5cex - Revision history

OCA at 08:37, 27 September 2023

2023-09-27T08:37:24Z

←Older revision		Revision as of 08:37, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cex]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CEX FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cex]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CEX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.105Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cex OCA], [https://pdbe.org/5cex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cex RCSB], [https://www.ebi.ac.uk/pdbsum/5cex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cex ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cex OCA], [https://pdbe.org/5cex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cex RCSB], [https://www.ebi.ac.uk/pdbsum/5cex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cex ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:02, 14 June 2023

2023-06-14T12:02:09Z

←Older revision		Revision as of 12:02, 14 June 2023
Line 3:		Line 3:
	<StructureSection load='5cex' size='340' side='right'caption='[[5cex]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5cex' size='340' side='right'caption='[[5cex]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5cex]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CEX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5cex]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CEX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cey\|5cey]], [[5cez\|5cez]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cex OCA], [https://pdbe.org/5cex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cex RCSB], [https://www.ebi.ac.uk/pdbsum/5cex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cex ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cex OCA], [~~http~~://pdbe.org/5cex PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cex RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cex PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cex ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Sandbox 20009\|Sandbox 20009]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Garces, F]]	+	[[Category: Garces F]]
-	[[Category: Wilson~~, I A]]~~	+	[[Category: Wilson IA]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Hiv-1]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 11:35, 27 March 2020

2020-03-27T11:35:49Z

←Older revision		Revision as of 11:35, 27 March 2020
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		+
	==Crystal Structure of Fab 32H+109L, a putative precursor of the PGT121 family of potent HIV-1 antibodies==		==Crystal Structure of Fab 32H+109L, a putative precursor of the PGT121 family of potent HIV-1 antibodies==
-	<StructureSection load='5cex' size='340' side='right' caption='[[5cex]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='5cex' size='340' side='right'caption='[[5cex]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5cex]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CEX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5cex]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CEX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cey\|5cey]], [[5cez\|5cez]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cey\|5cey]], [[5cez\|5cez]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cex OCA], [http://pdbe.org/5cex PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cex RCSB], [http://www.ebi.ac.uk/pdbsum/5cex PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cex OCA], [http://pdbe.org/5cex PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cex RCSB], [http://www.ebi.ac.uk/pdbsum/5cex PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cex ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 5cex" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5cex" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Garces, F]]		[[Category: Garces, F]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]

OCA at 04:49, 7 January 2016

2016-01-07T04:49:50Z

←Older revision		Revision as of 04:49, 7 January 2016
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cex OCA], [http://pdbe.org/5cex PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cex RCSB], [http://www.ebi.ac.uk/pdbsum/5cex PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cex OCA], [http://pdbe.org/5cex PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cex RCSB], [http://www.ebi.ac.uk/pdbsum/5cex PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The high-mannose patch on the HIV-1 envelope (Env) glycoprotein is the epicenter for binding of the potent broadly neutralizing PGT121 family of antibodies, but strategies for generating such antibodies by vaccination have not been defined. We generated structures of inferred antibody intermediates by X-ray crystallography and electron microscopy to elucidate the molecular events that occurred during evolution of this family. Binding analyses revealed that affinity maturation was primarily focused on avoiding, accommodating, or binding the N137 glycan. The overall antibody approach angle to Env was defined very early in the maturation process, yet some variation evolved in the PGT121 family branches that led to differences in glycan specificities in their respective epitopes. Furthermore, we determined a crystal structure of the recombinant BG505 SOSIP.664 HIV-1 trimer with a PGT121 family member at 3.0 A that, in concert with these antibody intermediate structures, provides insights to advance design of HIV vaccine candidates.
		+
		+	Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.,Garces F, Lee JH, de Val N, Torrents de la Pena A, Kong L, Puchades C, Hua Y, Stanfield RL, Burton DR, Moore JP, Sanders RW, Ward AB, Wilson IA Immunity. 2015 Dec 15;43(6):1053-63. doi: 10.1016/j.immuni.2015.11.007. PMID:26682982<ref>PMID:26682982</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5cex" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:48, 23 December 2015

2015-12-23T12:48:35Z

←Older revision		Revision as of 12:48, 23 December 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of Fab 32H+109L, a putative precursor of the PGT121 family of potent HIV-1 antibodies==
-		+	<StructureSection load='5cex' size='340' side='right' caption='[[5cex]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~The entry~~ 5cex is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5cex]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CEX FirstGlance]. <br>
-	~~Authors~~: ~~Garces, F~~.~~, Wilson, I~~.A.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cey\|5cey]], [[5cez\|5cez]]</td></tr>
-	~~Description~~:	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cex OCA], [http://pdbe.org/5cex PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cex RCSB], [http://www.ebi.ac.uk/pdbsum/5cex PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Wilson~~, I.A]]	+	__TOC__
		+	</StructureSection>
	[[Category: Garces, F]]		[[Category: Garces, F]]
		+	[[Category: Wilson, I A]]
		+	[[Category: Antibody]]
		+	[[Category: Hiv-1]]
		+	[[Category: Immune system]]

OCA at 13:03, 22 July 2015

2015-07-22T13:03:32Z

←Older revision		Revision as of 13:03, 22 July 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5cex is ON HOLD	+	The entry 5cex is ON HOLD until Paper Publication

	Authors: Garces, F., Wilson, I.A.		Authors: Garces, F., Wilson, I.A.

OCA: Protected "5cex" [edit=sysop:move=sysop]

2015-07-15T12:29:16Z

Protected "5cex" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:29, 15 July 2015

OCA: New page: '''Unreleased structure''' The entry 5cex is ON HOLD Authors: Garces, F., Wilson, I.A. Description: Category: Unreleased Structures Category: Wilson, I.A [[Category: Garces, F...

2015-07-15T12:29:15Z

New page: '''Unreleased structure''' The entry 5cex is ON HOLD Authors: Garces, F., Wilson, I.A. Description: Category: Unreleased Structures Category: Wilson, I.A [[Category: Garces, F...

New page

'''Unreleased structure'''

The entry 5cex is ON HOLD

Authors: Garces, F., Wilson, I.A.

Description:
[[Category: Unreleased Structures]]
[[Category: Wilson, I.A]]
[[Category: Garces, F]]