5c3i - Revision history

OCA at 16:06, 8 November 2023

2023-11-08T16:06:13Z

←Older revision		Revision as of 16:06, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5c3i]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C3I FirstGlance]. <br>		<table><tr><td colspan='2'>[[5c3i]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C3I FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3i OCA], [https://pdbe.org/5c3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c3i RCSB], [https://www.ebi.ac.uk/pdbsum/5c3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c3i ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3i OCA], [https://pdbe.org/5c3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c3i RCSB], [https://www.ebi.ac.uk/pdbsum/5c3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c3i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 06:18, 7 June 2023

2023-06-07T06:18:39Z

←Older revision		Revision as of 06:18, 7 June 2023
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	<StructureSection load='5c3i' size='340' side='right'caption='[[5c3i]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='5c3i' size='340' side='right'caption='[[5c3i]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5c3i]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5C3I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5c3i]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C3I FirstGlance]. <br>
-	</td></tr>~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3i OCA], [https://pdbe.org/5c3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c3i RCSB], [https://www.ebi.ac.uk/pdbsum/5c3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c3i ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5c3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3i OCA], [~~http~~://pdbe.org/5c3i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5c3i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5c3i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5c3i ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/MCM2_HUMAN MCM2_HUMAN]] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.<ref>PMID:8175912</ref> [[http://www.uniprot.org/uniprot/ASF1A_HUMAN ASF1A_HUMAN]] Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.<ref>PMID:10759893</ref> <ref>PMID:11897662</ref> <ref>PMID:12842904</ref> <ref>PMID:14718166</ref> <ref>PMID:15621527</ref> <ref>PMID:16151251</ref> <ref>PMID:15664198</ref>	+	[https://www.uniprot.org/uniprot/ASF1A_HUMAN ASF1A_HUMAN] Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.<ref>PMID:10759893</ref> <ref>PMID:11897662</ref> <ref>PMID:12842904</ref> <ref>PMID:14718166</ref> <ref>PMID:15621527</ref> <ref>PMID:16151251</ref> <ref>PMID:15664198</ref>
		+
		+	==See Also==
		+	*[[Anti-silencing factor 3D structures\|Anti-silencing factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~DNA helicase~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Wang, H]]	+	[[Category: Wang H]]
-	[[Category: Wang, M]]	+	[[Category: Wang M]]
-	[[Category: Xu~~, R M~~]]	+	[[Category: Xu RM]]
-	[[Category: Yang, N]]	+	[[Category: Yang N]]
-	~~[[Category: Asf1]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Histone]]~~	+
-	~~[[Category: Mcm protein]]~~	+
-	~~[[Category: Replication~~]]	+

OCA at 11:10, 18 March 2020

2020-03-18T11:10:10Z

←Older revision		Revision as of 11:10, 18 March 2020
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	==Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2==		==Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2==
-	<StructureSection load='5c3i' size='340' side='right' caption='[[5c3i]], [[Resolution\|resolution]] 3.50Å' scene=''>	+	<StructureSection load='5c3i' size='340' side='right'caption='[[5c3i]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5c3i]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C3I FirstGlance]. <br>		<table><tr><td colspan='2'>[[5c3i]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C3I FirstGlance]. <br>
Line 15:		Line 15:
	</StructureSection>		</StructureSection>
	[[Category: DNA helicase]]		[[Category: DNA helicase]]
		+	[[Category: Large Structures]]
	[[Category: Wang, H]]		[[Category: Wang, H]]
	[[Category: Wang, M]]		[[Category: Wang, M]]

OCA at 09:59, 18 October 2017

2017-10-18T09:59:01Z

←Older revision		Revision as of 09:59, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2==		==Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2==
	<StructureSection load='5c3i' size='340' side='right' caption='[[5c3i]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='5c3i' size='340' side='right' caption='[[5c3i]], [[Resolution\|resolution]] 3.50Å' scene=''>
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5c3i RCSB], [http://www.ebi.ac.uk/pdbsum/5c3i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3i OCA], [http://pdbe.org/5c3i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c3i RCSB], [http://www.ebi.ac.uk/pdbsum/5c3i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5c3i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 14:44, 29 July 2015

2015-07-29T14:44:58Z

←Older revision		Revision as of 14:44, 29 July 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2==
-		+	<StructureSection load='5c3i' size='340' side='right' caption='[[5c3i]], [[Resolution\|resolution]] 3.50Å' scene=''>
-	~~The entry~~ 5c3i is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5c3i]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C3I FirstGlance]. <br>
-	~~Authors~~: ~~Wang~~, H., ~~Wang, M~~., ~~Yang, N~~., ~~Xu, R~~.M.	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
-	~~Description~~: ~~Crystal structure~~ of the ~~quaternary~~ complex of ~~histone H3~~-~~H4 heterodimer with~~ chaperone ~~ASF1~~ and the ~~replicative~~ helicase ~~subunit MCM2~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5c3i RCSB], [http://www.ebi.ac.uk/pdbsum/5c3i PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MCM2_HUMAN MCM2_HUMAN]] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.<ref>PMID:8175912</ref> [[http://www.uniprot.org/uniprot/ASF1A_HUMAN ASF1A_HUMAN]] Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.<ref>PMID:10759893</ref> <ref>PMID:11897662</ref> <ref>PMID:12842904</ref> <ref>PMID:14718166</ref> <ref>PMID:15621527</ref> <ref>PMID:16151251</ref> <ref>PMID:15664198</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: DNA helicase]]
		+	[[Category: Wang, H]]
	[[Category: Wang, M]]		[[Category: Wang, M]]
-	[[Category: Xu, R.M]]	+	[[Category: Xu, R M]]
	[[Category: Yang, N]]		[[Category: Yang, N]]
-	[[Category: ~~Wang, H~~]]	+	[[Category: Asf1]]
		+	[[Category: Chaperone]]
		+	[[Category: Histone]]
		+	[[Category: Mcm protein]]
		+	[[Category: Replication]]

OCA at 12:08, 15 July 2015

2015-07-15T12:08:48Z

←Older revision		Revision as of 12:08, 15 July 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5c3i is ON HOLD	+	The entry 5c3i is ON HOLD until Paper Publication

	Authors: Wang, H., Wang, M., Yang, N., Xu, R.M.		Authors: Wang, H., Wang, M., Yang, N., Xu, R.M.

OCA: Protected "5c3i" [edit=sysop:move=sysop]

2015-06-24T12:02:08Z

Protected "5c3i" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:02, 24 June 2015

OCA: New page: '''Unreleased structure''' The entry 5c3i is ON HOLD Authors: Wang, H., Wang, M., Yang, N., Xu, R.M. Description: Crystal structure of the quaternary complex of histone H3-H4 heterodim...

2015-06-24T12:02:06Z

New page: '''Unreleased structure''' The entry 5c3i is ON HOLD Authors: Wang, H., Wang, M., Yang, N., Xu, R.M. Description: Crystal structure of the quaternary complex of histone H3-H4 heterodim...

New page

'''Unreleased structure'''

The entry 5c3i is ON HOLD

Authors: Wang, H., Wang, M., Yang, N., Xu, R.M.

Description: Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2
[[Category: Unreleased Structures]]
[[Category: Wang, M]]
[[Category: Xu, R.M]]
[[Category: Yang, N]]
[[Category: Wang, H]]