5cct - Revision history

OCA at 11:19, 10 January 2024

2024-01-10T11:19:43Z

←Older revision		Revision as of 11:19, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_virus_80alpha Staphylococcus virus 80alpha]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CCT FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_virus_80alpha Staphylococcus virus 80alpha]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CCT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cct OCA], [https://pdbe.org/5cct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cct RCSB], [https://www.ebi.ac.uk/pdbsum/5cct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cct ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cct OCA], [https://pdbe.org/5cct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cct RCSB], [https://www.ebi.ac.uk/pdbsum/5cct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cct ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:59, 14 June 2023

2023-06-14T11:59:13Z

←Older revision		Revision as of 11:59, 14 June 2023
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	<StructureSection load='5cct' size='340' side='right'caption='[[5cct]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5cct' size='340' side='right'caption='[[5cct]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5cct]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CCT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5cct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_virus_80alpha Staphylococcus virus 80alpha]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CCT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zez\|3zez]], [[5cco\|5cco]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cct OCA], [https://pdbe.org/5cct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cct RCSB], [https://www.ebi.ac.uk/pdbsum/5cct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cct ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cct OCA], [~~http~~://pdbe.org/5cct PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cct RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cct PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cct ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A4ZF98_9CAUD A4ZF98_9CAUD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alite, C]]	+	[[Category: Staphylococcus virus 80alpha]]
-	[[Category: Bowring, J]]	+	[[Category: Alite C]]
-	[[Category: Ciges~~, J R~~]]	+	[[Category: Bowring J]]
-	[[Category: Donderis, J]]	+	[[Category: Ciges JR]]
-	[[Category: Maiques, E]]	+	[[Category: Donderis J]]
-	[[Category: Marina, A]]	+	[[Category: Maiques E]]
-	[[Category: Penades~~, J R~~]]	+	[[Category: Marina A]]
-	[[Category: Quiles-Puchalt, N]]	+	[[Category: Penades JR]]
-	~~[[Category: Dut]]~~	+	[[Category: Quiles-Puchalt N]]
-	~~[[Category: Dutp]]~~	+
-	~~[[Category: G protein]]~~	+
-	~~[[Category: Gene transfer]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Moonlighting protein]]~~	+
-	~~[[Category: P-loop]]~~	+
-	~~[[Category: Pathogenicity island]]~~	+
-	~~[[Category: Phage]]~~	+
-	~~[[Category: Sapi induction~~]]	+

OCA at 11:32, 27 March 2020

2020-03-27T11:32:29Z

←Older revision		Revision as of 11:32, 27 March 2020
Line 1:		Line 1:

	==Staphylococcus bacteriophage 80alpha dUTPase G164S mutant with dUpNHpp.==		==Staphylococcus bacteriophage 80alpha dUTPase G164S mutant with dUpNHpp.==
-	<StructureSection load='5cct' size='340' side='right' caption='[[5cct]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5cct' size='340' side='right'caption='[[5cct]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cct]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CCT FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cct]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CCT FirstGlance]. <br>
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 5cct" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5cct" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DUTPase 3D structures\|DUTPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Alite, C]]		[[Category: Alite, C]]
	[[Category: Bowring, J]]		[[Category: Bowring, J]]

OCA at 18:35, 12 July 2016

2016-07-12T18:35:55Z

←Older revision		Revision as of 18:35, 12 July 2016
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zez\|3zez]], [[5cco\|5cco]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zez\|3zez]], [[5cco\|5cco]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cct OCA], [http://pdbe.org/5cct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cct RCSB], [http://www.ebi.ac.uk/pdbsum/5cct PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cct OCA], [http://pdbe.org/5cct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cct RCSB], [http://www.ebi.ac.uk/pdbsum/5cct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cct ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:58, 15 May 2016

2016-05-15T16:58:02Z

←Older revision		Revision as of 16:58, 15 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5cct is ~~ON HOLD~~	+	==Staphylococcus bacteriophage 80alpha dUTPase G164S mutant with dUpNHpp.==
		+	<StructureSection load='5cct' size='340' side='right' caption='[[5cct]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5cct]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CCT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zez\|3zez]], [[5cco\|5cco]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cct OCA], [http://pdbe.org/5cct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cct RCSB], [http://www.ebi.ac.uk/pdbsum/5cct PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have recently proposed that the trimeric staphylococcal phage encoded dUTPases (Duts) are signaling molecules that act analogously to eukaryotic G-proteins, using dUTP as a second messenger. To perform this regulatory role, the Duts require their characteristic extra motif VI, present in all the staphylococcal phage coded trimeric Duts, as well as the strongly conserved Dut motif V. Recently, however, an alternative model involving Duts in the transfer of the staphylococcal islands (SaPIs) has been suggested, questioning the implication of motifs V and VI. Here, using state-of the-art techniques, we have revisited the proposed models. Our results confirm that the mechanism by which the Duts derepress the SaPI cycle depends on dUTP and involves both motifs V and VI, as we have previously proposed. Surprisingly, the conserved Dut motif IV is also implicated in SaPI derepression. However, and in agreement with the proposed alternative model, the dUTP inhibits rather than inducing the process, as we had initially proposed. In summary, our results clarify, validate and establish the mechanism by which the Duts perform regulatory functions.

