4xx7 - Revision history

OCA at 07:51, 27 September 2023

2023-09-27T07:51:40Z

←Older revision		Revision as of 07:51, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xx7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XX7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xx7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XX7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.77Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xx7 OCA], [https://pdbe.org/4xx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xx7 RCSB], [https://www.ebi.ac.uk/pdbsum/4xx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xx7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xx7 OCA], [https://pdbe.org/4xx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xx7 RCSB], [https://www.ebi.ac.uk/pdbsum/4xx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xx7 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:55, 26 April 2023

2023-04-26T17:55:55Z

←Older revision		Revision as of 17:55, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4xx7' size='340' side='right'caption='[[4xx7]], [[Resolution\|resolution]] 1.77Å' scene=''>		<StructureSection load='4xx7' size='340' side='right'caption='[[4xx7]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xx7]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XX7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XX7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xx7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XX7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4grn\|4grn]], [[4gro\|4gro]], [[4p01\|4p01]], [[4p0h\|4p0h]], [[4pkz\|4pkz]], [[4plu\|4plu]], [[4trf\|4trf]], [[4tru\|4tru]], [[4xx8\|4xx8]], [[5bs9\|5bs9]], [[5bsc\|5bsc]], [[5bsi\|5bsi]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xx7 OCA], [https://pdbe.org/4xx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xx7 RCSB], [https://www.ebi.ac.uk/pdbsum/4xx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xx7 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xx7 OCA], [~~http~~://pdbe.org/4xx7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xx7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xx7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xx7 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[~~http~~://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:

	==See Also==		==See Also==
-	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]	+	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lolis, E]]	+	[[Category: Lolis E]]
-	[[Category: Pantouris, G]]	+	[[Category: Pantouris G]]
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Mutation]]~~	+
-	~~[[Category: Surface~~]]	+

OCA at 00:23, 6 June 2019

2019-06-06T00:23:13Z

←Older revision		Revision as of 00:23, 6 June 2019
Line 1:		Line 1:
		+
	==Crystal structure of M2A mutant of human macrophage migration inhibitory factor==		==Crystal structure of M2A mutant of human macrophage migration inhibitory factor==
-	<StructureSection load='4xx7' size='340' side='right' caption='[[4xx7]], [[Resolution\|resolution]] 1.77Å' scene=''>	+	<StructureSection load='4xx7' size='340' side='right'caption='[[4xx7]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xx7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XX7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XX7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xx7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XX7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XX7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4grn\|4grn]], [[4gro\|4gro]], [[4p01\|4p01]], [[4p0h\|4p0h]], [[4pkz\|4pkz]], [[4plu\|4plu]], [[4trf\|4trf]], [[4tru\|4tru]], [[4xx8\|4xx8]], [[5bs9\|5bs9]], [[5bsc\|5bsc]], [[5bsi\|5bsi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4grn\|4grn]], [[4gro\|4gro]], [[4p01\|4p01]], [[4p0h\|4p0h]], [[4pkz\|4pkz]], [[4plu\|4plu]], [[4trf\|4trf]], [[4tru\|4tru]], [[4xx8\|4xx8]], [[5bs9\|5bs9]], [[5bsc\|5bsc]], [[5bsi\|5bsi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xx7 OCA], [http://pdbe.org/4xx7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xx7 RCSB], [http://www.ebi.ac.uk/pdbsum/4xx7 PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xx7 OCA], [http://pdbe.org/4xx7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xx7 RCSB], [http://www.ebi.ac.uk/pdbsum/4xx7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xx7 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4xx7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xx7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lolis, E]]		[[Category: Lolis, E]]
	[[Category: Pantouris, G]]		[[Category: Pantouris, G]]

OCA at 14:35, 30 September 2015

2015-09-30T14:35:19Z

←Older revision		Revision as of 14:35, 30 September 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of M2A mutant of human macrophage migration inhibitory factor==
		+	<StructureSection load='4xx7' size='340' side='right' caption='[[4xx7]], [[Resolution\|resolution]] 1.77Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xx7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XX7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XX7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4grn\|4grn]], [[4gro\|4gro]], [[4p01\|4p01]], [[4p0h\|4p0h]], [[4pkz\|4pkz]], [[4plu\|4plu]], [[4trf\|4trf]], [[4tru\|4tru]], [[4xx8\|4xx8]], [[5bs9\|5bs9]], [[5bsc\|5bsc]], [[5bsi\|5bsi]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xx7 OCA], [http://pdbe.org/4xx7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xx7 RCSB], [http://www.ebi.ac.uk/pdbsum/4xx7 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	For more than 15 years, the tautomerase active site of macrophage migration inhibitory factor (MIF) and its catalytic residue Pro1 have been being targeted for the development of therapeutics that block activation of its cell surface receptor, CD74. Neither the biological role of the MIF catalytic site nor the mechanistic details of CD74 activation are well understood. The inherently unstable structure of CD74 remains the biggest obstacle in structural studies with MIF for understanding the basis of CD74 activation. Using a novel approach, we elucidate the mechanistic details that control activation of CD74 by MIF surface residues and identify structural parameters of inhibitors that reduce CD74 biological activation. We also find that N-terminal mutants located deep in the catalytic site affect surface residues immediately outside the catalytic site, which are responsible for reduction of CD74 activation.

-	~~The entry 4xx7 is ON HOLD until Paper Publication~~	+	An Analysis of MIF Structural Features that Control Functional Activation of CD74.,Pantouris G, Syed MA, Fan C, Rajasekaran D, Cho TY, Rosenberg EM Jr, Bucala R, Bhandari V, Lolis EJ Chem Biol. 2015 Sep 17;22(9):1197-205. doi: 10.1016/j.chembiol.2015.08.006. Epub , 2015 Sep 10. PMID:26364929<ref>PMID:26364929</ref>

-	~~Authors: Pantouris~~, G.~~, Lolis, E~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of M2A mutant of human macrophage migration inhibitory factor~~	+	<div class="pdbe-citations 4xx7" style="background-color:#fffaf0;"></div>
-	~~[[Category: Unreleased Structures]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Lolis, E]]		[[Category: Lolis, E]]
	[[Category: Pantouris, G]]		[[Category: Pantouris, G]]
		+	[[Category: Isomerase]]
		+	[[Category: Mutation]]
		+	[[Category: Surface]]

OCA at 10:48, 12 February 2015

2015-02-12T10:48:57Z

←Older revision		Revision as of 10:48, 12 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xx7 is ON HOLD	+	The entry 4xx7 is ON HOLD until Paper Publication

	Authors: Pantouris, G., Lolis, E.		Authors: Pantouris, G., Lolis, E.

OCA: Protected "4xx7" [edit=sysop:move=sysop]

2015-02-07T14:56:47Z

Protected "4xx7" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:56, 7 February 2015

OCA: New page: '''Unreleased structure''' The entry 4xx7 is ON HOLD Authors: Pantouris, G., Lolis, E. Description: Crystal structure of M2A mutant of human macrophage migration inhibitory factor [[Ca...

2015-02-07T14:56:46Z

New page: '''Unreleased structure''' The entry 4xx7 is ON HOLD Authors: Pantouris, G., Lolis, E. Description: Crystal structure of M2A mutant of human macrophage migration inhibitory factor [[Ca...

New page

'''Unreleased structure'''

The entry 4xx7 is ON HOLD

Authors: Pantouris, G., Lolis, E.

Description: Crystal structure of M2A mutant of human macrophage migration inhibitory factor
[[Category: Unreleased Structures]]
[[Category: Lolis, E]]
[[Category: Pantouris, G]]