5a49 - Revision history

OCA at 11:37, 9 May 2024

2024-05-09T11:37:03Z

←Older revision		Revision as of 11:37, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5a49]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A49 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a49]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A49 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a49 OCA], [https://pdbe.org/5a49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a49 RCSB], [https://www.ebi.ac.uk/pdbsum/5a49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a49 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.098Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a49 OCA], [https://pdbe.org/5a49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a49 RCSB], [https://www.ebi.ac.uk/pdbsum/5a49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a49 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 04:38, 25 May 2023

2023-05-25T04:38:39Z

←Older revision		Revision as of 04:38, 25 May 2023
Line 3:		Line 3:
	<StructureSection load='5a49' size='340' side='right'caption='[[5a49]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5a49' size='340' side='right'caption='[[5a49]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a49]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A49 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5A49 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a49]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A49 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a48\|5a48]], [[5a4a\|5a4a]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a49 OCA], [https://pdbe.org/5a49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a49 RCSB], [https://www.ebi.ac.uk/pdbsum/5a49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a49 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5a49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a49 OCA], [~~http~~://pdbe.org/5a49 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5a49 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5a49 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5a49 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/OSKA_DROME OSKA_DROME]] Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole.<ref>PMID:1641021</ref> <ref>PMID:2070416</ref> <ref>PMID:2070417</ref>	+	[https://www.uniprot.org/uniprot/OSKA_DROME OSKA_DROME] Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole.<ref>PMID:1641021</ref> <ref>PMID:2070416</ref> <ref>PMID:2070417</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ephrussi, A]]	+	[[Category: Ephrussi A]]
-	[[Category: Glatt, S]]	+	[[Category: Glatt S]]
-	[[Category: Jeske, M]]	+	[[Category: Jeske M]]
-	[[Category: Mueller~~, C W]]~~	+	[[Category: Mueller CW]]
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Germ plasm]]~~	+
-	~~[[Category: Ost-hth domain]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Protein binding interaction]]~~	+
-	~~[[Category: Vasa]]~~	+
-	~~[[Category: Winged helix-turn-helix~~]]	+

OCA at 08:33, 26 June 2019

2019-06-26T08:33:52Z

←Older revision		Revision as of 08:33, 26 June 2019
Line 1:		Line 1:

	==Crystal structure of the LOTUS domain (aa 139-222) of Drosophila Oskar in C222==		==Crystal structure of the LOTUS domain (aa 139-222) of Drosophila Oskar in C222==
-	<StructureSection load='5a49' size='340' side='right' caption='[[5a49]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='5a49' size='340' side='right'caption='[[5a49]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a49]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A49 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a49]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A49 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a48\|5a48]], [[5a4a\|5a4a]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a48\|5a48]], [[5a4a\|5a4a]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a49 OCA], [http://pdbe.org/5a49 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a49 RCSB], [http://www.ebi.ac.uk/pdbsum/5a49 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a49 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a49 OCA], [http://pdbe.org/5a49 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a49 RCSB], [http://www.ebi.ac.uk/pdbsum/5a49 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a49 ProSAT]</span></td></tr>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Ephrussi, A]]		[[Category: Ephrussi, A]]
	[[Category: Glatt, S]]		[[Category: Glatt, S]]

OCA at 16:09, 17 May 2017

2017-05-17T16:09:33Z

←Older revision		Revision as of 16:09, 17 May 2017
Line 1:		Line 1:
		+
	==Crystal structure of the LOTUS domain (aa 139-222) of Drosophila Oskar in C222==		==Crystal structure of the LOTUS domain (aa 139-222) of Drosophila Oskar in C222==
	<StructureSection load='5a49' size='340' side='right' caption='[[5a49]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5a49' size='340' side='right' caption='[[5a49]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[5a49]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A49 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a49]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A49 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a48\|5a48]], [[5a4a\|5a4a]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a48\|5a48]], [[5a4a\|5a4a]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a49 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a49 RCSB], [http://www.ebi.ac.uk/pdbsum/5a49 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a49 OCA], [http://pdbe.org/5a49 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a49 RCSB], [http://www.ebi.ac.uk/pdbsum/5a49 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a49 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5a49" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:30, 29 July 2015

