5a3g - Revision history

OCA at 04:37, 25 May 2023

2023-05-25T04:37:16Z

←Older revision		Revision as of 04:37, 25 May 2023
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	==Structure of herpesvirus nuclear egress complex subunit M50==		==Structure of herpesvirus nuclear egress complex subunit M50==
-	<StructureSection load='5a3g' size='340' side='right'caption='[[5a3g~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='5a3g' size='340' side='right'caption='[[5a3g]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a3g]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Muhv1 Muhv1~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5A3G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Murid_betaherpesvirus_1 Murid betaherpesvirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A3G FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5a3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3g OCA], [~~http~~://pdbe.org/5a3g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5a3g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5a3g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3g ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3g OCA], [https://pdbe.org/5a3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a3g RCSB], [https://www.ebi.ac.uk/pdbsum/5a3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3g ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/D3XDN8_MUHVS D3XDN8_MUHVS]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Muhv1~~]]	+	[[Category: Murid betaherpesvirus 1]]
-	[[Category: Arthanari, H]]	+	[[Category: Arthanari H]]
-	[[Category: Boeszoermenyi, A]]	+	[[Category: Boeszoermenyi A]]
-	[[Category: Coen~~, D M~~]]	+	[[Category: Coen DM]]
-	[[Category: Filman~~, D J~~]]	+	[[Category: Filman DJ]]
-	[[Category: Hogle~~, J M~~]]	+	[[Category: Hogle JM]]
-	[[Category: Leigh~~, K E~~]]	+	[[Category: Leigh KE]]
-	[[Category: Mansueto~~, M S~~]]	+	[[Category: Mansueto MS]]
-	[[Category: Sharma, M]]	+	[[Category: Sharma M]]
-	[[Category: Wagner, G]]	+	[[Category: Wagner G]]
-	~~[[Category: Nuclear egress]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 08:27, 26 June 2019

2019-06-26T08:27:05Z

←Older revision		Revision as of 08:27, 26 June 2019
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	==Structure of herpesvirus nuclear egress complex subunit M50==		==Structure of herpesvirus nuclear egress complex subunit M50==
-	<StructureSection load='5a3g' size='340' side='right' caption='[[5a3g]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='5a3g' size='340' side='right'caption='[[5a3g]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a3g]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A3G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a3g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Muhv1 Muhv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A3G FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3g OCA], [http://pdbe.org/5a3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a3g RCSB], [http://www.ebi.ac.uk/pdbsum/5a3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3g ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3g OCA], [http://pdbe.org/5a3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a3g RCSB], [http://www.ebi.ac.uk/pdbsum/5a3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3g ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Muhv1]]
	[[Category: Arthanari, H]]		[[Category: Arthanari, H]]
	[[Category: Boeszoermenyi, A]]		[[Category: Boeszoermenyi, A]]

OCA at 13:20, 10 May 2017

2017-05-10T13:20:21Z

←Older revision		Revision as of 13:20, 10 May 2017
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		+
	==Structure of herpesvirus nuclear egress complex subunit M50==		==Structure of herpesvirus nuclear egress complex subunit M50==
	<StructureSection load='5a3g' size='340' side='right' caption='[[5a3g]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='5a3g' size='340' side='right' caption='[[5a3g]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5a3g]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A3G FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a3g]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A3G FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a3g RCSB], [http://www.ebi.ac.uk/pdbsum/5a3g PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3g OCA], [http://pdbe.org/5a3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a3g RCSB], [http://www.ebi.ac.uk/pdbsum/5a3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3g ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5a3g" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:07, 22 July 2015

