4yvo - Revision history

OCA at 15:40, 8 November 2023

2023-11-08T15:40:04Z

←Older revision		Revision as of 15:40, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yvo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YVO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yvo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YVO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvo OCA], [https://pdbe.org/4yvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yvo RCSB], [https://www.ebi.ac.uk/pdbsum/4yvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yvo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvo OCA], [https://pdbe.org/4yvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yvo RCSB], [https://www.ebi.ac.uk/pdbsum/4yvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yvo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:28, 10 May 2023

2023-05-10T07:28:16Z

←Older revision		Revision as of 07:28, 10 May 2023
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	<StructureSection load='4yvo' size='340' side='right'caption='[[4yvo]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4yvo' size='340' side='right'caption='[[4yvo]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yvo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4YVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yvo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YVO FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yvq\|4yvq]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvo OCA], [https://pdbe.org/4yvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yvo RCSB], [https://www.ebi.ac.uk/pdbsum/4yvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yvo ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FLU, At3g14110, MAG2.7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4yvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvo OCA], [~~http~~://pdbe.org/4yvo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4yvo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4yvo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4yvo ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FLU_ARATH FLU_ARATH]] Negative regulator of tetrapyrrole biosynthesis (including chlorophyll) in chloroplasts, probably via HEMA1 repression. Inhibits especially the magnesium ion Mg(2+) branch of tetrapyrrole biosynthesis, but independently of heme.<ref>PMID:11606728</ref> <ref>PMID:14508004</ref> <ref>PMID:15584960</ref> <ref>PMID:18182022</ref>	+	[https://www.uniprot.org/uniprot/FLU_ARATH FLU_ARATH] Negative regulator of tetrapyrrole biosynthesis (including chlorophyll) in chloroplasts, probably via HEMA1 repression. Inhibits especially the magnesium ion Mg(2+) branch of tetrapyrrole biosynthesis, but independently of heme.<ref>PMID:11606728</ref> <ref>PMID:14508004</ref> <ref>PMID:15584960</ref> <ref>PMID:18182022</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liu, L]]	+	[[Category: Liu L]]
-	[[Category: Zhang, F]]	+	[[Category: Zhang F]]
-	[[Category: Zhang, M]]	+	[[Category: Zhang M]]
-	~~[[Category: Chloroplast]]~~	+
-	~~[[Category: Fluorescent protein]]~~	+
-	~~[[Category: Tpr~~]]	+

OCA at 07:25, 19 June 2019

2019-06-19T07:25:00Z

←Older revision		Revision as of 07:25, 19 June 2019
Line 1:		Line 1:

	==Crystal Structure of the TPR Domain of Arabidopsis FLU (FLU-TPR)==		==Crystal Structure of the TPR Domain of Arabidopsis FLU (FLU-TPR)==
-	<StructureSection load='4yvo' size='340' side='right' caption='[[4yvo]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='4yvo' size='340' side='right'caption='[[4yvo]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yvo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yvo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YVO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yvq\|4yvq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yvq\|4yvq]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FLU, At3g14110, MAG2.7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvo OCA], [http://pdbe.org/4yvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yvo RCSB], [http://www.ebi.ac.uk/pdbsum/4yvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yvo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvo OCA], [http://pdbe.org/4yvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yvo RCSB], [http://www.ebi.ac.uk/pdbsum/4yvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yvo ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Liu, L]]		[[Category: Liu, L]]
	[[Category: Zhang, F]]		[[Category: Zhang, F]]

OCA at 14:21, 27 April 2017

2017-04-27T14:21:54Z

←Older revision		Revision as of 14:21, 27 April 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the TPR Domain of Arabidopsis FLU (FLU-TPR)==		==Crystal Structure of the TPR Domain of Arabidopsis FLU (FLU-TPR)==
	<StructureSection load='4yvo' size='340' side='right' caption='[[4yvo]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4yvo' size='340' side='right' caption='[[4yvo]], [[Resolution\|resolution]] 1.45Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4yvo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YVO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yvo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YVO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yvq\|4yvq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yvq\|4yvq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yvo RCSB], [http://www.ebi.ac.uk/pdbsum/4yvo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvo OCA], [http://pdbe.org/4yvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yvo RCSB], [http://www.ebi.ac.uk/pdbsum/4yvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yvo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4yvo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:26, 22 July 2015

