4zah - Revision history

OCA at 08:15, 27 September 2023

2023-09-27T08:15:20Z

←Older revision		Revision as of 08:15, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zah]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4wfp 4wfp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZAH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zah]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4wfp 4wfp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZAH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T5K:[[(2R,3S,5R)-5-[5-METHYL-2,4-BIS(OXIDANYLIDENE)PYRIMIDIN-1-YL]-3-OXIDANYL-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(2R,3R,4S,5R,6R)-6-METHYL-5-[(E)-[2-METHYL-3-OXIDANYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]-3,4-BIS(OXIDANYL)OXAN-2-YL]+HYDROGEN+PHOSPHATE'>T5K</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.24Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T5K:[[(2R,3S,5R)-5-[5-METHYL-2,4-BIS(OXIDANYLIDENE)PYRIMIDIN-1-YL]-3-OXIDANYL-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(2R,3R,4S,5R,6R)-6-METHYL-5-[(E)-[2-METHYL-3-OXIDANYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]-3,4-BIS(OXIDANYL)OXAN-2-YL]+HYDROGEN+PHOSPHATE'>T5K</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zah OCA], [https://pdbe.org/4zah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zah RCSB], [https://www.ebi.ac.uk/pdbsum/4zah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zah ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zah OCA], [https://pdbe.org/4zah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zah RCSB], [https://www.ebi.ac.uk/pdbsum/4zah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zah ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:46, 10 May 2023

2023-05-10T07:46:48Z

←Older revision		Revision as of 07:46, 10 May 2023
Line 3:		Line 3:
	<StructureSection load='4zah' size='340' side='right'caption='[[4zah]], [[Resolution\|resolution]] 2.24Å' scene=''>		<StructureSection load='4zah' size='340' side='right'caption='[[4zah]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zah]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4wfp 4wfp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZAH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zah]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4wfp 4wfp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZAH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T5K:[[(2R,3S,5R)-5-[5-METHYL-2,4-BIS(OXIDANYLIDENE)PYRIMIDIN-1-YL]-3-OXIDANYL-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(2R,3R,4S,5R,6R)-6-METHYL-5-[(E)-[2-METHYL-3-OXIDANYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]-3,4-BIS(OXIDANYL)OXAN-2-YL]+HYDROGEN+PHOSPHATE'>T5K</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T5K:[[(2R,3S,5R)-5-[5-METHYL-2,4-BIS(OXIDANYLIDENE)PYRIMIDIN-1-YL]-3-OXIDANYL-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(2R,3R,4S,5R,6R)-6-METHYL-5-[(E)-[2-METHYL-3-OXIDANYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]-3,4-BIS(OXIDANYL)OXAN-2-YL]+HYDROGEN+PHOSPHATE'>T5K</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4piw\|4piw]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zah OCA], [https://pdbe.org/4zah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zah RCSB], [https://www.ebi.ac.uk/pdbsum/4zah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zah ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rffA, wecE, yifI, b3791, JW3765 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTDP-4-amino-4,6-dideoxygalactose_transaminase dTDP-4-amino-4,6-dideoxygalactose transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.59 2.6.1.59] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zah OCA], [~~http~~://pdbe.org/4zah PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zah RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zah PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zah ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~RFFA_ECOLI RFFA_ECOLI~~]~~] Sugar aminotransferase involved in enterobacterial common antigen~~ (~~ECA~~) ~~elongation~~.	+	[https://www.uniprot.org/uniprot/WECE_ECOLI WECE_ECOLI] Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D-galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D-Glc4O) and L-glutamate.[HAMAP-Rule:MF_02026]<ref>PMID:15271350</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: DTDP-4-amino-4,6-dideoxygalactose transaminase]]~~	+	[[Category: Cao H]]
-	[[Category: Cao, H]]	+	[[Category: Miller MD]]
-	[[Category: Miller~~, M D]]~~	+	[[Category: Phillips Jr GN]]
-	~~[[Category: NatPro, Enzyme Discovery for Natural Product Biosynthesis~~]]	+	[[Category: Singh S]]
-	[[Category: Phillips~~, G N~~]]	+	[[Category: Thorson JS]]
-	[[Category: Singh, S]]	+	[[Category: Wang F]]
-	[[Category: Thorson~~, J S~~]]	+	[[Category: Xu W]]
-	[[Category: Wang, F]]	+
-	[[Category: Xu, W]]	+
-	~~[[Category: Enzyme discovery for natural product biosynthesis]]~~	+
-	~~[[Category: Natpro]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Psi-biology]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Sugar aminotransferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:48, 4 December 2019

2019-12-04T08:48:59Z

←Older revision		Revision as of 08:48, 4 December 2019
Line 1:		Line 1:

