5aar - Revision history

OCA at 11:06, 10 January 2024

2024-01-10T11:06:42Z

←Older revision		Revision as of 11:06, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5aar]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AAR FirstGlance]. <br>		<table><tr><td colspan='2'>[[5aar]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AAR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.87Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aar OCA], [https://pdbe.org/5aar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aar RCSB], [https://www.ebi.ac.uk/pdbsum/5aar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aar ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aar OCA], [https://pdbe.org/5aar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aar RCSB], [https://www.ebi.ac.uk/pdbsum/5aar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aar ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:48, 25 May 2023

2023-05-25T04:48:12Z

←Older revision		Revision as of 04:48, 25 May 2023
Line 3:		Line 3:
	<StructureSection load='5aar' size='340' side='right'caption='[[5aar]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='5aar' size='340' side='right'caption='[[5aar]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5aar]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AAR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5AAR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5aar]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AAR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5aar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aar OCA], [~~http~~://pdbe.org/5aar PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5aar RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5aar PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5aar ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aar OCA], [https://pdbe.org/5aar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aar RCSB], [https://www.ebi.ac.uk/pdbsum/5aar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aar ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AKT1_ARATH AKT1_ARATH]] Highly selective inward-rectifying potassium channel that mediate potassium uptake by plant roots in response to low K(+) conditions, by a calcium-, CBL-, and CIPK-dependent pathway. Positively regulated by phosphorylation by CIPK23. Negatively regulated by a kinase-independent regulatory mechanism involving a competing direct binding of CBL10. Involved in the stomatal regulation by monitoring the turgor pressure in guard cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. May interact with the cytoskeleton or with regulatory proteins.<ref>PMID:12678562</ref> <ref>PMID:16814720</ref> <ref>PMID:16895985</ref> <ref>PMID:17898163</ref> <ref>PMID:9572739</ref>	+	[https://www.uniprot.org/uniprot/AKT1_ARATH AKT1_ARATH] Highly selective inward-rectifying potassium channel that mediate potassium uptake by plant roots in response to low K(+) conditions, by a calcium-, CBL-, and CIPK-dependent pathway. Positively regulated by phosphorylation by CIPK23. Negatively regulated by a kinase-independent regulatory mechanism involving a competing direct binding of CBL10. Involved in the stomatal regulation by monitoring the turgor pressure in guard cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. May interact with the cytoskeleton or with regulatory proteins.<ref>PMID:12678562</ref> <ref>PMID:16814720</ref> <ref>PMID:16895985</ref> <ref>PMID:17898163</ref> <ref>PMID:9572739</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5aar" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5aar" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Albert, A]]	+	[[Category: Albert A]]
-	[[Category: Chaves-Sanjuan, A]]	+	[[Category: Chaves-Sanjuan A]]
-	[[Category: Sanchez-Barrena~~, M J]]~~	+	[[Category: Sanchez-Barrena MJ]]
-	~~[[Category: Abiotic stress]]~~	+
-	~~[[Category: Ankyrin]]~~	+
-	~~[[Category: Ion homeostasis]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 07:07, 8 April 2020

