4y08 - Revision history

OCA at 10:51, 10 January 2024

2024-01-10T10:51:47Z

←Older revision		Revision as of 10:51, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4y08]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y08 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4y08]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y08 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.34Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y08 OCA], [https://pdbe.org/4y08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y08 RCSB], [https://www.ebi.ac.uk/pdbsum/4y08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y08 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y08 OCA], [https://pdbe.org/4y08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y08 RCSB], [https://www.ebi.ac.uk/pdbsum/4y08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y08 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 18:00, 26 April 2023

2023-04-26T18:00:46Z

←Older revision		Revision as of 18:00, 26 April 2023
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	==ONE MINUTE IRON LOADED HUMAN H FERRITIN==		==ONE MINUTE IRON LOADED HUMAN H FERRITIN==
-	<StructureSection load='4y08' size='340' side='right' caption='[[4y08]], [[Resolution\|resolution]] 1.34Å' scene=''>	+	<StructureSection load='4y08' size='340' side='right'caption='[[4y08]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y08]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y08 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Y08 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y08]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y08 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oyn\|4oyn]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y08 OCA], [https://pdbe.org/4y08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y08 RCSB], [https://www.ebi.ac.uk/pdbsum/4y08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y08 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4y08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y08 OCA], [~~http~~://pdbe.org/4y08 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4y08 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4y08 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4y08 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	+	[https://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4y08" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4y08" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ferroxidase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Mangani, S~~]]	+	[[Category: Di Pisa F]]
-	[[Category: ~~Pisa, F Di~~]]	+	[[Category: Mangani S]]
-	[[Category: Pozzi, C]]	+	[[Category: Pozzi C]]
-	~~[[Category: Ferritin heavy chain]]~~	+
-	~~[[Category: Iron homeostasis]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 15:21, 16 November 2017

2017-11-16T15:21:05Z

←Older revision		Revision as of 15:21, 16 November 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 4y08 is ~~ON HOLD until Paper~~ Publication	+	==ONE MINUTE IRON LOADED HUMAN H FERRITIN==
		+	<StructureSection load='4y08' size='340' side='right' caption='[[4y08]], [[Resolution\|resolution]] 1.34Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4y08]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y08 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oyn\|4oyn]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y08 OCA], [http://pdbe.org/4y08 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y08 RCSB], [http://www.ebi.ac.uk/pdbsum/4y08 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y08 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Maxi-ferritins are ubiquitous iron-storage proteins with a common cage architecture made up of 24 identical subunits of five alpha-helices that drive iron biomineralization through catalytic iron(II) oxidation occurring at oxidoreductase sites (OS). Structures of iron-bound human H ferritin were solved at high resolution by freezing ferritin crystals at different time intervals after exposure to a ferrous salt. Multiple binding sites were identified that define the iron path from the entry ion channels to the oxidoreductase sites. Similar data are available for another vertebrate ferritin: the M protein from Rana catesbeiana. A comparative analysis of the iron sites in the two proteins identifies new reaction intermediates and underlines clear differences in the pattern of ligands that define the additional iron sites that precede the oxidoreductase binding sites along this path. Stopped-flow kinetics assays revealed that human H ferritin has different levels of activity compared with its R. catesbeiana counterpart. The role of the different pattern of transient iron-binding sites in the OS is discussed with respect to the observed differences in activity across the species.

-	~~Authors: Pozzi~~, C., Di Pisa, F., ~~Mangani~~, S.	+	Iron binding to human heavy-chain ferritin.,Pozzi C, Di Pisa F, Bernacchioni C, Ciambellotti S, Turano P, Mangani S Acta Crystallogr D Biol Crystallogr. 2015 Sep 1;71(Pt 9):1909-20. doi:, 10.1107/S1399004715013073. Epub 2015 Aug 25. PMID:26327381<ref>PMID:26327381</ref>

-	~~Description~~: ~~ONE MINUTE IRON LOADED HUMAN H FERRITIN~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Pozzi, C~~]]	+	<div class="pdbe-citations 4y08" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ferroxidase]]
		+	[[Category: Human]]
	[[Category: Mangani, S]]		[[Category: Mangani, S]]
-	[[Category: Di Pisa, F]]	+	[[Category: Pisa, F Di]]
		+	[[Category: Pozzi, C]]
		+	[[Category: Ferritin heavy chain]]
		+	[[Category: Iron homeostasis]]
		+	[[Category: Oxidoreductase]]

OCA at 11:51, 18 February 2015

2015-02-18T11:51:00Z

←Older revision		Revision as of 11:51, 18 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4y08 is ON HOLD	+	The entry 4y08 is ON HOLD until Paper Publication

	Authors: Pozzi, C., Di Pisa, F., Mangani, S.		Authors: Pozzi, C., Di Pisa, F., Mangani, S.

OCA: Protected "4y08" [edit=sysop:move=sysop]

2015-02-12T10:56:42Z

Protected "4y08" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:56, 12 February 2015

OCA: New page: '''Unreleased structure''' The entry 4y08 is ON HOLD Authors: Pozzi, C., Di Pisa, F., Mangani, S. Description: ONE MINUTE IRON LOADED HUMAN H FERRITIN [[Category: Unreleased Structures...

2015-02-12T10:56:40Z

New page: '''Unreleased structure''' The entry 4y08 is ON HOLD Authors: Pozzi, C., Di Pisa, F., Mangani, S. Description: ONE MINUTE IRON LOADED HUMAN H FERRITIN [[Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 4y08 is ON HOLD

Authors: Pozzi, C., Di Pisa, F., Mangani, S.

Description: ONE MINUTE IRON LOADED HUMAN H FERRITIN
[[Category: Unreleased Structures]]
[[Category: Pozzi, C]]
[[Category: Mangani, S]]
[[Category: Di Pisa, F]]