4zhs - Revision history

OCA at 07:28, 18 May 2023

2023-05-18T07:28:24Z

←Older revision		Revision as of 07:28, 18 May 2023
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	<StructureSection load='4zhs' size='340' side='right'caption='[[4zhs]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4zhs' size='340' side='right'caption='[[4zhs]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zhs]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Trichophyton_rubrum_bmu01672~~ Trichophyton rubrum ~~bmu01672~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZHS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZHS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zhs]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichophyton_rubrum_BMU01672 Trichophyton rubrum BMU01672]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZHS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zhs OCA], [https://pdbe.org/4zhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zhs RCSB], [https://www.ebi.ac.uk/pdbsum/4zhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zhs ProSAT]</span></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[4zic\|4zic]]</td></tr>~~	+
-	~~<tr id='activity~~'>~~<td class="sblockLbl"><b>Activity:~~</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zhs OCA], [~~http~~://pdbe.org/4zhs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zhs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zhs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zhs ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A140UHG6_TRIRU A0A140UHG6_TRIRU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Aspartate-semialdehyde dehydrogenase 3D structures\|Aspartate-semialdehyde dehydrogenase 3D structures]]		*[[Aspartate-semialdehyde dehydrogenase 3D structures\|Aspartate-semialdehyde dehydrogenase 3D structures]]
-	*[[Retinoid X receptor\|Retinoid X receptor]]	+	*[[Retinoid X receptor 3D structures\|Retinoid X receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aspartate-semialdehyde dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Trichophyton rubrum ~~bmu01672~~]]	+	[[Category: Trichophyton rubrum BMU01672]]
-	[[Category: Cui, S]]	+	[[Category: Cui S]]
-	[[Category: Li, Q]]	+	[[Category: Li Q]]
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Tetramer]]~~	+
-	~~[[Category: Trichophyton rubrum~~]]	+

OCA at 07:36, 19 June 2019

2019-06-19T07:36:02Z

←Older revision		Revision as of 07:36, 19 June 2019
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	==Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Trichophyton rubrum==		==Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Trichophyton rubrum==
-	<StructureSection load='4zhs' size='340' side='right' caption='[[4zhs]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4zhs' size='340' side='right'caption='[[4zhs]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zhs]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZHS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zhs]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Trichophyton_rubrum_bmu01672 Trichophyton rubrum bmu01672]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZHS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zic\|4zic]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zic\|4zic]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zhs OCA], [http://pdbe.org/4zhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zhs RCSB], [http://www.ebi.ac.uk/pdbsum/4zhs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zhs OCA], [http://pdbe.org/4zhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zhs RCSB], [http://www.ebi.ac.uk/pdbsum/4zhs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zhs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 4zhs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4zhs" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aspartate-semialdehyde dehydrogenase 3D structures\|Aspartate-semialdehyde dehydrogenase 3D structures]]
		+	*[[Retinoid X receptor\|Retinoid X receptor]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Aspartate-semialdehyde dehydrogenase]]		[[Category: Aspartate-semialdehyde dehydrogenase]]
		+	[[Category: Large Structures]]
		+	[[Category: Trichophyton rubrum bmu01672]]
	[[Category: Cui, S]]		[[Category: Cui, S]]
	[[Category: Li, Q]]		[[Category: Li, Q]]

