5ccg - Revision history

OCA at 08:36, 27 September 2023

2023-09-27T08:36:56Z

←Older revision		Revision as of 08:36, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ccg]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CCG FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ccg]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CCG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ccg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccg OCA], [https://pdbe.org/5ccg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ccg RCSB], [https://www.ebi.ac.uk/pdbsum/5ccg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ccg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ccg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccg OCA], [https://pdbe.org/5ccg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ccg RCSB], [https://www.ebi.ac.uk/pdbsum/5ccg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ccg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:58, 14 June 2023

2023-06-14T11:58:27Z

←Older revision		Revision as of 11:58, 14 June 2023
Line 1:		Line 1:

	==Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form)==		==Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form)==
-	<StructureSection load='5ccg' size='340' side='right' caption='[[5ccg]], [[Resolution\|resolution]] 3.50Å' scene=''>	+	<StructureSection load='5ccg' size='340' side='right'caption='[[5ccg]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ccg]] is a 11 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CCG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ccg]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CCG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cch\|5cch]], [[5cci\|5cci]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ccg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccg OCA], [https://pdbe.org/5ccg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ccg RCSB], [https://www.ebi.ac.uk/pdbsum/5ccg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ccg ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Vamp2, Syb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Stx1a, Sap ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Snap25, Snap ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Syt1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ccg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccg OCA], [~~http~~://pdbe.org/5ccg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ccg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ccg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ccg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/SNP25_RAT SNP25_RAT]] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. [[http://www.uniprot.org/uniprot/VAMP2_RAT VAMP2_RAT]] Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). [[http://www.uniprot.org/uniprot/STX1A_RAT STX1A_RAT]] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. [[http://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.	+	[https://www.uniprot.org/uniprot/VAMP2_RAT VAMP2_RAT] Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5ccg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ccg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Synaptosomal-associated protein\|Synaptosomal-associated protein]]
		+	*[[Synaptotagmin 3D structures\|Synaptotagmin 3D structures]]
		+	*[[Syntaxin 3D structures\|Syntaxin 3D structures]]
		+	*[[Vesicle-associated membrane protein\|Vesicle-associated membrane protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat~~]]	+	[[Category: Large Structures]]
-	[[Category: Brunger~~, A T~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Lyubimov~~, A Y~~]]	+	[[Category: Brunger AT]]
-	[[Category: Uervirojnangkoorn, M]]	+	[[Category: Lyubimov AY]]
-	[[Category: Weis~~, W I~~]]	+	[[Category: Uervirojnangkoorn M]]
-	[[Category: Zeldin~~, O B~~]]	+	[[Category: Weis WI]]
-	[[Category: Zhao, M]]	+	[[Category: Zeldin OB]]
-	[[Category: Zhou, Q]]	+	[[Category: Zhao M]]
-	~~[[Category: Endocytosis]]~~	+	[[Category: Zhou Q]]
-	~~[[Category: Exocytosis]]~~	+
-	~~[[Category: Neuronal snare complex]]~~	+
-	~~[[Category: Synaptic fusion complex]]~~	+
-	~~[[Category: Synaptotagmin1]]~~	+
-	~~[[Category: Xfel structure~~]]	+

OCA at 18:08, 16 November 2017

2017-11-16T18:08:56Z

←Older revision		Revision as of 18:08, 16 November 2017
Line 1:		Line 1:
		+
	==Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form)==		==Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form)==
	<StructureSection load='5ccg' size='340' side='right' caption='[[5ccg]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='5ccg' size='340' side='right' caption='[[5ccg]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ccg]] is a 11 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CCG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ccg]] is a 11 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CCG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cch\|5cch]], [[5cci\|5cci]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cch\|5cch]], [[5cci\|5cci]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ccg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccg OCA], [http://pdbe.org/5ccg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ccg RCSB], [http://www.ebi.ac.uk/pdbsum/5ccg PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Vamp2, Syb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Stx1a, Sap ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Snap25, Snap ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Syt1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ccg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccg OCA], [http://pdbe.org/5ccg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ccg RCSB], [http://www.ebi.ac.uk/pdbsum/5ccg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ccg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Brunger, A T]]		[[Category: Brunger, A T]]
	[[Category: Lyubimov, A Y]]		[[Category: Lyubimov, A Y]]

OCA at 08:16, 30 September 2015

2015-09-30T08:16:14Z

←Older revision		Revision as of 08:16, 30 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cch\|5cch]], [[5cci\|5cci]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cch\|5cch]], [[5cci\|5cci]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ccg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ccg RCSB], [http://www.ebi.ac.uk/pdbsum/5ccg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ccg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccg OCA], [http://pdbe.org/5ccg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ccg RCSB], [http://www.ebi.ac.uk/pdbsum/5ccg PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5ccg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:42, 2 September 2015

