5cbf - Revision history

OCA at 08:36, 27 September 2023

2023-09-27T08:36:35Z

←Older revision		Revision as of 08:36, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cbf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Tsukamurella_paurometabola_DSM_20162 Tsukamurella paurometabola DSM 20162]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CBF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cbf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Tsukamurella_paurometabola_DSM_20162 Tsukamurella paurometabola DSM 20162]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CBF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.61Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cbf OCA], [https://pdbe.org/5cbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cbf RCSB], [https://www.ebi.ac.uk/pdbsum/5cbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cbf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cbf OCA], [https://pdbe.org/5cbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cbf RCSB], [https://www.ebi.ac.uk/pdbsum/5cbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cbf ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:55, 14 June 2023

2023-06-14T11:55:30Z

←Older revision		Revision as of 11:55, 14 June 2023
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	<StructureSection load='5cbf' size='340' side='right'caption='[[5cbf]], [[Resolution\|resolution]] 3.61Å' scene=''>		<StructureSection load='5cbf' size='340' side='right'caption='[[5cbf]], [[Resolution\|resolution]] 3.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5cbf]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Corynebacterium_paurometabolum Corynebacterium paurometabolum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CBF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CBF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5cbf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Tsukamurella_paurometabola_DSM_20162 Tsukamurella paurometabola DSM 20162]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CBF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cbg\|5cbg]], [[5cbh\|5cbh]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cbf OCA], [https://pdbe.org/5cbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cbf RCSB], [https://www.ebi.ac.uk/pdbsum/5cbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cbf ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tpau_1687 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=521096 Corynebacterium paurometabolum])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cbf OCA], [~~http~~://pdbe.org/5cbf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cbf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cbf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cbf ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/D5UM26_TSUPD D5UM26_TSUPD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Corynebacterium paurometabolum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blachowicz, L]]	+	[[Category: Tsukamurella paurometabola DSM 20162]]
-	[[Category: Dhakshnamoorthy, B]]	+	[[Category: Blachowicz L]]
-	[[Category: Rohaim, A]]	+	[[Category: Dhakshnamoorthy B]]
-	[[Category: Roux, B]]	+	[[Category: Rohaim A]]
-	[[Category: Rui, H]]	+	[[Category: Roux B]]
-	~~[[Category: 2tm helix ion channel family]]~~	+	[[Category: Rui H]]
-	~~[[Category: Calcium activated non-selective ion channel]]~~	+
-	~~[[Category: Ion transport]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Tetrameric cation channel]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 11:12, 25 December 2019

2019-12-25T11:12:07Z

←Older revision		Revision as of 11:12, 25 December 2019
Line 1:		Line 1:

	==Structural and Functional Characterization of a Calcium-activated Cation channel from Tsukamurella Paurometabola==		==Structural and Functional Characterization of a Calcium-activated Cation channel from Tsukamurella Paurometabola==
-	<StructureSection load='5cbf' size='340' side='right' caption='[[5cbf]], [[Resolution\|resolution]] 3.61Å' scene=''>	+	<StructureSection load='5cbf' size='340' side='right'caption='[[5cbf]], [[Resolution\|resolution]] 3.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cbf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_paurometabolum Corynebacterium paurometabolum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CBF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CBF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cbf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_paurometabolum Corynebacterium paurometabolum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CBF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CBF FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Corynebacterium paurometabolum]]		[[Category: Corynebacterium paurometabolum]]
		+	[[Category: Large Structures]]
	[[Category: Blachowicz, L]]		[[Category: Blachowicz, L]]
	[[Category: Dhakshnamoorthy, B]]		[[Category: Dhakshnamoorthy, B]]

OCA at 06:02, 8 March 2018

2018-03-08T06:02:48Z

←Older revision		Revision as of 06:02, 8 March 2018
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cbf OCA], [http://pdbe.org/5cbf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cbf RCSB], [http://www.ebi.ac.uk/pdbsum/5cbf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cbf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cbf OCA], [http://pdbe.org/5cbf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cbf RCSB], [http://www.ebi.ac.uk/pdbsum/5cbf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cbf ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The selectivity filter is an essential functional element of K(+) channels that is highly conserved both in terms of its primary sequence and its three-dimensional structure. Here, we investigate the properties of an ion channel from the Gram-positive bacterium Tsukamurella paurometabola with a selectivity filter formed by an uncommon proline-rich sequence. Electrophysiological recordings show that it is a non-selective cation channel and that its activity depends on Ca(2+) concentration. In the crystal structure, the selectivity filter adopts a novel conformation with Ca(2+) ions bound within the filter near the pore helix where they are coordinated by backbone oxygen atoms, a recurrent motif found in multiple proteins. The binding of Ca(2+) ion in the selectivity filter controls the widening of the pore as shown in crystal structures and in molecular dynamics simulations. The structural, functional and computational data provide a characterization of this calcium-gated cationic channel.
		+
		+	Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola.,Dhakshnamoorthy B, Rohaim A, Rui H, Blachowicz L, Roux B Nat Commun. 2016 Sep 28;7:12753. doi: 10.1038/ncomms12753. PMID:27678077<ref>PMID:27678077</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5cbf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Corynebacterium paurometabolum]]		[[Category: Corynebacterium paurometabolum]]
-	[[Category: ~~Balasundaresan~~, D]]	+	[[Category: Blachowicz, L]]
-	[[Category: ~~Benoit~~, R]]	+	[[Category: Dhakshnamoorthy, B]]
		+	[[Category: Rohaim, A]]
		+	[[Category: Roux, B]]
		+	[[Category: Rui, H]]
	[[Category: 2tm helix ion channel family]]		[[Category: 2tm helix ion channel family]]
	[[Category: Calcium activated non-selective ion channel]]		[[Category: Calcium activated non-selective ion channel]]

