4z2d - Revision history

OCA at 10:57, 10 January 2024

2024-01-10T10:57:21Z

←Older revision		Revision as of 10:57, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4z2d]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z2D FirstGlance]. <br>		<table><tr><td colspan='2'>[[4z2d]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z2D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LFX:(3S)-9-FLUORO-3-METHYL-10-(4-METHYLPIPERAZIN-1-YL)-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC+ACID'>LFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.38Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LFX:(3S)-9-FLUORO-3-METHYL-10-(4-METHYLPIPERAZIN-1-YL)-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC+ACID'>LFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2d OCA], [https://pdbe.org/4z2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z2d RCSB], [https://www.ebi.ac.uk/pdbsum/4z2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2d OCA], [https://pdbe.org/4z2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z2d RCSB], [https://www.ebi.ac.uk/pdbsum/4z2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2d ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:36, 10 May 2023

2023-05-10T07:36:10Z

←Older revision		Revision as of 07:36, 10 May 2023
Line 3:		Line 3:
	<StructureSection load='4z2d' size='340' side='right'caption='[[4z2d]], [[Resolution\|resolution]] 3.38Å' scene=''>		<StructureSection load='4z2d' size='340' side='right'caption='[[4z2d]], [[Resolution\|resolution]] 3.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4z2d]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus~~ pneumoniae~~" (klein 1884) weichselbaum 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Z2D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4z2d]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z2D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFX:(3S)-9-FLUORO-3-METHYL-10-(4-METHYLPIPERAZIN-1-YL)-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC+ACID'>LFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LFX:(3S)-9-FLUORO-3-METHYL-10-(4-METHYLPIPERAZIN-1-YL)-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC+ACID'>LFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4koe\|4koe]], [[4pxp\|4pxp]], [[3rad\|3rad]], [[3rae\|3rae]], [[3raf\|3raf]], [[3ksb\|3ksb]], [[3ksa\|3ksa]], [[4i3h\|4i3h]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2d OCA], [https://pdbe.org/4z2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z2d RCSB], [https://www.ebi.ac.uk/pdbsum/4z2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2d ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gyrA, BM52_0349 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886]), gyrB, BM52_1967, DJ38_04430 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4z2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2d OCA], [~~http~~://pdbe.org/4z2d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4z2d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4z2d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2d ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~Q9R867_STREE Q9R867_STREE]~~] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897] [[http://www.uniprot.org/uniprot/Q59957_STREE Q59957_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01898]	+	[https://www.uniprot.org/uniprot/GYRA_STRR6 GYRA_STRR6] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897]

	==See Also==		==See Also==
-	*[[Gyrase\|Gyrase]]	+	*[[Gyrase 3D Structures\|Gyrase 3D Structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Crevel~~, I M.~~T]]	+	[[Category: Streptococcus pneumoniae]]
-	[[Category: Fisher~~, L M~~]]	+	[[Category: Crevel IM-T]]
-	[[Category: Laponogov, I]]	+	[[Category: Fisher LM]]
-	[[Category: Pan, X S]]	+	[[Category: Laponogov I]]
-	[[Category: Sanderson~~, M R~~]]	+	[[Category: Pan X-S]]
-	[[Category: Selvarajah, J]]	+	[[Category: Sanderson MR]]
-	[[Category: Veselkov~~, D A]]~~	+	[[Category: Selvarajah J]]
-	~~[[Category: Cleavage complex]]~~	+	[[Category: Veselkov DA]]
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Gyrase]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Quinolone~~]]	+

OCA at 07:26, 19 June 2019

2019-06-19T07:26:48Z

←Older revision		Revision as of 07:26, 19 June 2019
Line 1:		Line 1:

	==Quinolone(Levofloxacin)-DNA cleavage complex of gyrase from S. pneumoniae==		==Quinolone(Levofloxacin)-DNA cleavage complex of gyrase from S. pneumoniae==
-	<StructureSection load='4z2d' size='340' side='right' caption='[[4z2d]], [[Resolution\|resolution]] 3.38Å' scene=''>	+	<StructureSection load='4z2d' size='340' side='right'caption='[[4z2d]], [[Resolution\|resolution]] 3.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4z2d]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4z2d]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFX:(3S)-9-FLUORO-3-METHYL-10-(4-METHYLPIPERAZIN-1-YL)-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC+ACID'>LFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFX:(3S)-9-FLUORO-3-METHYL-10-(4-METHYLPIPERAZIN-1-YL)-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC+ACID'>LFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4koe\|4koe]], [[4pxp\|4pxp]], [[3rad\|3rad]], [[3rae\|3rae]], [[3raf\|3raf]], [[3ksb\|3ksb]], [[3ksa\|3ksa]], [[4i3h\|4i3h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4koe\|4koe]], [[4pxp\|4pxp]], [[3rad\|3rad]], [[3rae\|3rae]], [[3raf\|3raf]], [[3ksb\|3ksb]], [[3ksa\|3ksa]], [[4i3h\|4i3h]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gyrA, BM52_0349 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886]), gyrB, BM52_1967, DJ38_04430 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2d OCA], [http://pdbe.org/4z2d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2d RCSB], [http://www.ebi.ac.uk/pdbsum/4z2d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2d OCA], [http://pdbe.org/4z2d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2d RCSB], [http://www.ebi.ac.uk/pdbsum/4z2d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2d ProSAT]</span></td></tr>
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/Q9R867_STREE Q9R867_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897] [[http://www.uniprot.org/uniprot/Q59957_STREE Q59957_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01898]		[[http://www.uniprot.org/uniprot/Q9R867_STREE Q9R867_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897] [[http://www.uniprot.org/uniprot/Q59957_STREE Q59957_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01898]
		+
		+	==See Also==
		+	*[[Gyrase\|Gyrase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Crevel, I M.T]]		[[Category: Crevel, I M.T]]
	[[Category: Fisher, L M]]		[[Category: Fisher, L M]]