2015-09-02T06:42:55Z

←Older revision		Revision as of 06:42, 2 September 2015
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SNP25_RAT SNP25_RAT]] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. [[http://www.uniprot.org/uniprot/VAMP2_RAT VAMP2_RAT]] Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). [[http://www.uniprot.org/uniprot/STX1A_RAT STX1A_RAT]] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. [[http://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.		[[http://www.uniprot.org/uniprot/SNP25_RAT SNP25_RAT]] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. [[http://www.uniprot.org/uniprot/VAMP2_RAT VAMP2_RAT]] Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). [[http://www.uniprot.org/uniprot/STX1A_RAT STX1A_RAT]] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. [[http://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Synaptotagmin-1 and neuronal SNARE proteins have central roles in evoked synchronous neurotransmitter release; however, it is unknown how they cooperate to trigger synaptic vesicle fusion. Here we report atomic-resolution crystal structures of Ca2+- and Mg2+-bound complexes between synaptotagmin-1 and the neuronal SNARE complex, one of which was determined with diffraction data from an X-ray free-electron laser, leading to an atomic-resolution structure with accurate rotamer assignments for many side chains. The structures reveal several interfaces, including a large, specific, Ca2+-independent and conserved interface. Tests of this interface by mutagenesis suggest that it is essential for Ca2+-triggered neurotransmitter release in mouse hippocampal neuronal synapses and for Ca2+-triggered vesicle fusion in a reconstituted system. We propose that this interface forms before Ca2+ triggering, moves en bloc as Ca2+ influx promotes the interactions between synaptotagmin-1 and the plasma membrane, and consequently remodels the membrane to promote fusion, possibly in conjunction with other interfaces.
		+
		+	Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.,Zhou Q, Lai Y, Bacaj T, Zhao M, Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Brewster AS, Sauter NK, Cohen AE, Soltis SM, Alonso-Mori R, Chollet M, Lemke HT, Pfuetzner RA, Choi UB, Weis WI, Diao J, Sudhof TC, Brunger AT Nature. 2015 Aug 17. doi: 10.1038/nature14975. PMID:26280336<ref>PMID:26280336</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:55, 12 August 2015

2015-08-12T14:55:04Z

←Older revision		Revision as of 14:55, 12 August 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form)==
-		+	<StructureSection load='5ccg' size='340' side='right' caption='[[5ccg]], [[Resolution\|resolution]] 3.50Å' scene=''>
-	~~The entry~~ 5ccg is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ccg]] is a 11 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CCG FirstGlance]. <br>
-	~~Authors~~: ~~Zhou~~, Q.~~, Zhao, M~~.~~, Lyubimov, A~~.Y., ~~Uervirojnangkoorn, M~~.~~, Zeldin, O~~.B., ~~Weis, W~~.I., ~~Brunger, A~~.T.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cch\|5cch]], [[5cci\|5cci]]</td></tr>
-	~~Description~~: ~~Structure~~ of the ~~Ca2~~+-~~bound~~ synaptic ~~fusion complex~~ (~~long unit cell form~~)	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ccg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ccg RCSB], [http://www.ebi.ac.uk/pdbsum/5ccg PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: Lyubimov, A.Y]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SNP25_RAT SNP25_RAT]] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. [[http://www.uniprot.org/uniprot/VAMP2_RAT VAMP2_RAT]] Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). [[http://www.uniprot.org/uniprot/STX1A_RAT STX1A_RAT]] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. [[http://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brunger, A T]]
		+	[[Category: Lyubimov, A Y]]
	[[Category: Uervirojnangkoorn, M]]		[[Category: Uervirojnangkoorn, M]]
-	[[Category: ~~Zhou~~, Q]]	+	[[Category: Weis, W I]]
		+	[[Category: Zeldin, O B]]
	[[Category: Zhao, M]]		[[Category: Zhao, M]]
-	[[Category: ~~Brunger~~, ~~A.T~~]]	+	[[Category: Zhou, Q]]
-	[[Category: ~~Zeldin, O.B~~]]	+	[[Category: Endocytosis]]
-	[[Category: ~~Weis, W.I~~]]	+	[[Category: Exocytosis]]
		+	[[Category: Neuronal snare complex]]
		+	[[Category: Synaptic fusion complex]]
		+	[[Category: Synaptotagmin1]]
		+	[[Category: Xfel structure]]

OCA at 12:22, 15 July 2015

2015-07-15T12:22:28Z

←Older revision		Revision as of 12:22, 15 July 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ccg is ON HOLD	+	The entry 5ccg is ON HOLD until Paper Publication

	Authors: Zhou, Q., Zhao, M., Lyubimov, A.Y., Uervirojnangkoorn, M., Zeldin, O.B., Weis, W.I., Brunger, A.T.		Authors: Zhou, Q., Zhao, M., Lyubimov, A.Y., Uervirojnangkoorn, M., Zeldin, O.B., Weis, W.I., Brunger, A.T.

OCA: Protected "5ccg" [edit=sysop:move=sysop]

2015-07-08T13:59:53Z

Protected "5ccg" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:59, 8 July 2015

OCA: New page: '''Unreleased structure''' The entry 5ccg is ON HOLD Authors: Zhou, Q., Zhao, M., Lyubimov, A.Y., Uervirojnangkoorn, M., Zeldin, O.B., Weis, W.I., Brunger, A.T. Description: Structure ...

2015-07-08T13:59:51Z

New page: '''Unreleased structure''' The entry 5ccg is ON HOLD Authors: Zhou, Q., Zhao, M., Lyubimov, A.Y., Uervirojnangkoorn, M., Zeldin, O.B., Weis, W.I., Brunger, A.T. Description: Structure ...

New page

'''Unreleased structure'''

The entry 5ccg is ON HOLD

Authors: Zhou, Q., Zhao, M., Lyubimov, A.Y., Uervirojnangkoorn, M., Zeldin, O.B., Weis, W.I., Brunger, A.T.

Description: Structure of the Ca2+-bound synaptic fusion complex (long unit cell form)
[[Category: Unreleased Structures]]
[[Category: Lyubimov, A.Y]]
[[Category: Uervirojnangkoorn, M]]
[[Category: Zhou, Q]]
[[Category: Zhao, M]]
[[Category: Brunger, A.T]]
[[Category: Zeldin, O.B]]
[[Category: Weis, W.I]]