	==Crystal structure of sugar aminotransferase WecE with External Aldimine VII from Escherichia coli K-12==		==Crystal structure of sugar aminotransferase WecE with External Aldimine VII from Escherichia coli K-12==
-	<StructureSection load='4zah' size='340' side='right' caption='[[4zah]], [[Resolution\|resolution]] 2.24Å' scene=''>	+	<StructureSection load='4zah' size='340' side='right'caption='[[4zah]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zah]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4wfp 4wfp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZAH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zah]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4wfp 4wfp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZAH FirstGlance]. <br>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: DTDP-4-amino-4,6-dideoxygalactose transaminase]]		[[Category: DTDP-4-amino-4,6-dideoxygalactose transaminase]]
	[[Category: Cao, H]]		[[Category: Cao, H]]

OCA at 12:20, 6 November 2017

2017-11-06T12:20:43Z

←Older revision		Revision as of 12:20, 6 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of sugar aminotransferase WecE with External Aldimine VII from Escherichia coli K-12==		==Crystal structure of sugar aminotransferase WecE with External Aldimine VII from Escherichia coli K-12==
	<StructureSection load='4zah' size='340' side='right' caption='[[4zah]], [[Resolution\|resolution]] 2.24Å' scene=''>		<StructureSection load='4zah' size='340' side='right' caption='[[4zah]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zah]] is a 8 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4wfp 4wfp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zah]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4wfp 4wfp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZAH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T5K:[[(2R,3S,5R)-5-[5-METHYL-2,4-BIS(OXIDANYLIDENE)PYRIMIDIN-1-YL]-3-OXIDANYL-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(2R,3R,4S,5R,6R)-6-METHYL-5-[(E)-[2-METHYL-3-OXIDANYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]-3,4-BIS(OXIDANYL)OXAN-2-YL]+HYDROGEN+PHOSPHATE'>T5K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T5K:[[(2R,3S,5R)-5-[5-METHYL-2,4-BIS(OXIDANYLIDENE)PYRIMIDIN-1-YL]-3-OXIDANYL-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(2R,3R,4S,5R,6R)-6-METHYL-5-[(E)-[2-METHYL-3-OXIDANYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]-3,4-BIS(OXIDANYL)OXAN-2-YL]+HYDROGEN+PHOSPHATE'>T5K</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4piw\|4piw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4piw\|4piw]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rffA, wecE, yifI, b3791, JW3765 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTDP-4-amino-4,6-dideoxygalactose_transaminase dTDP-4-amino-4,6-dideoxygalactose transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.59 2.6.1.59] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTDP-4-amino-4,6-dideoxygalactose_transaminase dTDP-4-amino-4,6-dideoxygalactose transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.59 2.6.1.59] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zah OCA], [http://pdbe.org/4zah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zah RCSB], [http://www.ebi.ac.uk/pdbsum/4zah PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zah OCA], [http://pdbe.org/4zah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zah RCSB], [http://www.ebi.ac.uk/pdbsum/4zah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zah ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ecoli]]
	[[Category: DTDP-4-amino-4,6-dideoxygalactose transaminase]]		[[Category: DTDP-4-amino-4,6-dideoxygalactose transaminase]]
	[[Category: Cao, H]]		[[Category: Cao, H]]

OCA at 07:40, 7 October 2015

2015-10-07T07:40:57Z

←Older revision		Revision as of 07:40, 7 October 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4piw\|4piw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4piw\|4piw]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTDP-4-amino-4,6-dideoxygalactose_transaminase dTDP-4-amino-4,6-dideoxygalactose transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.59 2.6.1.59] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTDP-4-amino-4,6-dideoxygalactose_transaminase dTDP-4-amino-4,6-dideoxygalactose transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.59 2.6.1.59] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zah RCSB], [http://www.ebi.ac.uk/pdbsum/4zah PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zah OCA], [http://pdbe.org/4zah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zah RCSB], [http://www.ebi.ac.uk/pdbsum/4zah PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4zah" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:44, 10 June 2015

2015-06-10T07:44:47Z

←Older revision		Revision as of 07:44, 10 June 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/RFFA_ECOLI RFFA_ECOLI]] Sugar aminotransferase involved in enterobacterial common antigen (ECA) elongation.		[[http://www.uniprot.org/uniprot/RFFA_ECOLI RFFA_ECOLI]] Sugar aminotransferase involved in enterobacterial common antigen (ECA) elongation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sugar aminotransferases (SATs) are an important class of tailoring enzymes that catalyze the 5'-pyridoxal phosphate (PLP)-dependent stereo- and regio- specific installation of an amino group from an amino acid donor (typically L-Glu or L-Gln) to a corresponding ketosugar nucleotide acceptor. Herein we report the strategic structural study of two homologous C4 SATs (Micromonospora echinospora CalS13 and Escherichia coli WecE) that utilize identical substrates but differ in their stereochemistry of aminotransfer. This study reveals for the first time a new mode of SAT sugar nucleotide binding and, in conjunction with previously reported SAT structural studies, provides the basis from which to propose a universal model for SAT stereo- and regiochemical control of amine installation. Specifically, the universal model put forth highlights catalytic divergence to derive solely from distinctions within nucleotide sugar orientation upon binding within a relatively fixed SAT active site where the available ligand bound structures of the three out of four representative C3 and C4 SAT examples provide a basis for the overall model. Importantly, this study presents a new predictive model to support SAT functional annotation, biochemical study and rational engineering.
		+
		+	The structural basis for the stereochemical control of amine installation in nucleotide sugar aminotransferases.,Wang F, Singh S, Xu W, Helmich KF, Miller MD, Cao H, Bingman CA, Thorson JS, Phillips GN ACS Chem Biol. 2015 May 29. PMID:26023720<ref>PMID:26023720</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:20, 30 April 2015

