4zsd - Revision history

OCA at 11:33, 9 May 2024

2024-05-09T11:33:57Z

←Older revision		Revision as of 11:33, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zsd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZSD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zsd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZSD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7I6:1-(4-AMINOBENZYL)-3-[(2S)-4-(METHYLSULFANYL)-1-{(2R)-2-[2-(METHYLSULFANYL)PHENYL]PYRROLIDIN-1-YL}-1-OXOBUTAN-2-YL]UREA'>7I6</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7I6:1-(4-AMINOBENZYL)-3-[(2S)-4-(METHYLSULFANYL)-1-{(2R)-2-[2-(METHYLSULFANYL)PHENYL]PYRROLIDIN-1-YL}-1-OXOBUTAN-2-YL]UREA'>7I6</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zsd OCA], [https://pdbe.org/4zsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zsd RCSB], [https://www.ebi.ac.uk/pdbsum/4zsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zsd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zsd OCA], [https://pdbe.org/4zsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zsd RCSB], [https://www.ebi.ac.uk/pdbsum/4zsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zsd ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:39, 18 May 2023

2023-05-18T07:39:50Z

←Older revision		Revision as of 07:39, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zsd' size='340' side='right'caption='[[4zsd]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4zsd' size='340' side='right'caption='[[4zsd]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zsd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZSD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZSD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zsd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZSD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7I6:1-(4-AMINOBENZYL)-3-[(2S)-4-(METHYLSULFANYL)-1-{(2R)-2-[2-(METHYLSULFANYL)PHENYL]PYRROLIDIN-1-YL}-1-OXOBUTAN-2-YL]UREA'>7I6</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7I6:1-(4-AMINOBENZYL)-3-[(2S)-4-(METHYLSULFANYL)-1-{(2R)-2-[2-(METHYLSULFANYL)PHENYL]PYRROLIDIN-1-YL}-1-OXOBUTAN-2-YL]UREA'>7I6</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j5c\|4j5c]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zsd OCA], [https://pdbe.org/4zsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zsd RCSB], [https://www.ebi.ac.uk/pdbsum/4zsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zsd ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPIF, CYP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zsd OCA], [~~http~~://pdbe.org/4zsd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zsd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zsd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zsd ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref>	+	[https://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Peptidylprolyl isomerase]]~~	+	[[Category: Allemand F]]
-	[[Category: Allemand, F]]	+	[[Category: Bourguet W]]
-	[[Category: Bourguet, W]]	+	[[Category: Delfosse V]]
-	[[Category: Delfosse, V]]	+	[[Category: Ferrer J-L]]
-	[[Category: Ferrer, J L]]	+	[[Category: Gelin M]]
-	[[Category: Gelin, M]]	+	[[Category: Guichou J-F]]
-	[[Category: Guichou, J F]]	+	[[Category: Hoh F]]
-	[[Category: Hoh, F]]	+	[[Category: Labesse G]]
-	[[Category: Labesse, G]]	+	[[Category: Pirocchi M]]
-	[[Category: Pirocchi, M]]	+	[[Category: Sallaz-Damaz Y]]
-	[[Category: Sallaz-Damaz, Y]]	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Isomerase inhibitor complex~~]]	+

OCA at 08:13, 26 June 2019

2019-06-26T08:13:55Z

←Older revision		Revision as of 08:13, 26 June 2019
Line 1:		Line 1:

	==Human Cyclophilin D Complexed with an Inhibitor at room temperature==		==Human Cyclophilin D Complexed with an Inhibitor at room temperature==
-	<StructureSection load='4zsd' size='340' side='right' caption='[[4zsd]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='4zsd' size='340' side='right'caption='[[4zsd]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zsd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZSD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zsd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZSD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7I6:1-(4-AMINOBENZYL)-3-[(2S)-4-(METHYLSULFANYL)-1-{(2R)-2-[2-(METHYLSULFANYL)PHENYL]PYRROLIDIN-1-YL}-1-OXOBUTAN-2-YL]UREA'>7I6</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7I6:1-(4-AMINOBENZYL)-3-[(2S)-4-(METHYLSULFANYL)-1-{(2R)-2-[2-(METHYLSULFANYL)PHENYL]PYRROLIDIN-1-YL}-1-OXOBUTAN-2-YL]UREA'>7I6</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j5c\|4j5c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j5c\|4j5c]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPIF, CYP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zsd OCA], [http://pdbe.org/4zsd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zsd RCSB], [http://www.ebi.ac.uk/pdbsum/4zsd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zsd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zsd OCA], [http://pdbe.org/4zsd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zsd RCSB], [http://www.ebi.ac.uk/pdbsum/4zsd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zsd ProSAT]</span></td></tr>
Line 22:		Line 23:

	==See Also==		==See Also==
-	*[[Cyclophilin\|Cyclophilin]]	+	*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Allemand, F]]		[[Category: Allemand, F]]

OCA at 14:12, 24 May 2017

2017-05-24T14:12:45Z

←Older revision		Revision as of 14:12, 24 May 2017
Line 1:		Line 1:
		+
	==Human Cyclophilin D Complexed with an Inhibitor at room temperature==		==Human Cyclophilin D Complexed with an Inhibitor at room temperature==
	<StructureSection load='4zsd' size='340' side='right' caption='[[4zsd]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4zsd' size='340' side='right' caption='[[4zsd]], [[Resolution\|resolution]] 1.45Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j5c\|4j5c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j5c\|4j5c]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zsd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zsd RCSB], [http://www.ebi.ac.uk/pdbsum/4zsd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zsd OCA], [http://pdbe.org/4zsd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zsd RCSB], [http://www.ebi.ac.uk/pdbsum/4zsd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zsd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4zsd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclophilin\|Cyclophilin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:17, 20 August 2015

