5cp5 - Revision history

OCA at 09:09, 20 March 2024

2024-03-20T09:09:05Z

←Older revision		Revision as of 09:09, 20 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cp5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CP5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cp5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CP5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EB0:1-ETHYL-N-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDROBENZO[CD]INDOLE-6-SULFONAMIDE'>EB0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.79Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EB0:1-ETHYL-N-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDROBENZO[CD]INDOLE-6-SULFONAMIDE'>EB0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp5 OCA], [https://pdbe.org/5cp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cp5 RCSB], [https://www.ebi.ac.uk/pdbsum/5cp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cp5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp5 OCA], [https://pdbe.org/5cp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cp5 RCSB], [https://www.ebi.ac.uk/pdbsum/5cp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cp5 ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).		[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The discovery of inhibitors of bromodomain and extra terminal domain (BET) has achieved great progress, and at least seven inhibitors have progressed into clinical trials for the treatment of cancer or inflammatory diseases. Here, we describe the identification, optimization, and evaluation of benzo[cd]indol-2(1H)-one containing compounds as a new class of BET bromodomain inhibitors, starting from structure-based virtual screening (SBVS). Through structure-based optimization, potent compounds were obtained with significantly improved activity. The two most potent compounds bind to the BRD4 bromodomain, with Kd values of 124 and 137 nM. Selected compounds exhibited high selectivity over other non-BET subfamily members. Notably, compound 85 demonstrated a reasonable antiproliferation effect on MV4;11 leukemia cells and exhibited a good pharmacokinetic profile with high oral bioavailability (75.8%) and moderate half-life (T1/2 = 3.95 h). The resulting lead molecule 85 represents a new, potent, and selective class of BET bromodomain inhibitors for the development of therapeutics to treat cancer and inflammatory diseases.
-
-	Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation.,Xue X, Zhang Y, Liu Z, Song M, Xing Y, Xiang Q, Wang Z, Tu Z, Zhou Y, Ding K, Xu Y J Med Chem. 2016 Jan 12. PMID:26731490<ref>PMID:26731490</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 5cp5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 12:21, 14 June 2023

2023-06-14T12:21:40Z

←Older revision		Revision as of 12:21, 14 June 2023
Line 3:		Line 3:
	<StructureSection load='5cp5' size='340' side='right'caption='[[5cp5]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='5cp5' size='340' side='right'caption='[[5cp5]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5cp5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5cp5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CP5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB0:1-ETHYL-N-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDROBENZO[CD]INDOLE-6-SULFONAMIDE'>EB0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EB0:1-ETHYL-N-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDROBENZO[CD]INDOLE-6-SULFONAMIDE'>EB0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5coi\|5coi]], [[5cpe\|5cpe]], [[5cqt\|5cqt]], [[5crm\|5crm]], [[5crz\|5crz]], [[5cs8\|5cs8]], [[5ctl\|5ctl]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp5 OCA], [https://pdbe.org/5cp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cp5 RCSB], [https://www.ebi.ac.uk/pdbsum/5cp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cp5 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp5 OCA], [~~http~~://pdbe.org/5cp5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cp5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cp5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cp5 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liu, Z]]	+	[[Category: Liu Z]]
-	[[Category: Song, M]]	+	[[Category: Song M]]
-	[[Category: Xu, Y]]	+	[[Category: Xu Y]]
-	[[Category: Xue, X]]	+	[[Category: Xue X]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Brd4]]~~	+
-	~~[[Category: Bromodomain]]~~	+
-	~~[[Category: Four alpha helice]]~~	+
-	~~[[Category: Signaling protein-inhibitor complex]]~~	+
-	~~[[Category: Transcription-transcr~~]]	+

OCA at 11:48, 27 March 2020

2020-03-27T11:48:18Z

←Older revision		Revision as of 11:48, 27 March 2020
Line 1:		Line 1:

	==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==		==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==
-	<StructureSection load='5cp5' size='340' side='right' caption='[[5cp5]], [[Resolution\|resolution]] 1.79Å' scene=''>	+	<StructureSection load='5cp5' size='340' side='right'caption='[[5cp5]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5cp5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5cp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CP5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB0:1-ETHYL-N-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDROBENZO[CD]INDOLE-6-SULFONAMIDE'>EB0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB0:1-ETHYL-N-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDROBENZO[CD]INDOLE-6-SULFONAMIDE'>EB0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5coi\|5coi]], [[5cpe\|5cpe]], [[5cqt\|5cqt]], [[5crm\|5crm]], [[5crz\|5crz]], [[5cs8\|5cs8]], [[5ctl\|5ctl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5coi\|5coi]], [[5cpe\|5cpe]], [[5cqt\|5cqt]], [[5crm\|5crm]], [[5crz\|5crz]], [[5cs8\|5cs8]], [[5ctl\|5ctl]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp5 OCA], [http://pdbe.org/5cp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cp5 RCSB], [http://www.ebi.ac.uk/pdbsum/5cp5 PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp5 OCA], [http://pdbe.org/5cp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cp5 RCSB], [http://www.ebi.ac.uk/pdbsum/5cp5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cp5 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 24:

	==See Also==		==See Also==
-	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]	+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Liu, Z]]		[[Category: Liu, Z]]
	[[Category: Song, M]]		[[Category: Song, M]]

