4yrg - Revision history

OCA at 08:05, 27 September 2023

2023-09-27T08:05:12Z

←Older revision		Revision as of 08:05, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yrg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YRG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yrg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YRG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HU:(6-BROMOPYRIDIN-2-YL)METHANOL'>4HU</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HU:(6-BROMOPYRIDIN-2-YL)METHANOL'>4HU</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yrg OCA], [https://pdbe.org/4yrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yrg RCSB], [https://www.ebi.ac.uk/pdbsum/4yrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yrg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yrg OCA], [https://pdbe.org/4yrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yrg RCSB], [https://www.ebi.ac.uk/pdbsum/4yrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yrg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:27, 3 May 2023

2023-05-03T08:27:58Z

←Older revision		Revision as of 08:27, 3 May 2023
Line 1:		Line 1:

	==Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with (6-bromopyridin-2-yl)methanol (Chem 149)==		==Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with (6-bromopyridin-2-yl)methanol (Chem 149)==
-	<StructureSection load='4yrg' size='340' side='right' caption='[[4yrg]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='4yrg' size='340' side='right'caption='[[4yrg]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yrg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Trycc Trycc~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YRG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4YRG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yrg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YRG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HU:(6-BROMOPYRIDIN-2-YL)METHANOL'>4HU</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HU:(6-BROMOPYRIDIN-2-YL)METHANOL'>4HU</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yp0\|4yp0]], [[4ypf\|4ypf]], [[4yrc\|4yrc]], [[4yre\|4yre]], [[4yrf\|4yrf]], [[4yri\|4yri]], [[4yrj\|4yrj]], [[4yrk\|4yrk]], [[4yrl\|4yrl]], [[4yrm\|4yrm]], [[4yrn\|4yrn]], [[4yro\|4yro]], [[4yrp\|4yrp]], [[4yrq\|4yrq]], [[4yrr\|4yrr]], [[4yrs\|4yrs]], [[4yrt\|4yrt]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yrg OCA], [https://pdbe.org/4yrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yrg RCSB], [https://www.ebi.ac.uk/pdbsum/4yrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yrg ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tc00.1047053507019.40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine--tRNA_ligase Histidine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.21 6.1.1.21] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yrg OCA], [~~http~~://pdbe.org/4yrg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4yrg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4yrg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4yrg ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q4DA54_TRYCC Q4DA54_TRYCC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4yrg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4yrg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Histidine--tRNA ligase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Trycc~~]]	+	[[Category: Trypanosoma cruzi strain CL Brener]]
-	[[Category: Hol~~, W G.J~~]]	+	[[Category: Hol WGJ]]
-	[[Category: Koh, C Y]]	+	[[Category: Koh C-Y]]
-	~~[[Category: Aar]]~~	+
-	~~[[Category: Aminoacyl-trna synthetase]]~~	+
-	~~[[Category: Hisr]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Ligase-ligase inhibitor complex]]~~	+
-	~~[[Category: Protein-inhibitor complex]]~~	+
-	~~[[Category: Trypanosoma cruzi~~]]	+

