4zry - Revision history

OCA at 08:23, 27 September 2023

2023-09-27T08:23:01Z

←Older revision		Revision as of 08:23, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zry]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZRY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zry]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZRY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zry OCA], [https://pdbe.org/4zry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zry RCSB], [https://www.ebi.ac.uk/pdbsum/4zry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zry ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3001251Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zry OCA], [https://pdbe.org/4zry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zry RCSB], [https://www.ebi.ac.uk/pdbsum/4zry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zry ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 07:39, 18 May 2023

2023-05-18T07:39:24Z

←Older revision		Revision as of 07:39, 18 May 2023
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	==Crystal structure of the heterocomplex between coil 2B domains of human intermediate filament proteins keratin 1 (KRT1) and keratin 10 (KRT10)==		==Crystal structure of the heterocomplex between coil 2B domains of human intermediate filament proteins keratin 1 (KRT1) and keratin 10 (KRT10)==
-	<StructureSection load='4zry' size='340' side='right' caption='[[4zry]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<StructureSection load='4zry' size='340' side='right'caption='[[4zry]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zry]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZRY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zry]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZRY FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KRT10, KPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), KRT1, KRTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zry OCA], [https://pdbe.org/4zry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zry RCSB], [https://www.ebi.ac.uk/pdbsum/4zry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zry ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zry OCA], [~~http~~://pdbe.org/4zry PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zry RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zry PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zry ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/K1C10_HUMAN K1C10_HUMAN]] Congenital reticular ichthyosiform erythroderma;Annular epidermolytic ichthyosis;Epidermolytic ichthyosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/K2C1_HUMAN K2C1_HUMAN]] Epidermolytic palmoplantar keratoderma;Ichthyosis hystrix of Curth-Macklin;Annular epidermolytic ichthyosis;Epidermolytic ichthyosis;Keratosis palmoplantaris striata. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/K1C10_HUMAN K1C10_HUMAN] Congenital reticular ichthyosiform erythroderma;Annular epidermolytic ichthyosis;Epidermolytic ichthyosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~K2C1_HUMAN K2C1_HUMAN~~]] May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.<ref>PMID:17956333</ref> <ref>PMID:21544310</ref>	+	[https://www.uniprot.org/uniprot/K1C10_HUMAN K1C10_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4zry" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4zry" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Keratins\|Keratins]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Bunick, C G~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Steitz, T A~~]]	+	[[Category: Bunick CG]]
-	[[Category: ~~Coiled-coil]]~~	+	[[Category: Steitz TA]]
-	~~[[Category: Epidermis]]~~	+
-	~~[[Category: Helix]]~~	+
-	~~[[Category: Intermediate filament]]~~	+
-	~~[[Category: Keratin]]~~	+
-	~~[[Category: Protein fibril]]~~	+
-	~~[[Category: Protein-protein complex]]~~	+
-	~~[[Category: Skin~~]]	+

OCA at 09:46, 22 November 2017

2017-11-22T09:46:26Z

←Older revision		Revision as of 09:46, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4zry' size='340' side='right' caption='[[4zry]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='4zry' size='340' side='right' caption='[[4zry]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zry]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZRY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zry]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZRY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zry OCA], [http://pdbe.org/4zry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zry RCSB], [http://www.ebi.ac.uk/pdbsum/4zry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zry ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KRT10, KPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), KRT1, KRTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zry OCA], [http://pdbe.org/4zry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zry RCSB], [http://www.ebi.ac.uk/pdbsum/4zry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zry ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Bunick, C G]]		[[Category: Bunick, C G]]
	[[Category: Steitz, T A]]		[[Category: Steitz, T A]]

OCA at 07:20, 18 January 2017

2017-01-18T07:20:26Z

←Older revision		Revision as of 07:20, 18 January 2017
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zry]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZRY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zry]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZRY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zry OCA], [http://pdbe.org/4zry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zry RCSB], [http://www.ebi.ac.uk/pdbsum/4zry PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zry OCA], [http://pdbe.org/4zry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zry RCSB], [http://www.ebi.ac.uk/pdbsum/4zry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zry ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/K2C1_HUMAN K2C1_HUMAN]] May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.<ref>PMID:17956333</ref> <ref>PMID:21544310</ref>		[[http://www.uniprot.org/uniprot/K2C1_HUMAN K2C1_HUMAN]] May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.<ref>PMID:17956333</ref> <ref>PMID:21544310</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Keratins 1 (K1) and 10 (K10) are the primary keratins expressed in differentiated epidermis. Mutations in K1/K10 are associated with human skin diseases. We determined the crystal structure of the complex between the distal (2B) helices of K1 and K10 to better understand how human keratin structure correlates with function. The 3.3 A resolution structure confirms many features inferred by previous biochemical analyses, but adds unexpected insights. It demonstrates a parallel, coiled-coil heterodimer with a predominantly hydrophobic intermolecular interface; this heterodimer formed a higher order complex with a second K1-K10-2B heterodimer via a Cys401K10 disulfide link, although the bond angle is unanticipated. The molecular surface analysis of K1-K10-2B identified several pockets, one adjacent to the disulfide linkage and conserved in K5-K14. The solvent accessible surface area of the K1-K10 structure is 20-25% hydrophobic. The 2B region contains mixed acidic and basic patches proximally (N-terminal), whereas it is largely acidic distally (C-terminal). Mapping of conserved and nonconserved residues between K1-K10 and K5-K14 onto the structure demonstrated the majority of unique residues align along the outer helical ridge. Finally, the structure permitted a fresh analysis of the deleterious effects caused by K1/K10 missense mutations found in patients with phenotypic skin disease.
		+
		+	The X-Ray Crystal Structure of the Keratin 1-Keratin 10 Helix 2B Heterodimer Reveals Molecular Surface Properties and Biochemical Insights into Human Skin Disease.,Bunick CG, Milstone LM J Invest Dermatol. 2017 Jan;137(1):142-150. doi: 10.1016/j.jid.2016.08.018. Epub , 2016 Sep 3. PMID:27595935<ref>PMID:27595935</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4zry" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:48, 1 June 2016