2015-04-30T11:20:04Z

←Older revision		Revision as of 11:20, 30 April 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of sugar aminotransferase WecE with External Aldimine VII from Escherichia coli K-12==
-		+	<StructureSection load='4zah' size='340' side='right' caption='[[4zah]], [[Resolution\|resolution]] 2.24Å' scene=''>
-	~~The entry~~ 4zah is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zah]] is a 8 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4wfp 4wfp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZAH FirstGlance]. <br>
-	~~Authors~~: ~~Wang~~, F., ~~Singh~~, S., ~~Cao~~, H., Xu, ~~W., Miller~~, M.D., ~~Thorson~~, J.S., ~~Phillips Jr~~., G.N., ~~Enzyme Discovery for Natural Product Biosynthesis (NatPro)~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T5K:[[(2R,3S,5R)-5-[5-METHYL-2,4-BIS(OXIDANYLIDENE)PYRIMIDIN-1-YL]-3-OXIDANYL-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(2R,3R,4S,5R,6R)-6-METHYL-5-[(E)-[2-METHYL-3-OXIDANYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]-3,4-BIS(OXIDANYL)OXAN-2-YL]+HYDROGEN+PHOSPHATE'>T5K</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4piw\|4piw]]</td></tr>
-	~~Description: Crystal structure of sugar aminotransferase WecE with External Aldimine VII from Escherichia coli K-12~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTDP-4-amino-4,6-dideoxygalactose_transaminase dTDP-4-amino-4,6-dideoxygalactose transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.59 2.6.1.59] </span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zah RCSB], [http://www.ebi.ac.uk/pdbsum/4zah PDBsum]</span></td></tr>
-	[[Category: ~~G.N~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RFFA_ECOLI RFFA_ECOLI]] Sugar aminotransferase involved in enterobacterial common antigen (ECA) elongation.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: DTDP-4-amino-4,6-dideoxygalactose transaminase]]
	[[Category: Cao, H]]		[[Category: Cao, H]]
-	[[Category: Miller, M.D]]	+	[[Category: Miller, M D]]
-	[[Category: Enzyme Discovery ~~For~~ Natural Product Biosynthesis ~~(Natpro)~~]]	+	[[Category: NatPro, Enzyme Discovery for Natural Product Biosynthesis]]
		+	[[Category: Phillips, G N]]
	[[Category: Singh, S]]		[[Category: Singh, S]]
		+	[[Category: Thorson, J S]]
	[[Category: Wang, F]]		[[Category: Wang, F]]
-	[[Category: Phillips Jr]]
-	[[Category: Thorson, J.S]]
	[[Category: Xu, W]]		[[Category: Xu, W]]
		+	[[Category: Enzyme discovery for natural product biosynthesis]]
		+	[[Category: Natpro]]
		+	[[Category: PSI, Protein structure initiative]]
		+	[[Category: Psi-biology]]
		+	[[Category: Structural genomic]]
		+	[[Category: Sugar aminotransferase]]
		+	[[Category: Transferase]]

OCA: Protected "4zah" [edit=sysop:move=sysop]

2015-04-22T11:37:58Z

Protected "4zah" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:37, 22 April 2015

OCA: New page: '''Unreleased structure''' The entry 4zah is ON HOLD Authors: Wang, F., Singh, S., Cao, H., Xu, W., Miller, M.D., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product...

2015-04-22T11:37:56Z

New page: '''Unreleased structure''' The entry 4zah is ON HOLD Authors: Wang, F., Singh, S., Cao, H., Xu, W., Miller, M.D., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product...

New page

'''Unreleased structure'''

The entry 4zah is ON HOLD

Authors: Wang, F., Singh, S., Cao, H., Xu, W., Miller, M.D., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)

Description: Crystal structure of sugar aminotransferase WecE with External Aldimine VII from Escherichia coli K-12
[[Category: Unreleased Structures]]
[[Category: G.N]]
[[Category: Cao, H]]
[[Category: Miller, M.D]]
[[Category: Enzyme Discovery For Natural Product Biosynthesis (Natpro)]]
[[Category: Singh, S]]
[[Category: Wang, F]]
[[Category: Phillips Jr]]
[[Category: Thorson, J.S]]
[[Category: Xu, W]]