OCA at 06:15, 18 April 2018

2018-04-18T06:15:57Z

←Older revision		Revision as of 06:15, 18 April 2018
Line 3:		Line 3:
	<StructureSection load='4yrg' size='340' side='right' caption='[[4yrg]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='4yrg' size='340' side='right' caption='[[4yrg]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yrg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YRG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YRG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yrg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YRG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YRG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HU:(6-BROMOPYRIDIN-2-YL)METHANOL'>4HU</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HU:(6-BROMOPYRIDIN-2-YL)METHANOL'>4HU</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yp0\|4yp0]], [[4ypf\|4ypf]], [[4yrc\|4yrc]], [[4yre\|4yre]], [[4yrf\|4yrf]], [[4yri\|4yri]], [[4yrj\|4yrj]], [[4yrk\|4yrk]], [[4yrl\|4yrl]], [[4yrm\|4yrm]], [[4yrn\|4yrn]], [[4yro\|4yro]], [[4yrp\|4yrp]], [[4yrq\|4yrq]], [[4yrr\|4yrr]], [[4yrs\|4yrs]], [[4yrt\|4yrt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yp0\|4yp0]], [[4ypf\|4ypf]], [[4yrc\|4yrc]], [[4yre\|4yre]], [[4yrf\|4yrf]], [[4yri\|4yri]], [[4yrj\|4yrj]], [[4yrk\|4yrk]], [[4yrl\|4yrl]], [[4yrm\|4yrm]], [[4yrn\|4yrn]], [[4yro\|4yro]], [[4yrp\|4yrp]], [[4yrq\|4yrq]], [[4yrr\|4yrr]], [[4yrs\|4yrs]], [[4yrt\|4yrt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tc00.1047053507019.40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine--tRNA_ligase Histidine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.21 6.1.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine--tRNA_ligase Histidine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.21 6.1.1.21] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yrg OCA], [http://pdbe.org/4yrg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yrg RCSB], [http://www.ebi.ac.uk/pdbsum/4yrg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yrg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yrg OCA], [http://pdbe.org/4yrg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yrg RCSB], [http://www.ebi.ac.uk/pdbsum/4yrg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yrg ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	American trypanosomiasis, commonly known as Chagas disease, is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. The chronic form of the infection often causes debilitating morbidity and mortality. However, the current treatment for the disease is typically inadequate owing to drug toxicity and poor efficacy, necessitating a continual effort to discover and develop new antiparasitic therapeutic agents. The structure of T. cruzi histidyl-tRNA synthetase (HisRS), a validated drug target, has previously been reported. Based on this structure and those of human cytosolic HisRS, opportunities for the development of specific inhibitors were identified. Here, efforts are reported to identify small molecules that bind to T. cruzi HisRS through fragment-based crystallographic screening in order to arrive at chemical starting points for the development of specific inhibitors. T. cruzi HisRS was soaked into 68 different cocktails from the Medical Structural Genomics of Pathogenic Protozoa (MSGPP) fragment library and diffraction data were collected to identify bound fragments after soaking. A total of 15 fragments were identified, all bound to the same site on the protein, revealing a fragment-binding hotspot adjacent to the ATP-binding pocket. On the basis of the initial hits, the design of reactive fragments targeting the hotspot which would be simultaneously covalently linked to a cysteine residue present only in trypanosomatid HisRS was initiated. Inhibition of T. cruzi HisRS was observed with the resultant reactive fragments and the anticipated binding mode was confirmed crystallographically. These results form a platform for the development of future generations of selective inhibitors for trypanosomatid HisRS.
		+
		+	A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.,Koh CY, Kallur Siddaramaiah L, Ranade RM, Nguyen J, Jian T, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG Acta Crystallogr D Biol Crystallogr. 2015 Aug 1;71(Pt 8):1684-98. doi:, 10.1107/S1399004715007683. Epub 2015 Jul 31. PMID:26249349<ref>PMID:26249349</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4yrg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Histidine--tRNA ligase]]		[[Category: Histidine--tRNA ligase]]
		+	[[Category: Trycc]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]
	[[Category: Koh, C Y]]		[[Category: Koh, C Y]]

OCA at 16:07, 17 May 2017

2017-05-17T16:07:56Z

←Older revision		Revision as of 16:07, 17 May 2017
Line 1:		Line 1:
		+
	==Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with (6-bromopyridin-2-yl)methanol (Chem 149)==		==Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with (6-bromopyridin-2-yl)methanol (Chem 149)==
	<StructureSection load='4yrg' size='340' side='right' caption='[[4yrg]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='4yrg' size='340' side='right' caption='[[4yrg]], [[Resolution\|resolution]] 2.15Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yp0\|4yp0]], [[4ypf\|4ypf]], [[4yrc\|4yrc]], [[4yre\|4yre]], [[4yrf\|4yrf]], [[4yri\|4yri]], [[4yrj\|4yrj]], [[4yrk\|4yrk]], [[4yrl\|4yrl]], [[4yrm\|4yrm]], [[4yrn\|4yrn]], [[4yro\|4yro]], [[4yrp\|4yrp]], [[4yrq\|4yrq]], [[4yrr\|4yrr]], [[4yrs\|4yrs]], [[4yrt\|4yrt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yp0\|4yp0]], [[4ypf\|4ypf]], [[4yrc\|4yrc]], [[4yre\|4yre]], [[4yrf\|4yrf]], [[4yri\|4yri]], [[4yrj\|4yrj]], [[4yrk\|4yrk]], [[4yrl\|4yrl]], [[4yrm\|4yrm]], [[4yrn\|4yrn]], [[4yro\|4yro]], [[4yrp\|4yrp]], [[4yrq\|4yrq]], [[4yrr\|4yrr]], [[4yrs\|4yrs]], [[4yrt\|4yrt]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine--tRNA_ligase Histidine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.21 6.1.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine--tRNA_ligase Histidine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.21 6.1.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yrg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yrg RCSB], [http://www.ebi.ac.uk/pdbsum/4yrg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yrg OCA], [http://pdbe.org/4yrg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yrg RCSB], [http://www.ebi.ac.uk/pdbsum/4yrg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yrg ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 14:50, 12 August 2015

