5ag7 - Revision history

OCA at 11:09, 10 January 2024

2024-01-10T11:09:11Z

←Older revision		Revision as of 11:09, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ag7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AG7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ag7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AG7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=XXL:ETHYL+(3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL)ACETATE'>XXL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=XXL:ETHYL+(3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL)ACETATE'>XXL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ag7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ag7 OCA], [https://pdbe.org/5ag7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ag7 RCSB], [https://www.ebi.ac.uk/pdbsum/5ag7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ag7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ag7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ag7 OCA], [https://pdbe.org/5ag7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ag7 RCSB], [https://www.ebi.ac.uk/pdbsum/5ag7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ag7 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:56, 25 May 2023

2023-05-25T04:56:53Z

←Older revision		Revision as of 04:56, 25 May 2023
Line 3:		Line 3:
	<StructureSection load='5ag7' size='340' side='right'caption='[[5ag7]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5ag7' size='340' side='right'caption='[[5ag7]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ag7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Leima Leima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AG7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AG7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ag7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AG7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=XXL:ETHYL+(3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL)ACETATE'>XXL</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=XXL:ETHYL+(3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL)ACETATE'>XXL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ag4\|5ag4]], [[5ag5\|5ag5]], [[5ag6\|5ag6]], [[5age\|5age]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ag7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ag7 OCA], [https://pdbe.org/5ag7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ag7 RCSB], [https://www.ebi.ac.uk/pdbsum/5ag7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ag7 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ag7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ag7 OCA], [~~http~~://pdbe.org/5ag7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ag7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ag7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ag7 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).	+	[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Glycylpeptide N-tetradecanoyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Leima~~]]	+	[[Category: Leishmania major]]
-	[[Category: Brand, S]]	+	[[Category: Brand S]]
-	[[Category: Brenk, R]]	+	[[Category: Brenk R]]
-	[[Category: Frearson~~, J A~~]]	+	[[Category: Frearson JA]]
-	[[Category: Gilbert~~, I H~~]]	+	[[Category: Gilbert IH]]
-	[[Category: McElroy~~, S P~~]]	+	[[Category: McElroy SP]]
-	[[Category: Read~~, K D~~]]	+	[[Category: Read KD]]
-	[[Category: Robinson~~, D A~~]]	+	[[Category: Robinson DA]]
-	[[Category: Smith, A]]	+	[[Category: Smith A]]
-	[[Category: Smith~~, V C~~]]	+	[[Category: Smith VC]]
-	[[Category: Spinks, D]]	+	[[Category: Spinks D]]
-	[[Category: Thompson, S]]	+	[[Category: Thompson S]]
-	[[Category: Torrie~~, L S~~]]	+	[[Category: Torrie LS]]
-	[[Category: Wyatt~~, P G]]~~	+	[[Category: Wyatt PG]]
-	~~[[Category: Acyltransferase]]~~	+
-	~~[[Category: Drug discovery]]~~	+
-	~~[[Category: N-myristoyltransferase]]~~	+
-	~~[[Category: Nmt]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:44, 4 March 2020

2020-03-04T07:44:29Z

←Older revision		Revision as of 07:44, 4 March 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A BENZOMORPHOLINE LIGAND==		==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A BENZOMORPHOLINE LIGAND==
-	<StructureSection load='5ag7' size='340' side='right' caption='[[5ag7]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5ag7' size='340' side='right'caption='[[5ag7]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ag7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AG7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ag7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AG7 FirstGlance]. <br>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Leima]]		[[Category: Leima]]
	[[Category: Brand, S]]		[[Category: Brand, S]]

OCA at 14:39, 16 November 2017

2017-11-16T14:39:50Z

←Older revision		Revision as of 14:39, 16 November 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A BENZOMORPHOLINE LIGAND==		==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A BENZOMORPHOLINE LIGAND==
	<StructureSection load='5ag7' size='340' side='right' caption='[[5ag7]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5ag7' size='340' side='right' caption='[[5ag7]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ag7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AG7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ag7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AG7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=XXL:ETHYL+(3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL)ACETATE'>XXL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=XXL:ETHYL+(3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL)ACETATE'>XXL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ag4\|5ag4]], [[5ag5\|5ag5]], [[5ag6\|5ag6]], [[5age\|5age]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ag4\|5ag4]], [[5ag5\|5ag5]], [[5ag6\|5ag6]], [[5age\|5age]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ag7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ag7 OCA], [http://pdbe.org/5ag7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ag7 RCSB], [http://www.ebi.ac.uk/pdbsum/5ag7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ag7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ag7 OCA], [http://pdbe.org/5ag7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ag7 RCSB], [http://www.ebi.ac.uk/pdbsum/5ag7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ag7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
		+	[[Category: Leima]]
	[[Category: Brand, S]]		[[Category: Brand, S]]
	[[Category: Brenk, R]]		[[Category: Brenk, R]]

OCA at 13:45, 7 October 2015

2015-10-07T13:45:00Z

←Older revision		Revision as of 13:45, 7 October 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A BENZOMORPHOLINE LIGAND==
		+	<StructureSection load='5ag7' size='340' side='right' caption='[[5ag7]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ag7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AG7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=XXL:ETHYL+(3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL)ACETATE'>XXL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ag4\|5ag4]], [[5ag5\|5ag5]], [[5ag6\|5ag6]], [[5age\|5age]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ag7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ag7 OCA], [http://pdbe.org/5ag7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ag7 RCSB], [http://www.ebi.ac.uk/pdbsum/5ag7 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The enzyme N-myristoyltransferase (NMT) from Trypanosoma brucei has been validated both chemically and biologically as a potential drug target for human African trypanosomiasis. We previously reported the development of some very potent compounds based around a pyrazole sulfonamide series, derived from a high-throughput screen. Herein we describe work around thiazolidinone and benzomorpholine scaffolds that were also identified in the screen. An X-ray crystal structure of the thiazolidinone hit in Leishmania major NMT showed the compound bound in the previously reported active site, utilising a novel binding mode. This provides potential for further optimisation. The benzomorpholinone was also found to bind in a similar region. Using an X-ray crystallography/structure-based design approach, the benzomorpholinone series was further optimised, increasing activity against T. brucei NMT by >1000-fold. A series of trypanocidal compounds were identified with suitable in vitro DMPK properties, including CNS exposure for further development. Further work is required to increase selectivity over the human NMT isoform and activity against T. brucei.

