5ch5 - Revision history

OCA at 08:37, 27 September 2023

2023-09-27T08:37:55Z

←Older revision		Revision as of 08:37, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ch5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lucilia_cuprina Lucilia cuprina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CH5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CH5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ch5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lucilia_cuprina Lucilia cuprina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CH5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CH5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.53Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ch5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ch5 OCA], [https://pdbe.org/5ch5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ch5 RCSB], [https://www.ebi.ac.uk/pdbsum/5ch5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ch5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ch5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ch5 OCA], [https://pdbe.org/5ch5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ch5 RCSB], [https://www.ebi.ac.uk/pdbsum/5ch5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ch5 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:06, 14 June 2023

2023-06-14T12:06:11Z

←Older revision		Revision as of 12:06, 14 June 2023
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	<StructureSection load='5ch5' size='340' side='right'caption='[[5ch5]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='5ch5' size='340' side='right'caption='[[5ch5]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ch5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Australian_sheep_blowfly Australian sheep blowfly~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CH5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CH5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ch5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lucilia_cuprina Lucilia cuprina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CH5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CH5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ch3\|5ch3]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ch5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ch5 OCA], [https://pdbe.org/5ch5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ch5 RCSB], [https://www.ebi.ac.uk/pdbsum/5ch5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ch5 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LcaE7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7375 Australian sheep blowfly])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ch5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ch5 OCA], [~~http~~://pdbe.org/5ch5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ch5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ch5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ch5 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q25252_LUCCU Q25252_LUCCU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Australian sheep blowfly]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Correy, G~~]]	+	[[Category: Lucilia cuprina]]
-	[[Category: ~~Jackson, C J~~]]	+	[[Category: Correy G]]
-	[[Category: ~~Mabbitt, P~~]]	+	[[Category: Jackson CJ]]
-	[[Category: ~~Carboxylesterase]]~~	+	[[Category: Mabbitt P]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Op-hydrolase]]~~	+
-	~~[[Category: Organophosphate]]~~	+
-	~~[[Category: Structural dynamic~~]]	+

OCA at 11:38, 27 March 2020

2020-03-27T11:38:13Z

←Older revision		Revision as of 11:38, 27 March 2020
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	==E3 alpha-esterase-7 carboxylesterase==		==E3 alpha-esterase-7 carboxylesterase==
-	<StructureSection load='5ch5' size='340' side='right' caption='[[5ch5]], [[Resolution\|resolution]] 1.53Å' scene=''>	+	<StructureSection load='5ch5' size='340' side='right'caption='[[5ch5]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ch5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CH5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ch5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Australian_sheep_blowfly Australian sheep blowfly]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CH5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ch3\|5ch3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ch3\|5ch3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LcaE7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7375 Australian sheep blowfly])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ch5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ch5 OCA], [http://pdbe.org/5ch5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ch5 RCSB], [http://www.ebi.ac.uk/pdbsum/5ch5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ch5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ch5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ch5 OCA], [http://pdbe.org/5ch5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ch5 RCSB], [http://www.ebi.ac.uk/pdbsum/5ch5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ch5 ProSAT]</span></td></tr>
	</table>		</table>
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5ch5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ch5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carboxylesterase 3D structures\|Carboxylesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Australian sheep blowfly]]
		+	[[Category: Large Structures]]
	[[Category: Correy, G]]		[[Category: Correy, G]]
	[[Category: Jackson, C J]]		[[Category: Jackson, C J]]

OCA at 02:33, 13 July 2016

2016-07-13T02:33:58Z

←Older revision		Revision as of 02:33, 13 July 2016
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ch3\|5ch3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ch3\|5ch3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ch5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ch5 OCA], [http://pdbe.org/5ch5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ch5 RCSB], [http://www.ebi.ac.uk/pdbsum/5ch5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ch5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ch5 OCA], [http://pdbe.org/5ch5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ch5 RCSB], [http://www.ebi.ac.uk/pdbsum/5ch5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ch5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:08, 20 June 2016