-	~~Authors: Maiques~~, E., Quiles-Puchalt, N., Donderis, J., Ciges~~, J.R.~~, Alite, C., Bowring, J., Penades~~, J.R.~~, Marina, A.	+	Another look at the mechanism involving trimeric dUTPases in Staphylococcus aureus pathogenicity island induction involves novel players in the party.,Maiques E, Quiles-Puchalt N, Donderis J, Ciges-Tomas JR, Alite C, Bowring JZ, Humphrey S, Penades JR, Marina A Nucleic Acids Res. 2016 Apr 25. pii: gkw317. PMID:27112567<ref>PMID:27112567</ref>

-	~~Description: Staphylococcus bacteriophage 80alpha dUTPase G164S mutant with dUpNHpp~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category: Quiles~~-~~Puchalt, N]]~~	+	<div class="pdbe-citations 5cct" style="background-color:#fffaf0;"></div>
-	~~[[Category~~: ~~Penades, J.R]]~~	+	== References ==
-	~~[[Category: Maiques, E]]~~	+	<references/>
-	~~[[Category: Bowring, J]]~~	+	__TOC__
-	~~[[Category: Ciges, J.R]]~~	+	</StructureSection>
	[[Category: Alite, C]]		[[Category: Alite, C]]
		+	[[Category: Bowring, J]]
		+	[[Category: Ciges, J R]]
	[[Category: Donderis, J]]		[[Category: Donderis, J]]
		+	[[Category: Maiques, E]]
	[[Category: Marina, A]]		[[Category: Marina, A]]
		+	[[Category: Penades, J R]]
		+	[[Category: Quiles-Puchalt, N]]
		+	[[Category: Dut]]
		+	[[Category: Dutp]]
		+	[[Category: G protein]]
		+	[[Category: Gene transfer]]
		+	[[Category: Hydrolase]]
		+	[[Category: Moonlighting protein]]
		+	[[Category: P-loop]]
		+	[[Category: Pathogenicity island]]
		+	[[Category: Phage]]
		+	[[Category: Sapi induction]]

OCA at 10:27, 16 December 2015

2015-12-16T10:27:40Z

←Older revision		Revision as of 10:27, 16 December 2015
Line 7:		Line 7:
	Description: Staphylococcus bacteriophage 80alpha dUTPase G164S mutant with dUpNHpp.		Description: Staphylococcus bacteriophage 80alpha dUTPase G164S mutant with dUpNHpp.
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Quiles-Puchalt, N]]
		+	[[Category: Penades, J.R]]
	[[Category: Maiques, E]]		[[Category: Maiques, E]]
	[[Category: Bowring, J]]		[[Category: Bowring, J]]
	[[Category: Ciges, J.R]]		[[Category: Ciges, J.R]]
-	[[Category: Quiles-Puchalt, N]]
-	[[Category: Penades, J.R]]
	[[Category: Alite, C]]		[[Category: Alite, C]]
	[[Category: Donderis, J]]		[[Category: Donderis, J]]
	[[Category: Marina, A]]		[[Category: Marina, A]]

OCA: Protected "5cct" [edit=sysop:move=sysop]

2015-07-15T12:23:15Z

Protected "5cct" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:23, 15 July 2015

OCA: New page: '''Unreleased structure''' The entry 5cct is ON HOLD Authors: Maiques, E., Quiles-Puchalt, N., Donderis, J., Ciges, J.R., Alite, C., Bowring, J., Penades, J.R., Marina, A. Description:...

2015-07-15T12:23:14Z

New page: '''Unreleased structure''' The entry 5cct is ON HOLD Authors: Maiques, E., Quiles-Puchalt, N., Donderis, J., Ciges, J.R., Alite, C., Bowring, J., Penades, J.R., Marina, A. Description:...

New page

'''Unreleased structure'''

The entry 5cct is ON HOLD

Authors: Maiques, E., Quiles-Puchalt, N., Donderis, J., Ciges, J.R., Alite, C., Bowring, J., Penades, J.R., Marina, A.

Description: Staphylococcus bacteriophage 80alpha dUTPase G164S mutant with dUpNHpp.
[[Category: Unreleased Structures]]
[[Category: Maiques, E]]
[[Category: Bowring, J]]
[[Category: Ciges, J.R]]
[[Category: Quiles-Puchalt, N]]
[[Category: Penades, J.R]]
[[Category: Alite, C]]
[[Category: Donderis, J]]
[[Category: Marina, A]]