2015-07-22T08:07:51Z

←Older revision		Revision as of 08:07, 22 July 2015
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a3g RCSB], [http://www.ebi.ac.uk/pdbsum/5a3g PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a3g RCSB], [http://www.ebi.ac.uk/pdbsum/5a3g PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Herpesviruses require a nuclear egress complex (NEC) for efficient transit of nucleocapsids from the nucleus to the cytoplasm. The NEC orchestrates multiple steps during herpesvirus nuclear egress, including disruption of nuclear lamina and particle budding through the inner nuclear membrane. In the important human pathogen human cytomegalovirus (HCMV), this complex consists of nuclear membrane protein UL50, and nucleoplasmic protein UL53, which is recruited to the nuclear membrane through its interaction with UL50. Here, we present an NMR-determined solution-state structure of the murine CMV homolog of UL50 (M50; residues 1-168) with a strikingly intricate protein fold that is matched by no other known protein folds in its entirety. Using NMR methods, we mapped the interaction of M50 with a highly conserved UL53-derived peptide, corresponding to a segment that is required for heterodimerization. The UL53 peptide binding site mapped onto an M50 surface groove, which harbors a large cavity. Point mutations of UL50 residues corresponding to surface residues in the characterized M50 heterodimerization interface substantially decreased UL50-UL53 binding in vitro, eliminated UL50-UL53 colocalization, prevented disruption of nuclear lamina, and halted productive virus replication in HCMV-infected cells. Our results provide detailed structural information on a key protein-protein interaction involved in nuclear egress and suggest that NEC subunit interactions can be an attractive drug target.
		+
		+	Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication.,Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ, Hogle JM, Wagner G, Coen DM, Arthanari H Proc Natl Acad Sci U S A. 2015 Jul 6. pii: 201511140. PMID:26150520<ref>PMID:26150520</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:39, 15 July 2015

2015-07-15T13:39:21Z

←Older revision		Revision as of 13:39, 15 July 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of herpesvirus nuclear egress complex subunit M50==
-		+	<StructureSection load='5a3g' size='340' side='right' caption='[[5a3g]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
-	~~The entry~~ 5a3g is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5a3g]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A3G FirstGlance]. <br>
-	~~Authors~~: ~~LEIGH, K~~.E.~~, BOESZOERMENYI, A~~.~~, MANSUETO, M~~.S.~~, SHARMA, M~~.~~, FILMAN, D~~.J.~~, COEN, D~~.M.~~, WAGNER, G~~.~~, HOGLE, J~~.M., ~~ARTHANARI, H.~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a3g RCSB], [http://www.ebi.ac.uk/pdbsum/5a3g PDBsum]</span></td></tr>
-		+	</table>
-	~~Description: Structure of herpesvirus nuclear egress complex subunit M50~~	+	__TOC__
-	[[~~Category~~: ~~Unreleased Structures]]~~	+	</StructureSection>
-	~~[[Category: Leigh, K~~.E]]	+
-	~~[[Category: Sharma~~, ~~M]]~~	+
-	[~~[Category~~: ~~Hogle, J~~.M]]	+
-	[~~[Category~~: ~~Filman, D~~.J]]	+
	[[Category: Arthanari, H]]		[[Category: Arthanari, H]]
	[[Category: Boeszoermenyi, A]]		[[Category: Boeszoermenyi, A]]
-	[[Category: Coen, D.M]]	+	[[Category: Coen, D M]]
		+	[[Category: Filman, D J]]
		+	[[Category: Hogle, J M]]
		+	[[Category: Leigh, K E]]
		+	[[Category: Mansueto, M S]]
		+	[[Category: Sharma, M]]
	[[Category: Wagner, G]]		[[Category: Wagner, G]]
-	[[Category: ~~Mansueto, M.S~~]]	+	[[Category: Nuclear egress]]
		+	[[Category: Viral protein]]

OCA: Protected "5a3g" [edit=sysop:move=sysop]

2015-06-10T12:35:51Z

Protected "5a3g" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:35, 10 June 2015

OCA: New page: '''Unreleased structure''' The entry 5a3g is ON HOLD Authors: LEIGH, K.E., BOESZOERMENYI, A., MANSUETO, M.S., SHARMA, M., FILMAN, D.J., COEN, D.M., WAGNER, G., HOGLE, J.M., ARTHANARI, H...

2015-06-10T12:35:50Z

New page: '''Unreleased structure''' The entry 5a3g is ON HOLD Authors: LEIGH, K.E., BOESZOERMENYI, A., MANSUETO, M.S., SHARMA, M., FILMAN, D.J., COEN, D.M., WAGNER, G., HOGLE, J.M., ARTHANARI, H...

New page

'''Unreleased structure'''

The entry 5a3g is ON HOLD

Authors: LEIGH, K.E., BOESZOERMENYI, A., MANSUETO, M.S., SHARMA, M., FILMAN, D.J., COEN, D.M., WAGNER, G., HOGLE, J.M., ARTHANARI, H.

Description: Structure of herpesvirus nuclear egress complex subunit M50
[[Category: Unreleased Structures]]
[[Category: Leigh, K.E]]
[[Category: Sharma, M]]
[[Category: Hogle, J.M]]
[[Category: Filman, D.J]]
[[Category: Arthanari, H]]
[[Category: Boeszoermenyi, A]]
[[Category: Coen, D.M]]
[[Category: Wagner, G]]
[[Category: Mansueto, M.S]]