2020-04-08T07:07:19Z

←Older revision		Revision as of 07:07, 8 April 2020
Line 3:		Line 3:
	<StructureSection load='5aar' size='340' side='right'caption='[[5aar]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='5aar' size='340' side='right'caption='[[5aar]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5aar]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AAR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AAR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5aar]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AAR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5AAR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5aar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aar OCA], [http://pdbe.org/5aar PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aar RCSB], [http://www.ebi.ac.uk/pdbsum/5aar PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aar ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5aar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aar OCA], [http://pdbe.org/5aar PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aar RCSB], [http://www.ebi.ac.uk/pdbsum/5aar PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aar ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/AKT1_ARATH AKT1_ARATH]] Highly selective inward-rectifying potassium channel that mediate potassium uptake by plant roots in response to low K(+) conditions, by a calcium-, CBL-, and CIPK-dependent pathway. Positively regulated by phosphorylation by CIPK23. Negatively regulated by a kinase-independent regulatory mechanism involving a competing direct binding of CBL10. Involved in the stomatal regulation by monitoring the turgor pressure in guard cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. May interact with the cytoskeleton or with regulatory proteins.<ref>PMID:12678562</ref> <ref>PMID:16814720</ref> <ref>PMID:16895985</ref> <ref>PMID:17898163</ref> <ref>PMID:9572739</ref>		[[http://www.uniprot.org/uniprot/AKT1_ARATH AKT1_ARATH]] Highly selective inward-rectifying potassium channel that mediate potassium uptake by plant roots in response to low K(+) conditions, by a calcium-, CBL-, and CIPK-dependent pathway. Positively regulated by phosphorylation by CIPK23. Negatively regulated by a kinase-independent regulatory mechanism involving a competing direct binding of CBL10. Involved in the stomatal regulation by monitoring the turgor pressure in guard cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. May interact with the cytoskeleton or with regulatory proteins.<ref>PMID:12678562</ref> <ref>PMID:16814720</ref> <ref>PMID:16895985</ref> <ref>PMID:17898163</ref> <ref>PMID:9572739</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plant growth largely depends on the maintenance of adequate intracellular levels of potassium (K(+)). The families of 10 Calcineurin B-Like (CBL) calcium sensors and 26 CBL-Interacting Protein Kinases (CIPKs) of Arabidopsis (Arabidopsis thaliana) decode the calcium signals elicited by environmental inputs to regulate different ion channels and transporters involved in the control of K(+) fluxes by phosphorylation-dependent and -independent events. However, the detailed molecular mechanisms governing target specificity require investigation. Here, we show that the physical interaction between CIPK23 and the noncanonical ankyrin domain in the cytosolic side of the inward-rectifier K(+) channel AKT1 regulates kinase docking and channel activation. Point mutations on this domain specifically alter binding to CIPK23, enhancing or impairing the ability of CIPK23 to regulate channel activity. Our data demonstrate the relevance of this protein-protein interaction that contributes to the formation of a complex between CIPK23/CBL1 and AKT1 in the membrane for the proper regulation of K(+) transport.
		+
		+	Recognition and Activation of the Plant AKT1 Potassium Channel by the Kinase CIPK23.,Sanchez-Barrena MJ, Chaves-Sanjuan A, Raddatz N, Mendoza I, Cortes A, Gago F, Gonzalez-Rubio JM, Benavente JL, Quintero FJ, Pardo JM, Albert A Plant Physiol. 2020 Apr;182(4):2143-2153. doi: 10.1104/pp.19.01084. Epub 2020 Feb, 3. PMID:32015077<ref>PMID:32015077</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5aar" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:09, 26 June 2019

2019-06-26T08:09:42Z

←Older revision		Revision as of 08:09, 26 June 2019
Line 1:		Line 1:

	==Structure of the ankyrin domain of an Arabidopsis Thaliana potassium channel==		==Structure of the ankyrin domain of an Arabidopsis Thaliana potassium channel==
-	<StructureSection load='5aar' size='340' side='right' caption='[[5aar]], [[Resolution\|resolution]] 1.87Å' scene=''>	+	<StructureSection load='5aar' size='340' side='right'caption='[[5aar]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5aar]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AAR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AAR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5aar]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AAR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AAR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aar OCA], [http://pdbe.org/5aar PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aar RCSB], [http://www.ebi.ac.uk/pdbsum/5aar PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aar ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aar OCA], [http://pdbe.org/5aar PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aar RCSB], [http://www.ebi.ac.uk/pdbsum/5aar PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aar ProSAT]</span></td></tr>
Line 13:		Line 13:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Albert, A]]		[[Category: Albert, A]]
	[[Category: Chaves-Sanjuan, A]]		[[Category: Chaves-Sanjuan, A]]