OCA at 15:08, 2 March 2016

2016-03-02T15:08:53Z

←Older revision		Revision as of 15:08, 2 March 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4zhs is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Trichophyton rubrum==
		+	<StructureSection load='4zhs' size='340' side='right' caption='[[4zhs]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4zhs]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZHS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zic\|4zic]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zhs OCA], [http://pdbe.org/4zhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zhs RCSB], [http://www.ebi.ac.uk/pdbsum/4zhs PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aspartate-beta-semialdehyde dehydrogenase (ASADH) catalyzes the second reaction in the aspartate pathway, a pathway required for the biosynthesis of one fifth of the essential amino acids in plants and microorganisms. Microarray analysis of a fungal pathogen T. rubrum responsible for most human dermatophytoses identified the upregulation of ASADH (trASADH) expression when the fungus is exposed to human skin, underscoring its potential as a drug target. Here we report the crystal structure of trASADH, revealing a tetrameric ASADH with a GAPDH-like fold. The tetramerization of trASADH was confirmed by sedimentation and SAXS experiments. Native PAGE demonstrated that this ASADH tetramerization is apparently universal in fungal species, unlike the functional dimer that is observed in all bacterial ASADHs. The helical subdomain in dimeric bacteria ASADH is replaced by the cover loop in archaeal/fungal ASADHs, presenting the determinant for this altered oligomerization. Mutations that disrupt the tetramerization of trASADH also abolish the catalytic activity, suggesting that the tetrameric state is required to produce the active fungal enzyme form. Our findings provide a basis to categorize ASADHs into dimeric and tetrameric enzymes, adopting a different orientation for NADP binding and offer a structural framework for designing drugs that can specifically target the fungal pathogens.

-	~~Authors:~~ Li, Q., Cui, S.	+	Structural Insights into the Tetrameric State of Aspartate-beta-semialdehyde Dehydrogenases from Fungal Species.,Li Q, Mu Z, Zhao R, Dahal G, Viola RE, Liu T, Jin Q, Cui S Sci Rep. 2016 Feb 12;6:21067. doi: 10.1038/srep21067. PMID:26869335<ref>PMID:26869335</ref>

-	~~Description: Crystal Structure~~ of ~~Aspartate Semialdehyde Dehydrogenase from Trichophyton rubrum~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Li, Q~~]]	+	<div class="pdbe-citations 4zhs" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Aspartate-semialdehyde dehydrogenase]]
	[[Category: Cui, S]]		[[Category: Cui, S]]
		+	[[Category: Li, Q]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Tetramer]]
		+	[[Category: Trichophyton rubrum]]

OCA at 09:20, 16 December 2015

2015-12-16T09:20:25Z

←Older revision		Revision as of 09:20, 16 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zhs is ON HOLD	+	The entry 4zhs is ON HOLD until Paper Publication

-	Authors: Li, Q., ~~Sheng~~, C.	+	Authors: Li, Q., Cui, S.

	Description: Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Trichophyton rubrum		Description: Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Trichophyton rubrum
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Sheng, C]]
	[[Category: Li, Q]]		[[Category: Li, Q]]
		+	[[Category: Cui, S]]

OCA at 10:46, 20 May 2015

2015-05-20T10:46:30Z

←Older revision		Revision as of 10:46, 20 May 2015
Line 3:		Line 3:
	The entry 4zhs is ON HOLD		The entry 4zhs is ON HOLD

-	Authors: ~~Qinqin~~ Li, ~~Cui sheng~~	+	Authors: Li, Q., Sheng, C.

	Description: Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Trichophyton rubrum		Description: Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Trichophyton rubrum
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Qinqin~~ Li, ~~Cui Sheng~~]]	+	[[Category: Sheng, C]]
		+	[[Category: Li, Q]]

OCA: Protected "4zhs" [edit=sysop:move=sysop]

2015-05-06T11:44:37Z

Protected "4zhs" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:44, 6 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zhs is ON HOLD Authors: Qinqin Li, Cui sheng Description: Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Trichophyton rubrum [[Cat...

2015-05-06T11:44:35Z

New page: '''Unreleased structure''' The entry 4zhs is ON HOLD Authors: Qinqin Li, Cui sheng Description: Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Trichophyton rubrum [[Cat...

New page

'''Unreleased structure'''

The entry 4zhs is ON HOLD

Authors: Qinqin Li, Cui sheng

Description: Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Trichophyton rubrum
[[Category: Unreleased Structures]]
[[Category: Qinqin Li, Cui Sheng]]