OCA at 15:25, 14 September 2016

2016-09-14T15:25:08Z

←Older revision		Revision as of 15:25, 14 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4z2d is ~~ON HOLD until Paper Publication~~	+	==Quinolone(Levofloxacin)-DNA cleavage complex of gyrase from S. pneumoniae==
-		+	<StructureSection load='4z2d' size='340' side='right' caption='[[4z2d]], [[Resolution\|resolution]] 3.38Å' scene=''>
-	~~Authors~~: ~~Laponogov~~, I., ~~Veselkov~~, D.A., ~~Pan, X~~.-S., ~~Selvarajah~~, J., ~~Crevel, I~~.M.-T., ~~Fisher, L~~.M., ~~Sanderson, M~~.R.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4z2d]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2D FirstGlance]. <br>
-	~~Description~~: ~~Quinolone~~(~~Levofloxacin~~)-DNA ~~cleavage complex~~ of ~~gyrase from S~~. ~~pneumoniae~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFX:(3S)-9-FLUORO-3-METHYL-10-(4-METHYLPIPERAZIN-1-YL)-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC+ACID'>LFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4koe\|4koe]], [[4pxp\|4pxp]], [[3rad\|3rad]], [[3rae\|3rae]], [[3raf\|3raf]], [[3ksb\|3ksb]], [[3ksa\|3ksa]], [[4i3h\|4i3h]]</td></tr>
-	[[Category: Fisher, L.M]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
-	[[Category: Pan, X.-S]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2d OCA], [http://pdbe.org/4z2d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2d RCSB], [http://www.ebi.ac.uk/pdbsum/4z2d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2d ProSAT]</span></td></tr>
-	[[Category: Sanderson, M.R]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q9R867_STREE Q9R867_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897] [[http://www.uniprot.org/uniprot/Q59957_STREE Q59957_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01898]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Crevel, I M.T]]
		+	[[Category: Fisher, L M]]
		+	[[Category: Laponogov, I]]
		+	[[Category: Pan, X S]]
		+	[[Category: Sanderson, M R]]
	[[Category: Selvarajah, J]]		[[Category: Selvarajah, J]]
-	[[Category: Veselkov, D.A]]	+	[[Category: Veselkov, D A]]
-	[[Category: ~~Laponogov, I~~]]	+	[[Category: Cleavage complex]]
-	[[Category: ~~Crevel, I.M.-T~~]]	+	[[Category: Dna]]
		+	[[Category: Gyrase]]
		+	[[Category: Isomerase]]
		+	[[Category: Quinolone]]

OCA at 23:50, 30 November 2015

2015-11-30T23:50:26Z

←Older revision		Revision as of 23:50, 30 November 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4z2d is ON HOLD	+	The entry 4z2d is ON HOLD until Paper Publication

	Authors: Laponogov, I., Veselkov, D.A., Pan, X.-S., Selvarajah, J., Crevel, I.M.-T., Fisher, L.M., Sanderson, M.R.		Authors: Laponogov, I., Veselkov, D.A., Pan, X.-S., Selvarajah, J., Crevel, I.M.-T., Fisher, L.M., Sanderson, M.R.
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Fisher, L.M]]		[[Category: Fisher, L.M]]
-	[[Category: Selvarajah, J]]
-	[[Category: Laponogov, I]]
	[[Category: Pan, X.-S]]		[[Category: Pan, X.-S]]
	[[Category: Sanderson, M.R]]		[[Category: Sanderson, M.R]]
		+	[[Category: Selvarajah, J]]
	[[Category: Veselkov, D.A]]		[[Category: Veselkov, D.A]]
		+	[[Category: Laponogov, I]]
	[[Category: Crevel, I.M.-T]]		[[Category: Crevel, I.M.-T]]

OCA: Protected "4z2d" [edit=sysop:move=sysop]

2015-04-08T10:03:03Z

Protected "4z2d" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:03, 8 April 2015

OCA: New page: '''Unreleased structure''' The entry 4z2d is ON HOLD Authors: Laponogov, I., Veselkov, D.A., Pan, X.-S., Selvarajah, J., Crevel, I.M.-T., Fisher, L.M., Sanderson, M.R. Description: Qui...

2015-04-08T10:03:01Z

New page: '''Unreleased structure''' The entry 4z2d is ON HOLD Authors: Laponogov, I., Veselkov, D.A., Pan, X.-S., Selvarajah, J., Crevel, I.M.-T., Fisher, L.M., Sanderson, M.R. Description: Qui...

New page

'''Unreleased structure'''

The entry 4z2d is ON HOLD

Authors: Laponogov, I., Veselkov, D.A., Pan, X.-S., Selvarajah, J., Crevel, I.M.-T., Fisher, L.M., Sanderson, M.R.

Description: Quinolone(Levofloxacin)-DNA cleavage complex of gyrase from S. pneumoniae
[[Category: Unreleased Structures]]
[[Category: Fisher, L.M]]
[[Category: Selvarajah, J]]
[[Category: Laponogov, I]]
[[Category: Pan, X.-S]]
[[Category: Sanderson, M.R]]
[[Category: Veselkov, D.A]]
[[Category: Crevel, I.M.-T]]