2015-07-22T08:26:01Z

←Older revision		Revision as of 08:26, 22 July 2015
Line 8:		Line 8:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FLU_ARATH FLU_ARATH]] Negative regulator of tetrapyrrole biosynthesis (including chlorophyll) in chloroplasts, probably via HEMA1 repression. Inhibits especially the magnesium ion Mg(2+) branch of tetrapyrrole biosynthesis, but independently of heme.<ref>PMID:11606728</ref> <ref>PMID:14508004</ref> <ref>PMID:15584960</ref> <ref>PMID:18182022</ref>		[[http://www.uniprot.org/uniprot/FLU_ARATH FLU_ARATH]] Negative regulator of tetrapyrrole biosynthesis (including chlorophyll) in chloroplasts, probably via HEMA1 repression. Inhibits especially the magnesium ion Mg(2+) branch of tetrapyrrole biosynthesis, but independently of heme.<ref>PMID:11606728</ref> <ref>PMID:14508004</ref> <ref>PMID:15584960</ref> <ref>PMID:18182022</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The tetratricopeptide repeat (TPR)-containing protein FLU is a negative regulator of chlorophyll biosynthesis in plants. It directly interacts through its TPR domain with glutamyl-tRNA reductase (GluTR), the rate-limiting enzyme in the formation of delta-aminolevulinic acid (ALA). Delineation of how FLU binds to GluTR is important for understanding the molecular basis for FLU-mediated repression of synthesis of ALA, the universal tetrapyrrole precursor. Here, we characterize the FLU-GluTR interaction by solving the crystal structures of the uncomplexed TPR domain of FLU (FLU(TPR)) at 1.45-A resolution and the complex of the dimeric domain of GluTR bound to FLU(TPR) at 2.4-A resolution. Three non-canonical TPR motifs of each FLU(TPR) form a concave surface and clamp the helix bundle in the C-terminal dimeric domain of GluTR. We demonstrate that a 2:2 FLU(TPR)-GluTR complex is the functional unit for FLU-mediated GluTR regulation and suggest that the formation of the FLU-GluTR complex prevents glutamyl-tRNA, the GluTR substrate, from binding with this enzyme. These results also provide insights into the spatial regulation of ALA synthesis by the membrane-located FLU protein.
		+
		+	The Non-canonical Tetratricopeptide Repeat (TPR) Domain of Fluorescent (FLU) Mediates Complex Formation with Glutamyl-tRNA Reductase.,Zhang M, Zhang F, Fang Y, Chen X, Chen Y, Zhang W, Dai HE, Lin R, Liu L J Biol Chem. 2015 Jul 10;290(28):17559-65. doi: 10.1074/jbc.M115.662981. Epub, 2015 Jun 2. PMID:26037924<ref>PMID:26037924</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:11, 10 June 2015

2015-06-10T14:11:08Z

←Older revision		Revision as of 14:11, 10 June 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of the TPR Domain of Arabidopsis FLU (FLU-TPR)==
-		+	<StructureSection load='4yvo' size='340' side='right' caption='[[4yvo]], [[Resolution\|resolution]] 1.45Å' scene=''>
-	~~The entry~~ 4yvo is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4yvo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YVO FirstGlance]. <br>
-	~~Authors~~: ~~Zhang~~, M., ~~Zhang, F~~., ~~Liu, L~~.	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yvq\|4yvq]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yvo RCSB], [http://www.ebi.ac.uk/pdbsum/4yvo PDBsum]</span></td></tr>
-	~~Description:~~	+	</table>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FLU_ARATH FLU_ARATH]] Negative regulator of tetrapyrrole biosynthesis (including chlorophyll) in chloroplasts, probably via HEMA1 repression. Inhibits especially the magnesium ion Mg(2+) branch of tetrapyrrole biosynthesis, but independently of heme.<ref>PMID:11606728</ref> <ref>PMID:14508004</ref> <ref>PMID:15584960</ref> <ref>PMID:18182022</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Liu, L]]		[[Category: Liu, L]]
	[[Category: Zhang, F]]		[[Category: Zhang, F]]
	[[Category: Zhang, M]]		[[Category: Zhang, M]]
		+	[[Category: Chloroplast]]
		+	[[Category: Fluorescent protein]]
		+	[[Category: Tpr]]

OCA at 11:14, 22 April 2015

2015-04-22T11:14:01Z

←Older revision		Revision as of 11:14, 22 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4yvo is ON HOLD	+	The entry 4yvo is ON HOLD until Paper Publication

	Authors: Zhang, M., Zhang, F., Liu, L.		Authors: Zhang, M., Zhang, F., Liu, L.

OCA: Protected "4yvo" [edit=sysop:move=sysop]

2015-03-26T12:55:15Z

Protected "4yvo" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:55, 26 March 2015

OCA: New page: '''Unreleased structure''' The entry 4yvo is ON HOLD Authors: Zhang, M., Zhang, F., Liu, L. Description: Category: Unreleased Structures Category: Liu, L [[Category: Zhang, F]...

2015-03-26T12:55:14Z

New page: '''Unreleased structure''' The entry 4yvo is ON HOLD Authors: Zhang, M., Zhang, F., Liu, L. Description: Category: Unreleased Structures Category: Liu, L [[Category: Zhang, F]...

New page

'''Unreleased structure'''

The entry 4yvo is ON HOLD

Authors: Zhang, M., Zhang, F., Liu, L.

Description:
[[Category: Unreleased Structures]]
[[Category: Liu, L]]
[[Category: Zhang, F]]
[[Category: Zhang, M]]