4y8d - Revision history

OCA at 10:53, 10 January 2024

2024-01-10T10:53:53Z

←Older revision		Revision as of 10:53, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4y8d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y8D FirstGlance]. <br>		<table><tr><td colspan='2'>[[4y8d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y8D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=49J:2-METHOXY-4-[3-(MORPHOLIN-4-YL)[1,2]THIAZOLO[4,3-B]PYRIDIN-6-YL]ANILINE'>49J</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=49J:2-METHOXY-4-[3-(MORPHOLIN-4-YL)[1,2]THIAZOLO[4,3-B]PYRIDIN-6-YL]ANILINE'>49J</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y8d OCA], [https://pdbe.org/4y8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y8d RCSB], [https://www.ebi.ac.uk/pdbsum/4y8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y8d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y8d OCA], [https://pdbe.org/4y8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y8d RCSB], [https://www.ebi.ac.uk/pdbsum/4y8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y8d ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:02, 3 May 2023

2023-05-03T08:02:37Z

←Older revision		Revision as of 08:02, 3 May 2023
Line 3:		Line 3:
	<StructureSection load='4y8d' size='340' side='right'caption='[[4y8d]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4y8d' size='340' side='right'caption='[[4y8d]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y8d]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y8D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Y8D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y8d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y8D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=49J:2-METHOXY-4-[3-(MORPHOLIN-4-YL)[1,2]THIAZOLO[4,3-B]PYRIDIN-6-YL]ANILINE'>49J</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=49J:2-METHOXY-4-[3-(MORPHOLIN-4-YL)[1,2]THIAZOLO[4,3-B]PYRIDIN-6-YL]ANILINE'>49J</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y8d OCA], [https://pdbe.org/4y8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y8d RCSB], [https://www.ebi.ac.uk/pdbsum/4y8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y8d ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4y8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y8d OCA], [~~http~~://pdbe.org/4y8d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4y8d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4y8d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4y8d ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GAK_HUMAN GAK_HUMAN]] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.<ref>PMID:10625686</ref>	+	[https://www.uniprot.org/uniprot/GAK_HUMAN GAK_HUMAN] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.<ref>PMID:10625686</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Lama glama]]		[[Category: Lama glama]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Arrowsmith CH]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Bountra C]]
-	[[Category: Bountra, C]]	+	[[Category: Chaikuad A]]
-	[[Category: Chaikuad, A]]	+	[[Category: De Jonghe S]]
-	[[Category: ~~Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Heroven C]]
-	[[Category: Heroven, C]]	+	[[Category: Knapp S]]
-	~~[[Category: Jonghe, S De~~]]	+	[[Category: Nowak R]]
-	[[Category: Knapp, S]]	+	[[Category: Von Delft F]]
-	[[Category: Nowak, R]]	+
-	[[Category: ~~Structural genomic]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Nanobody]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 23:43, 5 June 2019

2019-06-05T23:43:38Z

←Older revision		Revision as of 23:43, 5 June 2019
Line 1:		Line 1:

	==Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor==		==Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor==
-	<StructureSection load='4y8d' size='340' side='right' caption='[[4y8d]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4y8d' size='340' side='right'caption='[[4y8d]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y8D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y8D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=49J:2-METHOXY-4-[3-(MORPHOLIN-4-YL)[1,2]THIAZOLO[4,3-B]PYRIDIN-6-YL]ANILINE'>49J</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=49J:2-METHOXY-4-[3-(MORPHOLIN-4-YL)[1,2]THIAZOLO[4,3-B]PYRIDIN-6-YL]ANILINE'>49J</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y8d OCA], [http://pdbe.org/4y8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y8d RCSB], [http://www.ebi.ac.uk/pdbsum/4y8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y8d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y8d OCA], [http://pdbe.org/4y8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y8d RCSB], [http://www.ebi.ac.uk/pdbsum/4y8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y8d ProSAT]</span></td></tr>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Lama glama]]		[[Category: Lama glama]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 01:55, 10 March 2017

2017-03-10T01:55:43Z

←Older revision		Revision as of 01:55, 10 March 2017
Line 1:		Line 1:
		+
	==Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor==		==Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor==
	<StructureSection load='4y8d' size='340' side='right' caption='[[4y8d]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4y8d' size='340' side='right' caption='[[4y8d]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=49J:2-METHOXY-4-[3-(MORPHOLIN-4-YL)[1,2]THIAZOLO[4,3-B]PYRIDIN-6-YL]ANILINE'>49J</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=49J:2-METHOXY-4-[3-(MORPHOLIN-4-YL)[1,2]THIAZOLO[4,3-B]PYRIDIN-6-YL]ANILINE'>49J</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y8d RCSB], [http://www.ebi.ac.uk/pdbsum/4y8d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y8d OCA], [http://pdbe.org/4y8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y8d RCSB], [http://www.ebi.ac.uk/pdbsum/4y8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y8d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4y8d" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:04, 8 April 2015

