5bpu - Revision history

OCA at 06:03, 7 June 2023

2023-06-07T06:03:13Z

←Older revision		Revision as of 06:03, 7 June 2023
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	<StructureSection load='5bpu' size='340' side='right'caption='[[5bpu]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5bpu' size='340' side='right'caption='[[5bpu]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5bpu]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5BPU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5bpu]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BPU FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=GGL:GAMMA-L-GLUTAMIC+ACID'>GGL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GGL:GAMMA-L-GLUTAMIC+ACID'>GGL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4my2\|4my2]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpu OCA], [https://pdbe.org/5bpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bpu RCSB], [https://www.ebi.ac.uk/pdbsum/5bpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpu ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDP, EVR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5bpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpu OCA], [~~http~~://pdbe.org/5bpu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5bpu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5bpu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpu ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN]] Retinopathy of prematurity;Familial exudative vitreoretinopathy;Coats disease;Persistent hyperplastic primary vitreous;Norrie disease. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN] Retinopathy of prematurity;Familial exudative vitreoretinopathy;Coats disease;Persistent hyperplastic primary vitreous;Norrie disease. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN]] Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.	+	[https://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN] Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chang, T H]]	+	[[Category: Synthetic construct]]
-	[[Category: Harlos, K]]	+	[[Category: Chang T-H]]
-	[[Category: Hsieh, F L]]	+	[[Category: Harlos K]]
-	[[Category: Jones~~, E Y]]~~	+	[[Category: Hsieh F-L]]
-	~~[[Category: Cystine-knot like growth factor]]~~	+	[[Category: Jones EY]]
-	~~[[Category: Ligand for frizzled 4 receptor]]~~	+
-	~~[[Category: Norrie disease protein]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Wnt signalling pathway~~]]	+

OCA at 06:08, 10 July 2019

2019-07-10T06:08:25Z

←Older revision		Revision as of 06:08, 10 July 2019
Line 1:		Line 1:

	==Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I==		==Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I==
-	<StructureSection load='5bpu' size='340' side='right' caption='[[5bpu]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5bpu' size='340' side='right'caption='[[5bpu]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5bpu]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPU FirstGlance]. <br>		<table><tr><td colspan='2'>[[5bpu]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPU FirstGlance]. <br>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chang, T H]]		[[Category: Chang, T H]]
	[[Category: Harlos, K]]		[[Category: Harlos, K]]

OCA at 07:06, 21 February 2019

2019-02-21T07:06:43Z

←Older revision		Revision as of 07:06, 21 February 2019
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	<StructureSection load='5bpu' size='340' side='right' caption='[[5bpu]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5bpu' size='340' side='right' caption='[[5bpu]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5bpu]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5bpu]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPU FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GGL:GAMMA-L-GLUTAMIC+ACID'>GGL</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GGL:GAMMA-L-GLUTAMIC+ACID'>GGL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4my2\|4my2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4my2\|4my2]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDP, EVR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpu OCA], [http://pdbe.org/5bpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpu RCSB], [http://www.ebi.ac.uk/pdbsum/5bpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpu OCA], [http://pdbe.org/5bpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpu RCSB], [http://www.ebi.ac.uk/pdbsum/5bpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpu ProSAT]</span></td></tr>
	</table>		</table>
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Chang, T H]]		[[Category: Chang, T H]]
	[[Category: Harlos, K]]		[[Category: Harlos, K]]

OCA at 13:27, 4 May 2017

2017-05-04T13:27:14Z

←Older revision		Revision as of 13:27, 4 May 2017
Line 1:		Line 1:
		+
	==Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I==		==Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I==
	<StructureSection load='5bpu' size='340' side='right' caption='[[5bpu]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5bpu' size='340' side='right' caption='[[5bpu]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GGL:GAMMA-L-GLUTAMIC+ACID'>GGL</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GGL:GAMMA-L-GLUTAMIC+ACID'>GGL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4my2\|4my2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4my2\|4my2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bpu RCSB], [http://www.ebi.ac.uk/pdbsum/5bpu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpu OCA], [http://pdbe.org/5bpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpu RCSB], [http://www.ebi.ac.uk/pdbsum/5bpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpu ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5bpu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:58, 22 July 2015