OCA at 09:10, 1 November 2017

2017-11-01T09:10:42Z

←Older revision		Revision as of 09:10, 1 November 2017
Line 3:		Line 3:
	<StructureSection load='5cbf' size='340' side='right' caption='[[5cbf]], [[Resolution\|resolution]] 3.61Å' scene=''>		<StructureSection load='5cbf' size='340' side='right' caption='[[5cbf]], [[Resolution\|resolution]] 3.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5cbf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CBF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CBF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5cbf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_paurometabolum Corynebacterium paurometabolum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CBF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CBF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cbg\|5cbg]], [[5cbh\|5cbh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cbg\|5cbg]], [[5cbh\|5cbh]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tpau_1687 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=521096 Corynebacterium paurometabolum])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cbf OCA], [http://pdbe.org/5cbf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cbf RCSB], [http://www.ebi.ac.uk/pdbsum/5cbf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cbf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cbf OCA], [http://pdbe.org/5cbf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cbf RCSB], [http://www.ebi.ac.uk/pdbsum/5cbf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cbf ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Corynebacterium paurometabolum]]
	[[Category: Balasundaresan, D]]		[[Category: Balasundaresan, D]]
	[[Category: Benoit, R]]		[[Category: Benoit, R]]

OCA at 15:25, 26 July 2016

2016-07-26T15:25:54Z

←Older revision		Revision as of 15:25, 26 July 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5cbf is ON HOLD until Paper Publication~~	+	==Structural and Functional Characterization of a Calcium-activated Cation channel from Tsukamurella Paurometabola==
-		+	<StructureSection load='5cbf' size='340' side='right' caption='[[5cbf]], [[Resolution\|resolution]] 3.61Å' scene=''>
-	~~Authors: Balasundaresan, D., Benoit, R.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5cbf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CBF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CBF FirstGlance]. <br>
-	~~Description:~~ Structural and Functional Characterization of a Calcium-activated Cation channel from Tsukamurella Paurometabola	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cbg\|5cbg]], [[5cbh\|5cbh]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cbf OCA], [http://pdbe.org/5cbf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cbf RCSB], [http://www.ebi.ac.uk/pdbsum/5cbf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cbf ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Balasundaresan, D]]		[[Category: Balasundaresan, D]]
	[[Category: Benoit, R]]		[[Category: Benoit, R]]
		+	[[Category: 2tm helix ion channel family]]
		+	[[Category: Calcium activated non-selective ion channel]]
		+	[[Category: Ion transport]]
		+	[[Category: Membrane protein]]
		+	[[Category: Tetrameric cation channel]]
		+	[[Category: Transport protein]]

OCA at 19:38, 12 July 2016

2016-07-12T19:38:13Z

←Older revision		Revision as of 19:38, 12 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5cbf is ON HOLD	+	The entry 5cbf is ON HOLD until Paper Publication

	Authors: Balasundaresan, D., Benoit, R.		Authors: Balasundaresan, D., Benoit, R.

OCA at 09:18, 20 June 2016

2016-06-20T09:18:34Z

←Older revision		Revision as of 09:18, 20 June 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5cbf is ON HOLD ~~until Paper Publication~~	+	The entry 5cbf is ON HOLD

	Authors: Balasundaresan, D., Benoit, R.		Authors: Balasundaresan, D., Benoit, R.

OCA at 12:59, 12 August 2015

2015-08-12T12:59:23Z

←Older revision		Revision as of 12:59, 12 August 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5cbf is ON HOLD	+	The entry 5cbf is ON HOLD until Paper Publication

	Authors: Balasundaresan, D., Benoit, R.		Authors: Balasundaresan, D., Benoit, R.

OCA at 12:20, 15 July 2015

2015-07-15T12:20:39Z

←Older revision		Revision as of 12:20, 15 July 2015
Line 3:		Line 3:
	The entry 5cbf is ON HOLD		The entry 5cbf is ON HOLD

-	Authors: ~~Dhakshnamoorthy~~ Balasundaresan, ~~Roux~~ Benoit	+	Authors: Balasundaresan, D., Benoit, R.

	Description: Structural and Functional Characterization of a Calcium-activated Cation channel from Tsukamurella Paurometabola		Description: Structural and Functional Characterization of a Calcium-activated Cation channel from Tsukamurella Paurometabola
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Dhakshnamoorthy~~ Balasundaresan, ~~Roux~~ Benoit]]	+	[[Category: Balasundaresan, D]]
		+	[[Category: Benoit, R]]