OCA at 19:54, 9 March 2016

2016-03-09T19:54:40Z

←Older revision		Revision as of 19:54, 9 March 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==		==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==
	<StructureSection load='5cp5' size='340' side='right' caption='[[5cp5]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='5cp5' size='340' side='right' caption='[[5cp5]], [[Resolution\|resolution]] 1.79Å' scene=''>
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).		[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The discovery of inhibitors of bromodomain and extra terminal domain (BET) has achieved great progress, and at least seven inhibitors have progressed into clinical trials for the treatment of cancer or inflammatory diseases. Here, we describe the identification, optimization, and evaluation of benzo[cd]indol-2(1H)-one containing compounds as a new class of BET bromodomain inhibitors, starting from structure-based virtual screening (SBVS). Through structure-based optimization, potent compounds were obtained with significantly improved activity. The two most potent compounds bind to the BRD4 bromodomain, with Kd values of 124 and 137 nM. Selected compounds exhibited high selectivity over other non-BET subfamily members. Notably, compound 85 demonstrated a reasonable antiproliferation effect on MV4;11 leukemia cells and exhibited a good pharmacokinetic profile with high oral bioavailability (75.8%) and moderate half-life (T1/2 = 3.95 h). The resulting lead molecule 85 represents a new, potent, and selective class of BET bromodomain inhibitors for the development of therapeutics to treat cancer and inflammatory diseases.
		+
		+	Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation.,Xue X, Zhang Y, Liu Z, Song M, Xing Y, Xiang Q, Wang Z, Tu Z, Zhou Y, Ding K, Xu Y J Med Chem. 2016 Jan 12. PMID:26731490<ref>PMID:26731490</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5cp5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:25, 27 January 2016

2016-01-27T18:25:56Z

←Older revision		Revision as of 18:25, 27 January 2016
Line 22:		Line 22:
	[[Category: Brd4]]		[[Category: Brd4]]
	[[Category: Bromodomain]]		[[Category: Bromodomain]]
-	[[Category: Dna binding protein-dna binding protein complex]]
	[[Category: Four alpha helice]]		[[Category: Four alpha helice]]
-	[[Category: ~~Inhibitor~~ complex]]	+	[[Category: Signaling protein-inhibitor complex]]
	[[Category: Transcription-transcr]]		[[Category: Transcription-transcr]]

OCA at 20:29, 13 January 2016

2016-01-13T20:29:50Z

←Older revision		Revision as of 20:29, 13 January 2016
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==
-		+	<StructureSection load='5cp5' size='340' side='right' caption='[[5cp5]], [[Resolution\|resolution]] 1.79Å' scene=''>
-	~~The entry 5cp5 is ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5cp5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CP5 FirstGlance]. <br>
-	~~Authors: Zhang, Y., Song, M., Liu, Z., Xue, X., Xu, Y.~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB0:1-ETHYL-N-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDROBENZO[CD]INDOLE-6-SULFONAMIDE'>EB0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5coi\|5coi]], [[5cpe\|5cpe]], [[5cqt\|5cqt]], [[5crm\|5crm]], [[5crz\|5crz]], [[5cs8\|5cs8]], [[5ctl\|5ctl]]</td></tr>
-	~~Description:~~ Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp5 OCA], [http://pdbe.org/5cp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cp5 RCSB], [http://www.ebi.ac.uk/pdbsum/5cp5 PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: Xu, Y]]	+	== Disease ==
-	[[~~Category~~: ~~Zhang~~, Y]]	+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
-	[[~~Category~~: ~~Xue~~, X]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Liu, Z]]		[[Category: Liu, Z]]
	[[Category: Song, M]]		[[Category: Song, M]]
		+	[[Category: Xu, Y]]
		+	[[Category: Xue, X]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Brd4]]
		+	[[Category: Bromodomain]]
		+	[[Category: Dna binding protein-dna binding protein complex]]
		+	[[Category: Four alpha helice]]
		+	[[Category: Inhibitor complex]]
		+	[[Category: Transcription-transcr]]

OCA at 10:39, 16 December 2015

2015-12-16T10:39:52Z

←Older revision		Revision as of 10:39, 16 December 2015
Line 9:		Line 9:
	[[Category: Xu, Y]]		[[Category: Xu, Y]]
	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]
		+	[[Category: Xue, X]]
	[[Category: Liu, Z]]		[[Category: Liu, Z]]
	[[Category: Song, M]]		[[Category: Song, M]]
-	[[Category: Xue, X]]

OCA at 12:01, 26 August 2015

2015-08-26T12:01:41Z

←Older revision		Revision as of 12:01, 26 August 2015
Line 3:		Line 3:
	The entry 5cp5 is ON HOLD until Paper Publication		The entry 5cp5 is ON HOLD until Paper Publication

-	Authors: Zhang, Y., Song, M., Liu, Z., Xue, X.	+	Authors: Zhang, Y., Song, M., Liu, Z., Xue, X., Xu, Y.

-	Description: Crystal Structure ~~Analysis~~ of the BRD4(1)	+	Description: Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Xu, Y]]
	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]
	[[Category: Liu, Z]]		[[Category: Liu, Z]]
	[[Category: Song, M]]		[[Category: Song, M]]
	[[Category: Xue, X]]		[[Category: Xue, X]]

OCA at 13:20, 12 August 2015

2015-08-12T13:20:43Z

←Older revision		Revision as of 13:20, 12 August 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5cp5 is ON HOLD	+	The entry 5cp5 is ON HOLD until Paper Publication

	Authors: Zhang, Y., Song, M., Liu, Z., Xue, X.		Authors: Zhang, Y., Song, M., Liu, Z., Xue, X.

OCA: Protected "5cp5" [edit=sysop:move=sysop]

2015-07-29T13:40:37Z

Protected "5cp5" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:40, 29 July 2015