2015-07-22T07:58:37Z

←Older revision		Revision as of 07:58, 22 July 2015
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN]] Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.		[[http://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN]] Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Wnt signalling regulates multiple processes including angiogenesis, inflammation, and tumorigenesis. Norrin (Norrie Disease Protein) is a cystine-knot like growth factor. Although unrelated to Wnt, Norrin activates the Wnt/beta-catenin pathway. Signal complex formation involves Frizzled4 (Fz4), low-density lipoprotein receptor related protein 5/6 (Lrp5/6), Tetraspanin-12 and glycosaminoglycans (GAGs). Here, we report crystallographic and small-angle X-ray scattering analyses of Norrin in complex with Fz4 cysteine-rich domain (Fz4CRD), of this complex bound with GAG analogues, and of unliganded Norrin and Fz4CRD. Our structural, biophysical and cellular data, map Fz4 and putative Lrp5/6 binding sites to distinct patches on Norrin, and reveal a GAG binding site spanning Norrin and Fz4CRD. These results explain numerous disease-associated mutations. Comparison with the Xenopus Wnt8-mouse Fz8CRD complex reveals Norrin mimics Wnt for Frizzled recognition. The production and characterization of wild-type and mutant Norrins reported here open new avenues for the development of therapeutics to combat abnormal Norrin/Wnt signalling.
		+
		+	Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.,Chang TH, Hsieh FL, Zebisch M, Harlos K, Elegheert J, Jones EY Elife. 2015 Jul 9;4. doi: 10.7554/eLife.06554. PMID:26158506<ref>PMID:26158506</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:27, 1 July 2015

2015-07-01T12:27:49Z

←Older revision		Revision as of 12:27, 1 July 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I==
-		+	<StructureSection load='5bpu' size='340' side='right' caption='[[5bpu]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~The entry~~ 5bpu is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5bpu]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPU FirstGlance]. <br>
-	~~Authors~~: ~~Chang, T~~.-H., ~~Hsieh, F~~.-L., ~~Harlos, K~~., ~~Jones, E~~.Y.	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GGL:GAMMA-L-GLUTAMIC+ACID'>GGL</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4my2\|4my2]]</td></tr>
-	~~Description:~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bpu RCSB], [http://www.ebi.ac.uk/pdbsum/5bpu PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Hsieh~~, F.-L]]	+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN]] Retinopathy of prematurity;Familial exudative vitreoretinopathy;Coats disease;Persistent hyperplastic primary vitreous;Norrie disease. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN]] Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chang, T H]]
	[[Category: Harlos, K]]		[[Category: Harlos, K]]
-	[[Category: Jones, E.Y]]	+	[[Category: Hsieh, F L]]
-	[[Category: ~~Chang, T.~~-H]]	+	[[Category: Jones, E Y]]
		+	[[Category: Cystine-knot like growth factor]]
		+	[[Category: Ligand for frizzled 4 receptor]]
		+	[[Category: Norrie disease protein]]
		+	[[Category: Signaling protein]]
		+	[[Category: Wnt signalling pathway]]

OCA: Protected "5bpu" [edit=sysop:move=sysop]

2015-06-03T11:47:07Z

Protected "5bpu" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:47, 3 June 2015

OCA: New page: '''Unreleased structure''' The entry 5bpu is ON HOLD Authors: Chang, T.-H., Hsieh, F.-L., Harlos, K., Jones, E.Y. Description: Category: Unreleased Structures [[Category: Hsieh, F...

2015-06-03T11:47:06Z

New page: '''Unreleased structure''' The entry 5bpu is ON HOLD Authors: Chang, T.-H., Hsieh, F.-L., Harlos, K., Jones, E.Y. Description: Category: Unreleased Structures [[Category: Hsieh, F...

New page

'''Unreleased structure'''

The entry 5bpu is ON HOLD

Authors: Chang, T.-H., Hsieh, F.-L., Harlos, K., Jones, E.Y.

Description:
[[Category: Unreleased Structures]]
[[Category: Hsieh, F.-L]]
[[Category: Harlos, K]]
[[Category: Jones, E.Y]]
[[Category: Chang, T.-H]]