2016-06-20T15:08:51Z

←Older revision		Revision as of 15:08, 20 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ch5 is ~~ON HOLD~~	+	==E3 alpha-esterase-7 carboxylesterase==
		+	<StructureSection load='5ch5' size='340' side='right' caption='[[5ch5]], [[Resolution\|resolution]] 1.53Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ch5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CH5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ch3\|5ch3]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ch5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ch5 OCA], [http://pdbe.org/5ch5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ch5 RCSB], [http://www.ebi.ac.uk/pdbsum/5ch5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The proper function of enzymes often depends upon their efficient interconversion between particular conformational sub-states on a free-energy landscape. Experimentally characterizing these sub-states is challenging, which has limited our understanding of the role of protein dynamics in many enzymes. Here, we have used a combination of kinetic crystallography and detailed analysis of crystallographic protein ensembles to map the accessible conformational landscape of an insect carboxylesterase (LcalphaE7) as it traverses all steps in its catalytic cycle. LcalphaE7 is of special interest because of its evolving role in organophosphate insecticide resistance. Our results reveal that a dynamically coupled network of residues extends from the substrate-binding site to a surface loop. Interestingly, the coupling of this network that is apparent in the apoenzyme appears to be reduced in the phosphorylated enzyme intermediate. Altogether, the results of this work highlight the importance of protein dynamics to enzyme function and the evolution of new activity.

-	~~Authors~~:	+	Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography.,Correy GJ, Carr PD, Meirelles T, Mabbitt PD, Fraser NJ, Weik M, Jackson CJ Structure. 2016 Jun 7;24(6):977-87. doi: 10.1016/j.str.2016.04.009. Epub 2016 May, 19. PMID:27210287<ref>PMID:27210287</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5ch5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Correy, G]]
		+	[[Category: Jackson, C J]]
		+	[[Category: Mabbitt, P]]
		+	[[Category: Carboxylesterase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Op-hydrolase]]
		+	[[Category: Organophosphate]]
		+	[[Category: Structural dynamic]]

OCA at 11:28, 15 May 2016

2016-05-15T11:28:24Z

←Older revision		Revision as of 11:28, 15 May 2016
Line 3:		Line 3:
	The entry 5ch5 is ON HOLD		The entry 5ch5 is ON HOLD

-	Authors: ~~Correy, G., Mabbitt, P., Jackson, C.J.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Correy, G]]
-	[[Category: Jackson, C.J]]
-	[[Category: Mabbitt, P]]

OCA at 10:31, 16 December 2015

2015-12-16T10:31:30Z

←Older revision		Revision as of 10:31, 16 December 2015
Line 7:		Line 7:
	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Correy, G]]
	[[Category: Jackson, C.J]]		[[Category: Jackson, C.J]]
	[[Category: Mabbitt, P]]		[[Category: Mabbitt, P]]
-	[[Category: Correy, G]]

OCA at 13:24, 29 July 2015

2015-07-29T13:24:45Z

←Older revision		Revision as of 13:24, 29 July 2015
Line 3:		Line 3:
	The entry 5ch5 is ON HOLD		The entry 5ch5 is ON HOLD

-	Authors: Correy, G. Mabbitt, P. Jackson, CJ.	+	Authors: Correy, G., Mabbitt, P., Jackson, C.J.

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Correy~~, G. Mabbitt, P~~. Jackson~~, Cj]]	+	[[Category: Jackson, C.J]]
		+	[[Category: Mabbitt, P]]
		+	[[Category: Correy, G]]

OCA: Protected "5ch5" [edit=sysop:move=sysop]

2015-07-15T12:34:58Z

Protected "5ch5" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:34, 15 July 2015

OCA: New page: '''Unreleased structure''' The entry 5ch5 is ON HOLD Authors: Correy, G. Mabbitt, P. Jackson, CJ. Description: Category: Unreleased Structures [[Category: Correy, G. Mabbitt, P. J...

2015-07-15T12:34:57Z

New page: '''Unreleased structure''' The entry 5ch5 is ON HOLD Authors: Correy, G. Mabbitt, P. Jackson, CJ. Description: Category: Unreleased Structures [[Category: Correy, G. Mabbitt, P. J...

New page

'''Unreleased structure'''

The entry 5ch5 is ON HOLD

Authors: Correy, G. Mabbitt, P. Jackson, CJ.

Description:
[[Category: Unreleased Structures]]
[[Category: Correy, G. Mabbitt, P. Jackson, Cj]]