5d1u - Revision history

OCA at 08:42, 27 September 2023

2023-09-27T08:42:27Z

←Older revision		Revision as of 08:42, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5d1u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D1U FirstGlance]. <br>		<table><tr><td colspan='2'>[[5d1u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D1U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=56P:N~2~-(6-AMINOHEXYL)-N~2~-[(4-FLUORO-3-METHYLPHENYL)SULFONYL]-N-HYDROXY-D-ALANINAMIDE'>56P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8503Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=56P:N~2~-(6-AMINOHEXYL)-N~2~-[(4-FLUORO-3-METHYLPHENYL)SULFONYL]-N-HYDROXY-D-ALANINAMIDE'>56P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d1u OCA], [https://pdbe.org/5d1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d1u RCSB], [https://www.ebi.ac.uk/pdbsum/5d1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d1u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d1u OCA], [https://pdbe.org/5d1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d1u RCSB], [https://www.ebi.ac.uk/pdbsum/5d1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d1u ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:18, 21 June 2023

2023-06-21T10:18:28Z

←Older revision		Revision as of 10:18, 21 June 2023
Line 3:		Line 3:
	<StructureSection load='5d1u' size='340' side='right'caption='[[5d1u]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='5d1u' size='340' side='right'caption='[[5d1u]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5d1u]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var.~~ anthracis~~" (cohn 1872) smith et al. 1946~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D1U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5D1U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5d1u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D1U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=56P:N~2~-(6-AMINOHEXYL)-N~2~-[(4-FLUORO-3-METHYLPHENYL)SULFONYL]-N-HYDROXY-D-ALANINAMIDE'>56P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=56P:N~2~-(6-AMINOHEXYL)-N~2~-[(4-FLUORO-3-METHYLPHENYL)SULFONYL]-N-HYDROXY-D-ALANINAMIDE'>56P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yqy\|1yqy]], [[4pkq\|4pkq]], [[4pkr\|4pkr]], [[4pks\|4pks]], [[4pkt\|4pkt]], [[4pku\|4pku]], [[4pkv\|4pkv]], [[4pkw\|4pkw]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d1u OCA], [https://pdbe.org/5d1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d1u RCSB], [https://www.ebi.ac.uk/pdbsum/5d1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d1u ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lef, pXO1-107, BXA0172, GBAA_pXO1_0172 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.83 3.4.24.83] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5d1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d1u OCA], [~~http~~://pdbe.org/5d1u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5d1u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5d1u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5d1u ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LEF_BACAN LEF_BACAN]] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. LF is the lethal factor that, when associated with PA, causes death. LF is not toxic by itself. It is a protease that cleaves the N-terminal of most dual specificity mitogen-activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N-terminal proline-rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein-protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LeTx intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates.<ref>PMID:9563949</ref> <ref>PMID:9703991</ref> <ref>PMID:10475971</ref> <ref>PMID:11104681</ref> <ref>PMID:10338520</ref>	+	[https://www.uniprot.org/uniprot/LEF_BACAN LEF_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. LF is the lethal factor that, when associated with PA, causes death. LF is not toxic by itself. It is a protease that cleaves the N-terminal of most dual specificity mitogen-activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N-terminal proline-rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein-protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LeTx intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates.<ref>PMID:9563949</ref> <ref>PMID:9703991</ref> <ref>PMID:10475971</ref> <ref>PMID:11104681</ref> <ref>PMID:10338520</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hydrolase~~]]	+	[[Category: Bacillus anthracis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Finzel~~, B C~~]]	+	[[Category: Finzel BC]]
-	[[Category: Maize~~, K M]]~~	+	[[Category: Maize KM]]
-	~~[[Category: Anthrax toxin]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Lethal factor]]~~	+
-	~~[[Category: Ligand-induced conformational change]]~~	+
-	~~[[Category: Metalloprotease]]~~	+
-	~~[[Category: Metalloproteinase]]~~	+
-	~~[[Category: Structural dynamic~~]]	+

