4yxu - Revision history

OCA at 10:56, 10 January 2024

2024-01-10T10:56:35Z

←Older revision		Revision as of 10:56, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yxu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YXU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yxu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YXU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4JE:4-PROPYLBENZENESULFONAMIDE'>4JE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.08Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4JE:4-PROPYLBENZENESULFONAMIDE'>4JE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxu OCA], [https://pdbe.org/4yxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yxu RCSB], [https://www.ebi.ac.uk/pdbsum/4yxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxu OCA], [https://pdbe.org/4yxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yxu RCSB], [https://www.ebi.ac.uk/pdbsum/4yxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxu ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:30, 10 May 2023

2023-05-10T07:30:32Z

←Older revision		Revision as of 07:30, 10 May 2023
Line 3:		Line 3:
	<StructureSection load='4yxu' size='340' side='right'caption='[[4yxu]], [[Resolution\|resolution]] 1.08Å' scene=''>		<StructureSection load='4yxu' size='340' side='right'caption='[[4yxu]], [[Resolution\|resolution]] 1.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yxu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4YXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yxu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YXU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4JE:4-PROPYLBENZENESULFONAMIDE'>4JE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4JE:4-PROPYLBENZENESULFONAMIDE'>4JE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yxo\|4yxo]], [[4yx4\|4yx4]], [[4yxi\|4yxi]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxu OCA], [https://pdbe.org/4yxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yxu RCSB], [https://www.ebi.ac.uk/pdbsum/4yxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxu ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4yxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxu OCA], [~~http~~://pdbe.org/4yxu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4yxu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4yxu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxu ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 30:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carbonate dehydratase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Heine, A]]	+	[[Category: Heine A]]
-	[[Category: Klebe, G]]	+	[[Category: Klebe G]]
-	[[Category: Rechlin, C]]	+	[[Category: Rechlin C]]
-	~~[[Category: Lyase~~]]	+

OCA at 07:25, 19 June 2019

2019-06-19T07:25:20Z

←Older revision		Revision as of 07:25, 19 June 2019
Line 1:		Line 1:

	==Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4).==		==Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4).==
-	<StructureSection load='4yxu' size='340' side='right' caption='[[4yxu]], [[Resolution\|resolution]] 1.08Å' scene=''>	+	<StructureSection load='4yxu' size='340' side='right'caption='[[4yxu]], [[Resolution\|resolution]] 1.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yxu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yxu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4JE:4-PROPYLBENZENESULFONAMIDE'>4JE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4JE:4-PROPYLBENZENESULFONAMIDE'>4JE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yxo\|4yxo]], [[4yx4\|4yx4]], [[4yxi\|4yxi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yxo\|4yxo]], [[4yx4\|4yx4]], [[4yxi\|4yxi]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxu OCA], [http://pdbe.org/4yxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yxu RCSB], [http://www.ebi.ac.uk/pdbsum/4yxu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxu OCA], [http://pdbe.org/4yxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yxu RCSB], [http://www.ebi.ac.uk/pdbsum/4yxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxu ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 22:		Line 23:
	</div>		</div>
	<div class="pdbe-citations 4yxu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4yxu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Heine, A]]		[[Category: Heine, A]]
	[[Category: Klebe, G]]		[[Category: Klebe, G]]
	[[Category: Rechlin, C]]		[[Category: Rechlin, C]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 08:21, 1 June 2016

2016-06-01T08:21:25Z

←Older revision		Revision as of 08:21, 1 June 2016
Line 1:		Line 1:
		+
	==Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4).==		==Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4).==
	<StructureSection load='4yxu' size='340' side='right' caption='[[4yxu]], [[Resolution\|resolution]] 1.08Å' scene=''>		<StructureSection load='4yxu' size='340' side='right' caption='[[4yxu]], [[Resolution\|resolution]] 1.08Å' scene=''>

OCA at 15:45, 3 February 2016

2016-02-03T15:45:04Z

←Older revision		Revision as of 15:45, 3 February 2016
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4).==
		+	<StructureSection load='4yxu' size='340' side='right' caption='[[4yxu]], [[Resolution\|resolution]] 1.08Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4yxu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4JE:4-PROPYLBENZENESULFONAMIDE'>4JE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yxo\|4yxo]], [[4yx4\|4yx4]], [[4yxi\|4yxi]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxu OCA], [http://pdbe.org/4yxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yxu RCSB], [http://www.ebi.ac.uk/pdbsum/4yxu PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The binding of sulfonamides to human carbonic anhydrase II (hCAII) is a complex and long-debated example of protein-ligand recognition and interaction. In this study, we investigate the para-substituted n-alkyl and hydroxyethylene-benzenesulfonamides, providing a complete reconstruction of their binding pathway to hCAII by means of large-scale molecular dynamics simulations, density functional calculations, surface plasmon resonance (SPR) measurements, and X-ray crystallography experiments. Our analysis shows that the protein-ligand association rate (kon) dramatically increases with the ligand's hydrophobicity, pointing to the existence of a prebinding stage largely stabilized by a favorable packing of the ligand's apolar moieties with the hCAII "hydrophobic wall". The characterization of the binding pathway allows an unprecedented understanding of the structure-kinetic relationship in hCAII/benzenesulfonamide complexes, depicting a paradigmatic scenario for the multistep binding process in protein-ligand systems.

-	~~The entry 4yxu is ON HOLD until Mar 23 2017~~	+	Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies.,Gaspari R, Rechlin C, Heine A, Bottegoni G, Rocchia W, Schwarz D, Bomke J, Gerber HD, Klebe G, Cavalli A J Med Chem. 2016 Jan 12. PMID:26700575<ref>PMID:26700575</ref>

-	~~Authors: Rechlin~~, C.~~, Heine, A~~.~~, Klebe, G~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4).~~	+	<div class="pdbe-citations 4yxu" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Carbonate dehydratase]]
	[[Category: Heine, A]]		[[Category: Heine, A]]
		+	[[Category: Klebe, G]]
	[[Category: Rechlin, C]]		[[Category: Rechlin, C]]
-	[[Category: ~~Klebe, G~~]]	+	[[Category: Lyase]]

OCA at 23:46, 30 November 2015

2015-11-30T23:46:24Z

←Older revision		Revision as of 23:46, 30 November 2015
Line 7:		Line 7:
	Description: Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4).		Description: Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4).
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Heine, A]]
	[[Category: Rechlin, C]]		[[Category: Rechlin, C]]
	[[Category: Klebe, G]]		[[Category: Klebe, G]]
-	[[Category: Heine, A]]

OCA: Protected "4yxu" [edit=sysop:move=sysop]

2015-04-01T12:01:40Z

Protected "4yxu" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:01, 1 April 2015

OCA: New page: '''Unreleased structure''' The entry 4yxu is ON HOLD until Mar 23 2017 Authors: Rechlin, C., Heine, A., Klebe, G. Description: Human Carbonic Anhydrase II complexed with an inhibitor w...

2015-04-01T12:01:39Z

New page: '''Unreleased structure''' The entry 4yxu is ON HOLD until Mar 23 2017 Authors: Rechlin, C., Heine, A., Klebe, G. Description: Human Carbonic Anhydrase II complexed with an inhibitor w...

New page

'''Unreleased structure'''

The entry 4yxu is ON HOLD until Mar 23 2017

Authors: Rechlin, C., Heine, A., Klebe, G.

Description: Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4).
[[Category: Unreleased Structures]]
[[Category: Rechlin, C]]
[[Category: Klebe, G]]
[[Category: Heine, A]]