OCA at 06:48, 10 September 2016

2016-09-10T06:48:47Z

←Older revision		Revision as of 06:48, 10 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5aar is ~~ON HOLD until Paper Publication~~	+	==Structure of the ankyrin domain of an Arabidopsis Thaliana potassium channel==
-		+	<StructureSection load='5aar' size='340' side='right' caption='[[5aar]], [[Resolution\|resolution]] 1.87Å' scene=''>
-	~~Authors~~: ~~Chaves~~-~~Sanjuan, A~~., ~~Sanchez~~-~~Barrena~~, M.J., ~~Albert~~, A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5aar]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AAR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AAR FirstGlance]. <br>
-	~~Description: Structure of the ankyrin domain of an Arabidopsis Thaliana potassium channel~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aar OCA], [http://pdbe.org/5aar PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aar RCSB], [http://www.ebi.ac.uk/pdbsum/5aar PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aar ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AKT1_ARATH AKT1_ARATH]] Highly selective inward-rectifying potassium channel that mediate potassium uptake by plant roots in response to low K(+) conditions, by a calcium-, CBL-, and CIPK-dependent pathway. Positively regulated by phosphorylation by CIPK23. Negatively regulated by a kinase-independent regulatory mechanism involving a competing direct binding of CBL10. Involved in the stomatal regulation by monitoring the turgor pressure in guard cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. May interact with the cytoskeleton or with regulatory proteins.<ref>PMID:12678562</ref> <ref>PMID:16814720</ref> <ref>PMID:16895985</ref> <ref>PMID:17898163</ref> <ref>PMID:9572739</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Albert, A]]		[[Category: Albert, A]]
-	[[Category: Sanchez-Barrena, M.J]]
	[[Category: Chaves-Sanjuan, A]]		[[Category: Chaves-Sanjuan, A]]
		+	[[Category: Sanchez-Barrena, M J]]
		+	[[Category: Abiotic stress]]
		+	[[Category: Ankyrin]]
		+	[[Category: Ion homeostasis]]
		+	[[Category: Transport protein]]

OCA at 00:26, 1 December 2015

2015-12-01T00:26:19Z

←Older revision		Revision as of 00:26, 1 December 2015
Line 7:		Line 7:
	Description: Structure of the ankyrin domain of an Arabidopsis Thaliana potassium channel		Description: Structure of the ankyrin domain of an Arabidopsis Thaliana potassium channel
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Albert, A]]
	[[Category: Sanchez-Barrena, M.J]]		[[Category: Sanchez-Barrena, M.J]]
	[[Category: Chaves-Sanjuan, A]]		[[Category: Chaves-Sanjuan, A]]
-	[[Category: Albert, A]]

OCA: Protected "5aar" [edit=sysop:move=sysop]

2015-08-05T17:35:27Z

Protected "5aar" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:35, 5 August 2015

OCA: New page: '''Unreleased structure''' The entry 5aar is ON HOLD until Paper Publication Authors: Chaves-Sanjuan, A., Sanchez-Barrena, M.J., Albert, A. Description: Structure of the ankyrin domain...

2015-08-05T17:35:26Z

New page: '''Unreleased structure''' The entry 5aar is ON HOLD until Paper Publication Authors: Chaves-Sanjuan, A., Sanchez-Barrena, M.J., Albert, A. Description: Structure of the ankyrin domain...

New page

'''Unreleased structure'''

The entry 5aar is ON HOLD until Paper Publication

Authors: Chaves-Sanjuan, A., Sanchez-Barrena, M.J., Albert, A.

Description: Structure of the ankyrin domain of an Arabidopsis Thaliana potassium channel
[[Category: Unreleased Structures]]
[[Category: Sanchez-Barrena, M.J]]
[[Category: Chaves-Sanjuan, A]]
[[Category: Albert, A]]