2015-08-12T14:50:45Z

←Older revision		Revision as of 14:50, 12 August 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with (6-bromopyridin-2-yl)methanol (Chem 149)==
-		+	<StructureSection load='4yrg' size='340' side='right' caption='[[4yrg]], [[Resolution\|resolution]] 2.15Å' scene=''>
-	~~The entry~~ 4yrg is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4yrg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YRG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YRG FirstGlance]. <br>
-	~~Authors~~: ~~Koh~~, C.-Y., ~~Hol~~, W.G.J.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HU:(6-BROMOPYRIDIN-2-YL)METHANOL'>4HU</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yp0\|4yp0]], [[4ypf\|4ypf]], [[4yrc\|4yrc]], [[4yre\|4yre]], [[4yrf\|4yrf]], [[4yri\|4yri]], [[4yrj\|4yrj]], [[4yrk\|4yrk]], [[4yrl\|4yrl]], [[4yrm\|4yrm]], [[4yrn\|4yrn]], [[4yro\|4yro]], [[4yrp\|4yrp]], [[4yrq\|4yrq]], [[4yrr\|4yrr]], [[4yrs\|4yrs]], [[4yrt\|4yrt]]</td></tr>
-	~~Description:~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine--tRNA_ligase Histidine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.21 6.1.1.21] </span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yrg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yrg RCSB], [http://www.ebi.ac.uk/pdbsum/4yrg PDBsum]</span></td></tr>
-	[[Category: Hol, W.G.J]]	+	</table>
-	[[Category: Koh, C.-Y]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Histidine--tRNA ligase]]
		+	[[Category: Hol, W G.J]]
		+	[[Category: Koh, C Y]]
		+	[[Category: Aar]]
		+	[[Category: Aminoacyl-trna synthetase]]
		+	[[Category: Hisr]]
		+	[[Category: Ligase]]
		+	[[Category: Ligase-ligase inhibitor complex]]
		+	[[Category: Protein-inhibitor complex]]
		+	[[Category: Trypanosoma cruzi]]

OCA at 13:45, 27 May 2015

2015-05-27T13:45:46Z

←Older revision		Revision as of 13:45, 27 May 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4yrg is ON HOLD	+	The entry 4yrg is ON HOLD until Paper Publication

	Authors: Koh, C.-Y., Hol, W.G.J.		Authors: Koh, C.-Y., Hol, W.G.J.

OCA at 11:49, 1 April 2015

2015-04-01T11:49:00Z

←Older revision		Revision as of 11:49, 1 April 2015
Line 3:		Line 3:
	The entry 4yrg is ON HOLD		The entry 4yrg is ON HOLD

-	Authors: Koh, ~~Cho Yeow~~, Hol, ~~Wim~~ G.J.	+	Authors: Koh, C.-Y., Hol, W.G.J.

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Koh, Cho Yeow,~~ Hol, ~~Wim~~ G.J]]	+	[[Category: Hol, W.G.J]]
		+	[[Category: Koh, C.-Y]]

OCA: Protected "4yrg" [edit=sysop:move=sysop]

2015-03-26T12:44:30Z

Protected "4yrg" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:44, 26 March 2015

OCA: New page: '''Unreleased structure''' The entry 4yrg is ON HOLD Authors: Koh, Cho Yeow, Hol, Wim G.J. Description: Category: Unreleased Structures Category: Koh, Cho Yeow, Hol, Wim G.J

2015-03-26T12:44:28Z

New page: '''Unreleased structure''' The entry 4yrg is ON HOLD Authors: Koh, Cho Yeow, Hol, Wim G.J. Description: Category: Unreleased Structures Category: Koh, Cho Yeow, Hol, Wim G.J

New page

'''Unreleased structure'''

The entry 4yrg is ON HOLD

Authors: Koh, Cho Yeow, Hol, Wim G.J.

Description:
[[Category: Unreleased Structures]]
[[Category: Koh, Cho Yeow, Hol, Wim G.J]]