4zks - Revision history

OCA at 07:31, 18 May 2023

2023-05-18T07:31:47Z

←Older revision		Revision as of 07:31, 18 May 2023
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	<StructureSection load='4zks' size='340' side='right'caption='[[4zks]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4zks' size='340' side='right'caption='[[4zks]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zks]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZKS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zks]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZKS FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zkn\|4zkn]], [[4zko\|4zko]], [[4zkr\|4zkr]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zks OCA], [https://pdbe.org/4zks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zks RCSB], [https://www.ebi.ac.uk/pdbsum/4zks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zks ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zks OCA], [~~http~~://pdbe.org/4zks PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zks RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zks PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zks ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[~~http~~://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>	+	[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.	+	[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

	==See Also==		==See Also==
	*[[Plasminogen activator\|Plasminogen activator]]		*[[Plasminogen activator\|Plasminogen activator]]
-	*[[Urokinase\|Urokinase]]	+	*[[Urokinase 3D Structures\|Urokinase 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~U-plasminogen activator~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Andreasen~~, P A~~]]	+	[[Category: Andreasen PA]]
-	[[Category: Huang, M]]	+	[[Category: Huang M]]
-	[[Category: Jiang, L]]	+	[[Category: Jiang L]]
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Peptides inhibitor]]~~	+
-	~~[[Category: Serine protease]]~~	+
-	~~[[Category: Upa~~]]	+

OCA at 08:29, 26 June 2019

2019-06-26T08:29:24Z

←Older revision		Revision as of 08:29, 26 June 2019
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	==The crystal structure of upain-1-W3A in complex with inactive uPA (uPA-S195A) at pH7.4==		==The crystal structure of upain-1-W3A in complex with inactive uPA (uPA-S195A) at pH7.4==
-	<StructureSection load='4zks' size='340' side='right' caption='[[4zks]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='4zks' size='340' side='right'caption='[[4zks]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zks]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zks]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zkn\|4zkn]], [[4zko\|4zko]], [[4zkr\|4zkr]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zkn\|4zkn]], [[4zko\|4zko]], [[4zkr\|4zkr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zks OCA], [http://pdbe.org/4zks PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zks RCSB], [http://www.ebi.ac.uk/pdbsum/4zks PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zks OCA], [http://pdbe.org/4zks PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zks RCSB], [http://www.ebi.ac.uk/pdbsum/4zks PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zks ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 12:		Line 13:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.		[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
		+
		+	==See Also==
		+	*[[Plasminogen activator\|Plasminogen activator]]
		+	*[[Urokinase\|Urokinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]
	[[Category: Andreasen, P A]]		[[Category: Andreasen, P A]]

OCA at 15:47, 1 June 2016

2016-06-01T15:47:27Z

←Older revision		Revision as of 15:47, 1 June 2016
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-	'''Unreleased structure'''

-	~~The entry 4zks is ON HOLD until Paper Publication~~	+	==The crystal structure of upain-1-W3A in complex with inactive uPA (uPA-S195A) at pH7.4==
-		+	<StructureSection load='4zks' size='340' side='right' caption='[[4zks]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~Authors: Jiang, L., Andreasen, P.A., Huang, M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zks]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKS FirstGlance]. <br>
-	~~Description:~~ The crystal structure of upain-1-W3A in complex with inactive uPA (uPA-S195A) at pH7.4	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zkn\|4zkn]], [[4zko\|4zko]], [[4zkr\|4zkr]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zks OCA], [http://pdbe.org/4zks PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zks RCSB], [http://www.ebi.ac.uk/pdbsum/4zks PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: U-plasminogen activator]]
		+	[[Category: Andreasen, P A]]
	[[Category: Huang, M]]		[[Category: Huang, M]]
	[[Category: Jiang, L]]		[[Category: Jiang, L]]
-	[[Category: ~~Andreasen, P.A~~]]	+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Peptides inhibitor]]
		+	[[Category: Serine protease]]
		+	[[Category: Upa]]

OCA at 00:04, 1 December 2015

2015-12-01T00:04:02Z

←Older revision		Revision as of 00:04, 1 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zks is ON HOLD	+	The entry 4zks is ON HOLD until Paper Publication

	Authors: Jiang, L., Andreasen, P.A., Huang, M.		Authors: Jiang, L., Andreasen, P.A., Huang, M.

OCA: Protected "4zks" [edit=sysop:move=sysop]

2015-05-06T11:53:33Z

Protected "4zks" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:53, 6 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zks is ON HOLD Authors: Jiang, L., Andreasen, P.A., Huang, M. Description: The crystal structure of upain-1-W3A in complex with inactive uPA (uPA-...

2015-05-06T11:53:32Z

New page: '''Unreleased structure''' The entry 4zks is ON HOLD Authors: Jiang, L., Andreasen, P.A., Huang, M. Description: The crystal structure of upain-1-W3A in complex with inactive uPA (uPA-...

New page

'''Unreleased structure'''

The entry 4zks is ON HOLD

Authors: Jiang, L., Andreasen, P.A., Huang, M.

Description: The crystal structure of upain-1-W3A in complex with inactive uPA (uPA-S195A) at pH7.4
[[Category: Unreleased Structures]]
[[Category: Huang, M]]
[[Category: Jiang, L]]
[[Category: Andreasen, P.A]]