OCA at 16:01, 11 December 2019

2019-12-11T16:01:19Z

←Older revision		Revision as of 16:01, 11 December 2019
Line 1:		Line 1:

	==Anthrax toxin lethal factor with hydroxamic acid inhibitor==		==Anthrax toxin lethal factor with hydroxamic acid inhibitor==
-	<StructureSection load='5d1u' size='340' side='right' caption='[[5d1u]], [[Resolution\|resolution]] 2.85Å' scene=''>	+	<StructureSection load='5d1u' size='340' side='right'caption='[[5d1u]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5d1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D1U FirstGlance]. <br>		<table><tr><td colspan='2'>[[5d1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D1U FirstGlance]. <br>
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5d1u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5d1u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Anthrax lethal factor 3D structures\|Anthrax lethal factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
		+	[[Category: Large Structures]]
	[[Category: Finzel, B C]]		[[Category: Finzel, B C]]
	[[Category: Maize, K M]]		[[Category: Maize, K M]]

OCA at 14:04, 16 November 2017

2017-11-16T14:04:43Z

←Older revision		Revision as of 14:04, 16 November 2017
Line 1:		Line 1:
		+
	==Anthrax toxin lethal factor with hydroxamic acid inhibitor==		==Anthrax toxin lethal factor with hydroxamic acid inhibitor==
	<StructureSection load='5d1u' size='340' side='right' caption='[[5d1u]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='5d1u' size='340' side='right' caption='[[5d1u]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5d1u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D1U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5d1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D1U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=56P:N~2~-(6-AMINOHEXYL)-N~2~-[(4-FLUORO-3-METHYLPHENYL)SULFONYL]-N-HYDROXY-D-ALANINAMIDE'>56P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=56P:N~2~-(6-AMINOHEXYL)-N~2~-[(4-FLUORO-3-METHYLPHENYL)SULFONYL]-N-HYDROXY-D-ALANINAMIDE'>56P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yqy\|1yqy]], [[4pkq\|4pkq]], [[4pkr\|4pkr]], [[4pks\|4pks]], [[4pkt\|4pkt]], [[4pku\|4pku]], [[4pkv\|4pkv]], [[4pkw\|4pkw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yqy\|1yqy]], [[4pkq\|4pkq]], [[4pkr\|4pkr]], [[4pks\|4pks]], [[4pkt\|4pkt]], [[4pku\|4pku]], [[4pkv\|4pkv]], [[4pkw\|4pkw]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lef, pXO1-107, BXA0172, GBAA_pXO1_0172 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.83 3.4.24.83] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.83 3.4.24.83] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d1u OCA], [http://pdbe.org/5d1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d1u RCSB], [http://www.ebi.ac.uk/pdbsum/5d1u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d1u OCA], [http://pdbe.org/5d1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d1u RCSB], [http://www.ebi.ac.uk/pdbsum/5d1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d1u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:00, 30 November 2015