2015-08-20T06:17:14Z

←Older revision		Revision as of 06:17, 20 August 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref>		[[http://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	X-ray crystallography is an established technique for ligand screening in fragment-based drug-design projects, but the required manual handling steps - soaking crystals with ligand and the subsequent harvesting - are tedious and limit the throughput of the process. Here, an alternative approach is reported: crystallization plates are pre-coated with potential binders prior to protein crystallization and X-ray diffraction is performed directly `in situ' (or in-plate). Its performance is demonstrated on distinct and relevant therapeutic targets currently being studied for ligand screening by X-ray crystallography using either a bending-magnet beamline or a rotating-anode generator. The possibility of using DMSO stock solutions of the ligands to be coated opens up a route to screening most chemical libraries.
		+
		+	Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.,Gelin M, Delfosse V, Allemand F, Hoh F, Sallaz-Damaz Y, Pirocchi M, Bourguet W, Ferrer JL, Labesse G, Guichou JF Acta Crystallogr D Biol Crystallogr. 2015 Aug 1;71(Pt 8):1777-87. doi:, 10.1107/S1399004715010342. Epub 2015 Jul 31. PMID:26249358<ref>PMID:26249358</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:52, 12 August 2015

2015-08-12T14:52:37Z

←Older revision		Revision as of 14:52, 12 August 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Human Cyclophilin D Complexed with an Inhibitor at room temperature==
-		+	<StructureSection load='4zsd' size='340' side='right' caption='[[4zsd]], [[Resolution\|resolution]] 1.45Å' scene=''>
-	~~The entry~~ 4zsd is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zsd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZSD FirstGlance]. <br>
-	~~Authors~~: ~~Gelin, M~~.~~, Delfosse, V~~., ~~Allemand, F~~.~~, Hoh, F~~.~~, Sallaz~~-~~Damaz, Y~~., ~~Pirocchi, M~~.~~, Bourguet, W~~.~~, Ferrer, J~~.-~~L., Labesse~~, G., ~~Guichou, J~~.-F.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7I6:1-(4-AMINOBENZYL)-3-[(2S)-4-(METHYLSULFANYL)-1-{(2R)-2-[2-(METHYLSULFANYL)PHENYL]PYRROLIDIN-1-YL}-1-OXOBUTAN-2-YL]UREA'>7I6</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j5c\|4j5c]]</td></tr>
-	~~Description: Human Cyclophilin D Complexed with an Inhibitor at room temperature~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zsd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zsd RCSB], [http://www.ebi.ac.uk/pdbsum/4zsd PDBsum]</span></td></tr>
-	~~[[Category: Guichou, J~~.-F]]	+	</table>
-	[[Category: ~~Delfosse, V~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Peptidylprolyl isomerase]]
	[[Category: Allemand, F]]		[[Category: Allemand, F]]
-	[[Category: Labesse, G]]
-	[[Category: Sallaz-Damaz, Y]]
-	[[Category: Gelin, M]]
	[[Category: Bourguet, W]]		[[Category: Bourguet, W]]
-	[[Category: Ferrer, J.-L]]	+	[[Category: Delfosse, V]]
		+	[[Category: Ferrer, J L]]
		+	[[Category: Gelin, M]]
		+	[[Category: Guichou, J F]]
	[[Category: Hoh, F]]		[[Category: Hoh, F]]
		+	[[Category: Labesse, G]]
	[[Category: Pirocchi, M]]		[[Category: Pirocchi, M]]
		+	[[Category: Sallaz-Damaz, Y]]
		+	[[Category: Isomerase]]
		+	[[Category: Isomerase inhibitor complex]]

OCA: Protected "4zsd" [edit=sysop:move=sysop]

2015-05-20T11:06:46Z

Protected "4zsd" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:06, 20 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zsd is ON HOLD Authors: Gelin, M., Delfosse, V., Allemand, F., Hoh, F., Sallaz-Damaz, Y., Pirocchi, M., Bourguet, W., Ferrer, J.-L., Labesse, G., G...

2015-05-20T11:06:45Z

New page: '''Unreleased structure''' The entry 4zsd is ON HOLD Authors: Gelin, M., Delfosse, V., Allemand, F., Hoh, F., Sallaz-Damaz, Y., Pirocchi, M., Bourguet, W., Ferrer, J.-L., Labesse, G., G...

New page

'''Unreleased structure'''

The entry 4zsd is ON HOLD

Authors: Gelin, M., Delfosse, V., Allemand, F., Hoh, F., Sallaz-Damaz, Y., Pirocchi, M., Bourguet, W., Ferrer, J.-L., Labesse, G., Guichou, J.-F.

Description: Human Cyclophilin D Complexed with an Inhibitor at room temperature
[[Category: Unreleased Structures]]
[[Category: Guichou, J.-F]]
[[Category: Delfosse, V]]
[[Category: Allemand, F]]
[[Category: Labesse, G]]
[[Category: Sallaz-Damaz, Y]]
[[Category: Gelin, M]]
[[Category: Bourguet, W]]
[[Category: Ferrer, J.-L]]
[[Category: Hoh, F]]
[[Category: Pirocchi, M]]