4y9w - Revision history

OCA at 08:04, 3 May 2023

2023-05-03T08:04:41Z

←Older revision		Revision as of 08:04, 3 May 2023
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	<StructureSection load='4y9w' size='340' side='right'caption='[[4y9w]], [[Resolution\|resolution]] 0.83Å' scene=''>		<StructureSection load='4y9w' size='340' side='right'caption='[[4y9w]], [[Resolution\|resolution]] 0.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y9w]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Candida_parapsilosis Candida parapsilosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y9W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Y9W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y9w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_parapsilosis Candida parapsilosis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y9W FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fv3\|3fv3]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y9w OCA], [https://pdbe.org/4y9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y9w RCSB], [https://www.ebi.ac.uk/pdbsum/4y9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y9w ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4y9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y9w OCA], [~~http~~://pdbe.org/4y9w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4y9w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4y9w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4y9w ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G8B6Y8_CANPC G8B6Y8_CANPC]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The virulence of the Candida pathogens is enhanced by the production of secreted aspartic proteases, which therefore represent possible targets for drug design. Here, the crystal structure of the secreted aspartic protease Sapp2p from Candida parapsilosis was determined. Sapp2p was isolated from its natural source and crystallized in complex with pepstatin A, a classical aspartic protease inhibitor. The atomic resolution of 0.83 A allowed the protonation states of the active-site residues to be inferred. A detailed comparison of the structure of Sapp2p with the structure of Sapp1p, the most abundant C. parapsilosis secreted aspartic protease, was performed. The analysis, which included advanced quantum-chemical interaction-energy calculations, uncovered molecular details that allowed the experimentally observed equipotent inhibition of both isoenzymes by pepstatin A to be rationalized.
		+
		+	Atomic resolution crystal structure of Sapp2p, a secreted aspartic protease from Candida parapsilosis.,Dostal J, Pecina A, Hruskova-Heidingsfeldova O, Mareckova L, Pichova I, Rezacova P, Lepsik M, Brynda J Acta Crystallogr D Biol Crystallogr. 2015 Dec 1;71(Pt 12):2494-504. doi:, 10.1107/S1399004715019392. Epub 2015 Nov 27. PMID:26627656<ref>PMID:26627656</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4y9w" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Candida parapsilosis]]		[[Category: Candida parapsilosis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brynda, J]]	+	[[Category: Synthetic construct]]
-	[[Category: Dostal, J]]	+	[[Category: Brynda J]]
-	[[Category: Hruskova-Heidingsfeldova, O]]	+	[[Category: Dostal J]]
-	[[Category: Mareckova, L]]	+	[[Category: Hruskova-Heidingsfeldova O]]
-	[[Category: Pichova, I]]	+	[[Category: Mareckova L]]
-	[[Category: Rezacova, P]]	+	[[Category: Pichova I]]
-	~~[[Category: Aspartic acid endopeptidase]]~~	+	[[Category: Rezacova P]]
-	~~[[Category: Candidapepsin]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:14, 12 June 2019

2019-06-12T07:14:03Z

←Older revision		Revision as of 07:14, 12 June 2019
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	==Aspartic Proteinase Sapp2 Secreted from Candida Parapsilosis at 0.82 A Resolution.==		==Aspartic Proteinase Sapp2 Secreted from Candida Parapsilosis at 0.82 A Resolution.==
-	<StructureSection load='4y9w' size='340' side='right' caption='[[4y9w]], [[Resolution\|resolution]] 0.83Å' scene=''>	+	<StructureSection load='4y9w' size='340' side='right'caption='[[4y9w]], [[Resolution\|resolution]] 0.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4y9w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_parapsilosis Candida parapsilosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y9W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y9W FirstGlance]. <br>		<table><tr><td colspan='2'>[[4y9w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_parapsilosis Candida parapsilosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y9W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y9W FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Candida parapsilosis]]		[[Category: Candida parapsilosis]]
		+	[[Category: Large Structures]]
	[[Category: Brynda, J]]		[[Category: Brynda, J]]
	[[Category: Dostal, J]]		[[Category: Dostal, J]]

