4zk0 - Revision history

OCA at 11:00, 10 January 2024

2024-01-10T11:00:29Z

←Older revision		Revision as of 11:00, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zk0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZK0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zk0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZK0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk0 OCA], [https://pdbe.org/4zk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zk0 RCSB], [https://www.ebi.ac.uk/pdbsum/4zk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zk0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk0 OCA], [https://pdbe.org/4zk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zk0 RCSB], [https://www.ebi.ac.uk/pdbsum/4zk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zk0 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:31, 18 May 2023

2023-05-18T07:31:05Z

←Older revision		Revision as of 07:31, 18 May 2023
Line 1:		Line 1:

	==Psoriasis pathogenesis - Pso p27 constitute a compact structure forming large aggregates. High pH structure==		==Psoriasis pathogenesis - Pso p27 constitute a compact structure forming large aggregates. High pH structure==
-	<StructureSection load='4zk0' size='340' side='right' caption='[[4zk0]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='4zk0' size='340' side='right'caption='[[4zk0]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zk0]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZK0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zk0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZK0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB4, PI11, SCCA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk0 OCA], [https://pdbe.org/4zk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zk0 RCSB], [https://www.ebi.ac.uk/pdbsum/4zk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zk0 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk0 OCA], [~~http~~://pdbe.org/4zk0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zk0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zk0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zk0 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SPB3_HUMAN SPB3_HUMAN]] May act as a protease inhibitor to modulate the host immune response against tumor cells.	+	[https://www.uniprot.org/uniprot/SPB3_HUMAN SPB3_HUMAN] May act as a protease inhibitor to modulate the host immune response against tumor cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4zk0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4zk0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Serpin 3D structures\|Serpin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Helland, R]]	+	[[Category: Large Structures]]
-	[[Category: Iversen~~, O J~~]]	+	[[Category: Helland R]]
-	[[Category: Lysvand, H]]	+	[[Category: Iversen OJ]]
-	[[Category: Slupphaug, G]]	+	[[Category: Lysvand H]]
-	~~[[Category: Autoimmunity]]~~	+	[[Category: Slupphaug G]]
-	~~[[Category: Hydrolase inhibitor]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Pathogenesis]]~~	+
-	~~[[Category: Pso p27]]~~	+
-	~~[[Category: Pso p27-complex]]~~	+
-	~~[[Category: Psoriasis]]~~	+
-	~~[[Category: Scca1]]~~	+
-	~~[[Category: Serpinb3~~]]	+

OCA at 09:44, 22 November 2017

2017-11-22T09:44:35Z

←Older revision		Revision as of 09:44, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4zk0' size='340' side='right' caption='[[4zk0]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='4zk0' size='340' side='right' caption='[[4zk0]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zk0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZK0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zk0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZK0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB4, PI11, SCCA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk0 OCA], [http://pdbe.org/4zk0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zk0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zk0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zk0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk0 OCA], [http://pdbe.org/4zk0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zk0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zk0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zk0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SPB3_HUMAN SPB3_HUMAN]] May act as a protease inhibitor to modulate the host immune response against tumor cells.		[[http://www.uniprot.org/uniprot/SPB3_HUMAN SPB3_HUMAN]] May act as a protease inhibitor to modulate the host immune response against tumor cells.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Psoriasis is a chronic inflammatory skin disease. The absence of microbial organisms as potential causal agents has given rise to the hypothesis that the inflammation is due to an autoimmune reaction. The defined inflamed areas of the skin lesions argue for an immunological disease with a local production of a causal antigen. Pso p27 is a protein generated in mast cells in psoriatic plaques, but not in uninvolved skin. We recently demonstrated that the Pso p27 is generated by cleavage of SerpinB3 (SCCA1) in the presence of mast cell associated chymase. In this communication we demonstrate by X-ray crystallographic analysis that the cleavage products associate into a complex similar to SCCA1, but with the reactive centre loop inserted into a 5-stranded central beta-sheet. Native gel electrophoresis show that these Pso p27 complexes form large aggregates which may be of significance with respect to an immunogenic role of Pso p27.
		+
		+	Psoriasis pathogenesis - Pso p27 constitutes a compact structure forming large aggregates.,Lysvand H, Helland R, Hagen L, Slupphaug G, Iversen OJ Biochem Biophys Rep. 2015 Jun 9;2:132-136. doi: 10.1016/j.bbrep.2015.06.001., eCollection 2015 Jul. PMID:29124154<ref>PMID:29124154</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4zk0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Helland, R]]		[[Category: Helland, R]]
	[[Category: Iversen, O J]]		[[Category: Iversen, O J]]