-	~~The entry 5ag7 is ON HOLD until Paper Publication~~	+	Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.,Spinks D, Smith V, Thompson S, Robinson DA, Luksch T, Smith A, Torrie LS, McElroy S, Stojanovski L, Norval S, Collie IT, Hallyburton I, Rao B, Brand S, Brenk R, Frearson JA, Read KD, Wyatt PG, Gilbert IH ChemMedChem. 2015 Sep 23. doi: 10.1002/cmdc.201500301. PMID:26395087<ref>PMID:26395087</ref>

-	~~Authors: Robinson~~, D.~~A., Spinks, D., Smith, V.C., Thompson,~~ S.~~, Smith, A., Torrie, L.S., McElroy, S.P., Brand, S., Brenk, R., Frearson, J.A., Read, K.D., Wyatt, P.G., Gilbert, I.H~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N~~-~~MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL~~-~~COA AND A BENZOMORPHOLINE LIGAND~~	+	<div class="pdbe-citations 5ag7" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
-	[[Category: ~~Smith~~, ~~V.C~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Glycylpeptide N-tetradecanoyltransferase]]
		+	[[Category: Brand, S]]
	[[Category: Brenk, R]]		[[Category: Brenk, R]]
		+	[[Category: Frearson, J A]]
		+	[[Category: Gilbert, I H]]
		+	[[Category: McElroy, S P]]
		+	[[Category: Read, K D]]
		+	[[Category: Robinson, D A]]
	[[Category: Smith, A]]		[[Category: Smith, A]]
-	[[Category: ~~Robinson~~, ~~D.A]]~~	+	[[Category: Smith, V C]]
-	~~[[Category: Gilbert, I.H]]~~	+
-	~~[[Category: Frearson, J.A~~]]	+
	[[Category: Spinks, D]]		[[Category: Spinks, D]]
-	[[Category: Read, K.D]]
-	[[Category: Brand, S]]
-	[[Category: Torrie, L.S]]
-	[[Category: Mcelroy, S.P]]
-	[[Category: Wyatt, P.G]]
	[[Category: Thompson, S]]		[[Category: Thompson, S]]
		+	[[Category: Torrie, L S]]
		+	[[Category: Wyatt, P G]]
		+	[[Category: Acyltransferase]]
		+	[[Category: Drug discovery]]
		+	[[Category: N-myristoyltransferase]]
		+	[[Category: Nmt]]
		+	[[Category: Transferase]]

OCA at 11:01, 12 February 2015

2015-02-12T11:01:46Z

←Older revision		Revision as of 11:01, 12 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ag7 is ON HOLD	+	The entry 5ag7 is ON HOLD until Paper Publication

	Authors: Robinson, D.A., Spinks, D., Smith, V.C., Thompson, S., Smith, A., Torrie, L.S., McElroy, S.P., Brand, S., Brenk, R., Frearson, J.A., Read, K.D., Wyatt, P.G., Gilbert, I.H.		Authors: Robinson, D.A., Spinks, D., Smith, V.C., Thompson, S., Smith, A., Torrie, L.S., McElroy, S.P., Brand, S., Brenk, R., Frearson, J.A., Read, K.D., Wyatt, P.G., Gilbert, I.H.

OCA: Protected "5ag7" [edit=sysop:move=sysop]

2015-02-07T15:02:12Z

Protected "5ag7" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:02, 7 February 2015

OCA: New page: '''Unreleased structure''' The entry 5ag7 is ON HOLD Authors: Robinson, D.A., Spinks, D., Smith, V.C., Thompson, S., Smith, A., Torrie, L.S., McElroy, S.P., Brand, S., Brenk, R., Frears...

2015-02-07T15:02:10Z

New page: '''Unreleased structure''' The entry 5ag7 is ON HOLD Authors: Robinson, D.A., Spinks, D., Smith, V.C., Thompson, S., Smith, A., Torrie, L.S., McElroy, S.P., Brand, S., Brenk, R., Frears...

New page

'''Unreleased structure'''

The entry 5ag7 is ON HOLD

Authors: Robinson, D.A., Spinks, D., Smith, V.C., Thompson, S., Smith, A., Torrie, L.S., McElroy, S.P., Brand, S., Brenk, R., Frearson, J.A., Read, K.D., Wyatt, P.G., Gilbert, I.H.

Description: CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A BENZOMORPHOLINE LIGAND
[[Category: Unreleased Structures]]
[[Category: Smith, V.C]]
[[Category: Brenk, R]]
[[Category: Smith, A]]
[[Category: Robinson, D.A]]
[[Category: Gilbert, I.H]]
[[Category: Frearson, J.A]]
[[Category: Spinks, D]]
[[Category: Read, K.D]]
[[Category: Brand, S]]
[[Category: Torrie, L.S]]
[[Category: Mcelroy, S.P]]
[[Category: Wyatt, P.G]]
[[Category: Thompson, S]]