5cea - Revision history

OCA at 11:44, 9 May 2024

2024-05-09T11:44:51Z

←Older revision		Revision as of 11:44, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cea]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bdellovibrio_bacteriovorus_HD100 Bdellovibrio bacteriovorus HD100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CEA FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cea]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bdellovibrio_bacteriovorus_HD100 Bdellovibrio bacteriovorus HD100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CEA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cea OCA], [https://pdbe.org/5cea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cea RCSB], [https://www.ebi.ac.uk/pdbsum/5cea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cea ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cea OCA], [https://pdbe.org/5cea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cea RCSB], [https://www.ebi.ac.uk/pdbsum/5cea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cea ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 12:01, 14 June 2023

2023-06-14T12:01:11Z

←Older revision		Revision as of 12:01, 14 June 2023
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	<StructureSection load='5cea' size='340' side='right'caption='[[5cea]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='5cea' size='340' side='right'caption='[[5cea]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5cea]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bdeba Bdeba~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CEA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5cea]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bdellovibrio_bacteriovorus_HD100 Bdellovibrio bacteriovorus HD100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CEA FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bd3460 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264462 BDEBA])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cea OCA], [https://pdbe.org/5cea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cea RCSB], [https://www.ebi.ac.uk/pdbsum/5cea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cea ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cea OCA], [~~http~~://pdbe.org/5cea PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cea RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cea PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cea ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6MHS9_BDEBA Q6MHS9_BDEBA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bdeba~~]]	+	[[Category: Bdellovibrio bacteriovorus HD100]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cadby~~, I T~~]]	+	[[Category: Cadby IT]]
-	[[Category: Lambert, C]]	+	[[Category: Lambert C]]
-	[[Category: Lovering~~, A L~~]]	+	[[Category: Lovering AL]]
-	[[Category: Sockett~~, R E]]~~	+	[[Category: Sockett RE]]
-	~~[[Category: Ankyrin repeat]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 11:34, 27 March 2020

2020-03-27T11:34:39Z

←Older revision		Revision as of 11:34, 27 March 2020
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		+
	==Bd3460 Immunity Protein from Bdellovibrio bacteriovorus==		==Bd3460 Immunity Protein from Bdellovibrio bacteriovorus==
-	<StructureSection load='5cea' size='340' side='right' caption='[[5cea]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='5cea' size='340' side='right'caption='[[5cea]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5cea]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CEA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5cea]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdeba Bdeba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CEA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cea OCA], [http://pdbe.org/5cea PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cea RCSB], [http://www.ebi.ac.uk/pdbsum/5cea PDBsum]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bd3460 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264462 BDEBA])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cea OCA], [http://pdbe.org/5cea PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cea RCSB], [http://www.ebi.ac.uk/pdbsum/5cea PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cea ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bdeba]]
		+	[[Category: Large Structures]]
	[[Category: Cadby, I T]]		[[Category: Cadby, I T]]
	[[Category: Lambert, C]]		[[Category: Lambert, C]]

