5aul - Revision history

OCA at 15:48, 8 November 2023

2023-11-08T15:48:15Z

←Older revision		Revision as of 15:48, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5aul]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AUL FirstGlance]. <br>		<table><tr><td colspan='2'>[[5aul]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AUL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aul OCA], [https://pdbe.org/5aul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aul RCSB], [https://www.ebi.ac.uk/pdbsum/5aul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aul ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aul OCA], [https://pdbe.org/5aul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aul RCSB], [https://www.ebi.ac.uk/pdbsum/5aul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aul ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:26, 31 May 2023

2023-05-31T06:26:21Z

←Older revision		Revision as of 06:26, 31 May 2023
Line 3:		Line 3:
	<StructureSection load='5aul' size='340' side='right'caption='[[5aul]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='5aul' size='340' side='right'caption='[[5aul]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5aul]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AUL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5aul]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AUL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~GOL~~:~~GLYCEROL~~'>~~GOL~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~CSO~~:~~S-HYDROXYCYSTEINE~~'>~~CSO~~</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aul OCA], [https://pdbe.org/5aul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aul RCSB], [https://www.ebi.ac.uk/pdbsum/5aul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aul ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wa4\|3wa4]]</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3R1, GRB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5aul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aul OCA], [~~http~~://pdbe.org/5aul PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5aul RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5aul PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5aul ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/P85A_HUMAN P85A_HUMAN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.<ref>PMID:7518429</ref> <ref>PMID:17626883</ref> <ref>PMID:19805105</ref> ~~[[http://www.uniprot.org/uniprot/CD28_HUMAN CD28_HUMAN]] Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.~~	+	[https://www.uniprot.org/uniprot/P85A_HUMAN P85A_HUMAN] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.<ref>PMID:7518429</ref> <ref>PMID:17626883</ref> <ref>PMID:19805105</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ikura, T]]	+	[[Category: Ikura T]]
-	[[Category: Inaba, S]]	+	[[Category: Inaba S]]
-	[[Category: Ito, N]]	+	[[Category: Ito N]]
-	[[Category: Morii, H]]	+	[[Category: Morii H]]
-	[[Category: Numoto, N]]	+	[[Category: Numoto N]]
-	[[Category: Oda, M]]	+	[[Category: Oda M]]
-	~~[[Category: Antigen]]~~	+
-	~~[[Category: Phosphopeptide]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:35, 3 July 2019

2019-07-03T07:35:18Z

←Older revision		Revision as of 07:35, 3 July 2019
Line 1:		Line 1:

	==PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex==		==PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex==
-	<StructureSection load='5aul' size='340' side='right' caption='[[5aul]], [[Resolution\|resolution]] 1.10Å' scene=''>	+	<StructureSection load='5aul' size='340' side='right'caption='[[5aul]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5aul]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AUL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5aul]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AUL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wa4\|3wa4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wa4\|3wa4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3R1, GRB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aul OCA], [http://pdbe.org/5aul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aul RCSB], [http://www.ebi.ac.uk/pdbsum/5aul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aul ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aul OCA], [http://pdbe.org/5aul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aul RCSB], [http://www.ebi.ac.uk/pdbsum/5aul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aul ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ikura, T]]		[[Category: Ikura, T]]
	[[Category: Inaba, S]]		[[Category: Inaba, S]]

OCA at 06:12, 10 May 2017

2017-05-10T06:12:31Z

←Older revision		Revision as of 06:12, 10 May 2017
Line 7:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wa4\|3wa4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wa4\|3wa4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aul OCA], [http://pdbe.org/5aul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aul RCSB], [http://www.ebi.ac.uk/pdbsum/5aul PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aul OCA], [http://pdbe.org/5aul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aul RCSB], [http://www.ebi.ac.uk/pdbsum/5aul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aul ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/P85A_HUMAN P85A_HUMAN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.<ref>PMID:7518429</ref> <ref>PMID:17626883</ref> <ref>PMID:19805105</ref> [[http://www.uniprot.org/uniprot/CD28_HUMAN CD28_HUMAN]] Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.		[[http://www.uniprot.org/uniprot/P85A_HUMAN P85A_HUMAN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.<ref>PMID:7518429</ref> <ref>PMID:17626883</ref> <ref>PMID:19805105</ref> [[http://www.uniprot.org/uniprot/CD28_HUMAN CD28_HUMAN]] Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Full activation of T cells and differentiation into effector T cells are essential for many immune responses and require co-stimulatory signaling via the CD28 receptor. Extracellular ligand binding to CD28 recruits protein-tyrosine kinases to its cytoplasmic tail, which contains a YMNM motif. Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2), Grb2-related adaptor downstream of Shc (Gads), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 with variable affinity, and all are important for CD28-mediated co-stimulatory function. However, the mechanism of how these proteins recognize and compete for CD28 is unclear. To visualize their interactions with CD28, we have determined the crystal structures of Gads SH2 and two p85 SH2 domains in complex with a CD28-derived phosphopeptide. The high resolution structures obtained revealed that, whereas the CD28 phosphopeptide bound to Gads SH2 is in a bent conformation similar to that when bound to Grb2 SH2, it adopts a more extended conformation when bound to the N- and C-terminal SH2 domains of p85. These differences observed in the peptide-protein interactions correlated well with the affinity and other thermodynamic parameters for each interaction determined by isothermal titration calorimetry. The detailed insight into these interactions reported here may inform the development of compounds that specifically inhibit the association of CD28 with these adaptor proteins to suppress excessive T cell responses, such as in allergies and autoimmune diseases.
		+
		+	Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins.,Inaba S, Numoto N, Ogawa S, Morii H, Ikura T, Abe R, Ito N, Oda M J Biol Chem. 2017 Jan 20;292(3):1052-1060. doi: 10.1074/jbc.M116.755173. Epub, 2016 Dec 6. PMID:27927989<ref>PMID:27927989</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5aul" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:53, 1 June 2016

