5a4x - Revision history

OCA at 11:03, 10 January 2024

2024-01-10T11:03:56Z

←Older revision		Revision as of 11:03, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5a4x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A4X FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a4x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A4X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4x OCA], [https://pdbe.org/5a4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a4x RCSB], [https://www.ebi.ac.uk/pdbsum/5a4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4x OCA], [https://pdbe.org/5a4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a4x RCSB], [https://www.ebi.ac.uk/pdbsum/5a4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4x ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:39, 25 May 2023

2023-05-25T04:39:36Z

←Older revision		Revision as of 04:39, 25 May 2023
Line 3:		Line 3:
	<StructureSection load='5a4x' size='340' side='right'caption='[[5a4x]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5a4x' size='340' side='right'caption='[[5a4x]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a4x]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5A4X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a4x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A4X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a50\|5a50]], [[5a51\|5a51]], [[5a52\|5a52]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4x OCA], [https://pdbe.org/5a4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a4x RCSB], [https://www.ebi.ac.uk/pdbsum/5a4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4x ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5a4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4x OCA], [~~http~~://pdbe.org/5a4x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5a4x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5a4x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4x ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CAR4_ARATH CAR4_ARATH] Mediates the transient calcium-dependent interaction of PYR/PYL/RCAR abscisic acid (ABA) receptors with the plasma membrane and thus regulates ABA sensitivity (PubMed:26719420, PubMed:25465408). Stimulates the GTPase/ATPase activities of YchF1, and regulates its subcellular localization. Promotes tolerance towards salinity stress by limiting the accumulation of reactive oxygen species (ROS) (PubMed:23550829). Promotes resistance to bacterial pathogens (e.g. Xanthomonas oryzae pv. oryzae and P. syringae pv. tomato DC3000) (By similarity). Binds liposomes in the absence of exogenous Ca(2+), but this activity is enhanced in the presence of Ca(2+) and generates membrane curvature (PubMed:26719420).[UniProtKB:Q6YWF1]<ref>PMID:23550829</ref> <ref>PMID:25465408</ref> <ref>PMID:26719420</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Albert, A]]	+	[[Category: Albert A]]
-	[[Category: Diaz, M]]	+	[[Category: Diaz M]]
-	~~[[Category: C2 domain]]~~	+
-	~~[[Category: Calcium binding protein]]~~	+
-	~~[[Category: Lipid binding protein~~]]	+

OCA at 08:43, 26 June 2019

2019-06-26T08:43:29Z

←Older revision		Revision as of 08:43, 26 June 2019
Line 1:		Line 1:

	==The crystal structure of Arabidopsis thaliana CAR4 in complex with two calcium ions and Zn==		==The crystal structure of Arabidopsis thaliana CAR4 in complex with two calcium ions and Zn==
-	<StructureSection load='5a4x' size='340' side='right' caption='[[5a4x]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5a4x' size='340' side='right'caption='[[5a4x]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a4x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A4X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a4x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A4X FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a50\|5a50]], [[5a51\|5a51]], [[5a52\|5a52]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a50\|5a50]], [[5a51\|5a51]], [[5a52\|5a52]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4x OCA], [http://pdbe.org/5a4x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a4x RCSB], [http://www.ebi.ac.uk/pdbsum/5a4x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4x OCA], [http://pdbe.org/5a4x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a4x RCSB], [http://www.ebi.ac.uk/pdbsum/5a4x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4x ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Albert, A]]		[[Category: Albert, A]]
	[[Category: Diaz, M]]		[[Category: Diaz, M]]