2015-11-30T20:00:34Z

←Older revision		Revision as of 20:00, 30 November 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Anthrax toxin lethal factor with hydroxamic acid inhibitor==
		+	<StructureSection load='5d1u' size='340' side='right' caption='[[5d1u]], [[Resolution\|resolution]] 2.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5d1u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D1U FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=56P:N~2~-(6-AMINOHEXYL)-N~2~-[(4-FLUORO-3-METHYLPHENYL)SULFONYL]-N-HYDROXY-D-ALANINAMIDE'>56P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yqy\|1yqy]], [[4pkq\|4pkq]], [[4pkr\|4pkr]], [[4pks\|4pks]], [[4pkt\|4pkt]], [[4pku\|4pku]], [[4pkv\|4pkv]], [[4pkw\|4pkw]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.83 3.4.24.83] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d1u OCA], [http://pdbe.org/5d1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d1u RCSB], [http://www.ebi.ac.uk/pdbsum/5d1u PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LEF_BACAN LEF_BACAN]] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. LF is the lethal factor that, when associated with PA, causes death. LF is not toxic by itself. It is a protease that cleaves the N-terminal of most dual specificity mitogen-activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N-terminal proline-rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein-protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LeTx intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates.<ref>PMID:9563949</ref> <ref>PMID:9703991</ref> <ref>PMID:10475971</ref> <ref>PMID:11104681</ref> <ref>PMID:10338520</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The lethal factor (LF) enzyme secreted by Bacillus anthracis is a zinc hydrolase that is chiefly responsible for anthrax-related cell death. Although many studies of the design of small molecule LF inhibitors have been conducted, no LF inhibitor is yet available as a therapeutic agent. Inhibitors with considerable chemical diversity have been developed and investigated; however, the LF S2' subsite has not yet been systematically explored as a potential target for lead optimization. Here we present synthesis, experimental evaluation, modeling, and structural biology for a novel series of sulfonamide hydroxamate LF inhibitor analogues specifically designed to extend into, and probe chemical preferences of, this S2' subsite. We discovered that this region accommodates a wide variety of chemical functionalities and that a broad selection of ligand structural modifications directed to this area can be incorporated without significant deleterious alterations in biological activity. We also identified key residues in this subsite that can potentially be targeted to improve inhibitor binding.

-	~~The entry 5d1u is ON HOLD until Paper Publication~~	+	Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.,Kurbanov EK, Chiu TL, Solberg J, Francis S, Maize KM, Fernandez J, Johnson RL, Hawkinson JE, Walters MA, Finzel BC, Amin EA J Med Chem. 2015 Nov 12;58(21):8723-33. doi: 10.1021/acs.jmedchem.5b01446. Epub, 2015 Oct 29. PMID:26492514<ref>PMID:26492514</ref>

-	~~Authors: Maize~~, K.M., Finzel, B.C.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: Anthrax toxin ~~lethal factor with hydroxamic acid~~ inhibitor	+	<div class="pdbe-citations 5d1u" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
-	[[Category: ~~Maize, K.M~~]]	+	<references/>
-	[[Category: ~~Finzel, B.C~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Hydrolase]]
		+	[[Category: Finzel, B C]]
		+	[[Category: Maize, K M]]
		+	[[Category: Anthrax toxin]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Lethal factor]]
		+	[[Category: Ligand-induced conformational change]]
		+	[[Category: Metalloprotease]]
		+	[[Category: Metalloproteinase]]
		+	[[Category: Structural dynamic]]

OCA at 11:16, 20 August 2015

2015-08-20T11:16:42Z

←Older revision		Revision as of 11:16, 20 August 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5d1u is ON HOLD	+	The entry 5d1u is ON HOLD until Paper Publication

	Authors: Maize, K.M., Finzel, B.C.		Authors: Maize, K.M., Finzel, B.C.

OCA: Protected "5d1u" [edit=sysop:move=sysop]

2015-08-12T13:43:06Z

Protected "5d1u" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:43, 12 August 2015

OCA: New page: '''Unreleased structure''' The entry 5d1u is ON HOLD Authors: Maize, K.M., Finzel, B.C. Description: Anthrax toxin lethal factor with hydroxamic acid inhibitor [[Category: Unreleased S...

2015-08-12T13:43:05Z

New page: '''Unreleased structure''' The entry 5d1u is ON HOLD Authors: Maize, K.M., Finzel, B.C. Description: Anthrax toxin lethal factor with hydroxamic acid inhibitor [[Category: Unreleased S...

New page

'''Unreleased structure'''

The entry 5d1u is ON HOLD

Authors: Maize, K.M., Finzel, B.C.

Description: Anthrax toxin lethal factor with hydroxamic acid inhibitor
[[Category: Unreleased Structures]]
[[Category: Maize, K.M]]
[[Category: Finzel, B.C]]