2015-07-29T08:30:54Z

←Older revision		Revision as of 08:30, 29 July 2015
Line 8:		Line 8:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/OSKA_DROME OSKA_DROME]] Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole.<ref>PMID:1641021</ref> <ref>PMID:2070416</ref> <ref>PMID:2070417</ref>		[[http://www.uniprot.org/uniprot/OSKA_DROME OSKA_DROME]] Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole.<ref>PMID:1641021</ref> <ref>PMID:2070416</ref> <ref>PMID:2070417</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In many animals, the germ plasm segregates germline from soma during early development. Oskar protein is known for its ability to induce germ plasm formation and germ cells in Drosophila. However, the molecular basis of germ plasm formation remains unclear. Here, we show that Oskar is an RNA-binding protein in vivo, crosslinking to nanos, polar granule component, and germ cell-less mRNAs, each of which has a role in germline formation. Furthermore, we present high-resolution crystal structures of the two Oskar domains. RNA-binding maps in vitro to the C-terminal domain, which shows structural similarity to SGNH hydrolases. The highly conserved N-terminal LOTUS domain forms dimers and mediates Oskar interaction with the germline-specific RNA helicase Vasa in vitro. Our findings suggest a dual function of Oskar in RNA and Vasa binding, providing molecular clues to its germ plasm function.
		+
		+	The Crystal Structure of the Drosophila Germline Inducer Oskar Identifies Two Domains with Distinct Vasa Helicase- and RNA-Binding Activities.,Jeske M, Bordi M, Glatt S, Muller S, Rybin V, Muller CW, Ephrussi A Cell Rep. 2015 Jul 15. pii: S2211-1247(15)00681-6. doi:, 10.1016/j.celrep.2015.06.055. PMID:26190108<ref>PMID:26190108</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:19, 22 July 2015

2015-07-22T14:19:35Z

←Older revision		Revision as of 14:19, 22 July 2015
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	==Crystal structure of the LOTUS domain (aa 139-222) of Drosophila Oskar in C222==
-		+	<StructureSection load='5a49' size='340' side='right' caption='[[5a49]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~The entry 5a49 is ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5a49]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A49 FirstGlance]. <br>
-	~~Authors: Jeske, M., Glatt, S., Ephrussi, A., Mueller, C.W.~~	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a48\|5a48]], [[5a4a\|5a4a]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a49 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a49 RCSB], [http://www.ebi.ac.uk/pdbsum/5a49 PDBsum]</span></td></tr>
-	~~Description:~~ Crystal structure of the LOTUS domain (aa 139-222) of Drosophila Oskar in C222	+	</table>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	== Function ==
-	[[~~Category~~: ~~Mueller~~, ~~C.W~~]]	+	[[http://www.uniprot.org/uniprot/OSKA_DROME OSKA_DROME]] Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole.<ref>PMID:1641021</ref> <ref>PMID:2070416</ref> <ref>PMID:2070417</ref>
-	[[~~Category~~: ~~Jeske~~, M]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Ephrussi, A]]		[[Category: Ephrussi, A]]
	[[Category: Glatt, S]]		[[Category: Glatt, S]]
		+	[[Category: Jeske, M]]
		+	[[Category: Mueller, C W]]
		+	[[Category: Dimer]]
		+	[[Category: Germ plasm]]
		+	[[Category: Ost-hth domain]]
		+	[[Category: Protein binding]]
		+	[[Category: Protein binding interaction]]
		+	[[Category: Vasa]]
		+	[[Category: Winged helix-turn-helix]]

OCA: Protected "5a49" [edit=sysop:move=sysop]

2015-06-17T13:31:03Z

Protected "5a49" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:31, 17 June 2015

OCA: New page: '''Unreleased structure''' The entry 5a49 is ON HOLD until Paper Publication Authors: Jeske, M., Glatt, S., Ephrussi, A., Mueller, C.W. Description: Crystal structure of the LOTUS doma...

2015-06-17T13:31:02Z

New page: '''Unreleased structure''' The entry 5a49 is ON HOLD until Paper Publication Authors: Jeske, M., Glatt, S., Ephrussi, A., Mueller, C.W. Description: Crystal structure of the LOTUS doma...

New page

'''Unreleased structure'''

The entry 5a49 is ON HOLD until Paper Publication

Authors: Jeske, M., Glatt, S., Ephrussi, A., Mueller, C.W.

Description: Crystal structure of the LOTUS domain (aa 139-222) of Drosophila Oskar in C222
[[Category: Unreleased Structures]]
[[Category: Mueller, C.W]]
[[Category: Jeske, M]]
[[Category: Ephrussi, A]]
[[Category: Glatt, S]]