2015-04-08T11:04:05Z

←Older revision		Revision as of 11:04, 8 April 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor==
		+	<StructureSection load='4y8d' size='340' side='right' caption='[[4y8d]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4y8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y8D FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=49J:2-METHOXY-4-[3-(MORPHOLIN-4-YL)[1,2]THIAZOLO[4,3-B]PYRIDIN-6-YL]ANILINE'>49J</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y8d RCSB], [http://www.ebi.ac.uk/pdbsum/4y8d PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GAK_HUMAN GAK_HUMAN]] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.<ref>PMID:10625686</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclin-G associated kinase (GAK) emerged as a promising drug target for the treatment of viral infections. However, no potent and selective GAK inhibitors have been reported in the literature to date. This paper describes the discovery of isothiazolo[5,4-b]pyridines as selective GAK inhibitors, with the most potent congeners displaying low nanomolar binding affinity for GAK. Co-crystallization experiments revealed that these compounds behaved as classic type I ATP-competitive kinase inhibitors. In addition, we have demonstrated that these compounds exhibit a potent activity against hepatitis C virus (HCV) by inhibiting two temporally distinct steps in the HCV lifecycle (i.e. viral entry and assembly). Hence, these GAK inhibitors represent chemical probes to study GAK function in different disease areas where GAK has been implicated (including viral infection, cancer and Parkinson's disease).

-	~~The entry 4y8d is ON HOLD~~	+	Selective inhibitors of Cyclin-G associated kinase (GAK) as anti-HCV agents.,Kovackova S, Chang L, Bekerman E, Neveu G, Barouch-Bentov R, Chaikuad A, Heroven C, Sala M, De Jonghe SC, Knapp S, Einav S, Herdewijn P J Med Chem. 2015 Mar 30. PMID:25822739<ref>PMID:25822739</ref>

-	~~Authors: Chaikuad~~, A.~~, Heroven, C., Nowak, R., De Jonghe,~~ S.~~, von Delft, F~~.~~, Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of Cyclin~~-~~G associated~~ kinase ~~(GAK) complexed with selective 12i inhibitor~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: ~~Nowak~~, R]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Lama glama]]
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
	[[Category: Chaikuad, A]]		[[Category: Chaikuad, A]]
-	[[Category: De Jonghe, S]]	+	[[Category: Delft, F von]]
		+	[[Category: Edwards, A M]]
		+	[[Category: Heroven, C]]
		+	[[Category: Jonghe, S De]]
	[[Category: Knapp, S]]		[[Category: Knapp, S]]
-	[[Category: ~~Bountra~~, C]]	+	[[Category: Nowak, R]]
-	[[Category: ~~Arrowsmith, C.H~~]]	+	[[Category: Structural genomic]]
-	[[Category: ~~Von Delft, F~~]]	+	[[Category: Inhibitor]]
-	[[Category: ~~Edwards, A.M~~]]	+	[[Category: Kinase]]
-	[[Category: ~~Heroven, C~~]]	+	[[Category: Nanobody]]
-	[[Category: ~~Structural Genomics Consortium (~~Sgc)]]	+	[[Category: Sgc]]
		+	[[Category: Transferase]]

OCA: Protected "4y8d" [edit=sysop:move=sysop]

2015-02-25T12:48:32Z

Protected "4y8d" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:48, 25 February 2015

OCA: New page: '''Unreleased structure''' The entry 4y8d is ON HOLD Authors: Chaikuad, A., Heroven, C., Nowak, R., De Jonghe, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S....

2015-02-25T12:48:31Z

New page: '''Unreleased structure''' The entry 4y8d is ON HOLD Authors: Chaikuad, A., Heroven, C., Nowak, R., De Jonghe, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S....

New page

'''Unreleased structure'''

The entry 4y8d is ON HOLD

Authors: Chaikuad, A., Heroven, C., Nowak, R., De Jonghe, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

Description: Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor
[[Category: Unreleased Structures]]
[[Category: Nowak, R]]
[[Category: Chaikuad, A]]
[[Category: De Jonghe, S]]
[[Category: Knapp, S]]
[[Category: Bountra, C]]
[[Category: Arrowsmith, C.H]]
[[Category: Von Delft, F]]
[[Category: Edwards, A.M]]
[[Category: Heroven, C]]
[[Category: Structural Genomics Consortium (Sgc)]]