OCA at 18:29, 10 December 2016

2016-12-10T18:29:50Z

←Older revision		Revision as of 18:29, 10 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4y9w is ~~ON HOLD~~	+	==Aspartic Proteinase Sapp2 Secreted from Candida Parapsilosis at 0.82 A Resolution.==
-		+	<StructureSection load='4y9w' size='340' side='right' caption='[[4y9w]], [[Resolution\|resolution]] 0.83Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4y9w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_parapsilosis Candida parapsilosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y9W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y9W FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fv3\|3fv3]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y9w OCA], [http://pdbe.org/4y9w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y9w RCSB], [http://www.ebi.ac.uk/pdbsum/4y9w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y9w ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Candida parapsilosis]]
		+	[[Category: Brynda, J]]
		+	[[Category: Dostal, J]]
		+	[[Category: Hruskova-Heidingsfeldova, O]]
		+	[[Category: Mareckova, L]]
		+	[[Category: Pichova, I]]
		+	[[Category: Rezacova, P]]
		+	[[Category: Aspartic acid endopeptidase]]
		+	[[Category: Candidapepsin]]
		+	[[Category: Hydrolase]]

OCA at 11:27, 2 November 2016

2016-11-02T11:27:12Z

←Older revision		Revision as of 11:27, 2 November 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4y9w is ON HOLD ~~until sometime in the future~~	+	The entry 4y9w is ON HOLD

	Authors:		Authors:

OCA at 11:39, 26 October 2016

2016-10-26T11:39:56Z

←Older revision		Revision as of 11:39, 26 October 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4y9w is ON HOLD	+	The entry 4y9w is ON HOLD until sometime in the future

	Authors:		Authors:

OCA at 10:31, 15 May 2016

2016-05-15T10:31:45Z

←Older revision		Revision as of 10:31, 15 May 2016
Line 3:		Line 3:
	The entry 4y9w is ON HOLD		The entry 4y9w is ON HOLD

-	Authors: ~~Dostal, J., Brynda, J., Hruskova-Heidingsfeldova, O., Rezacova, P., Mareckova, L., Pichova, I.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Pichova, I]]
-	[[Category: Mareckova, L]]
-	[[Category: Brynda, J]]
-	[[Category: Dostal, J]]
-	[[Category: Rezacova, P]]
-	[[Category: Hruskova-Heidingsfeldova, O]]

OCA at 23:29, 30 November 2015

2015-11-30T23:29:54Z

←Older revision		Revision as of 23:29, 30 November 2015
Line 7:		Line 7:
	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Pichova, I]]
	[[Category: Mareckova, L]]		[[Category: Mareckova, L]]
	[[Category: Brynda, J]]		[[Category: Brynda, J]]
	[[Category: Dostal, J]]		[[Category: Dostal, J]]
-	[[Category: Hruskova-Heidingsfeldova, O]]
-	[[Category: Pichova, I]]
	[[Category: Rezacova, P]]		[[Category: Rezacova, P]]
		+	[[Category: Hruskova-Heidingsfeldova, O]]

OCA: Protected "4y9w" [edit=sysop:move=sysop]

2015-02-25T12:52:13Z

Protected "4y9w" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:52, 25 February 2015

OCA: New page: '''Unreleased structure''' The entry 4y9w is ON HOLD Authors: Dostal, J., Brynda, J., Hruskova-Heidingsfeldova, O., Rezacova, P., Mareckova, L., Pichova, I. Description: [[Category: U...

2015-02-25T12:52:12Z

New page: '''Unreleased structure''' The entry 4y9w is ON HOLD Authors: Dostal, J., Brynda, J., Hruskova-Heidingsfeldova, O., Rezacova, P., Mareckova, L., Pichova, I. Description: [[Category: U...

New page

'''Unreleased structure'''

The entry 4y9w is ON HOLD

Authors: Dostal, J., Brynda, J., Hruskova-Heidingsfeldova, O., Rezacova, P., Mareckova, L., Pichova, I.

Description:
[[Category: Unreleased Structures]]
[[Category: Mareckova, L]]
[[Category: Brynda, J]]
[[Category: Dostal, J]]
[[Category: Hruskova-Heidingsfeldova, O]]
[[Category: Pichova, I]]
[[Category: Rezacova, P]]