OCA at 15:02, 2 March 2016

2016-03-02T15:02:25Z

←Older revision		Revision as of 15:02, 2 March 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 5a4x is ~~ON HOLD until Paper~~ Publication	+	==The crystal structure of Arabidopsis thaliana CAR4 in complex with two calcium ions and Zn==
		+	<StructureSection load='5a4x' size='340' side='right' caption='[[5a4x]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5a4x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A4X FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a50\|5a50]], [[5a51\|5a51]], [[5a52\|5a52]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4x OCA], [http://pdbe.org/5a4x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a4x RCSB], [http://www.ebi.ac.uk/pdbsum/5a4x PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Regulation of ion transport in plants is essential for cell function. Abiotic stress unbalances cell ion homeostasis, and plants tend to readjust it, regulating membrane transporters and channels. The plant hormone abscisic acid (ABA) and the second messenger Ca(2+) are central in such processes, as they are involved in the regulation of protein kinases and phosphatases that control ion transport activity in response to environmental stimuli. The identification and characterization of the molecular mechanisms underlying the effect of ABA and Ca(2+) signaling pathways on membrane function are central and could provide opportunities for crop improvement. The C2-domain ABA-related (CAR) family of small proteins is involved in the Ca(2+)-dependent recruitment of the pyrabactin resistance 1/PYR1-like (PYR/PYL) ABA receptors to the membrane. However, to fully understand CAR function, it is necessary to define a molecular mechanism that integrates Ca(2+) sensing, membrane interaction, and the recognition of the PYR/PYL interacting partners. We present structural and biochemical data showing that CARs are peripheral membrane proteins that functionally cluster on the membrane and generate strong positive membrane curvature in a Ca(2+)-dependent manner. These features represent a mechanism for the generation, stabilization, and/or specific recognition of membrane discontinuities. Such structures may act as signaling platforms involved in the recruitment of PYR/PYL receptors and other signaling components involved in cell responses to stress.

-	~~Authors:~~ Diaz, M., ~~Albert~~, A.	+	Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling.,Diaz M, Sanchez-Barrena MJ, Gonzalez-Rubio JM, Rodriguez L, Fernandez D, Antoni R, Yunta C, Belda-Palazon B, Gonzalez-Guzman M, Peirats-Llobet M, Menendez M, Boskovic J, Marquez JA, Rodriguez PL, Albert A Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E396-405. doi:, 10.1073/pnas.1512779113. Epub 2015 Dec 30. PMID:26719420<ref>PMID:26719420</ref>

-	~~Description: The crystal structure~~ of ~~Arabidopsis thaliana CAR4 in complex with two calcium ions and Zn~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5a4x" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Albert, A]]		[[Category: Albert, A]]
	[[Category: Diaz, M]]		[[Category: Diaz, M]]
		+	[[Category: C2 domain]]
		+	[[Category: Calcium binding protein]]
		+	[[Category: Lipid binding protein]]

OCA at 10:26, 1 July 2015

2015-07-01T10:26:38Z

←Older revision		Revision as of 10:26, 1 July 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5a4x is ON HOLD	+	The entry 5a4x is ON HOLD until Paper Publication

	Authors: Diaz, M., Albert, A.		Authors: Diaz, M., Albert, A.

OCA: Protected "5a4x" [edit=sysop:move=sysop]

2015-06-24T11:18:03Z

Protected "5a4x" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:18, 24 June 2015

OCA: New page: '''Unreleased structure''' The entry 5a4x is ON HOLD Authors: Diaz, M., Albert, A. Description: The crystal structure of Arabidopsis thaliana CAR4 in complex with two calcium ions and ...

2015-06-24T11:18:02Z

New page: '''Unreleased structure''' The entry 5a4x is ON HOLD Authors: Diaz, M., Albert, A. Description: The crystal structure of Arabidopsis thaliana CAR4 in complex with two calcium ions and ...

New page

'''Unreleased structure'''

The entry 5a4x is ON HOLD

Authors: Diaz, M., Albert, A.

Description: The crystal structure of Arabidopsis thaliana CAR4 in complex with two calcium ions and Zn
[[Category: Unreleased Structures]]
[[Category: Albert, A]]
[[Category: Diaz, M]]