4zfu - Revision history

OCA at 15:43, 8 November 2023

2023-11-08T15:43:46Z

←Older revision		Revision as of 15:43, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.53Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfu OCA], [https://pdbe.org/4zfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfu RCSB], [https://www.ebi.ac.uk/pdbsum/4zfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfu OCA], [https://pdbe.org/4zfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfu RCSB], [https://www.ebi.ac.uk/pdbsum/4zfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfu ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:26, 18 May 2023

2023-05-18T07:26:14Z

←Older revision		Revision as of 07:26, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zfu' size='340' side='right'caption='[[4zfu]], [[Resolution\|resolution]] 2.53Å' scene=''>		<StructureSection load='4zfu' size='340' side='right'caption='[[4zfu]], [[Resolution\|resolution]] 2.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zfu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZFU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4z8s\|4z8s]], [[4zfw\|4zfw]], [[4zfy\|4zfy]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfu OCA], [https://pdbe.org/4zfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfu RCSB], [https://www.ebi.ac.uk/pdbsum/4zfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfu ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfu OCA], [~~http~~://pdbe.org/4zfu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zfu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zfu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfu ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B7X8M2_MOMCH B7X8M2_MOMCH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Momordica charantia]]		[[Category: Momordica charantia]]
-	~~[[Category: RRNA N-glycosylase]]~~	+	[[Category: Chandran T]]
-	[[Category: Chandran, T]]	+	[[Category: Sharma A]]
-	[[Category: Sharma, A]]	+	[[Category: Vijayan M]]
-	[[Category: Vijayan, M]]	+
-	~~[[Category: Beta-trefoil]]~~	+
-	~~[[Category: Galactose binding lectin]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Type ii rip~~]]	+

OCA at 06:59, 19 June 2019

2019-06-19T06:59:42Z

←Older revision		Revision as of 06:59, 19 June 2019
Line 1:		Line 1:

	==Structural studies on a non-toxic homologue of type II RIPs from Momordica charantia (bitter gourd) in complex with N-acetyl D galactosamine==		==Structural studies on a non-toxic homologue of type II RIPs from Momordica charantia (bitter gourd) in complex with N-acetyl D galactosamine==
-	<StructureSection load='4zfu' size='340' side='right' caption='[[4zfu]], [[Resolution\|resolution]] 2.53Å' scene=''>	+	<StructureSection load='4zfu' size='340' side='right'caption='[[4zfu]], [[Resolution\|resolution]] 2.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zfu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zfu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFU FirstGlance]. <br>
Line 7:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4z8s\|4z8s]], [[4zfw\|4zfw]], [[4zfy\|4zfy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4z8s\|4z8s]], [[4zfw\|4zfw]], [[4zfy\|4zfy]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfu OCA], [http://pdbe.org/4zfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zfu RCSB], [http://www.ebi.ac.uk/pdbsum/4zfu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfu OCA], [http://pdbe.org/4zfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zfu RCSB], [http://www.ebi.ac.uk/pdbsum/4zfu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Momordica charantia]]		[[Category: Momordica charantia]]
	[[Category: RRNA N-glycosylase]]		[[Category: RRNA N-glycosylase]]

OCA at 12:58, 11 May 2016

2016-05-11T12:58:03Z

←Older revision		Revision as of 12:58, 11 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4zfu is ~~ON HOLD until Paper~~ Publication	+	==Structural studies on a non-toxic homologue of type II RIPs from Momordica charantia (bitter gourd) in complex with N-acetyl D galactosamine==
		+	<StructureSection load='4zfu' size='340' side='right' caption='[[4zfu]], [[Resolution\|resolution]] 2.53Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4zfu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4z8s\|4z8s]], [[4zfw\|4zfw]], [[4zfy\|4zfy]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfu OCA], [http://pdbe.org/4zfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zfu RCSB], [http://www.ebi.ac.uk/pdbsum/4zfu PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structures of nine independent crystals of bitter gourd seed lectin (BGSL), a non-toxic homologue of type II RIPs, and its sugar complexes have been determined. The four-chain, two-fold symmetric, protein is made up of two identical two-chain modules, each consisting of a catalytic chain and a lectin chain, connected by a disulphide bridge. The lectin chain is made up of two domains. Each domain carries a carbohydrate binding site in type II RIPs of known structure. BGSL has a sugar binding site only on one domain, thus impairing its interaction at the cell surface. The adenine binding site in the catalytic chain is defective. Thus, defects in sugar binding as well as adenine binding appear to contribute to the non-toxicity of the lectin. The plasticity of the molecule is mainly caused by the presence of two possible well defined conformations of a surface loop in the lectin chain. One of them is chosen in the sugar complexes, in a case of conformational selection, as the chosen conformation facilitates an additional interaction with the sugar, involving an arginyl residue in the loop. The N-glycosylation of the lectin involves a plant-specific glycan while that in toxic type II RIPs of known structure involves a glycan which is animal as well as plant specific.

-	~~Authors~~: ~~Chandran~~, T., ~~Sharma~~, A., Vijayan, M.	+	Structural studies on a non-toxic homologue of type II RIPs from bitter gourd: Molecular basis of non-toxicity, conformational selection and glycan structure.,Chandran T, Sharma A, Vijayan M J Biosci. 2015 Dec;40(5):929-41. PMID:26648038<ref>PMID:26648038</ref>

-	~~Description: Structural studies on~~ a ~~non-toxic homologue~~ of ~~type II RIPs from~~ Momordica charantia ~~(bitter gourd) in complex with N-acetyl D galactosamine~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 4zfu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Momordica charantia]]
		+	[[Category: RRNA N-glycosylase]]
	[[Category: Chandran, T]]		[[Category: Chandran, T]]
-	[[Category: Vijayan, M]]
	[[Category: Sharma, A]]		[[Category: Sharma, A]]
		+	[[Category: Vijayan, M]]
		+	[[Category: Beta-trefoil]]
		+	[[Category: Galactose binding lectin]]
		+	[[Category: Hydrolase]]
		+	[[Category: Type ii rip]]

OCA at 10:50, 3 June 2015

2015-06-03T10:50:26Z

←Older revision		Revision as of 10:50, 3 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zfu is ON HOLD	+	The entry 4zfu is ON HOLD until Paper Publication

	Authors: Chandran, T., Sharma, A., Vijayan, M.		Authors: Chandran, T., Sharma, A., Vijayan, M.

OCA: Protected "4zfu" [edit=sysop:move=sysop]

2015-04-30T10:19:05Z

Protected "4zfu" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:19, 30 April 2015

OCA: New page: '''Unreleased structure''' The entry 4zfu is ON HOLD Authors: Chandran, T., Sharma, A., Vijayan, M. Description: Structural studies on a non-toxic homologue of type II RIPs from Momord...

2015-04-30T10:19:03Z

New page: '''Unreleased structure''' The entry 4zfu is ON HOLD Authors: Chandran, T., Sharma, A., Vijayan, M. Description: Structural studies on a non-toxic homologue of type II RIPs from Momord...

New page

'''Unreleased structure'''

The entry 4zfu is ON HOLD

Authors: Chandran, T., Sharma, A., Vijayan, M.

Description: Structural studies on a non-toxic homologue of type II RIPs from Momordica charantia (bitter gourd) in complex with N-acetyl D galactosamine
[[Category: Unreleased Structures]]
[[Category: Chandran, T]]
[[Category: Vijayan, M]]
[[Category: Sharma, A]]