OCA at 13:47, 5 April 2017

2017-04-05T13:47:05Z

←Older revision		Revision as of 13:47, 5 April 2017
Line 1:		Line 1:
		+
	==Psoriasis pathogenesis - Pso p27 constitute a compact structure forming large aggregates. High pH structure==		==Psoriasis pathogenesis - Pso p27 constitute a compact structure forming large aggregates. High pH structure==
	<StructureSection load='4zk0' size='340' side='right' caption='[[4zk0]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='4zk0' size='340' side='right' caption='[[4zk0]], [[Resolution\|resolution]] 2.15Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4zk0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZK0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zk0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZK0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zk0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zk0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk0 OCA], [http://pdbe.org/4zk0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zk0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zk0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zk0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 12:26, 1 July 2015

2015-07-01T12:26:29Z

←Older revision		Revision as of 12:26, 1 July 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Psoriasis pathogenesis - Pso p27 constitute a compact structure forming large aggregates. High pH structure==
-		+	<StructureSection load='4zk0' size='340' side='right' caption='[[4zk0]], [[Resolution\|resolution]] 2.15Å' scene=''>
-	~~The entry~~ 4zk0 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zk0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZK0 FirstGlance]. <br>
-	~~Authors~~: ~~Helland, R~~., ~~Lysvand, H~~., ~~Slupphaug, G~~., ~~Iversen, O~~.J.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zk0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zk0 PDBsum]</span></td></tr>
-	~~Description~~: ~~Psoriasis pathogenesis -Pso p27 constitute~~ a ~~compact structure forming large aggregates~~. ~~High pH structure~~	+	</table>
-	[[Category: ~~Unreleased Structures~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SPB3_HUMAN SPB3_HUMAN]] May act as a protease inhibitor to modulate the host immune response against tumor cells.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Helland, R]]
		+	[[Category: Iversen, O J]]
	[[Category: Lysvand, H]]		[[Category: Lysvand, H]]
	[[Category: Slupphaug, G]]		[[Category: Slupphaug, G]]
-	[[Category: ~~Helland, R~~]]	+	[[Category: Autoimmunity]]
-	[[Category: ~~Iversen, O.J~~]]	+	[[Category: Hydrolase inhibitor]]
		+	[[Category: Immune system]]
		+	[[Category: Pathogenesis]]
		+	[[Category: Pso p27]]
		+	[[Category: Pso p27-complex]]
		+	[[Category: Psoriasis]]
		+	[[Category: Scca1]]
		+	[[Category: Serpinb3]]

OCA: Protected "4zk0" [edit=sysop:move=sysop]

2015-05-06T11:51:20Z

Protected "4zk0" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:51, 6 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zk0 is ON HOLD until Paper Publication Authors: Helland, R., Lysvand, H., Slupphaug, G., Iversen, O.J. Description: Psoriasis pathogenesis -Pso p2...

2015-05-06T11:51:19Z

New page: '''Unreleased structure''' The entry 4zk0 is ON HOLD until Paper Publication Authors: Helland, R., Lysvand, H., Slupphaug, G., Iversen, O.J. Description: Psoriasis pathogenesis -Pso p2...

New page

'''Unreleased structure'''

The entry 4zk0 is ON HOLD until Paper Publication

Authors: Helland, R., Lysvand, H., Slupphaug, G., Iversen, O.J.

Description: Psoriasis pathogenesis -Pso p27 constitute a compact structure forming large aggregates. High pH structure
[[Category: Unreleased Structures]]
[[Category: Lysvand, H]]
[[Category: Slupphaug, G]]
[[Category: Helland, R]]
[[Category: Iversen, O.J]]