OCA at 06:57, 16 December 2015

2015-12-16T06:57:53Z

←Older revision		Revision as of 06:57, 16 December 2015
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	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cea OCA], [http://pdbe.org/5cea PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cea RCSB], [http://www.ebi.ac.uk/pdbsum/5cea PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cea OCA], [http://pdbe.org/5cea PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cea RCSB], [http://www.ebi.ac.uk/pdbsum/5cea PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Predatory Bdellovibrio bacteriovorus are natural antimicrobial organisms, killing other bacteria by whole-cell invasion. Self-protection against prey-metabolizing enzymes is important for the evolution of predation. Initial prey entry involves the predator's peptidoglycan DD-endopeptidases, which decrosslink cell walls and prevent wasteful entry by a second predator. Here we identify and characterize a self-protection protein from B. bacteriovorus, Bd3460, which displays an ankyrin-based fold common to intracellular pathogens of eukaryotes. Co-crystal structures reveal Bd3460 complexation of dual targets, binding a conserved epitope of each of the Bd3459 and Bd0816 endopeptidases. Complexation inhibits endopeptidase activity and cell wall decrosslinking in vitro. Self-protection is vital - DeltaBd3460 Bdellovibrio deleteriously decrosslink self-peptidoglycan upon invasion, adopt a round morphology, and lose predatory capacity and cellular integrity. Our analysis provides the first mechanistic examination of self-protection in Bdellovibrio, documents protection-multiplicity for products of two different genomic loci, and reveals an important evolutionary adaptation to an invasive predatory bacterial lifestyle.
		+
		+	Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus.,Lambert C, Cadby IT, Till R, Bui NK, Lerner TR, Hughes WS, Lee DJ, Alderwick LJ, Vollmer W, Sockett ER, Lovering AL Nat Commun. 2015 Dec 2;6:8884. doi: 10.1038/ncomms9884. PMID:26626559<ref>PMID:26626559</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5cea" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:48, 9 December 2015

2015-12-09T13:48:34Z

←Older revision		Revision as of 13:48, 9 December 2015
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-	'''~~Unreleased structure~~'''	+	==Bd3460 Immunity Protein from Bdellovibrio bacteriovorus==
-		+	<StructureSection load='5cea' size='340' side='right' caption='[[5cea]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~The entry~~ 5cea is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5cea]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CEA FirstGlance]. <br>
-	~~Authors~~: ~~Lovering, A~~.L., ~~Cadby, I~~.T., ~~Lambert, C~~., ~~Sockett~~, R.E.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cea OCA], [http://pdbe.org/5cea PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cea RCSB], [http://www.ebi.ac.uk/pdbsum/5cea PDBsum]</span></td></tr>
-		+	</table>
-	~~Description: Bd3460 Immunity Protein from Bdellovibrio bacteriovorus~~	+	__TOC__
-	[[Category: ~~Unreleased Structures~~]]	+	</StructureSection>
		+	[[Category: Cadby, I T]]
	[[Category: Lambert, C]]		[[Category: Lambert, C]]
-	[[Category: ~~Cadby~~, ~~I.T~~]]	+	[[Category: Lovering, A L]]
-	[[Category: ~~Lovering~~, ~~A.L~~]]	+	[[Category: Sockett, R E]]
-	[[Category: ~~Sockett, R.E~~]]	+	[[Category: Ankyrin repeat]]
		+	[[Category: Protein binding]]

OCA at 13:19, 29 July 2015

2015-07-29T13:19:53Z

←Older revision		Revision as of 13:19, 29 July 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5cea is ON HOLD	+	The entry 5cea is ON HOLD until Paper Publication

	Authors: Lovering, A.L., Cadby, I.T., Lambert, C., Sockett, R.E.		Authors: Lovering, A.L., Cadby, I.T., Lambert, C., Sockett, R.E.

OCA: Protected "5cea" [edit=sysop:move=sysop]

2015-07-15T12:27:30Z

Protected "5cea" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:27, 15 July 2015

OCA: New page: '''Unreleased structure''' The entry 5cea is ON HOLD Authors: Lovering, A.L., Cadby, I.T., Lambert, C., Sockett, R.E. Description: Bd3460 Immunity Protein from Bdellovibrio bacteriovor...

2015-07-15T12:27:28Z

New page: '''Unreleased structure''' The entry 5cea is ON HOLD Authors: Lovering, A.L., Cadby, I.T., Lambert, C., Sockett, R.E. Description: Bd3460 Immunity Protein from Bdellovibrio bacteriovor...

New page

'''Unreleased structure'''

The entry 5cea is ON HOLD

Authors: Lovering, A.L., Cadby, I.T., Lambert, C., Sockett, R.E.

Description: Bd3460 Immunity Protein from Bdellovibrio bacteriovorus
[[Category: Unreleased Structures]]
[[Category: Lambert, C]]
[[Category: Cadby, I.T]]
[[Category: Lovering, A.L]]
[[Category: Sockett, R.E]]