2016-06-01T15:48:08Z

←Older revision		Revision as of 15:48, 1 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 4zry is ON HOLD until Paper Publication~~	+	==Crystal structure of the heterocomplex between coil 2B domains of human intermediate filament proteins keratin 1 (KRT1) and keratin 10 (KRT10)==
-		+	<StructureSection load='4zry' size='340' side='right' caption='[[4zry]], [[Resolution\|resolution]] 3.30Å' scene=''>
-	~~Authors: Bunick, C.G., Steitz, T.A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zry]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZRY FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the heterocomplex between coil 2B domains of human intermediate filament proteins keratin 1 (KRT1) and keratin 10 (KRT10)	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zry OCA], [http://pdbe.org/4zry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zry RCSB], [http://www.ebi.ac.uk/pdbsum/4zry PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Steitz~~, T.A]]	+	== Disease ==
-	[[Category: Bunick, C.G]]	+	[[http://www.uniprot.org/uniprot/K1C10_HUMAN K1C10_HUMAN]] Congenital reticular ichthyosiform erythroderma;Annular epidermolytic ichthyosis;Epidermolytic ichthyosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/K2C1_HUMAN K2C1_HUMAN]] Epidermolytic palmoplantar keratoderma;Ichthyosis hystrix of Curth-Macklin;Annular epidermolytic ichthyosis;Epidermolytic ichthyosis;Keratosis palmoplantaris striata. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/K2C1_HUMAN K2C1_HUMAN]] May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.<ref>PMID:17956333</ref> <ref>PMID:21544310</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bunick, C G]]
		+	[[Category: Steitz, T A]]
		+	[[Category: Coiled-coil]]
		+	[[Category: Epidermis]]
		+	[[Category: Helix]]
		+	[[Category: Intermediate filament]]
		+	[[Category: Keratin]]
		+	[[Category: Protein fibril]]
		+	[[Category: Protein-protein complex]]
		+	[[Category: Skin]]

OCA at 00:09, 1 December 2015

2015-12-01T00:09:55Z

←Older revision		Revision as of 00:09, 1 December 2015
Line 7:		Line 7:
	Description: Crystal structure of the heterocomplex between coil 2B domains of human intermediate filament proteins keratin 1 (KRT1) and keratin 10 (KRT10)		Description: Crystal structure of the heterocomplex between coil 2B domains of human intermediate filament proteins keratin 1 (KRT1) and keratin 10 (KRT10)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Bunick, C.G]]
	[[Category: Steitz, T.A]]		[[Category: Steitz, T.A]]
		+	[[Category: Bunick, C.G]]

OCA at 14:39, 27 May 2015

2015-05-27T14:39:14Z

←Older revision		Revision as of 14:39, 27 May 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zry is ON HOLD	+	The entry 4zry is ON HOLD until Paper Publication

	Authors: Bunick, C.G., Steitz, T.A.		Authors: Bunick, C.G., Steitz, T.A.

OCA: Protected "4zry" [edit=sysop:move=sysop]

2015-05-20T11:05:15Z

Protected "4zry" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:05, 20 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zry is ON HOLD Authors: Bunick, C.G., Steitz, T.A. Description: Crystal structure of the heterocomplex between coil 2B domains of human intermedia...

2015-05-20T11:05:14Z

New page: '''Unreleased structure''' The entry 4zry is ON HOLD Authors: Bunick, C.G., Steitz, T.A. Description: Crystal structure of the heterocomplex between coil 2B domains of human intermedia...

New page

'''Unreleased structure'''

The entry 4zry is ON HOLD

Authors: Bunick, C.G., Steitz, T.A.

Description: Crystal structure of the heterocomplex between coil 2B domains of human intermediate filament proteins keratin 1 (KRT1) and keratin 10 (KRT10)
[[Category: Unreleased Structures]]
[[Category: Bunick, C.G]]
[[Category: Steitz, T.A]]