2016-06-01T22:53:45Z

←Older revision		Revision as of 22:53, 1 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5aul is ~~ON HOLD until Paper Publication~~	+	==PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex==
-		+	<StructureSection load='5aul' size='340' side='right' caption='[[5aul]], [[Resolution\|resolution]] 1.10Å' scene=''>
-	~~Authors~~: ~~Inaba,~~ S., ~~Numoto~~, N., ~~Morii~~, H., ~~Ikura~~, T., ~~Oda~~, M., ~~Ito~~, N.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5aul]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AUL FirstGlance]. <br>
-	~~Description: PI3K p85 C-terminal SH2 domain~~/~~CD28-derived peptide complex~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wa4\|3wa4]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aul OCA], [http://pdbe.org/5aul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aul RCSB], [http://www.ebi.ac.uk/pdbsum/5aul PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/P85A_HUMAN P85A_HUMAN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.<ref>PMID:7518429</ref> <ref>PMID:17626883</ref> <ref>PMID:19805105</ref> [[http://www.uniprot.org/uniprot/CD28_HUMAN CD28_HUMAN]] Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ikura, T]]
	[[Category: Inaba, S]]		[[Category: Inaba, S]]
		+	[[Category: Ito, N]]
		+	[[Category: Morii, H]]
	[[Category: Numoto, N]]		[[Category: Numoto, N]]
	[[Category: Oda, M]]		[[Category: Oda, M]]
-	[[Category: ~~Morii, H~~]]	+	[[Category: Antigen]]
-	[[Category: ~~Ito, N~~]]	+	[[Category: Phosphopeptide]]
-	[[Category: ~~Ikura, T~~]]	+	[[Category: Signaling protein]]

OCA at 09:56, 16 December 2015

2015-12-16T09:56:57Z

←Older revision		Revision as of 09:56, 16 December 2015
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Inaba, S]]		[[Category: Inaba, S]]
-	[[Category: Morii, H]]
	[[Category: Numoto, N]]		[[Category: Numoto, N]]
	[[Category: Oda, M]]		[[Category: Oda, M]]
		+	[[Category: Morii, H]]
	[[Category: Ito, N]]		[[Category: Ito, N]]
	[[Category: Ikura, T]]		[[Category: Ikura, T]]

OCA at 11:24, 20 May 2015

2015-05-20T11:24:15Z

←Older revision		Revision as of 11:24, 20 May 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5aul is ON HOLD	+	The entry 5aul is ON HOLD until Paper Publication

	Authors: Inaba, S., Numoto, N., Morii, H., Ikura, T., Oda, M., Ito, N.		Authors: Inaba, S., Numoto, N., Morii, H., Ikura, T., Oda, M., Ito, N.

OCA: Protected "5aul" [edit=sysop:move=sysop]

2015-05-06T12:09:04Z

Protected "5aul" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:09, 6 May 2015

OCA: New page: '''Unreleased structure''' The entry 5aul is ON HOLD Authors: Inaba, S., Numoto, N., Morii, H., Ikura, T., Oda, M., Ito, N. Description: PI3K p85 C-terminal SH2 domain/CD28-derived pep...

2015-05-06T12:09:03Z

New page: '''Unreleased structure''' The entry 5aul is ON HOLD Authors: Inaba, S., Numoto, N., Morii, H., Ikura, T., Oda, M., Ito, N. Description: PI3K p85 C-terminal SH2 domain/CD28-derived pep...

New page

'''Unreleased structure'''

The entry 5aul is ON HOLD

Authors: Inaba, S., Numoto, N., Morii, H., Ikura, T., Oda, M., Ito, N.

Description: PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex
[[Category: Unreleased Structures]]
[[Category: Inaba, S]]
[[Category: Morii, H]]
[[Category: Numoto, N]]
[[Category: Oda, M]]
[[Category: Ito, N]]
[[Category: Ikura, T]]