Mora-Rey, T., Finzel, B.C.

Description: Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 90
[[Category: Unreleased Structures]]
[[Category: De La Mora-Rey, T]]
[[Category: Finzel, B.C]]